CURRICULUM VITAE 1. Date: November, 2004 PERSONAL 2. Name: Kermit L. Carraway 3. Office Phone: (305) 243-6512 1. Current Rank: Professor 2. Primary Department: Cell Biology and Anatomy 3. Secondary or Joint Appointments: Biochemistry and Molecular Biology 4. Citizenship: U.S.A. 5. Visa Type: N/A HIGHER EDUCATION 6. Institutional: Mississippi State University, State College, Mississippi, B.S., 1962, Chemistry. University of Illinois, Urbana, Illinois, Ph.D., 1966, Chemistry. 7. Non-Institutional: None 8. Certification, licensure: None
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CURRICULUM VITAE
1. Date: November, 2004
PERSONAL
2. Name: Kermit L. Carraway
3. Office Phone: (305) 243-6512
1. Current Rank: Professor
2. Primary Department: Cell Biology and Anatomy
3. Secondary or Joint Appointments: Biochemistry and Molecular Biology
4. Citizenship: U.S.A.
5. Visa Type: N/A
HIGHER EDUCATION
6. Institutional:
Mississippi State University, State College, Mississippi, B.S., 1962, Chemistry.
University of Illinois, Urbana, Illinois, Ph.D., 1966, Chemistry.
7. Non-Institutional: None
8. Certification, licensure: None
EXPERIENCE
9. Academic:
1997 - present Professor of Cell Biology and Anatomy, University of Miami School of Medicine, Miami, Florida; Professor of Biochemistry and Molecular Biology
1981- 1997 Professor and Chairman of Cell Biology and Anatomy, University of Miami School of Medicine, Miami, Florida. Professor of Biochemistry
1981- Program Leader, Comprehensive Cancer Center of University of Miami
1984-1992 Program Director, Cell and Molecular Biology Training Program
1978-1981 Regents Professor, Oklahoma State University1976-1979 Program Director, Presidential Challenge Grant for
Biomaterials Research, Oklahoma State University1976 Visiting Associate, California Institute of Technology
with Jean Paul Revel1976-1978 Professor of Biochemistry, Oklahoma State
University1971-1975 Associate Professor of Biochemistry, Oklahoma State
University1968-1971 Assistant Professor of Biochemistry, Oklahoma State
University1966-1968 NIH Postdoctoral Fellow with Dr. D.E. Koshland, Jr.,
University of California, Berkeley. Chemical modifications of proteins and development of model systems for enzyme catalysis
1963-1966 NSF Predoctoral Fellow with Dr. Nelson J. Leonard, University of Illinois at Urbana-Champaign. Thesis title, "Synthesis and Properties of Some Derivatives of Adenine."
1962-1963 Teaching Assistant, Chemistry Department, University of Illinois
10. Non-Academic:
1962 Summer Research Trainee, E.I. DuPont, Wilmington, Delaware1961 Summer Research Trainee, Oak Ridge National Laboratory, Oak
Ridge, Tennessee
11. Military: None
PUBLICATIONS
12. Books and Monographs Published:
Carraway, K.L. and Carraway, C.A.C., eds. (1992) The Cytoskeleton: A Practical Approach, IRL/Oxford University Press, Oxford, UK.
Carraway, K.L., Carraway, C.A.C. and Carraway, K.L. III. (1997) Signaling and the Cytoskeleton, Springer, Berlin.
Carraway, K.L. and Carraway, C.A.C., eds. (1999) Cytoskeleton: Signaling and Cell Regulation: A Practical Approach, IRL/Oxford University Press, Oxford, UK.
13. Juried or Refereed Journal Articles and Exhibitions:
1. Leonard, N.J., Carraway, K.L. and Helgeson, J.P. (1965) Characterization of Nx, N-Disubstituted Adenines by Ultraviolet Adsorption Spectra, J. Heteterocycl. Chem., 2, 291.
2.Leonard, N.J., Achmatowicz, S., Loeppky, R.N., Carraway K.L., Grimm, W.A.H., Sweykowka, A., Hamzi, H.Q. and Skoog, F. (1966) Development of Cytokinin Activity by Rearrangement of 1- Substituted Adenines to 6-Substituted Aminopurines: Inactivation by N6, 1-Cyclization, Proc. Nat. Acad. Sci., 56, 709.
3. Leonard, N.J. and Carraway, K.L. (1966) 5-Amino-5-Deoxyribose Derivatives. Synthesis and Use in Preparation of 'Reversed' Nucleosides, J. Heterocycl. Chem., 3, 485.
4. Skoog, F., Hamzi, H.W., Sweykowska, A., Leonard, N.J., Carraway, K.L., Fujii, T., Helgeson, J.P. and Loeppky, R.N. (1967) Cytokinins: Structure/Activity Relationships, Phytochem., 6, 1169-1192.
5. Carraway, K.L., Rasmussen, M. and Helgeson, J.P. (1968) Cyclization of 6-Isopentenyladenine at the 1-Position, Synthetic procedures in Nucleic Acid Chemistry, 1, Interscience, p. 529.
6. Carraway, K.L., Huang, P.C. and Scott, T.G. (1968) Synthesis of 9- Alkyl-Adenines from the Sodium Salt of Adenine, Synthetic Procedures in Nucleic Acid Chemistry, 1, Interscience, p. 3.
7. Carraway, K.L. and Koshland, D.E., Jr. (1968) Reaction of Tyrosine Residues in Proteins with Carbodiimide Reagents, Biochim. Biophys. Acta., 160, 272-274.
8. Carraway, K.L., Spoerl, P. and Koshland, D.E., Jr. (1969) Carboxyl Group Modification in Chymotrypsin and Chymotrpsinogen, J. Mol. Biol, 42, 133-137.
9. Carraway, K.L. and Triplett, R.B. (1970) Reaction of Carbodiimides with Protein Sulfhydryl Groups, Biochim. Biophys. Acta, 200, 564.,
10. Carraway, K.L. and Kobylka, D. (1970) Comparative Studies of Erythrocyte Membranes by Gel Electrophoresis, Biochim, Biophys. Acta, 219, 238-241.
11. Carraway, K.L., Kobylka, D. and Triplett, R.B. (1971) Surface Proteins of Erythrocyte Membranes, Biochim. Biophys. Acta, 241: 934-940.
12. Koshland, D.E., Jr., Carraway, K.L., Dafforn, G.A., Gass, J.D. and Storm, D.R. (1971) The Importance of Orientation Factors in Enzymatic Reactions, Cold Spring Harbor Symposia on Quantative Biology, 36, 13-20.13. Carraway, K.L. and Koshland, D.E., Jr. (1972) Carbodiimide Modification of Proteins, Methods in Enzymol., 25B, 616-623.
14. Carraway, K.L. and Huggins, J.W. (1972) Reactivity of Amino Groups in Phospholipid Dispersions, Chem. Phys. Lipids, 8, 56-64.
15. Carraway, K.L., Lam, A., Kobylka, D. and Huggins, J.W. (1972) Anomalous Staining of Membrane Lipids on Acrylamide Gels, Anal. Biochem., 45, 325-331.
16. Carraway, K.L., Kobylka, D., Summers, J. and Carraway, C.A. (1972) Chemical Modification of Erythrocyte Membranes: Double Labeling with Acetic Anhydride, Chem. Phys. Lipids, 8, 65-81.
17. Kobylka, D., Khettry, A., Shin, B.C. and Carraway, K.L. (1972) Proteins and Glycoproteins of the Erythrocyte Membrane, Arch. Biochem. Biophys., 148, 475-487.
18. Carraway, K.L. and Shin, B.C. (1972) Specific Modification, Isolation and Partial Characterization of an Erythrocyte Membrane Protein, J. Biol. Chem., 247, 2102-2108.
19. Shin, B.C., Huggins, J.W. and Carraway, K.L. (1972) Effects of pH, Concentration and Aging on the Malonaldehyde Reaction with Proteins, Lipids, 7, 229-233.
20. Triplett, R.B., Summers, J., Ellis, D.E. and Carraway, K.L. (1972) Solubilization, Disaggregation and Chromatography of Erythrocyte Membranes, Biochim. Biophys. Acta, 266, 484-493.
21. Triplett, R.B. and Carraway, K.L. (1972) Proteolytic Digestion of Erythrocytes, Resealed Ghosts, and Isolated Membranes, Biochemistry, 11, 2897-2903.
22. Kobylka, D. and Carraway, K.L. (1972) Proteins and Glycoproteins of the Milk Fat Globule Membrane, Biochim. Biophys. Acta, 288 282- 295.
23. Triplett, R.B., Wingate, J.M. and Carraway, K.L. (1972) Calcium Effects on Erythrocyte Membrane Proteins, Biochem. Biophys. Res. Commun., 49 1014-1020.
24. Mitchell, E.D., Riquetti, P., Loring, R.H. and Carraway, K.L. (1973) Quaternary Structure of Bacillus subtilis α-Amylase. Anomalous Behavior in Sodium Dodecyl Sulfate, Biochim. Biophys. Acta, 295, 314-322.
25. Shin, B.C. and Carraway, K.L. (1973) Association of Glyceraldehyde 3-Phosphate Dehydrogenase with the Human Erythrocyte Membrane, J.Biol. Chem., 248, 1436-1444.
26. Kobylka, D. and Carraway, K.L. (1973) Proteolytic Digestion of the Milk Fat Globule Membrane, Biochim. Biophys. Acta, 133-140.
27. Shin, B.C. and Carraway, K.L. (1973) Cell Surface Constituents of Sarcoma 180 Ascites Tumor Cells, Biochim. Biophys. Acta, 330, 254-268.28. Shin, B.C. and Carraway, K.L. (1974) Lactoperoxidase Labeling of Erythrocyte Membranes from the Inside and Outside, Biochim. Biophys. Acta. 345 141-153.
29. Carraway, K.L., Triplett, R.B. and Anderson, D.R. (1975) Calcium Promoted Aggregation of Erythrocyte Membrane Proteins, Biochim. Biophys. Acta, 379, 571-581.
30. Carraway, K.L., Colton, D.G., Shin, B.C. and Triplett, R.B. (1975) Species Variability in the Modification of Erythrocyte Surface Proteins by Enzymatic Probes, Biochim. Biophys. Acta, 382, 181- 192.
31. Decker, R.V. and Carraway, K.L. (1975) Circular Dichroism of Erythrocyte Membrane Glycoproteins, Biochim. Biophys. Acta, 386, 52-61.
32. Hudson, B.G., Wegener, L.J., Wingate, J.M. and Carraway, K.L. (1975) Chemical Studies of Erythrocyte Membrane Glycoproteins From Several
Species, Comp. Biochem. Physiol., 51B, 127-135.
