‐ 1 ‐ @ Aboca ‐ Sansepolcro @ Aboca ‐ Sansepolcro June 11‐13, 2014 Complex substances for Botanical Drugs, Herbal Medicinal Products, Medical Devices, Medical Foods
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@ Aboca ‐ Sansepolcro
June 11‐13, 2014
@ Aboca ‐ Sansepolcro
June 11‐13, 2014
Complex substances for Botanical Drugs, Herbal Medicinal Products, Medical Devices, Medical Foods
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Organised by
Under the patronage of
Centro Studi e Ricerche “Giovanni Galli” ‐ UniMI
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COMMITTEES
SCIENTIFIC COMMITTEE Valentino Mercati (Chairman, Aboca)
Vincenza Andrisano (Università di Bologna) Giuseppe Avellone (Università di Palermo) Gianluca Bartolucci (Università di Firenze) Marina Carini (Università di Milano) Donatella Caruso (Università di Milano) Luigi Colombo (Merck Serono) Maristella Colombo (Nerviano Medical Sciences) Nunziatina De Tommasi (Università di Salerno) Gianluca Giorgi (Università di Siena) Luca Grigi (Aboca) Jacopo Lucci (Aboca) Anna Maidecchi (Aboca) Marcello Marchetti (Angelini, Pomezia) Gabriella Massolini (Università di Pavia) Luisa Mattoli (Aboca) Pietro Traldi (CNR, Padova) Sauro Vittori (Università di Camerino)
ORGANISING COMMITTEE Luisa Mattoli (Chairman, Aboca)
Giuliana Bianco (Università della Basilicata) Michele Boriosi (Aboca) Michela Burico (Aboca) Vincenzo Cunsolo (Università di Catania) Anna Zita Di Carlo (Aboca) Roberta Galarini (IZSUM, Perugia) Fulvio Magni (Università di Milano Bicocca) Giorgio G. Mellerio (Università di Pavia) Michele Suman (Barilla, Parma)
CONFERENCE SECRETARIAT Ufficio Relazioni Esterne (Aboca)
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The 8th MS‐Pharmaday conference is kindly
supported and sponsored by:
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SCIENTIFIC PROGRAM
Wednesday, June 11th, 2014
11:00 Shuttle bus from the Arezzo railway station
11:30 – 14:30 REGISTRATION
12:00 SATELLITE WORKSHOP
Waters: La mobilità ionica e sue applicazioni nel settore alimentare
Sergio Gallo, Waters
13:00 LUNCH @ ABOCA
14:30 WELCOME & OPENING REMARKS
Valentino Mercati Aboca Luisa Mattoli Aboca Gabriella Massolini Univ. Pavia Gianluca Giorgi Univ. Siena
DSM Awards & Fellowships Ceremony
15:00 Session 1
Chair: Luisa Mattoli, Maristella Colombo
15:00 THE HOLISTIC VIEW OF NATURAL EXTRACTS
Pietro Traldi , Valentino Mercati, CNR, Padova, Aboca (Italy)
15:40 DSM Award for Young Researchers 2014 QUANTIFICATION OF “CHOLESTEROL LOWERING” SOYASAPONINS
IN LEGUMES AND ASSESSMENT OF THEIR BIOACCESSIBILITY G. Caprioli, G. Sagratini, M. Ricciutelli, S. Vittori, University of
Camerino, Camerino (Italy)
16:10 Poster Session ‐ coffee break
