-8 UC J: < i;, *'LCV..5, EZmi, ?f'@ ld: i *1@>{zP>'* Jly.j. J:; rj. i! (blind staggers t"alkali disease ti:!:') {, *ll ,,*'Lt V. 5,. i.;:-i: u :,{b,.4 io!1 1!{b,\. ji …

{z u > :iJ:z. . tz u >{1: . 4 (7j< !i{b{z U >, 7'<7 .y !i{b*z P > :. 1 < )

[CAS N0. 7782-49-2]

,,, j j ;j O. l mg/, 3

2000( H . 12)1:F-.t: U > !*iit 'lih{L '4!, . !.:!>ii! ' : *T. tp tt{ ~. .i:j% , j!. tjtjjtj!j!: lRj* 1=, - 2, 0, + 4, + 6@>1 :+fiii -j ,5,. +: p ;, jd:j$t*.;g:!1:;gLjj 'EE ' i ~. , tt lit7e :!: UC J: < i;, *'LCV. .5, EZmi, ?f'@ld:i *1@>{z P >'* Jly. j. J:; rj. i! (blind staggers t" alkali disease ti:!:') {,*ll , *'Lt V. ,5,.

i. ; :-i: u :,{b, . 4 io!1 1!{b, \. ji , j

Selenium (Se) it; #! * *: 19:1. '7i: :/=ld;1;tf @?i iR35z, 1:il{*. 1 iT. :R: 78.96, 1i , i:217 C , i\, 688t:.SeleniUm diOXide (Se02) 1'1t9. ' i!it' * 1 . 5i'+ft

:L. ' / ~ )P!= Ji ;, ' F Jl. i9!76 *'Lit;j5.{:P > :.{ . ,.

Sodium Selenite (NazSe03) !!* 't:!* ftli 5i'T'!it172.94, ;1<1. J: < i; !* 7 ), h ,J ' !>i< L, ;4;$:t, ! t':!i;ii:.Sodium Selenate (Na2SeO, ) 1:1t9. *ti i 5i'T'lit

188.95, ;j<j= g: < j 1*'.5,.Selenium Sulfide (SeS) :i!i tf@. 1, df*. 5i';f'lit 111.03,7k .:C. / -jp!=7j<jj .

SeleniUm OxyChlOride (SeOC12) :!;; it'1't:'36 3!' 0>t , Z, !! 't ;i { . 53',' fit 165.87, !!.;:i 10.8C ii! . 177.6 C.2 11;;i ::E:j ti !=iti;\T@> ! lt {z u >,{1: i. 4 i;6, J: < *ii! *'Ltv*zi. E, = P ;, jj;:7 > ,E= * /* t(NH, )2SeOg! $1 {9 : ':> X O, 7 iV:;b n 4 }: it;;

.lt P >'{b7 ,V = '> Z* (A12Se3) '{: P >'{1:71< ;0 L ii ,2jLj ;+$@>"i

4z , >'{1:1, 'X77< (Bi2Se3) '1':! { Wf3E.!zP >'{1, zb F ,>/* (CdSe) >Y;i :{ , i{;f i , } ; t ,i;iiti{

*t , :,{bib JP:,' * Z* (CaSe) fjj, ', Z. y '.lz , :,{b4 > 7, >A (lnSe) :Fi! { 1, f .!t P ? !:$ld (TT) (CUSeO, .) $;! :t:13:$ !1 i' ; !@> t5.,*z P >'{1:$1d (ll) (CUSe) ,d'iPy-)L, 5i'ft\OA t!;

A ,t:P :,'{1:1tt;! (AS2Se) 7Y XO)!! j j.;9:{E'!2 L' ;' (Se02) 19:{E !1, !: L'C\lf?}; *L;t:4 sy@>L!=\,%. 7!'*'0 ;!:j!6{Bj :lj! f:i{ ;2, @> 1. { *>*'L ,5,.-li {1:{z b > (SeS) /j*!jly!j Oj; 4;;, 7b 1, ';! 4i:, 71y 4.tZ >, / : j'Lli:;:: !:'@>1 jjjj :, jnn' .= {E+2 U > !:i m

=lib{1:'{2 U :' (SeS2) 4 .3t '. :70>i ; , 7b 1, ';! 4i;0>fi*:t;,;, :, *' > 7- F1"@> 7 '19ilL ;, icot -1 {1: 2 P ?!: jfEii