33. Shin, B.C., Ebner, K.E., Hudson, B.G. and Carraway, K.L. (1975) Membrane Glycoprotein Differences Between Normal Lactating Mammary Tissue and the R3230 AC Mammary Tumor, Cancer Res., 35, 1135-1140.
34. Huggins, J.W., Chesnut, R.W., Durham, N.N. and Carraway, K.L. (1975) Glycoprotein Differences Between the Ascites and Cultured Forms of the Sarcoma 180 Tumor, Biochem. Biophys. Res. Commun., 65, 497-502.
35. Carraway, K.L. (1975) Covalent Labeling of Membranes, Biochim. Biophys. Acta, Reviews on Biomembranes, 415, 379-410.
36. Carraway, C.A., Jett, G. and Carraway, K.L. (1975) Cooperative Effects in the Perturbation of Membrane Enzymes by Concanavalin A, Biochem. Biophys. Res. Commun., 67, 1301-1306.
37. Adams, D., Markes, M.E., Leivo, W.J. and Carraway, K.L. (1976) Electron Spin Resonance Analysis of Irreversible Changes Induced by Calcium Perturbation of Erythrocyte Membranes, Biochim. Biophys. Acta, 426, 38-45.
38. Carraway, C.A. and Carraway, K.L. (1976) Concanavalin A Perturbation of Membrane Enzymes of Mammary Gland, J. Supramolec. Struc., 4, 121-126.
39. Huggins, J.W., Chesnut, R.W., Durham, N.N. and Carraway, K.L. (1976) Molecular Changes in Cell Surface Membranes Resulting from Trypsinization of Sarcoma 180 Tumor Cells, Biochim. Biophys. Acta, 426, 630-637.
40. Moore, P.B., Anderson, D.R., Huggins, J.W. and Carraway, K.L. (1976) Cytoskeletal Proteins Associated with Cell Surface Envelopes from Sarcoma 180 Ascites Tumor Cells, Biochem. Biophys. Res. Commun., 72, 288-294.
41. Carraway, K.L., Fogle, D.D., Chesnut, R.W., Huggins, J.W. and Carraway, C.A.C. (1976) Ecto-enzymes of Mammary Gland and Its Tumors. Lectin Inhibition of 5'-Nucleotidase of the 13762 Rat Mammary Ascites Carcinoma, J.Biol. Chem., 251, 6173-6178.
42. Huggins, J.W. and Carraway, K.L. (1976) Purification of Plasma Membranes from Rat Mammary Gland by a Density Perturbation Procedure, J. Supramolec. Struc., 5, 59-63.
43. Snow, L.D., Colton, D.G. and Carraway, K.L. (1977) Purification and Properties of the Major Sialoglycoprotein of the Milk Fat Globule Membrane, Arch. Biochem. Biophys., 179, 690-697.
44. Tsao, D., Colton, D.G., Chang, J.S., Buck, R.L., Hudson, B.G. and Carraway, K.L. (1977) Alterations of Red Cell Membranes from Phenylhydrazine-Treated Rabbits, Biochim. Biophys. Acta, 469, 61- 73.
45. Anderson, D.R., Davis, J.L. and Carraway, K.L. (1977) Calcium- promoted Changes of the Human Erythrocyte Membrane, J. Biol. Chem., 252, 6617-6623.
46. Moore, P.B. and Carraway, K.L. (1978) Proteolytic Enhancement of Gelation of Ascites Tumor Cell Extracts. Relationship to Actin Binding Protein, Biochem. Biophys. Res. Comm., 80, 560-567.
47. Moore, P.B., Ownby, C.L. and Carraway, K.L., (1978) Interactions of Cytoskeletal Elements with the Plasma Membrane of Sarcoma 180 Ascites Tumor Cells, Exp. Cell Res. 115, 331-342.
48. Carraway, K.L., Huggins, J.W., Sherblom, A.P., Chesnut, R.W., Buck, R.L. Howard, S.P., Ownby, C.L. and Carraway, C.A.C. (1978) Membrane Glycoproteins of Rat Mammary Gland and Its Metastasizing and Nonmetastasizing Tumors. ACS Symposium Series No. 80, Glycoproteins and Glycolipids in Disease Processes, pp. 432-445.
49. Bell, P.B., Miller, M.M., Carraway, K.L., and Revel, J.P. (1978) SEM-Revealed Changes in the Distribution of the Triton-Insoluble Cytoskeleton of Chinese Hamster Ovary Cells Induced by Dibutyryl Cyclic AMP-SEM, AMF O'Hare II, pp. 899-906.
50. Markes, M.W., Adams, D.A., Carraway, K.L. and Leivo, W.J. (1978) ESR Study of Spectrin-Phospholipid Interactions. In Biomolecular Structure and Function (P.F. Agris, ed.) Academic Press, New York, pp. 109-113.
51. Freytag, J.W., Dalrymple, P.N., Maguire, M.H., Strickland, D.K., Carraway, K.L., and Hudson, B.G. (1978) Glomerular Basement Membrane: Studies on Its Structure and Interaction with Platelets, J. Biol. Chem., 253, 9069-9074.
52. Moore, P.B., Sherblom, A.P., and Carraway, K.L. (1979) Gelation of Sarcoma 180 Extracts. Membrane Involvement and the Elimination of the Temperature Dependence by Proteolysis. Exp. Cell Res., 121, 399-406.
53. Doss, R.C., Carraway, C.A.C. and Carraway, K.L. (1979) Multiple Forms of 5' -Nucleotidase from Lactating Rat Mammary Gland Resulting from the Association of the Enzyme with Different Membrane Fractions. Biochim. Biophys. Acta., 570, 96-106.
54. Davis, J.L., Chandler, D.K.F., Riquetti, P., Rogers, S., Kocan, K.M., Ownby, C.L., Hudson, B.G. and Carraway, K.L. (1979) Interaction of Bovine Platelets
with Bovine Glomerular Basement Membrane. Thromb. Haemostasis, 42, 1217-1229.
55. Carraway, K.L., Doss, R.C., Huggins, J.W., Chesnut, R.W. and Carraway, C.A.C. (1979) Effects of cytoskeletal perturbant drugs on ecto 5'-nucleotidase, a concanavalin a receptor. J. Cell Biol. 83, 529-543. 56. Buck, R.L., Sherblom, A.P. and Carraway, K.L. (1979) Sialoglycoprotein Differences between Xenotransplantable and Nonxenotransplantable Ascites Sublines of the 13762 Rat Mammary Adenocarcinoma, Arch. Biochem. Biophys., 198, 12-21.
57. Huggins, J.W., Trenbeath, T.P., Chesnut, R.W., Carraway, C.A.C. and Carraway, K.L. (1980) Purification of plasma membranes of rat mammary gland. Comparisons of subfractions with rat milk fat globule membrane, Exp. Cell Res., 126, 279-288.
58. Snow, L.D., Doss, R.C. and Carraway, K.L. (1980) Cooperativity of the Concanavalin A Inhibition of Bovine Milk Fat Globule Membrane 5'-Nucleotidase. Response to Extraction of Nucleotidase and Putative Cytoplasmic Surface Coat Components, Biochim. Biophys. Acta 611, 333-341.
59. Sherblom, A.P., Buck, R.L. and Carraway, K.L. (1980) Purification of the Major Sialoglycoproteins of 13762 MAT-B1 and MAT-C1 Rat Ascites Mammary Adenocarcinoma Cells by Density Gradient Centrifugation in Cesium Chloride and Guanidine Hydrochloride, J. Biol. Chem. 255, 783-790.
60. Huggins, J.W., Trenbeath, T.P. Yeltman, D.R. and Carraway, K.L. (1980) Restricted Concanavalin A Redistribution on the Branched Microvilli of an Ascites Tumor Subline, Exp. Cell Res., 127, 27-46.
61. Sherblom, A.P., Huggins, J.W., Chesnut, R. W., Buck, R.L., Ownby, C.L., Dermer, G.B. and Carraway, K.L. (1980) Cell Surface Properties of Ascites Sublines of the 13762 Rat Mammary Adenocarcinoma. Relationship of the Major Sialoglycoprotein to Xenotransplantability, Exp. Cell Res., 126, 417-426.
62. Huggins, J.W., Trenbeath, T.P., Sherblom, A.P., Howard, S.C. and Carraway, K.L. (1980) Glycoprotein Differences in Solid and Ascites Forms of the 13762 Rat Mammary Adenocarcinoma, Cancer Res., 40, 1873-1878.
63. Howard, S.C., Sherblom, A.P., Chesnut, R.W., Carraway, C.A.C. and Carraway, K.L. (1980) Changes in Expression of a Major Sialoglycoprotein Associated with Ascites Forms of a Mammary Adenocarcinoma, Biochim.
Biophys. Acta, 631, 79-89.
64. Sherblom, A.P. and Carraway, K.L. (1980) Sulfate Incorporation into the Major Sialoglycoprotein of the MAT-B1 Subline of the 13762 Rat Ascites Mammary Adenocarcinoma, Biochemistry 19, 1213- 1219.
65. Carraway, C.A.C., Corrado, F.J., Fogle, D.D., and Carraway, K.L. (1980) Ecto-Enzymes of Mammary Gland and Its Tumors. Ca2+-or Mg2+-Stimulated Adenosine Triphosphatase and Its Peturbation by Concanavalin A, Biochem. J. 191, 45-51.
66. Carraway, K.L., Huggins, J.W., Cerra, R.F., Yeltman, D.R., and Carraway, C.A.C. (1980) α-Actinin-containing branched microvilli isolated from an ascites adenocarcinoma, Nature, 285, 508-510.
67. Sherblom, A.P., and Carraway, K.L. (1980) A Complex of Two Cell Surface Glycoproteins from Ascites Mammary Adenocarcinoma Cells. J.Biol. Chem., 255, 12051-12059.
68. Howard, S.C., Sherblom, A.P., Huggins, J.W., Carraway, C.A.C., and Carraway, K.L. (1981) Shedding of the Major Plasma Membrane Sialoglycoprotein from the Surface of 13762 Rat Ascites Mammary Adenocarcinoma Cells. Arch Biochem. Biophys., 201, 40-50.
69. Mitchell, E.D., Jr., Loring, R., Carraway, K.L., and Cunningham, B. (1981) Oxidative Inactivation of B. Subtilis Analyase by Chloroperoxidase. Proc. Okla. Acad. Sci. 61, 43-48.
70. Yeltman, D.R., Jung, G., and Carraway, K.L. (1981) Isolation of α-Actinin from Sarcoma 180 Ascites Cell Plasma Membranes and Comparison with Smooth Muscle Actinin. Biochim. Biophys. Acta. 668, 207-208.
71. Helm, R.M., and Carraway, K.L. (1981) Evidence for the Association of Two Cell Surface Glycoproteins of 13762 Mammary Ascites Tumor Cells. Concomitant Redistribution of Major Concanavalin A and Peanut Agglutinin Binding Proteins. Exp. Cell Res. 135, 418-424.