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17:00 Session 2
Chair: Marcello Marchetti
17:00 THE CLASH OF THE “OMICS” AND ITS APPLICATIONS Lello Zolla et al. University della Tuscia, Viterbo (Italy)
17:30 End of session
17:30 Shuttle bus to Aboca Museum in Sansepolcro: guided tour
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Thursday, June 12th, 2014
9:00 Session 3
Chair: Gianluca Bartolucci, Giuliana Bianco
9:00 ACCELERATING EXPERIMENTAL METABOLITE IDENTIFICATION BY BIO COMPUTATIONAL MODELING
G. Cruciani, University of Perugia (Italy)
9:40 CHARACTERIZATION OF HEALTH‐PROMOTING GRAPE COMPOUNDS BY SUSPECT SCREENING METABOLOMICS
R. Flamini, M. De Rosso, A. Dalla Vedova, A. Panighel, L. Bavaresco, CRA‐VIT, Conegliano (TV) (Italy)
10:00 LIQUID CHROMATOGRAPHIC/ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRIC STUDY OF POLYPHENOLIC COMPOUND IN BERRIES
Samuele Scurati, ABSciex
10:20 STABILITY IN BIOLOGICAL FLUIDS BY LC‐MS/MS ANALYSIS OF MULTI‐DRUGS RESISTENCE INHIBITORS
M. Menicatti, L. Guandalini, S. Dei, E. Floriddia, E. Teodori, G. Bartolucci, University of Florence, Sesto F.no (Italy)
10:40 Poster Session ‐ coffee break
11:30 Session 4
Chair: Donatella Caruso, Roberta Galarini
11:30 GC‐MS/MS ANALYSIS OF TRACE LEVEL DECHLORANE FLAME RETARDANTS IN FOOD AND FEED AND POSSIBLE EXPOSURE ROUTE TO HUMANS
C. Calaprice, B. L’Homme, C. Brasseur, C. D. Calvano, J.‐F. Focant, Politecnico di Bari (Italy)
11:50 BIOTHERAPEUTICS: THE BRUKER MS TOOLBOX FOR IN DEPTH CHARACTERIZATION
Catherine Evans, Bruker Daltonics, UK
12:10 LIPIDOME OF FARMED Sparus aurata: LYSOPHOSPHATIDYL‐CHOLINES AS SEAFOOD QUALITY BIOMARKERS
S. Granafei, I. Losito, S. Salivo, P. Q. Tranchida, L. Mondello, F. Palmisano, T.R.I. Cataldi, University of Bari (Italy)
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12:30 DEVELOPMENT OF A MULTICLASS METHOD FOR THE DETERMINATION OF VETERINARY DRUG RESIDUES IN MEAT
S. Moretti, G. Dusi, S. Pellicciotti, G. Saluti, D. Giusepponi, R. Rossi, R. Galarini, IZSUM, Perugia (Italy)
12:50 End of session 13:00 LUNCH @ ABOCA
14:30 Session 5
Chair: Vincenza Andrisano, Giorgio Mellerio
14:30 COMPREHENSIVE LIQUID CHROMATOGRAPHY COUPLED TO TANDEM MASS SPECTROMETRY FOR THE CHARACTERIZATION OF POLYPHENOLS IN MATE EXTRACTS
F. Cacciola, P. Donato, P. Dugo, L. Mondello, University of Messina (Italy)
15:00 UPC2™ : UNA SOLUZIONE ANALITICA PER INCREMENTARE LA SELETTIVITÀ NEI LABORATORI CROMATOGRAFICI
A. Perissi, Waters Italia, Milano (Italy)
15:20 FURTHER INSIGHTS INTO THE MECHANISM OF ACTION OF THE ANTI‐CANCER DITERPENE ORIDONIN PROVIDED BY DIFFERENT COMPOUND‐CENTRIC PROTEOMIC APPROACHES
F. Dal Piaz, M. Vasaturo, R. Cotugno, M. A. Belisario, N. De Tommasi, University of Salerno, Fisciano (SA, Italy)