{z P >'ii;;'J' } U *' Z. (Na2Se04) y=, $!!1!Fl;1 , Ji!l!j*im l ; ;, !E. 1: P >'n;:+ } U ,> A (Na Se0 ) 7 ' X 9!i i!=*31*

g ! :j, j :OtE, "'

110.96,

gL jj

t

.5, t* f}. 01 5! , " 1ml ; :H 3. {{:iata) 1! :11;!!: '0f @>{ l.1: P > 1*1 ', 11j:1 , j!:jj\*. , 1 "i! t'L , !: ;g'; . ,jt. ; , "i. 3jtrt, {z V 7i 1 75*jt5v. !;t!;tt@>j to! 1. *z, >{;1:t!!*'\f ' *LtV*. , 0'C', llj'1 ;<i' >1}t4X *L. !: :! ' . i;, }'L. 5,. Selenite ' selenium oxychloride !*;! !;i:on!!1 1 0> !;: ij\ 'C l! . qX *'L .d, . !: *t*R{ ' i'L t V. ,Selenite ;, selenomethionine @>!tJ4 1tOl %$1 1i!!431t:, ' *L '*'L 92 % , 91 % 'C' !j*;!= j ll 'C' O l q!(;fyt ;. V . "l, F O> jj& j "C' {jl (selenomethionine) ,S J: 0, j (sodium selenite) 0> {z P :,{1: ;'!1*1!,: :!i ;1= 1!&"!!: i'L,bioavailability !,: ' *'L- '*t. 84 %, 97 %'C3j, . , '. "/, g @> sodium selenite (74Se) :' 6 A@>!0 !3C;i ;"tt '!=;i; .j :!:i, L ;t= *i !! , int!Rit:' @> i}3!Ell* Rli (mean residence

time) !,:{ut /c 200-285!1* 111i'C'35 1) : t:f;ft*": (tissuepool) <:'ld: 115 ~ 285 H 'C'35 0 i::. 12 B j t:!,:, j; ! . jitO 65 %:*S 90 B Zi'!,; i 35 %7!*, i;jj: L. t v*7:: "). 7 ,>-j b :,' *' > 7- d. O selenium sulfide !*, ";;iEil @, d5 ,!!eM l= i:"ji ' , C !: 1. "J 0 trt, ,!j :'it C ' C. !: 7!t%jll *Ltv. t5, '). i!!t"!! *$ *'cit: +: P > (1,1; . 1 selenite) !t giu-tathione (GSH) 4 ! il!i l& L selenopersullide (GSSeH) *1;, , j= hydrogen selenide : t:'iS:76 *L6 " . .= 0>selenide lt:!1:{* 1tOj;e ;' :b<j jV*t:ab, ?! +)1, {1: *'Ldimethylselenide [(CH3)2Se] !:i::o t: b , "JP 5" + =!'>/{- :*',d. :,, y-+, (GSH-Px) @>!1}1'1'\1$( i} i , : i'L. ,. 7::, .{z , >'76;! '\ji${b ; *'L. 5, C 2: >;*>. ,:** E ,\f T. :'! -; ..5, C l!: lC J: o t superoxide anion radical;:: !:'O>j j, : t:;!:0>5 !1;0)Tijjj ' 7!t;j<ll *'Lt ly *; , 5. 6).b) 6. i. tii!, } 'Jor4 'C'! 4*1=, ii i<;:: V*i*; j'i*, 'j!fl&E'11flt CO> 1 1*:{ng@>fy;3;;&' J: b ji v*. jjjiAj@>{z V >. j g !;tj v. 7!Stit !: L. e ia:!jj , ;- v *. t= r != ,s i* . , {z u 7 @>at!* j9:1*, ii*(20~ 200 /, g/L)'. "), im (i~ 2 /, g/L)" " ', 1;L\L (7~ 30 "g/L)""' " ' t:', {1!0>*11ji&, Ej !! , ll\, ,!'t ,. . @> J: ;) *:{z P ># 1;Eld:1 , 1= J: o z:'f 4!! ! !i''C, .tr U >it j:!OJ:J t:' . 3 L;!: 1: 0.1z L, . :,'lj, j'@1*,inn : " , {z P >,' *< . *t. '*'L 3.200 !!g/L ' 2.680 /ig/L : tttiirij L /:: 1

3i.

c) ;;kil!