72. Howard, S.C., Hull, S.R., Huggins, J.W., Carraway, C.A.C., and Carraway, K.L. (1982) Relationship between xenotransplantability and cell surface properties of ascites sublines of a rat mammary adenocarcinoma. J. Natl. Cancer Inst. 69, 33-40.
73. Carraway, C.A.C., Cerra, R.F., Bell, P.B., and Carraway, K.L. (1982) Identification of a Protein Associated with Both Membrane and Cytoskeleton Fractions from Branched but not Unbranched Microvilli of an Ascites Tumor, Biochim. Biophys. Acta, 719, 126- 139.
74. Carraway, K.L., Cerra, R.F., Jung, G., and Carraway, C.A.C. (1982) Membrane-Associated Actin from the Microvillar Membranes of Ascites Tumor Cells. J. Cell Biol. 94, 624-630.
75. Carraway, K.L., and Carraway, C.A.C. (1982) Isolation and Characterization of Plasma Membranes, In: Antibody as a Tool: The Application of Immunochemistry (J.J. Marchalonis and G.W. Warr, Eds.) John Wiley, Chichester, England, pp. 509-559.
76. Carraway, K.L., Huggins, J.W., Sherblom, A.P., Howard, S.C., Hull, S.R., Cerra, R.F., Jung, G., and Carraway, C.A.C. (1982) Survival Mechanisms of a Mammary Adenocarcinoma, In Membranes in Tumor Growth, (T. Galeotti, et al, eds.) Elsevier North Holland Biomedical Press, pp. 205-212.
77. Carraway, K.L. (1982) Proteolytic Enzyme Treatment, In: Red Cell Membranes: A Methodological Approach (J. C. Ellory and J.D. Young, eds.) Academic Press, London, pp. 239-250.
78. Carraway, C.A.C., Craik, J.R., Rubin, R.W., and Carraway, K.L. (1983) Identification of a Cytoskeleton-Associated Glycoprotein from Isolated Microvilli of Mammary Ascites Tumor, Exp. Cell Res. 143, 301-306.
79. Carraway, C.A.C., Jung, G., and Carraway, K.L. (1983) Isolation of actin-containing transmembrane complexes from ascites adenocarcinoma sublines having mobile and immobile receptors, proc. Nat. Acad. Sci. USA, 80, 430-434.
80. Carraway, C.A.C., Jung, G., and Carraway, K.L. (1983) Organizational Forms of Actin in 13762 Ascites Mammary Tumor Cell Microvilli. Cell Motil. 3, 491-500.
81. Jung, G., Helm, R.M., Carraway, C.A.C., and Carraway, K.L. (1984) Mechanism of Concanavalin A-Induced Anchorage of the Major Cell Surface Glycoproteins to the Submembrane Cytoskeleton in 13762 Ascites Mammary Adenocarcinoma Cells. J. Cell Biol. 98, 179-187.
82. Hull, S.R., Laine, R.A., Kaizu, T., Rodriguez, I. and Carraway, K.L. (1984) Structures of the 0-linked Oligosaccharides of the Major Cell Surface Sialoglycoprotein of MAT-B1 and MAT-C1 Ascites Sublines of the 13762 Rat Mammary Adenocarcinoma, J. Biol. Chem. 259, 4866-4877.
83. Carraway, K.L., and Carraway, C.A.C. (1984) Plasma Membrane-Microfilament Interactions in Animal Cells. Bioessays, l, 55-58.
84. Carraway, K.L., and Carraway, C.A.C. (1985) Cell Surface Receptors and Transduction Mechanisms. In Biology of Fertilization. C. Metz and A. Monroy, eds. Academic Press, New York, pp. 23-55.
85. Carraway, C.A.C., Jung, G., Hinkley, R.E., and Carraway, K.L. (1985) Isolation of Microvillar Microfilaments and Associated Transmembrane Complex from Ascites Cell Microvilli. Exp. Cell Res. 157, 71-82.
86. Craik, J.D., Carraway, C.A.C., and Carraway, K.L. (1985) Transmembrane Modulation of the Concanavalin A Inhibition of 5'-Nucleotidase Is Not Due to a Direct Association of the Enzyme with the Cytoskeleton. Biochim. Biophys. Acta 845, 27-33.
87. Jung, G., Andrews, D.M., Carraway, K.L., and Carraway, C.A.C. (1985) Actin-associated Cell Surface Glycoprotein from Ascites Cell Microvilli: A Disulfide-linked Multimer. J. Cell. Biochem. 28, 243-252.
88. Liu, Y., Carraway, C.A.C., and Carraway, K.L. (1986) Nonmuscle Tropomyosin from Ascites Tumor Cell Microvilli. J. Biol. Chem. 261, 4568-4573.
89. Carraway, K.L., and Spielman, J. (1986) Structural and Functional Aspects of Tumor Cell Sialomucins. Mol. Cell. Biochem. 72, 108-120.
90. Spielman, J., Rockley, N.L. and Carraway, K.L. (1987) Temporal Aspects of O-Glycosylation and Cell Surface Expression of Ascites Sialoglycoprotein-1, the Major Cell Surface Sialomucin of 13762 Mammary Ascites Tumor Cells. J. Biol. Chem. 262, 269-275.
91. Carraway, K.L. III, Liu, Y., Puett, D., Carraway, K.L. and Carraway, C.A.C. (1987) Phenothiazine Binding by a homolog of calpactin, the pp60src tyrosine kinase substrate. FASEB J., 1, 46-50.
92. Carraway, K.L., Pratt, M.M. and Burgess, D.R. (1987) The Cytoskeleton: Past, Present and Future. Bioessays 7, 147-148.
93. Liu, Y., Brew, K., Carraway, K.L. and Carraway, C.A.C. (1987) Isolation of a Calcium-sensitive, 35,000-Dalton Microfilament- and Liposome-binding Protein from Ascites Tumor Cell Microvilli: Identification as Monomeric Calpactin. J. Cellular Biochem. 35, 185-204.
94. Carraway, K.L., Spielman, J. and Carraway, C.A.C. (1988) Molecular Mechanisms Regulating Cell Surface Organization and their Relationship to Tumor Survival. in Recognition Mechanisms in Biological Systems. Chapman, G.P., Ainsworth, C.C. and Chatham, C.J. eds., Cambridge University Press, Cambridge, U.K., 20-38.
95. Hull, S.R. and Carraway, K.L. (1988) Mechanism of Expression of Thomsen-Friedenreich (T) antigen at the Cell Surface of a Mammary Adenocarcinoma. FASEB J. 2, 2380-2384.
96. Spielman, J., Hull, S.R., Sheng, Z., Kanterman, R., Bright, A. and Carraway, K.L. (1988) Biosynthesis of a tumor cell surface sialomucin: Maturation and effects of monensin. J. Biol. Chem. 263, 9621-9629.
97. Vanderpuye, O.A., Carraway, C.A.C. and Carraway, K.L. (1988) Microfilament association of ASGP-2, the concanavalin A-binding glycoprotein of the cell surface sialomucin complex of 13762 rat mammary ascites tumor cells. Exp. Cell Res. 178, 211-223.
98. Carraway, K.L. and Carraway, C.A.C. (1989) Membrane-Cytoskeleton Interactions in Animal Cells. BBA Reviews in Biomembranes 988, 147-171.
99. Hull, S.R. and Carraway, K.L. (1989) Sulfation of the tumor cell surface sialomucin of the 13762 rat mammary adenocarcinoma. J. Cell. Biochem. 40, 67-81.
100. Liu, Y., Carraway, K.L. and Carraway, C.A.C. (1989) Isolation and characterization of a 58 kda membrane- and microfilament-associated protein from ascites tumor cell microvilli. J. Biol. Chem. 264, 1208-1214.
101. Carraway, K.L. and Hull, S.R. (1989) O-Glycosylation Pathway for Mucin-type Glycoproteins. BioEssays 10, 117-121.
102. Hull, S.R., Spielman, J. and Carraway, K.L. (1989) Biosynthesis of the cell surface sialomucin from ascites 13762 rat mammary adenocarcinoma cells: Intracellular maturation. In Breast Cancer Immunodiagnosis and Immunotherapy (Ceriani, R.L., ed.) Plenum Publishing Co., pp. 71-79.
103. Ye, X., Metcalf, T.N. III, Andrews, D.M., Carraway, C.A.C. and Carraway, K.L. (1989) Strong association of bovine IgM with microvilli and their microfilament core from 13762 ascites tumor cells. Exp. Cell Res. 182, 160-172.
104. Sheng, Z., Vanderpuye, O.A., Hull, S.R., Carraway, C.A.C. and Carraway, K.L. (1989) Topography and microfilament core association of a cell surface glycoprotein of ascites tumor cell microvilli. J. Cell Biochem. 40, 453-466.
105. Hull, S.R., Bright, A., Carraway, K.L., Abe, M., Hayes, D.F. and Kufe, D.W. (1989) Oligosaccharide differences in the DF3 sialomucin antigen from
normal human milk and the BT-20 human breast carcinoma cell line. Cancer Commun. 1, 261-267.
106. Hull, S.R., Sheng, Z., Vanderpuye, O., David, C. and Carraway, K.L. (1990) Isolation and partial characterization of ascites sialoglycoprotein-2 (ASGP-2) of the cell surface sialomucin complex of 13762 rat mammary adenocarcinoma cells. Biochem. J. 265, 121-129.
107. Carraway, K.L. (1990) Membranes and microfilaments: Interactions and role in cellular dynamics. BioEssays 12, 90-92.
108. Sheng, Z., Hull, S.R. and Carraway, K.L. (1990) Biosynthesis of the cell surface sialomucin complex of ascites 13762 rat mammary adenocarcinoma cells from a high Mr precursor. J. Biol. Chem. 265, 8505-8510.
109. Carraway, K.L. and Hull, S.R. (1991) Cell surface mucin-type glycoproteins and mucin-like domains. Glycobiology 1, 131-138.
110. Hull, S.R., Sugarman, E.D., Spielman, J. and Carraway, K.L. (1991) Biosynthetic maturation of an ascites tumor cell surface sialomucin. Evidence for O-glycosylation of cell surface glycoprotein by the addition of new oligosaccharides during recycling. J. Biol. Chem. 266, 13580-13586.
111. Carraway, C.A.C., Fang, H., Ye, X., Juang, S.-H., Liu, Y., Carvajal, M. and Carraway, K.L. (1991) Membrane-microfilament interactions in ascites tumor cell microvilli. Identification and isolation of a large microfilament-associated glycoprotein complex. J. Biol. Chem. 266, 16238-16246.