15:40 MASS SPECTROMETRIC CHARACTERIZATION OF HUMAN SERUM ALBUMIN DIMER: A NEW POTENTIAL BIOMARKER IN CHRONIC LIVER DISEASES
M. Naldi, M. Baldassarre, M. Nati, M. Laggetta, F. A. Giannone, M. Domenicali, P. Caraceni, M. Bernardi, C. Bertucci, S. Orsola‐Malpighi University Hospital, Bologna (Italy)
16:00 DESI‐HRMS FOR THE FAST AND SENSITIVE INVESTIGATION OF MODEL DRUG INTERACTIONS WITH NATURAL POLYSACCHARIDE IN TABLETS
L. Elviri, S. De Robertis, S. Baldassarre, R. Bettini, University of Parma (Italy)
16:20 ACID CATALYZED GLUCOSE DEHYDRATION IN THE GAS PHASE: A MASS SPECTROMETRIC APPROACH A. Ricci, B. Di Rienzo, F. Pepi, A. Troiani, S. Garzoli, P.Giacomello,
Second University of Naples, Caserta (Italy)
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16:40 End of Session
16:45 Shuttle bus to the museum in Monterchi to admire the Madonna
del Parto fresco by Piero della Francesca, a very famous early Italian renaissance painter (1412‐1492)
20:30 Social dinner
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Friday, June 13th, 2014
9:15 Session 6
Chair: Gabriella Massolini, Sauro Vittori
9:15 HIGH RESOLUTION LC‐MS APPROACHES FOR DECIPHERING THE COMPLEXITY OF NATURAL EXTRACTS – NOVEL METABOLITE PROFILING, DEREPLICATION AND METABOLOMICS ASPECTS
Jean‐Luc Wolfender, University of Geneva (Switzerland)
9:55 COMPARATIVE STUDY ON DIFFERENT POPULATIONS OF CULTIVATED, WILD AND COMMERCIAL GENTIANA LUTEA L. BY LC/ESI‐MS AND HPLC/DAD
A. M. Mustafa, G. Caprioli, M. Ricciutelli, F. Maggi, G. Sagratini, S. Vittori, University of Camerino (Italy)
10:15 ESSENTIAL OIL CHEMOTYPIFICATION AND SECRETORY STRUCTURES OF THE NEGLECTED HORTICULTURAL CROP SMYRNIUM OLUSATRUM L. (APIACEAE)
F. Maggi, A. Bianco, L. Maleci Bini et al. ‐ University of Camerino (Italy)
10:35 SPETTROMETRIA DI MASSA AD ALTISSIMA RISOLUZIONE NELLE APPLICAZIONI IN AMBITO FARMACEUTICO E BIOFARMACEUTICO
P. Nebuloni, Thermo Fisher Scientific S.p.A., Rodano (MI, Italy)
10:55 Poster Session ‐ coffee break
11:45 Session 7
Chair: Fulvio Magni, Marina Carini
11:45 MALDI IMAGING MASS SPECTROMETRY (IMS) OF CORONAL SECTIONS OF MICE BRAIN: PROTEINS EXPRESSION OF SERT KNOCKOUT VERSUS WILD‐TYPE
R. Zianni, R. Ye, J. Norris, R. D. Blakely, T.R.I Cataldi, R. M. Caprioli University of Bari (Italy)
12:05 MALDI‐IMS ON EX‐VIVO FINE NEEDLE ASPIRATION (FNA) OF FOLLICULAR AND MEDULLARY THYROID TUMORS
G. De Sio, F. Pagni, V. Mainini, M. Garancini, A. Vanzati, V. Giardini, M. Scardilli, A. J. Smith, P. Goffredo, F. Magni, University of Milano‐Bicocca, Milan (Italy)
12:25 Valentino Mercati, presidente e fondatore di Aboca, racconta: un progetto di vita, imprenditorialità, giovani
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12:50 End of session …. Arrivederci!!