.lz P > !* dimethylselenide ;*!';;;;'C trimethylse!enoni-

Um [ (CH3)3Se'] 4 :*' > !: t* b l;i*d" \;;kiU: *; *'L - ,.;6, L, ?!cliti fiSt;'lt dimethylselenide ;*t"f* t, F!=!tlt <;1,. C *L;fy*j ll!!Jl61 @>=- :"= ' !;!@> il 'C3> , }:: . > *'Lt , * . ,.d) -tt t, - > 0>i!t, ja;i*;{z P > !d:-yj'C * ;jj lit56;{ !: L. tilt 'G, GSH-PxO>j jg: 1;{tlClj! b j , *'Li 1, :i9: :7!' , d:{ , 'lUij ' ,.l ;b', GSH ,!ljj jj{ i:: !:iO{1:f j@> SH !: 0>1;Zlj; :7!t};$ < i*jl 1. 1ii"f{1:iill'Cdb , GSH @>i lt ?er:fk:E l Rt@>t; 7t<! ::!:75*{z P 7@>i ' 0>j lj*;: L'C: . 1 *Ltv*.5,. jjj 1:0> J: ;i !. hydrogen selenide 7!*.{z P >'7b ;'\ :{1: *1. t , li*:, 3 :, 1: , ii '"Ei ; {> 4!j'yl:0>j ;!= L 'C:

.

. 20o

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: .{:k z P >'lt, @>!1; i!!t l, : =. :,'.= ' !;! 'C', dimethylse-lenide l= j j " ,. :!< !: , y j* t:,, j!t, il Zi j jN , . . '= ~1;*0!@;:!*, 4X75**Rf ' *LtV. , "i. % . , !,;sodium selenite sodium selenate 75*1iit {>.! ,'j :, j , *<j; jV\ C !: 7!ti:n > *'Lt Vtt ,. :it:, selenium sulfide > ele-mental selenium lt'hTii ' *tl 1, \i::&> !*lt !tl 1, \. y

} tO* Dl -! -!. J:, z P :'{k' '4 1@>L050 1 , sodiumselenite 75*7.0 mg/kg, selenium sulfide *t138 mg/kg 'C3> 1) elemental seleniumO LD, 01t 6.700 mg/kg :'elemental selenium !=1 ,% 1'L , i!}, '1*; 1% ;b 1. 1*! !i5;

ti' 85 ;:, !: '; .. ! *'Lt V. ;!, "4'. ? * X @>j; 1:1;$:-! -1. J: ; ,

sodium selenite !: selenocystine O> LD, , @>!1:ii!t'Ci* '*t **L7.08 mg/kg !: 76 mg/kg'C', ! 1 ;{z L, >@>;!7z5*$!$, 75*gjjv* c }: :j!**&t - jt. t: " '. : t:, selenium oxy-chloride l, :f!:M z5* i 1!&;1X *L ,. i" * . t: &>, * 'lf \@>! ::1*i;@ 16; !. ,J . , !it/i E t!t (minimum lethal dose) 1*7 mg/kg 'C'35 . , "b) lE, t , $!$1!t

fi11!= 2.5 ~ 10 ppm Oi!$1;E (Se : 1, t) 'C' selenome-

thionine, sodium selenite 35, v, !,: sodium selenate :t:.i .*!', dt v F (Sprague-Dawley) 1.1 .'!'- , !:,l :j, :j! ibtj:i6;. j!E: .;j Lt: " '. ~, g: b*;,, 2.5 ppm j 0> 6;a i@)&8;;?Zi'it, ;fjt@?fi!:!{ 'C3:, 0 t: t 5 ppm :;7y F O>{*"tl, :*t !!

!

*1. JL'<j 76.0 t:, ;,:, S, lO ppm i

lt y F !t 29 B J;4, ', 1= ~f<t8Et L i::. !!!:t;!:.{z l, . >{b :'!1 !:; 'j . i= p >-.{1: .! @>tL*;:t!,:, !! ;{z P ;, 1= J: ,{*.! i ,!, Oj;E&;. V*@>;!j** ;;jj +z P 7 J: b ; ,* C ::bt *'Lit:. fi4!= 15 ~ 30 ppm @>ie!1;E'C'sodium selenite i!'60 B 1!6t :! - U /:: ),, e y F ti*, ,j* k, { f>;!

:' t; im.

