$>A7;/: F 7

Page 1 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/1.jpg' width='140' height='200' /> Page 2 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/2.jpg' width='140' height='200' /> Page 3 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/3.jpg' width='140' height='200' /> Page 4 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/4.jpg' width='140' height='200' /> Page 5 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/5.jpg' width='140' height='200' /> Page 6 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/6.jpg' width='140' height='200' /> Page 7 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/7.jpg' width='140' height='200' /> Page 8 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/8.jpg' width='140' height='200' /> Page 9 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/9.jpg' width='140' height='200' /> STAMPEDEComparisonOpen: Oct-2005Closed: Mar-2013Accrual: 2962

Number of patients1184 A Standard-of-care (SOC)593 B SOC + zoledronic acid592 C SOC + docetaxel593 E SOC + zoledronic acid + docetaxel

Page 10 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/10.jpg' width='140' height='200' /> Docetaxel: Survival – M1 Patients

Page 11 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/11.jpg' width='140' height='200' /> Page 12 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/12.jpg' width='140' height='200' /> Page 13 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/13.jpg' width='140' height='200' /> Page 14 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/14.jpg' width='140' height='200' /> Page 15 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/15.jpg' width='140' height='200' /> Page 16 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/16.jpg' width='140' height='200' /> Page 17 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/17.jpg' width='140' height='200' /> Page 18 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/18.jpg' width='140' height='200' /> Page 19 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/19.jpg' width='140' height='200' /> Robinson Cell 161:1215, 2015

23%

Page 20 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/20.jpg' width='140' height='200' /> Mateo NEJM 373:1697, 2015

Page 21 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/21.jpg' width='140' height='200' /> Page 22 A7;/: F 7<A= A63 /</53;3<A ...images.researchtopractice.com/2017/Meetings/RTPLive/Asco...01_OH_ASCO GU_2017_v4si Author frendina Created' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader034.cupdf.com/reader034/viewer/2022051510/5ff88dfee7d55150a67db9a9/html5/thumbnails/22.jpg' width='140' height='200' /> Local Therapy

Androgen Deprivation

Therapies After LHRH Agonists

and Antiandrogens

Chemotherapy

Postchemotherapy

Death

motherapa

PostchemP t hP h

$>A7;/: F 7

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