112. Sheng, Z., Wu, K., Carraway, K.L. and Fregien, N. (1992) Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex: A new member of the epidermal growth factor superfamily. J. Biol. Chem. 267, 16341-16346.
113. Carraway, K.L., Fregien, N., Carraway, C.A.C. and Carraway, K.L. III (1992) Tumor sialomucin complexes as tumor antigens and modulators of cellular interactions and proliferation. J. Cell Sci. 103, 299-307.
114. Carraway, C.A.C., Carvajal, M.E., Li, Y. and Carraway, K.L. (1993) Association of p185neu with microfilaments via a large glycoprotein complex in mammary carcinoma microvilli. Evidence for a microfilament-associated signal transduction particle. J. Biol. Chem. 268, 5582-5587.
115. Wu, K., Fregien, N. and Carraway, K.L. (1994) Molecular cloning and sequencing of the mucin subunit of a heterodimeric, bifunctional cell surface glycoprotein complex of ascites rat mammary adenocarcinoma cells. J. Biol.
Chem. 269, 11950-11955.
116. Juang, S.-H., Huang, J., Li, Y., Salas, P.J.I., Fregien, N., Carraway, C.A.C. and Carraway, K.L. (1994) Molecular cloning and sequencing of a 58 kda membrane- and microfilament-associated protein from ascites tumor cell microvilli with sequence similarities to retroviral gag proteins, J. Biol. Chem. 269, 15067-15075.
117. Wu, K., Salas, P.J.I., Yee, L., Fregien, N. and Carraway, K.L. (1994) Tissue and tumor expression of a cell surface glycoprotein complex containing an integral membrane glycoprotein activator of p185neu. Oncogene 9, 3139-3147.
118. Carraway, K.L. and Fregien, N. (1995) Mucin structure and function: Insights from molecular biology. Trends Glycosci. Glycotechnol. 7, 31-44.
119. Carraway, K.L. and Carraway, C.A.C. (1995) Signaling, mitogenesis and the cytoskeleton: where the action is. BioEssays 17, 171-175.
120. Carraway, C.A.C. and Carraway, K.L. (1996) Interactions of membrane receptors and cell signaling systems with the cytoskeleton. In Treatise on the Cytoskeleton (J.E. Hesketh and I.F. Pryme, eds.), vol. 2, JAI Press, Inc., Greenwich, CT, pp. 207-238.
121. Rossi, E.A., McNeer, R., Price-Schiavi, S.A., Komatsu, M., Van den Brande, J.M.H., Thompson, J.F., Carraway, C.A.C., Fregien, N.L. and Carraway, K.L. (1996) Sialomucin complex, a heterodimeric glycoprotein complex: Expression as a soluble, secretable form in lactating mammary gland and colon. J. Biol. Chem. 271, 33476-33485.
122. Carraway, K.L. (1997) Anatomy departments and anatomy education: reflections and myths. Clin. Anat. 10, 60.
123. Carraway, K.L., Carraway, C.A.C. and Carraway, K.L. III (1997) ErbB-3 and ErbB-4 in the Physiology and Pathology of the Mammary Gland (invited review) J. Mammary Gland Biology and Neoplasia 2, 187-198.
124. McNeer, R.R., Price-Schiavi, S., Komatsu, M., Fregien, N., Carraway, C.A.C. and Carraway, K.L. (1997) Sialomucin complex in tumors and tissues. Front. Bioscience 2, 449-459.
125. Carraway, K.L. (1997) Sialomucin complex. Emerging Therapeutic Targets 1, 187-189.
126. Komatsu, M., Carraway, C.A.C., Fregien, N.L. and Carraway, K.L. (1997) Reversible disruption of cell-matrix and cell-cell interactions by overexpression of
sialomucin complex. J. Biol. Chem. 272, 33245-33254.
127. McNeer, R.R., Huang, D., Fregien, N.L. and Carraway, K.L. (1998) Sialomucin complex in the rat respiratory tract: a model for its role in epithelial protection. Biochem. J. 330, 737-744.
128. McNeer, R.R., Carraway, C.A.C., Fregien, N.L. and Carraway, K.L. (1998) Characterization of the expression and steroid hormone control of sialomucin complex in the rat uterus: Implications for uterine receptivity. J. Cell. Physiol. 176, 110-119.
129. Price-Schiavi, S.A., Meller, D., Jing, X., Merritt, J., Carvajal, M.E., Tseng, S.C.G. and Carraway, K.L. (1998) Sialomucin complex at the rat ocular surface: a new model for ocular surface protection. Biochem. J. 335, 457-463.
130. Price-Schiavi, S.A., Carraway, C.A.C., Fregien, N. and Carraway, K.L. (1998) Post-transcriptional regulation of a milk membrane protein, the sialomucin complex (ascites sialoglycoprotein (ASGP)-1/ASGP-2, rat Muc4) by TGFβ. J. Biol. Chem. 273, 35228-35237.
131. Carraway, K.L. and Komatsu, M. (1999) Sialomucin complex (rat Muc4) promotion of tumor cell progression. Proc. 22nd Congress Intl Assoc. Breast Cancer Res. 123-126.
132. Komatsu, M., Yee, L. and Carraway, K.L. (1999) Overexpression of sialomucin complex, a rat homolog of MUC4, inhibits tumor killing by lymphokine-activated killer cells. Cancer Res.59, 2229-2236.
133. Carraway, K.L. III, Rossi, E.A., Komatsu, M., Price-Schiavi, S.A., Huang, D., Guy, P.M., Carvajal, M.E., Fregien, N., Carraway, C.A.C. and Carraway, K.L. (1999) An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J. Biol. Chem. 274, 5263-5266.
134. Huang, J., Zhang, B.-T., Li, Y., Mayer, B., Carraway, K.L. and Carraway, C.A.C. (1999) c-Src Association with and Phosphorylation of p58gag, a Membrane- and Microfilament-associated Retroviral Gag-like Protein in a Xenotransplantable Rat Mammary Tumor. Oncogene 18, 4099-4107.
135. Carraway, C.A.C., Carvajal, M.E., and K.L. Carraway. (1999) Association of the Ras/MAP Kinase Signal Transduction Pathway with Microfilaments. Evidence for a p185neu-containing Cell Surface Signal Transduction Particle. J. Biol. Chem. 274, 25659-25667.
136. Li, Y., Carraway, K.L. and Carraway, C.A.C. (1999) Molecular associations of the core glycoprotein complex from a microfilament-associated signal transduction particle from ascites tumor cell microvilli. J. Biol. Chem. 274, 25651-25658.
137. Carraway, C.A.C. and Carraway, K.L. (1999) p58gag. In: Guidebook to the Cytoskeletal and Motor Proteins. T. Kreis and R.D. Vale, eds. Oxford University Press, pp.
138. Idris, N. and Carraway, K.L. (1999) Sialomucin complex (Muc4) expression in the rat female reproductive tract. Biol Reprod 61, 1431-1438.
139. Carraway, K.L., Price-Schiavi, S.A., Zhu, X. and Komatsu, M. (1999) Regulation of expression of sialomucin complex (rat Muc4), the intramembrane ligand for ErbB2, at the transcriptional, translational and post-translational levels in rat mammary gland. Cancer Control 6, 613-614.
140. Pflugfelder, S.C., Liu, Z., Monroy, D., Li, D.-Q., Carvajal, M.E., Price-Schiavi, S.A., Idris, N., Solomon, A., Perez, A. and Carraway, K.L. (2000) Detection of Sialomucin Complex (MUC4) in human ocular surface epithelium and tear fluid. Invest. Ophthalmol. Vis. Sci. 41, 1316-1326.
141. Carraway, K.L. (2000) Preparation of membrane mucin. In Methods in Molecular Biology, Vol. 125. Glycoprotein Methods and Protocols: The Mucins, T. Corfield, ed., Humana Press, Totowa, NJ, pp. 15-26.
142. Liu, Z., Carvajal, M., Carraway, C.A.C., Carraway, K.L. and Pflugfelder, S.C. (2000) Increased expression of the type 1 growth factor receptor family in the conjunctival epithelium of patients with keratoconjunctivitis sicca. Am. J. Ophthalmol. 129, 472-480.
143. Carraway, K.L., Price-Schiavi, S.A., Komatsu, M., Idris, N., Perez, A., Li, P., Jepson, S., Zhu, X., Carvajal, M.E. and Carraway, C.A.C. (2000) Multiple facets of sialomucin complex/Muc4, a membrane mucin and Erbb2 ligand, in tumors and tissues. Front. Bioscience 5, d95-107. 144. Komatsu, M., Tatum, L., Altman, N.H., Carraway, C.A.C. and Carraway, K.L. (2000) Potentiation of metastasis by cell surface sialomucin complex (rat muc4), a multifunctional anti-adhesive glycoprotein. Int. J. Cancer 87, 480-486.
145. Dursun, D., Monroy, D., Knighton, R., Tervo, T., Vesaluoma, M., Carraway, K., Feuer, W. and Pflugfelder, S.C. (2000) The effects of experimental tear film removal on corneal surface regularity and barrier function. Ophthalmology107, 1754-1760.
146. Price-Schiavi, S.A., Zhu, X., Aquinin, R. and Carraway, K.L. (2000) Sialomucin complex (rat muc4) is regulated by transforming growth factor in mammary gland by a novel post-translational mechanism. J. Biol. Chem. 275, 17800-17807.
147. Price-Schiavi, S.A., Perez, A., Barco, R. and Carraway, K.L. (2000) Cloning and characterization of the 5' flanking region of the Sialomucin complex/Rat Muc4 gene: promoter activity in cultured cells. Biochem. J. 349, 641-649.
148. Idris, N. and Carraway, K.L. (2000) Regulation of Sialomucin Complex/Muc4 expression in rat uterine luminal epithelial cells by transforming growth factor-$: implications for
blastocyst implantation. J. Cell. Physiol. 185, 310-316.
149. Zhu, X., Price-Schiavi, S.A. and Carraway, K.L. (2000) Extracellular regulated kinase (erk)-dependent regulation of sialomucin complex/MUC4, the intramembrane ErbB2 ligand, in mammary epithelial cells. Oncogene 19, 4354-4361.
150. Hu, Y., Carvajal, M.E. and Carraway, K.L. (2000) Sialomucin complex (rMuc4) expression during development of the rat cornea. Curr. Eye Res. 21, 820-823.
151. Liu, Z., Carvajal, M., Carraway, C.A.C., Carraway, K.L. and Pflugfelder, S.C. (2001) Expression of type 1 growth factor receptors in human ocular surface epithelia. Cornea 20, 81-85.
152. Weed, D.T., Gomez-Fernandez, C., Bonfante, E., Lee, T.D., Pacheco, J., Carvajal, M.E., Goodwin, W.J. and Carraway, K.L. (2001) MUC4 (Sialomucin Complex) expression in salivary tumors and squamous cell carcinoma of the upper aerodigestive tract. Otolaryngol. Head Neck Surg. 124, 127-141.
