© 2015 BrightSpec, Inc. 770 Harris St. Suite 104B, Charlottesville, VA 22903 www.brightspec.com Molecular rotational spectroscopy provides a spectral signature with extreme sensitivity to the mass distribution (3D structure) of the molecule. Instruments for measuring rotational spectra using pulsed jet sources offer high sensitivity and high spectral resolution. As a result, it is possible to perform direct quantitative analysis of complex mixtures without chromatographic separation. For samples that include chiral molecules, rotational spectroscopy can identify diastereomers of molecules with multiple chiral centers and, with fundamental advances in the past two years*, can perform enantiomeric excess measurements on the diastereomers. *David Patterson, Melanie Schnell, John M. Doyle, “Enantiomer-specific detection of chiral molecules via microwave spectroscopy”, Nature 497, 475 (2013). Broadband Rotational Spectrum of the Volatile Head Space (65˚C) 770 Harris St. Suite 104B, Charlottesville, VA 22903 www.brightspec.com Spec Molecular Rotational Resonance Spectroscopy Direct Chiral Analysis of Complex Mixtures by FT-MRR Spectroscopy Luca Evangelisti, Nathan Seifert, Lorenzo Spada, and Brooks H. Pate, Department of Chemistry, University of Virginia Matt Muckle, Justin Neill, and Roger Reynolds, BrightSpec, Inc., Charlottesville, VA Identification of the Diastereomers of 8-mercaptomenthone M. Sandasi, G.P.P. Kamatou, M. Baranska, and A.M. Viljoen, “Application of vibrational spectroscopy in the quality assessment of Buchu oil obtained from two commercially important Agathosma species (Rutaceae)”, South African J. of Botany 76, 692-700 (2010). Buchu Oil (betulina) Buchu Oil (crenulata) Z-8-mercaptomenthone E-8-mercaptomenthone