13:00 LUNCH @ ABOCA
14:30 Shuttle bus and guided tour of the production facility and
laboratories at the headquarters of Aboca in Pistrino
16:30 Shuttle bus to the Arezzo railway station
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POSTER COMMUNICATIONS
P1 OFFICINAL HERBS: FINGERPRINT OF HYDROALCOHOLIC EXTRACTS BY HPLC‐UV‐MS
Valentina Santoro, Ilenia Siciliano, Federica Dal Bello, Claudio Medana and Claudio Baiocchi, University of Turin (Italy)
P2 COMPOSITION AND BIOLOGICAL ACTIVITY OF ESSENTIAL OILS FROM THE CAMEROONIAN BUSH ONION (AFROSTYRAX LEPIDOPHYLLUS) AND GARLIC TREE (SCORODOPHLOEUS ZENKERI)
Hervet P. D. Foganga, Filippo Maggi, Luciano Barboni, Massimo Bramucci, Giulio Lupidi, Fabrizio Papa, Dezemona Petrelli, Luana Quassinti, Léon A. Tapondjou, Luca A. Vitali, Hilaire M. Womeni, Sauro Vittori, University of Camerino, Camerino (Italy)
P3 CHARACTERIZATION OF ESSENTIAL OIL COMPONENTS IN COSMETIC PRODUCTS BY GC‐MS
A. De Simone, V. Andrisano, University of Bologna, Rimini (Italy)
P4 TARGETED LC‐MS/MS FOR THE SIMULTANEOUS AND SENSITIVE QUANTITATIVE PROFILING OF NATURALLY OCCURRING ACTIVE COMPOUNDS IN GINKGO BILOBA
Lisa Elviri, Flavia Bianchi, Lorenza Vicentini, Paolo Andreatta, Ruggero Bettini, Università di Parma, Parma (Italy)
P5 GLUCOSINOLATES AND ACYL CONJUGATES DIVERSITY IN BARBAREA VULGARIS SEEDS EXPLORED BY LC/MS USING FOURIER‐TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY AND INFRARED MULTIPHOTON DISSOCIATION (FTICR‐MS IRMPD)
G. Bianco, Agerbik N., F. Lelario, R. Pascale, S. A. Bufo, T. R. I. Cataldi, University of Basilicata, Potenza (Italy)
P6 MYRTUS COMMUNIS LEAF EXTRACTS TESTED ON PROKARYOTIC AND MAMMALIAN CELLS
S. Bernardini, F. Mastrogiovanni, L. Gallipoli, G.M. Balestra, D. Pollini, V. Gallorini, D. Triggiani, E. Ovidi, A. Tiezzi, Università degli Studi della Tuscia, Viterbo (Italy)
P7 URINARY METABOLIC PROFILING OF RATS TREATED WITH CURCUMIN USING HPLC‐MS
Matteo Stocchero, Stefano Dall’Acqua, Elisabetta Schievano, S‐IN Soluzioni Informatiche, Vicenza (Italy)
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P8 CORRELATION BETWEEN TRICHOME DENSITY, ARTEMISININ ACCUMULATION AND ADS GENE ACTIVITY IN ARTEMISIA ANNUA
Palmira Ianni, , Andrea Tartarini, Loretta Pace, Laura Spanò, Università degli Studi dell’Aquila, L’Aquila (Italy)
P9 ALTERNATIVE BIOLOGICAL FLUID FOR METABOLOMIC APPROACHES TO SCREEN STEROID ABUSE IN BEEF CATTLE
Giorgio Saluti, Simone Moretti, Jennifer Pascali, Giancarlo Biancotto, Roberto Angeletti, Nicola Cimino, Anna Calì, Roberta Galarini, IZSUM, Perugia (Italy)
P10 VALIDATION OF AN HPLC‐MS/MS METHOD FOR QUANTITATIVE DETERMINATION OF TRABECTEDIN IN TUMOR TISSUES FROM XENOGRAFT MICE
Laura Ceriani, Monique Zangarini, Simonetta Andrea Licandro, Maurizio D’Incalci, Massimo Zucchetti, IRCCS “Mario Negri”, Milan (Italy)
P11 THE INFLUENCE OF TYPE‐2 DIABETES MELLITUS ON MITOCHONDRIAL PROTEIN PROFILE
Simona Porcu, Annunziata Lapolla, Mario Zoratti, Francesco Piarulli, Daniela Basso, Marco Roverso, Roberta Seraglia, Pietro Traldi, Università di Padova, Padova (Italy)