153. Li, P., Price-Schiavi, S.A., Rudland, P.S. and Carraway, K.L. (2001) Sialomucin Complex (rat Muc4) Transmembrane subunit binds the differentiation marker peanut lectin in the normal rat mammary gland. J. Cell. Physiol. 186, 397-405.
154. Komatsu, M., Jepson, S., Arango, M.E., Carraway, C.A.C. and Carraway, K.L.(2001) Muc4/Sialomucin Complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor. Oncogene 20, 461-470.
155. Li, P., Arango, M.E., Perez, R.E., Reis, C.A., Bonfante, E.L., Weed, D. and Carraway, K.L. (2001) Expression and Localization of Immunoreactive-Sialomucin Complex (Muc4) in Salivary Glands. Tissue Cell 33, 111-118.
156. Carraway, K.L. and Carraway, C.A.C. Signaling by tyrosine kinases. In Cancer Handbook (M.R. Alison, ed.), Macmillan Reference Ltd., London, pp. 161-177.
157. Carraway, K.L. and Idris, N. (2001) Regulation of sialomucin complex/Muc4 in the female rat reproductive tract. Biochem. Soc. Trans. 29, 162-166.
158. Carraway, K.L., Price-Schiavi, S.A., Komatsu, M., Jepson, S., Perez, A. and Carraway, C.A.C. 2001. Muc4/sialomucin complex in the mammary gland and breast cancer. J. Mammary Gland Biol. Neoplasia 6, 323-337.
159. Idris, N., Carraway, C.A.C. and Carraway, K.L. 2001. Differential localization of erbb2 in different tissues of the rat female reproductive tract: implications for the use of specific antibodies for ErbB2 analysis. J. Cell. Physiol. 189, 162-170.
160. Arango, M.E., Li, P., Komatsu, M., Montes, C., Carraway, C.A.C. and Carraway, K.L. 2001. Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal gland. Invest. Ophthalmol. Vis. Sci. 42, 2749-2756.
161. Carraway, K.L., Perez, A., Idris, N., Jepson, S., Arango, M., Komatsu, M., Haq, B., Price-Schiavi, S.A., Zhang, J. and Carraway, C.A.C. (2002) Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Prog. Nucleic Acids Res. Molec. Biol. 171, 149-185.
162. Carraway, K.L., Carvajal, M.E., Li, P. and Carraway, C.A.C. (2002) ErbB2 and its ligand Muc4 (sialomucin complex) in rat lacrimal gland. Adv. Exper. Med. Biol. 506, 289-295.
163. Price-Schiavi, S.A., Jepson, S., Li, P., Arango, M., Rudland, P.S., Yee, L. and Carraway, K.L. 2002. Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance. Int. J. Cancer 99, 783-791.
164. Jepson, S., Komatsu, M., Haq, B., Arango, M.E., Huang, D., Carraway, C.A.C. and Carraway, K.L. 2002. Muc4/Sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27kip, but does not activate mitogen-activated kinase or protein kinase B/Akt pathways. Oncogene 21, 7524-7532.
165. Swan, J.S., Arango, M.E., Carraway, C.A.C. and Carraway, K.L. 2002. An ErbB2-Muc4 complex in rat ocular surface epithelia. Curr. Eye Res. 24, 397-402.
166. Komatsu, M., Arango, M.E. and Carraway, K.L. 2002. Synthesis and secretion of Muc4/Sialomucin Complex: Implication of intracellular proteolysis. Biochem. J. 368, 41-48.
167. Plaut, K. and Carraway, K.L. 2002. Evolution and comparative biology of the mammary gland. J. Mammary Gland Biol. and Neoplasia 7, 223-224.
168. Carraway, K.L., Ramsauer, V.P., Haq, B. and Carraway, C.A.C. 2003. Cell signaling through membrane mucins. BioEssays 25, 66-71.
169. Ferrell, A.D., Malayer, J.R., Carraway, K.L. and Geisert, R.D. 2003. Sialomucin complex (Muc4) expression in porcine endometrium during the oestrous cycle and early pregnancy. Reprod. Dom. Anim. 38, 63-65.
170. Hu, Y.-P., Haq, B., Carraway, K.L., Savaraj, N. and Lampidis, T. 2003. Multidrug resistance correlates with overexpression of muc4 but inversely with P-gp and MRP in transfected human melanoma cells. Biochem. Pharmacol. 65, 1419 - 1425.
171. Fischer, B.M., Cuellar, J.G., Diehl, M.L., deFreytas, A.M., Zhang, J., Carraway, K.L. and Voynow, J.A. 2003. Neutrophil elastase increases muc4 expression in normal human bronchial epithelial cells. Am. J. Physiol. 284, L671-679.
172. Soto, P., Price-Schiavi, S.A. and Carraway, K.L. 2003. SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-β and interferon-γ pathways in rat mammary epithelial cells. J. Biol. Chem. 278, 20338-20344.
173. Ramsauer, V.P., Carraway, C.A.C., Salas, P.J.I. and Carraway, K.L. 2003. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J. Biol. Chem. 278, 30142-30147.
174. Perez, A., Barco, R., Fernandez, I., Price-Schiavi, S A. and Carraway, K.L. 2003. PEA3 transactivates the Muc4/sialomucin complex promoter in mammary Epithelial and tumor cells. J. Biol. Chem. 278, 36942-36952.
175. Weed, D.T., Gomez-Fernandez, C., Pacheco, J., Ruiz, J., Hamilton-Nelson, K., Arnold, D.J., Civantos, F.J., Zhang, J., Yasin, M., Goodwin, W.J. and Carraway, K.L. 2004. MUC4 (Sialomucin Complex) and ErbB2 expression in major and minor salivary gland mucoepidermoid carcinoma. Head Neck 26. 353-364.
176. Weed, D.T., Gomez-Fernandez, C., Yasin, M., Hamilton-Nelson, K., Rodriguez, M.,Zhang, J. and Carraway, K.L. 2004. MUC4 and ErbB2 Expression in Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Correlation With Clinical Outcomes. Laryngoscope 114(Suppl 101): 1-32.
177. Lomako, J., Lomako, W., Carraway, C.A.C. and Carraway, K.L. 2005. Non-apoptotic desquamation of cells from corneal epithelium: putative role for Muc4/sialomucin complex in cell release and survival. J Cell Physiol 202: 115-124.
178. Rong, M., Rossi, E.A., Zhang, J., McNeer, R.R., Van Den Brande, J.M.H., Yasin, M., Weed, D. T., Carraway, C.A.C., Thompson, J. F. and Carraway, K.L. 2005. Expression and Localization of Muc4/Sialomucin Complex (SMC) in the Adult and Developing Rat Intestine: Implications for Muc4/SMC Function. J. Cell. Physiol. 202: 275-284.
179. Price-Schiavi, S.A., Andrechek, E., Idris, N., Li, P., Rong, M., Zhang, J., Carraway, C.A.C., Muller, W.J. and Carraway, K.L. 2005. Expression, location and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. J. Cell. Physiol.2005: 203: 44-53.
180. Franzmann, E.J., Reategu, E.P., Carraway, K.L., Hamilton, K. L., Weed, D. T. and Goodwin, W.J. 2005. Salivary Soluble CD44: A Potential Molecular Marker for Head and Neck Cancer. Cancer Epidemiol. Biomarkers Prev. 14: 1–5.
181. Nagy, P., Friedländer, E., Tanner, M., Kapanen, A.I., Carraway, K.L., Isola, J. and Jovin, T.M. 2005. Decreased accessibility and lack of activation of erbB2 in a Herceptin-resistant, MUC-4-expressing breast cancer cell line.
Cancer Res. 65: 473-482.
182. Zhang, J., Perez, A., Yasin, M., Soto, P., Rong, M., Theodoropoulos, G., Carraway, C.A.C. and Carraway, K.L. 2005. Presence of MUC4 in human milk and at the luminal surfaces of blood vessels. J. Cell. Physiol. 204: 166-177.
183. Carraway, K.L., Ramsauer, V.P. and Carraway, C.A.C. 2005. Glycoprotein contributions to mammary gland and mammary tumor structure and function: roles of adherens junctions, ErbBs and membrane MUCs. J. Cell. Biochem., in press.
14. Other Works, Publications and Abstracts:
Published Abstracts, selected, 1990-2003
S.R. Hull, J. Spielman and K.L. Carraway. 1990. Addition of O-linked oligosaccharides during recycling of a tumor cell surface sialomucin. FASEB J. 4: A2306.
K.L. Carraway, Z. Sheng and N. Fregien. 1991. EGF-like Sequences in a Major Integral Membrane Glycoprotein of a Rat Mammary Tumor. J. Cell Biol. 115: 60a.
C.A.C. Carraway, H. Fang, X. Ye, S.-H. Juang, Y. Li, M. Carvajal and K.L. Carraway. 1991. Purification from mammary tumor cell microvilli of a large, epithelial tissue-specific glycoprotein multimer which binds microfilaments. J. Cell Biol. 115: 167a.
K.L. Carraway, K.L. Carraway III, R.A. Cerione and C.A.C. Carraway. 1992. Epidermal growth factor-like activity in a cell surface transmembrane glycoprotein. FASEB J. 6: A47.
C.A.C. Carraway, S.-H. Juang and K.L. Carraway. 1992. Microfilament-associated kinases and phosphatases in isolated microvilli from rat mammary tumors. FASEB J. 6: A341.
K.L. Carraway, C.A.C. Carraway, K.L. Carraway III, P.M. Guy and R.A. Cerione. 1992. Integral membrane protein ligand for the epidermal growth factor receptor and p185neu. Molec. Biol. Cell 3: 281a.
C.A.C. Carraway, M.E. Carvajal, Y. Li and K.L. Carraway. 1992. Interaction of p185neu with microfilament-associated transmembrane complex of ascites tumor cell microvilli. Molec. Biol. Cell 3: 366a.
Carraway, C.A.C., Carvajal, M.E., Li, Y. and Carraway, K.L. (1993) A p185neu-containing signal transduction particle associated with microvillar microfilaments of mammary tumor cells. Miami Short Reports 3, 75.
Carraway, K.L., Carraway, K.L. III, Guy, P.M., Cerione, R.A., Carvajal,
M.E. and Carraway, C.A.C. (1993) Integral membrane growth factors and the intramembrane mechanism for stimulation: an hypothesis for autonomous tumor growth. Miami Short Reports 3, 76.
Carraway, K.L., Lorenzo, D., Guy, P.M., Carvajal, M.E., Cerione, R.A., Carraway, K.L. III, and Carraway, C.A.C. (1994) Integral membrane glycoprotein activator for p185neu: A mechanism for auto-activation of ascites tumor cells. J. Cell. Biochem. 18B: 274.
