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Nonfasting Lipids, Lipoproteins, and Apolipoproteins in Individuals With and Without Diabetes: 58 434 Individuals from the Copenhagen General Population Study
Participants randomly selected from the general population of Copenhagen, Denmark
Total participants between 2003 and 2009N= 58434 With diabetes (self-reported, taking insulin or other antidiabetic medication, random plasma glucose >11 mmol/L)N= 2270
Fresh blood samples collected at Copenhagen University Hospital
Standard hospital assays (Konelab) used to measure glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apolipoprotein A1, apolipoprotein B and albumin
Non-HDL cholesterol = total cholesterol – HDL cholesterol
If triglycerides <4 mmol/L, LDL cholesterol was calculated by the Friedewald equation
• Mean plasma triglycerides only increased a maximum of 0.2 mmol/L after normal food intake in both diabetic and nondiabetic individuals
• Reduction in LDL cholesterol observed after normal food intake in both diabetic and nondiabetic individuals most likely caused by hemodilution due to fluid intake
• Apolipoprotein B concentrations did not change after normal food intake
• Non-HDL cholesterol was found to be quite stable
DiscussionDiscussionStill controversial whether lipid profiles should be measured fasting or nonfasting; present data suggest that nonfasting samples can be used in diabetics and nondiabetics alike
Nonfasting blood sampling would simplify the process for both patients and general practitioners/hospitals
In Denmark: nonfasting lipid measurements as a standard is recommended by the Danish Society for Clinical Biochemistry - and by 2010 implemented in most of the country
In Denmark: if nonfasting triglycerides are >4 mmol/L, the clinician can choose to measure triglycerides fasting. However, most do not use this option.