P12 DETECTION OF ANTINEOPLASTIC DRUGS BY LDI, MALDI AND SALDI METHODOLOGIES
E. Calandra, S. Crotti,E. Marangon,M. Agostini,G. Toffoli, P.Traldi, CNR‐‐‐IENI, Padova (Italy)
P13 DETERMINATION OF THE DEPTH OF PACLITAXEL PENETRATION IN PERITONEAL WALL AFTER HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY BY NANO‐PARTICLE ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY IMAGING
Lavinia Morosi, Massimo Zucchetti, Silvia Giordano, Enrico Davoli, Federico Coccolini, Luca Ansaloni, Maurizio D’Incalci, IRCCS ”Mario Negri”, Milano (Italy)
P14 RATIONAL DESIGN AND ANALYTICAL CHARACTERIZATION BY MASS SPECTROMETRY OF POTENTIAL NEO‐GLYCOVACCINES AGAINST TUBERCULOSIS
Alice Pedrali, Sara Tengattini, Caterina Temporini, Teodora Bavaro, Immacolata Serra, Luciano Piubelli, Marco Terreni, Gabriella Massolini, University of Pavia, Pavia (Italy)
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P15 FAST GC‐TOF MS ANALYSIS OF MEDIUM CHAIN FATTY ACIDS (MCFA) IN COLORECTAL PATHOLOGIES MONITORING
E. Agnoletto, S. Crotti, V. Di Marco, U. Saini, M. Bergna, M. Agostini, P. Traldi, University of Padua, Padova (Italy)
P16 A NEW COMPLETE PROTEOMIC APPROACH: THE STUDY CASE OF ERYTHROPOIETIN
Alessandra Gianoncelli, Michela Bertuzzi, Sara Bonini, Rajesh Kumar, Sara Vezzoli, Maurizio Memo, University of Brescia, Brescia (Italy)
P17 ANALYTICAL CHARACTERIZATION OF THE MAIN COMPONENTS IN PATCHES RESPONSIBLE FOR ALLERGIC CONTACT DERMATITIS
Cosima D. Calvano, Antonella Aresta, Nicoletta Ditaranto, Caterina Foti, Carlo G. Zambonin, Università degli Studi di Bari Aldo Moro, Bari (Italy)
P18 ESI‐MS FINGERPRINT AND FRACTAL DIMENSION OF COLILEN IBS® Michela Burico, Luisa Mattoli, Giada Fodaroni, Valentino Mercati,
Pietro Traldi, Eugenio Ragazzi, Aboca SpA, Sansepolcro (AR, Italy)
P19 CHARACTERIZATION OF MYRIOCIN AND SOME DERIVATIVES BY ELECTROSPRAY AND QTRAP MASS SPECTROMETRY
Federico Maria Rubino, Paola Signorelli, Jelena S. Lazarevic´, Rita Paroni, University of Milan (Italy)
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DSM Awards for Young Researchers 2014
PREMIO DSM‐SCI PER GIOVANI OPERANTI NEL CAMPO DELLA
SPETTROMETRIA DI MASSA
La Divisione di Spettrometria di Massa della Società Chimica Italiana ha istituito a partire dall’anno 2000 il “Premio DSM‐SCI per giovani operanti nel campo della spettrometria di massa” che conferisce a un giovane di età non superiore a 35 anni per il miglior lavoro a carattere sperimentale, tesi di laurea, dottorato di ricerca o articolo a stampa, avente come settore di riferimento la spettrometria di massa.
Vincitore per l’anno 2014 è il
Dr Giovanni Caprioli
Università di Camerino
per lo studio e la caratterizzazione di alimenti mediante un uso prominente della spettrometria di massa.
Vincitori delle precedenti edizioni:
2000: dr David Bongiorno 2001: dr.ssa Antonina Gucciardi 2002: dr.ssa Maria Pia Vitale 2003: dr.ssa Sara Rinalducci 2004: dr.ssa Ester Marotta 2005: dr.ssa Ingrid Zagnoni 2006: dr.ssa Vera Muccilli 2007: ex‐equo dr.sse Francesca Attanasio, Maria Chiara Monti 2008: dr.ssa Valeria Cavatorta 2009: dr.ssa Caterina Fraschetti 2010: dr.ssa Alessandra Tata