Carraway, C.A.C., Juang, S.-H., Li, Y., Huang, J., Gallo, A., Mayer, B., Fregien, N. and Carraway, K.L. (1994) Molecular cloning and sequencing of a 58 kDa membrane- and mcirofilament-associated Gag-like protein from ascites tumor cell microvilli which binds Src SH3 domain. J. Cell. Biochem. 18B: 232.
Rossi, E.A., Carraway, K.L. III, Fregien, N.L., Carraway, C.A.C. and Carraway, K.L. (1996) A new Neu ligand: Evidence for an intramembrane autocrine mechanism for receptor stimulation in mammary cancer. Proc. Am. Assoc. Cancer Res. 37: 40.
Carraway, K.L., Rossi, E.A., Fregien, N.L. and Carraway, C.A.C. (1996) ASGP-2, a putative ligand for p185neu, is expressed in the lactating mammary gland and secreted into milk. Proc. Am. Assoc. Cancer Res. 37: 40-41.
Carraway, C.A.C., Carvajal, M.E., Li, Y. and Carraway, K.L. (1996) A p185neu- and cadherin-containing signal transduction particle in an aggressive ascites mammary tumor cell: A microfilament-associated complex of signaling complexes. Proc. Am. Assoc. Cancer Res. 37: 49.
Carraway, K.L., Price-Schiavi, S., Rossi, E. and Fregien, N. (1997) Sialomucin/ErbB-2 Ligand Complex (ASGP-1/ASGP-2) in Mammary Gland. Proc. Am. Assoc. Cancer Res. 38: 66.
Komatsu, M., Fregien, N., Carraway, C.A.C. and Carraway, K.L. (1997) Sialomucin complex disrupts cell adhesion and reduces tumor cell killing by natural killer cells. Mol. Biol. Cell 8: 67a.
Carraway, C.A.C., Carvajal, M.E., Li, Y. and Carraway (1997) Crosstalk at the membrane-microfilament interface in an aggressive mammary tumor cell: ErbB3, PLCγ, p85 and tyrosine phosphatases associated with the p185neu-containing, microfilament-associated signal transduction particle. Proc. Am. Assoc. Cancer Res. 38: 138.
Price-Schiavi, S.A., Jing, X., Merritt, J., Tseng, S.C.G., Carraway, K.L. (1998) Expression of sialomucin complex, a heterodimeric, multifunctional mucin, in normal rat eye. Invest. Ophthalmol. Vis. Sci. 39: S535.
Pflugfelder, S.C., Monroy, D., Jones, D.T., Carvajal, M., Price-Schiavi, S., Idris, N. and Carraway, K.L. (1998) Detection of sialomucin complex in human ocular surface epithelium and tear fluid. Invest. Ophthalmol. Vis. Sci. 39: S665.
Carraway, K.L. (1998) Membrane mucins at the ocular surface. Exp.
Eye Res. 67: S183.Carraway, C.A.C., Carvajal, M.E., Komatsu, M. and Carraway, K.L.
(1998) Crosstalk at the membrane-microfilament interface: An ErbB2- and E-cadherin-containing signal transduction particle in an aggressive, non-adhesive ascites mammary tumor cell. Anticancer Res. 17: 3829.
Carraway, K.L., Komatsu, M. and Carraway, C.A.C. (1998) Functional activities and contribution to metastasis of sialomucin complex, a mucin/ErbB2 ligand complex. Anticancer Res. 17: 3829-3830.
Price-Schiavi, S.A., Carraway, C.A.C., Fregien, N. and Carraway, K.L. (1998) Post-transcriptional regulation of a milk membrane protein sialomucin complex by TGF-β. Mol. Biol. Cell 9: 489a.
Komatsu, M., Tatum, L., and Carraway, K.L. (1999) Regulated tumor metastasis by the modulation of sialomucin complex/MUC4 expression. Proc. Am. Assoc. Cancer Res. 40: 451.
Price-Schiavi, S.A., Zhu, X. and Carraway, K.L. 1999. Characterization of the TGF-β effect on sialomucin complex in normal rat mammary epithelial cells. FASEB J. 13: A1540.
Zhu, X., Price-Schiavi, S.A., and Carraway, K.L. 1999. MAP kinase-dependent and -independent regulation of Sialomucin Complex/rat Muc4 expression. FASEB J. 13: A1511.
Carothers-Carraway, C.A., Carvajal, M.E., Li, Y., Carraway, K.L. and Carraway, K.L. III. 1999. Constitutively activated ErbB2 assembles a microfilament-associated signal transduction particle containing all of the Ras to MAPK mitogenic pathway components. FASEB J. 13: A1511.
Zhu, X., Price-Schiavi, S.A., and Carraway, K.L. 2000. Modulation of sialomucin complex/Muc4 expession in mammary epithelial cells. Miami Nature Biotechnology Short Reports, 11: 27.
Idris, N. and Carraway, K.L. 2000. Regulation of Sialomucin Complex/Muc4 by Transforming Growth Factor β (TGF-β) in the Rat Uterus. Miami Nature Biotechnology Short Reports, 11:33.
Jepson, S. and Carraway, K.L. 2000. Inhibition of apoptosis by overexpression of sialomucin complex (MUC4) in transfected A375 melanoma cells. Miami Nature Biotechnology Short Reports, 11: 54.
Perez, A., Price-Schiavi, S.A., Barco, R. and Carraway, K.L. 2000. Basic mechanisms of SMC/MUC4 transcriptional regulation. Miami Nature Biotechnology Short Reports, 11: 56.
Zhang, B., Huang, J., Carraway, K.L. and Carraway, C.A.C. 2000. Identification of actin-binding motifs of p58, a membrane- and microfilament-associated protein, via deletion mutants analysis. Miami Nature Biotechnology Short Reports, 11:60.
Weed, D.T., Gomez-Fernandez, C., Bonfante, E., Lee, T.D., Pacheco, J., Carvajal, M.E., Goodwin, W.J. and Carraway, K.L. 2000. MUC4 (sialomucin complex) expression in squamous cell carcinoma. Miami Nature
Biotechnology Short Reports, 11: 69.Idris, N. and Carraway, K.L. 2000. Regulation of Sialomucin Complex
transcript levels by Transforming Growth Factor β (TGF-β1). Proc. Am. Assoc. Cancer Res. 41: 375.
Jepson, S. and Carraway, K.L. 2000. Inhibition of apoptosis by overexpression of sialomucin complex (MUC4) in transfected A375 melanoma cells. Proc. Am. Assoc. Cancer Res. 41: 510.
Weed, D.T., Gomez-Fernandez, C., Bonfante, E.L., Lee, T.D., Pacheco, J., Carvajal, M.E., Goodwin, W.J. and Carraway, K.L. 2000. MUC4 (sialomucin complex) expression in squamous cell carcinoma of the upper digestive tract. Proc. Am. Assoc. Cancer Res. 41: 515.
Perez, A., Price-Schiavi, S.A., Barco, R. and Carraway, K.L. 2000. Basic mechanisms of SMC/MUC4 transcriptional regulation. Proc. Am. Assoc. Cancer Res. 41: 627.
Hu, H.-P., Scordilis, L., Carraway, K.L., Savaraj, N. and Lampidis, T.J. Association of P-GP and MRP-mediated MDR with sialomucin expression in tumor cells. 2000. Proc. Am. Assoc. Cancer Res. 41: 673.
Price-Schiavi, S.A., Ramsauer, V.P., Falkenberg, V.R. and Carraway, K.L. 2001. Effect of interferon-γ on Transforming Growth Factor β (TGF-β) regulation of sialomucin complex (SMC, rat Muc4). Proc. Am. Assoc. Cancer Res. 42: 525.
Soto, P. Komatsu, M. and Carraway, K.L. 2001. Interaction of sialomucin complex (SMC, Muc4) and selectins and their role in tumor metastasis. FASEB J. 15: A869.
Zhang, J., Komatsu, M., Carvajal, M. and Carraway, K.L. 2001. Synthesis of soluble form of sialomucin complex/Muc4. FASEB J. 15: A869.
Carraway, K.L., Carvajal, M.E. and Carraway, C.A.C. 2001. Type 1 growth factors in the rat lacrimal gland. Invest. Ophthalmol. Vis. Sci. 42: S32.
Weed D, Gomez-Fernandez C, Pacheco J, Ruiz J, Hamilton K, Arnold D, Civantos F, Yasin M, Goodwin WJ, Carraway K. 2002. MUC4 (sialomucin Complex) and ErbB2 Expression in Major and Minor Salivary Gland Mucoepidermoid Carcinoma. Proc American Association Cancer Research 43:192.
Ramsauer, V.P., Carraway, C.A.C. and Carraway, K.L. 2002. Muc4-ErbB2 complex formation in insect cells. Proc American Association Cancer Research 43: 723.
Pino, V., Barco, R., Perez, A. and Carraway, K. 2002. Muc4 untranslated regions control post-transcriptional regulation of gene expression. Proc American Association Cancer Research 43: 816.
Perez, A., Barco, R. and Carraway, K. 2002. Muc4 is a target of PEA3 transcriptional regulation. Proc American Association Cancer Research 43: 1133.
Carraway, K.L., Komatsu, M. and Arango, M.E. 2002. Synthesis and secretion of Muc4/Sialomucin complex: implication of intracellular proteolysis. Mol. Biol. Cell 13: 99a.
Carraway, K.L., Jepson, S., Komatsu, M., Arango, M.E., Haq, B. and Carraway, C.A.C. 2002. Muc4/Sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27kip, but does not activate mitogen-activated kinase or protein kinase B/Akt pathways. Mol. Biol. Cell 13: 435a.
Pino, V., Carraway, K.L. and Perez, A. 2003. Differences in UTR-mediated Muc4 post-transcriptional regulation between normal and cancer cells. Proc. Amer. Assoc. Cancer Res. 44: 256.
Ramsauer, V.P., Carraway, C.A.C. and Carraway, K.L. 2003. Muc4 translocates ErbB2 to the apical surface of Caco-2 polarized epithelial cells. Proc. Amer. Assoc. Cancer Res. 44: 1161.
Theodore, G., Carraway, C.A.C. and Carraway, K.L. 2003. Regulation of Muc4/Sialomucin complex expression by retinoic acid, insulin-like growth factor and the extracellular matrix in airway epithelia. Mol. Biol. Cell 14: 263a.
Carraway, K.L., Lomako, J., Lomako, W. and Carraway, C.A.C. 2003. A role for Muc4/Sialomucin Complex in stratified epithelia: Possible contribution to non-apoptotic desquamation of rat corneal epithelium. Mol. Biol. Cell 14: 264a.
George Theodore and Kermit L. Carraway. Regulation of SMC/Muc4 Expression by Retinoic Acid, IGF and the Extracellular Matrix in Airway Epithelia. American Society for Cell Biology, and Anatomy, University of Miami School of Medicine, Miami, FL
Patent
K.L. Carraway, C.A.C. Carraway, N. FregienPatent Number: 5,624,816Transmembrane Glycoprotein ASGP-2: Nucleotide Sequences and Recombinant
Production of Proteins
15. Other Works Accepted for Publication: None
PROFESSIONAL
16. Funded Research Performed:
Active Support
Structure/Biosynthesis of a Tumor Sialomucin Complex, Principal Investigator, NIH CA 52498, 4/01-3/06, $1,513,278.
Minority predoctoral supplement for Pedro SotoMinority predoctoral supplement for Vanessa Pino
Ocular surface protection by sialomucin complex, PI, NIH NEI RO1 EY12343, 8/1/04-7/31/08, Approx $900,000
Investigation of the role of sialomucin complex (SMC)/Muc4, a unique intramembranous HER2/ErbB2 ligand, as a suppressor of apoptosis. DAMD BC011233, predoctoral fellowship for Bushra Haq, M.D./ George Theodore, 4/1/02-3/31/05, $66,000.
Function of HER2/ErbB2 ligand sialomucin complex/Muc4, PI, NIH CA 74072, 12/02-11/06, $909,000.
Previously awarded grant support
Chemical Studies on the Red Blood Cell Membrane, Principal Investigator, Oklahoma State University, NIH GM 16870, 5/69-4/72, approx. $53,000.
Chemical Labeling of Cell Surface Components, Principal Investigator, Oklahoma State University, American Cancer Society, P-563, 12/69- 11/71, approx. $21,000.
Reactions of Oxidized Lipids with Proteins, Principal Investigator, Oklahoma State University, NIH HL 14081, 5/71-12/74, approx. $63,000.
Identification, Isolation and Characterization of Cell Surface Components, Principal Investigator, American Cancer Society, BC-77, 12/71-11/73, approx. $30,000.
Chemical Studies on Cell Membranes and Components, Principal Investigator, NIH HL 15687, 5/73-4/76, $72,000.
Membrane Changes During Erythrocyte Oxidant Stress, Principal Investigator, Oklahoma Heart Association, 7/73-6/75, $2,600.
Studies of the Biochemical Means by which Effector Molecules Bind to Mammary Cell Surfaces and the Manner in which They Influence Cellular Biochemistry, (shared with K.E. Ebner, Kansas University) NIH N0C1B 33910, 6/72-6/75, $296,000.
Interactions of Natural and Chemically Modified Biopolymers with Blood, Principal Investigator, NHLI-N01-H13-4-2983, 6/74-6/78, $242,000 (shared with Dr. B.G. Hudson, Kansas Univ.).
Glycoprotein Shedding and Mammary Tumor Metastasis, Principal Investigator, NIH-CA 1985, 6/75-5/79, $165,000.
Chemical Studies on Cell Membranes and Components, Principal Investigator, American Cancer Society, BC-246, 1/77-12/78, $73,000.
Presidential Challenge Grant on Biomembranes, Oklahoma State University, 7/76-6/79, approx. $75,000.
Biophysical Studies of Model and Tumor Cell Membranes, Principal Investigator, NSF PCM-76-01389, 4/76-10/77, $23,000 (shared with Dr. R.C. Powell, Physics, OSU).
Membrane-Cytoskeleton Interactions, Principal Investigator, NIH GM 25818, 12/78-11/81, $172,572.
Sialoglycoproteins of a Metastic Mammary Tumor, Principal Investigator, NIH CA 25173, 12/79-11/82, $135,265.
Ecto 5'-Nucleotidase as a Cell Surface Reporter, Principal Investigator (with C.A.C. Carraway), NIH CA 26085, 4/80-3/83, $136,361.
Structure, Shedding and Biosynthesis of a Mucin-Type Cell Surface Glycoprotein, Principal Investigator, NSF PCM 8000267, 7/15/80- 12/30/83, $55,997.
Role of Actinin in Cell Surface Phenomena, Principal Investigator, Florida Affiliate of American Cancer Society, 1/1/82-12/31/82, $10,000.
5'-Nucleotidase and Regulation of Adenosine, Principal Investigator, Miami Affiliate of American Heart Association, 7/1/83-6/30/84, $15,000.
Membrane Cytoskeleton Interactions, Co-principal Investigator (with C. Carraway), NSF PCM 8300771, 8/15/83-8/14/86, $190,000.
Actin-Containing Transmembrane Complex from Platelets, Principal Investigator, Florida Affiliate of American Heart Association, 7/1/84-6/30/85, $17,000.
Biosynthesis of Sulfated Mucin, Principal Investigator, Cystic Fibrosis Society, 7/85-6/87, $60,000.
Sialoglycoproteins of a Metastatic Mammary Tumor, Principal Investigator, NIH CA 31695, 2/1/84-5/30/89, $461,172.
Monoclonal Antibodies for Breast Cancer Prognosis and Therapy, Principal Investigator, State of Florida High Technology and Industry Council, 01/25/90-8/1/91, $17,424.
Actin-Containing Transmembrane Complex of Tumor Cells, Principal Investigator, NIH GM 33795, 7/1/86-6/30/92, $595,689.
Structure/Biosynthesis of a Tumor Sialomucin Complex, Principal Investigator, NIH CA 52498, 9/91-9/95, $340,000.
Membrane Ligand for Neu Oncogene-encoded Protein, Principal Investigator, Florida Division ACS, F92UM-1, 1/92-12-92, $20,000
Membrane-microfilament interactions in isolated platelet pseudopodia, Co-principal investigator (CAC Carraway, PI), AHA, FL affiliate, 92GIA/854, 7/92-6/94, $80,000.
Ligand for Neu Oncogene-encoded Receptor, Principal Investigator, American Cancer Society, 7/93-6-97, $300,000
Expression and Analysis of Activities of Human ASGP-2, a Transmembrane Ligand for the EGF Receptor and p185neu, Principal Investigator, Amgen Corp., 9/93-9/96, $282,520.
Heterodimeric, Bifunctional Glycoprotein Complex of Bronchial Epithelium, Principle Investigator, American Lung Association of Florida, 7/1/95-6/30/96, $50,000.
Sialomucin complex and uterine receptivity, NIH RO3 HD35472, Minority
supplement for Ricard Perez, 6/22/98-8/31/98, $3,050Sialomucin complex and uterine receptivity, PI, NIH RO3 HD35472, 9/97-
8/00, $153,000Structure/Biosynthesis of Tumor Sialomucin Complex, NCI 1 R01 CA52498, 96-00,
~$800,000Structure/Biosynthesis of Tumor Sialomucin Complex, NCI 1 R01 CA52498 SB01
Minority Supplement for Dr. Aymee Perez, 03/01/98 - 02/28/00, 1st year $78,538Regulation of Sialomucin Complex Expression and its Affect on HER Receptor
Function, DOD Breast Cancer Predoctoral Fellowship BC961227, Mentor for PI Shari Price-Shiavi, Nebila Idris
MUC4 abrogation of herceptin responsiveness in breast cancer, PI, DAMD 17-00-1-0685, 9/00-8/01, $75,000
HER2 ligand in human breast tumors, PI, NCI RO1 CA74072, 97-01, ~$800,000HER2 ligand in human breast tumors, PI, NCI RO1 CA74072, 7/98-6/02, $655,453.
Minority postdoctoral supplement for Dr. Victoria Ramsauer, 12/00-6/02.
Muc4 regulation in airway epithelium, PI, Florida Biomedical Research Program, 7/01-12/03, $340,220.
17. Editorial Responsibilities:
Editorial board, FASEB Journal 1986-91Special editor, October, 1987, issue of Bioessays on the cytoskeleton Deputy Editor-in-Chief, BioEssays, 1989Chairman, Editorial Board, BioEssays, 1990-95Editorial Board, BioEssays, 1990-Editorial Board, Journal of Cellular Biochemistry, 1989-Assistant Editor, Journal of Mammary Gland Biology and Neoplasia, 2000Scientific Committee, 22nd Congress of International Association for Breast Cancer Research, 1998International Advisory Committee, 3rd International Conference on the
Lacrimal Gland, Tear Film and Dry Eye SyndromeEditor, Miami Nature Biotechnology Short Reports, Vol. 11Co-Editor-in-chief, Journal of Mammary Gland Biology and Neoplasia, 2001-Faculty of 1000, Cell signaling, 2002-
18. Professional and Honorary Organizations:
Sigma XiAmerican Society for Biochemistry and Molecular Biology, American Society for Cell Biology, American Association for Cancer Research
International Association for Breast Cancer Research, Board of GovernorsAssociation for Research in Vison and OphthalmologyAmerican Cancer Society, Florida Division, Research CommitteeMammary Gland Gordon Conference, Advisory Board
19. Honors and Awards:
NSF Predoctoral Fellowships (Summer-1963, Cooperative 1963-1964), (National 1964-1966)NIH Postdoctoral Fellowships (1966-1968), Phi Eta Sigma, Phi Kappa Phi, B.S. (highest honors),Molecular Cytology Study Section, NIH, 1975-1978Sigma Xi Honorary Chapter Lecturer, Oklahoma State University, 1978Mid-American State Universities Association Honor Lecturer, 1978- 1979American Men and Women of ScienceWho's Who in the SouthWho's Who in Frontier Science and Technology
25. Post-Doctoral Fellowships:
NIH, 1966-68 with Dr. Daniel E. Koshland, Jr., University of California, Berkeley
26. Other Professional Activities:
Invited Lectures:Carnegie-Mellon Univeristy
University of Cincinnati Oklahoma State Univeristy Rice University Pennsylvania State University University of Washington University of Pennsylvania Johns Hopkins University University of Kansas Texas Tech University New Mexico State University Wistar Institute National Science Foundation North Texas State University Kansas State University
University of Nebraska, Lincoln University of Missouri Iowa State University University of Illinois University of Southern California University of Kentucky Purdue University Sloan Kettering Memorial Cancer Institute University of Toronto University of Miami University of Florida University of Oklahoma Health Sciences Center Baylor University School of Medicine University of Mainz, Germany Utrecht University, The Netherlands University of Bern, Switzerland Sydney University, Australia University of Alabama School of Medicine, Birmingham University of Calgary University of California School of Medicine, San Francisco University of Alabama, Tuscaloosa Mississippi State University University of Mississippi Medical School University of Colorado School of Medicine National Jewish Hospital, Denver Massachusetts General Hospital M.D. Anderson Hospital, Houston Imperial Cancer Research Fund, London Cornell University Boston University Monsanto, St. Louis Clinical Research Center, Northwick Hospital, Harrow, UK University of Arizona AMGEN Onyx, Inc. Hospital for Sick Children, University of Toronto Biotechnology Research Institute, Montreal
M.D. Anderson Cancer CenterUniversity of Florida Department of BiochemistryVeterans Administration Hospital, San FranciscoUniversity of Florida Interdisciplinary Reproductive Biology Group
Ohio State University School of Medicine (2): Departments of
Pathology and ImmunologyUniversity of Nebraska School of Medicine Department of
BiochemistryChildren’s Hospital of George Washington University Research
InstituteUniversity of Manchester, Manchester, EnglandUniversity of California-Davis Medical School, SacramentoUniversity of California-Davis Lung Biology Group, DavisUniversity of Iowa Pulmonary Research GroupILEX Oncology, Boston, MASunol Molecular, Miami, FLUniversity of North Carolina, Chapel Hill, Cystic Fibrosis CenterOhio State University Department of BiochemistryNeoprobe, Columbus, OH
Conference Lectures:Rothschild Conference on Membrane-Cytoskeleton Interactions,
Kiryat Anavim and Rehovot, Israel, 1976.Midwest Regional, American Chemical Society, Symposium on
Membranes, Carbondale,Illinois, 1976.
Gordon Conference on Mammary Biology, 1977.American Chemical Society, Symposium on Glycoproteins and
Glycolipids in DiseaseProcesses, Anaheim, 1978.
Symposium on Membranes and Tumor Growth, Rome, 1982.Symposium on Actin-Membrane Interactions, Chapel Hill, North
Carolina, 1983.American Society for Cell Biology, Minisymposium on Membrane-
CytoskeletonInteractions, 1984.
American Society of Zoology, Symposium on Complex Carbohydrates and Recognition,Baltimore, MD, 1985
Wye Conference on Cell Recognition, Wye, England, 1987Florida Biochemists Symposium, 1987Third International Workshop on Monoclonal Antibodies and Breast
Cancer, San Francisco,1988
Organizer and speaker, UCLA Conference on the Cytoskeleton and Cell Regulation,
Steamboat Springs, CO, 19902nd International Workshop on Carcinoma-associated Mucins,
Cambridge, UK, 1992ASBMB Conference on Kinases and Phosphatases, Keystone, CO,
1992ASCB Minisymposium on Receptors and Signal Transduction, Denver,
CO, 19923rd International Workshop on Carcinoma-associated Mucins,
Cambridge, UK, 1994American Association for Cancer Research, Toronto, Canada, 1995Miami Winter Symposium, Fort Lauderdale, FL, 1996NIH NICHD Conference on Human Uterine Receptivity for Blastocyst
Implantation,Bethesda, 1996.
4th International Workshop on Carcinoma-associated Mucins, Session chair and speaker,
Cambridge, UK, 1996Gordon Research Conference on Macromolecular Organization and
Cell Function, Oxford,UK, 1996.
Keystone Symposium on Adhesion and Signaling, Keystone, CO, 1997.
Ocular Surface and Tear Workshop, Miami, 1997.Gordon Research Conference on Mammary Biology, Plymouth, NH,
1997, session chair and speaker.5th International Workshop on Carcinoma-associated Mucins,
speaker, Cambridge, UK, 1998International Symposium on Eye Research, Symposium on Mucins,
Paris, 1998International Association for Breast Cancer Research, Athens, 1998Miami Winter Symposium, 1999, organizing committee and session
chairGordon Research Conference on Mammary Biology, Henniker, NH, 1999, session chair Joint Cancer Conference of the Florida Universities, Orlando, FL, 2000International Workshop on Mucins and Disease, speaker, Cambridge,
UK, 2000Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes, session chair and speaker, Maui, 2000Symposium on Glycobiology and Development, Biochemical Society/British Society for Developmental Biology meeting, Brighton, UK, 2000NCI Workshop on Glycobiology and Cancer, session scribe, Bethesda,
2002NCI-sponsored US/Japan Workshop on "MUC1 and Related Mucins in Tumor Metastasis and Anti-Tumor Immune Responses, speaker, Maui, 2003
International Workshop on Mucins in Health and Disease, speaker, Crete, 2003
International Association for Breast Cancer Research, speaker, Sacramento, CA, 2003
Fourth International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes, session chair and speaker, Fajardo, Puerto Rico, 2004
Manuscript reviews:
Journal of Biological Chemistry Journal of Cell Biology Biochimica et Biophysica Acta Biochemistry Science Archives Biochemistry Biophysics Journal of Cellular Physiology Analytical Biochemistry Cancer Research Lipids Journal of Clinical Investigation Proceedings of the National Academy of Science Gastroenterology Nature
Experimental Cell ResearchBiology of ReproductionBloodInvestigative Ophthalmology and Visual SciencesInternational Journal of CancerBritish Journal of CancerFASEB JournalEuropean Journal of CancerGlycoconjugate JournalGlycobiologyJournal of Cellular BiochemistryGene TherapyJournal of Cell ScienceJournal of ImmunologyJournal of Mammary Gland Biology and Neoplasia
Physiological ReviewsMolecular and Cell Biology OncogeneJournal of Leukocyte BiologyGenes, Chromosomes and CancerCurrent Eye ResearchAmerican Journal of PhysiologyCorneaExperimental Eye ResearchJournal of Dental ResearchMolecular Human ReproductionJournal of HistochemistryLife IUBMBTissue and CellMolecular Biology of the CellDevelopmental BiologyJournal of Physiology
Grant Proposal Reviews:
National Institutes of Health Molecular Cytology Study Section, 1975-78Special NCI study section for Metastasis grants- 1991Pathobiochemistry Study Section, ad hoc, 1998Special NCI study section for breast cancer grants, 1999NCI Program Project Grants Committee C (Basic Science), ad
hoc, 12/98 and 12/99 Site visits for NHLBI, NCI, NIGMS; 1972-presentAmerican Cancer SocietyNational Science FoundationU.S. ArmyUSDAVeterans AdministrationTexas Higher Education Coordinating CouncilDOD Breast Cancer Program, 1994, 1995, 1997, 2001, 2003State of California Breast Cancer Program, 1994, 1998, 1999Florida ACS
Grant proposal review committee 1986-91Research committee 2001-
NCI Site visits:Program Projects
PurdueNew England Deaconess/MIT/Harvard Medical SchoolMITEppley Institute, University of Nebraska Medical SchoolUCSF
Cancer CentersPurdueMITRoswell ParkUniversity of Kentucky
Department Reviews:
Department of Biochemistry, Cell Biology and Human Genetics, University of Texas Medical Branch, Galveston, 1987
Department of Anatomy and Cell Biology, Georgetown University, Washington, DC, 1988
Graduate Program Reviews, Texas Higher Education Coordinating Board, 1990
ConsultantDepartment of Defense/American Institute of Biological Sciences,
Scientific Peer Advisory and Review Services
TEACHING27. Teaching Awards Received: None
28. Teaching Specialization:Molecular cell biologyIBS 601- 1 lectureIBS 602- 3 lecturesTumor biology- course coordinator for 2000-02 fall semesterDevelopmental Biology- 1 lecture, 1 discussion session
29. Thesis and Dissertation Advising/Post-doctoral student supervision:
Doctoral students
Triplett, R.B. PhD 72 Oklahoma St.
Kobylka, D. PhD 72 Oklahoma St. Shin, B. PhD 73 Oklahoma St.Huggins, J.W. PhD 75 Oklahoma St. Anderson, D.R. PhD 76 Oklahoma St. Snow, L.D. PhD 76 Oklahoma St. Adams, D. PhD 77 Oklahoma St. Moore, P.B. PhD 78 Oklahoma St. Buck, R.L. PhD 78 Oklahoma St. Doss, R.C. PhD 79 Oklahoma St. Howard, S.C. PhD 80 Oklahoma St. Cerra, R. PhD 81 Oklahoma St. Hull, S.R. PhD 82 Oklahoma St. Jung, G. PhD 84 Oklahoma St. Spielman, J. PhD 87 MiamiSheng, Z. PhD 90 MiamiWu, K. PhD 94 MiamiRossi, E. PhD 96 MiamiMcNeer, R. PhD 97 MiamiKomatsu, M. PhD 98 MiamiPrice-Schiavi, S. PhD 99 MiamiIdris, N. PhD 01 MiamiHaq, B.Soto, P. PhD 04 MiamiTheodore, G.Pino. V.Tang, Fei
Postdoctoral research associates
Shin, B. 73-75 Oklahoma StateTsao, D. 74-76 Oklahoma StateColton, D.G. 74-77 Oklahoma StateChesnut, R.W. 75-78 Oklahoma StateDavis,J.L. 75-77 Oklahoma StateHuggins, J.W. 76-78 Oklahoma State Adams, D. 77-78Oklahoma State Sherblom, A.P. 77-80 Oklahoma StateHelm, R.M. 79-82 Oklahoma State/Miami Craik, J.D. 80-82 Oklahoma State/Miami Cerven, E. 80-82 Oklahoma State/Miami Hull, S.R. 85-91 MiamiMetcalf, T. 85-87 Miami
Vanderpuye, O. 85-88 MiamiBharathan, S. 90-92 MiamiPerez, A. 97-01MiamiZhu, Xiaoyun 98-99MiamiLi, Peter 98-99MiamiKomatsu, M. 98-99MiamiPereira, L. 99 MiamiJepson, S. 99-01MiamiRamsauer, V. 99- MiamiSwan, J. 00-01 MiamiLomako, J. 01- MiamiRong, Min 02- MiamiLomako, W. 03- Miami
SERVICE
30. University Committee and Administrative Responsibilities:
Committees: Miami onlyExecutive Advisory Council, University of Miami School of Medicine
M.D.-Ph.D. Advisory Committee Cancer Center Steering Committee Search Committee for Vice President and Dean, School of Medicine Search Committee for Chairman of Pharmacology Search Committee for Chairman of Microbiology and Immunology Cell and Molecular Biology Training Program Search Committee for Director of Cancer Center Search Committee for Chairman of Biochemistry and Molecular
Biology Search Committee for Chairman of Oncology
Task Force on Research and Graduate ProgramsScientific Advisory CommitteeUniversity Research CouncilLCME task forceSteering committee for Center for Vision Research
Graduate Program in Molecular Cell and Developmental Biology, chair
University of Miami School of Medicine School Council Leadership Team, Women’s Health Institute, University of Miami
Faculty mentor:Pedro Salas, Cell Biology and AnatomyDon Weed, OtolaryngologyNadia Ameen, PediatricsAymee Perez, Cell Biology and AnatomyCatherine Welsh, MedicineJie Li, DermatologyElizabeth Franzmann, OtolaryngologyZoyla Almeida, Gynecological Oncology
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