*. U >/*i ti ::!, 75tt8;; *c7t: " '. !$:;!!! L t: X @>, i. ),l= L-selenomethionine :'i;;;. n 1= 30 B 1"146; B 25 ~ 600"g Se/kgj ,! . Ci!:;! g 'c'!t " ', j sjEtk, !* q, ;j tlp*l

nn' T, ;1 ! :M 1*E ' ' L . li!i ii!i1 t (600 "gSe/kg) tld: 2 i! i;!1, J l=JEi= L /::, : it:, !1;:i! L;t:!Mi!j

: f! {*i . :Ett :1!!;T {> tP - *'L/::. *$:, ,:, t25 !, g/kg/day @>, i')Vti' t>, * 1;:0{*iE*&,!**t!;t, *'L7t:*'9;! :1! { @>t:&b }: *g' .. 1;, *'Lt:. L** L, C @>j -ft'C'4> 2 ij@> 5 *;, 1 m l=!;:M ;; t: jq {i:*< ,. i;, *'L, ; ': 'i 1;t .

*L , ' {z b >'j .@> 7:: "> !: ,g' . 7::.c) .1!tla:, i*;, 1 :

+: p >. 0>, j , i jjt@>t ;!: L t{*it* ,>i5t ti!i@ !:;

. !;, *'Lt ,* . 1 " '. Schroeder !: Mitchener !* , r' * ;<l= Se i !;E 3 ppm Ot6:;!<; ' 540 B W, 1; - L. , "$? ,> ;!. t:'

t"?; L j:: 20). , , } j=, s V* t@>

c @, J: ;j tj:i! j:E3 !t1d:, - B { it lkg 4i:: 0 200 ~ 250/tg @>; J -75t . ;'C; >, , !: ;g'; . , *'Lt v *; , "'.d) 3 -**A, j;t.lt b >, ,. tz P > {1:f .!1fj@>\%:75tA, jq;j. o v . t j*1 T&;,:* j

1 /:; 1L t ,\ v* Tnternational Agency for

.

l,41; !!!1 ;

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{*j j ,!, ,,;!fj jj *jj'$!.

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Research on Cancer" ' !,;, j!fy!j il=1 Ltlt:3 i7!tA, .1!t*<

;i) , !: v* 5 ;iE; !i*7j<ai:$j. ti, 35 , ; !: 'Fim L ;t:. : i::, i, Fl=1!U L'Cl*:, Group 3 (Not classitiable as to its car-cinogenicity to human) !: ,i' ti 1'flliL/::. 1980, F

National Cancer lnstitute (NCl) !*, selenium sulfide .* . t 1= F344 {> v l* !: B6C3Fi ? ,> x @>t! jtt; .*L **'L 50 1!E!=, 3 d5 , , V. 1* 15 mg/kg/day ti' 103 iU\5t , Lj:, 22). y F t:. jJ:{*:j j1H,!>7!'j $Jlll \-'Ci ; *Lj::7jt? * X 'C'1,:i"i ?1:'Ct";;' *L :b. o t:. ' v l*'Cltj m!t

!F'C' hepatocelluar carcinoma 7!*t!t"tilii;FZi'ftf:; $ iti:: t 7 *X 'C'1 i!*1 t'hepatocellular carcinoma *'alve-olar/bronchiolar carcinoma 7!*j:!1 $ *'L i::. . ' @>*;i;!! ,NCl!, v } !:iUt? * x t:'4= P >,@>367!tA, , 7bt"g, j t ,

-C1!: 1'fliLt:. t;EOC, National Toxicology Programi> selenium sulfide ; ' carcinogen !: Lt Group 2 (prob-able or possible carcinogen to human) 1. jj*;;;jUtv\

. , 23).e) ! . ftt 3 , ib;'ja:

! j ; ;j&j;$,!z u >{1:, . 1 ii*;&g j*ii, iift, :1=, 1, 1 $,*!8 (nonhuman primate) @> gj; :. mj " -, , 24i.

.lz P >i&1;: 3 ppm @>fi:7kC" ? * X ':> v F , ' 3 1U:{

.C'filT!f ~ 6 !: , .*1i!1:! 0 t:bt, !, : < ;::. 6 !: ti 1 j=>Ei= 3

> !Mlin ~ 6 @>7:, it !; *'L, $: t t Ol T***Rj , *'Lt:

. Ferm i;, (1990) !t, {;i:1;1:!=rt'*!;' 'it C* < , V. @>:ttt01 :7::1*'1 j :E*'i;fl , 'tR;$ U, 4= P > !:: i? jti;'C'1 v* {j& jjj , 1!t '$:. j ;0 :: *ft{ , L j:: " '. Taranta1 , (1991)!t* t 'J id:i;1 (*E!5: 20-50 B 0 30 B M) @? 40, tt@>*;E!t;'li')1' (macaque) 1. 0, 25, 150, 300 !!g/kg/dayOm

ft'C L-selenomethionine ;$!.* ,8- L /:: " '. 25 !!g/kg/day@>t;FL:'1*Et%1!@> Ll, $@>i!&f 1t;;, 1;, *L :*. o t:75t 150 ,5J: 0' 300 /!g/kg/day t l* if:f T '1 a1 . {4;iEj":,!*;j< .!;, *Li::. 150 /tg/kg/day @>t 'G lJ , i!E&! 68 B la l. li t@>1;**f;bt Bi= L , lo i i<'!,: : ; 35 H Ell= ,;$t

t= J: o tll;@>, Bifyt$fE . *L;!:. i !., !:E*! 123 H B !.,El {f75*j: *'Lt:{ *!! > \. t:. 300 /tg/kg/day @> 1@ !;ttl;t! 43 Et 1 !C tii, Pi; L . ,, @> l iit'C'!* !!f!! 53 D 13 1=#Bl {T. *tt8?;$ *'Lt:. Li5, L. C *L i;, @>t @)j j! , j, 0>j l { 03 9:@>jg:H;.,. jt , . > j* u - ,, , 1;{jjj05"- '(hisitorical control data) }:!!!:,<t, i*

zi'ti!*. o t:. i, :&Et iOO H 13 !=11fi{T: .+ '75. ,! b H} L;; L i::* i%E, llfijj-@>;!: *;, i1 31i ;ti '@>!jj!fr != jd:;::< ldtt :i! i! ltaa"> !;,*1. ;::75*0 7t:. Li::**o t, ;;;' 1

i L-selenomethionine @>{!!;i;j'il;;j:t!;t4j: '1={ v. !: *nyit: .

D t{ 4tt. 1, :Noda 1;, (1979) 1d: Salmonella typhimurium'C* sele-

nate E: selenjte @> t E $ ; 1 :j!t : . *R{!j. L : " '. t;* *- ;::. jt p> {B j. !1*i iJ: Jt i!6 L t: 1= } U :,' /< . libroblast.Chinese hamster ovary (CHO) cell;:: !:" C' chromo-

some aberration ;t:' i4 L, mouse, hamster, macaque@>*%'lt!'CO> clastogenicity 7i*: *1 i'LtV*. ,. :it:, sis.ter-chromatid exchange (SCE) 1*t;;'ii; L;t:1= f U >,/*T* !: Chinese hamster V79 cell !: 'C'*R{!i *'L/::.

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2) E F'C'@>;!tiClinton (1947) 1tiE!ll 1"1'C'i>it$i! !;E@> selenium fume!.! , j; *Li!:{ :8.1. ,av*t, 13 , 4:!., 111 111 *t ti < *li *'L, d: 7::g;j ; .* C .;' !: *&j!;' Lz!: " '. Wilson (1962)i, selenium oxide !C 37 4\7b<1 3;; it. t:!jljt!:1= ,s v. t, t ':!C i:;!! , !, !. i5ti . 0 , ;$tV. 'C 12 11*Mi;!1, , 1. ;1g; $,3 4 , itt j, j : ** jpg *t. , j ' : 1*:4 B Ml; v* t: *t i jg j != 1* j j;! L t: t: , E u jj: 30). E:j, jj ,,(1958) 1t .4z P ;,'*if$cy!1'F'; : '0>S!'i i\!,!E :. fjo t: 31). { : :. U$ 0> 5it iR!1;E lt , * 0.1 mg/m' 7!. , !j* $ 'C' * 46mg/m' !: :1< < :nn!i L t V, t:. .{z P 7{ ;j '@>tfiJij ll;

.

illil, , !=; JD! U t: ;.@>.{z P >'i&1!E!*, lO "g/L :b. 1 320 !!g/L (1 (:$C'C'1*: L. 0 !, g/lOO cc *. 1;, 32.0 "g/lOO cc) 1. *38: Ci* tBll:T;B;1= Jl%'*.5, lf3 ;!i' '!iiii${ :!:! ('{Z P ;' Fll , i;) @>FR. rl. .tz P ># g (iO /tg/L7!. , 50 !tg/L

: 'C'1* 1.0 /, g/lOO cc 7!. 1;, 5.0 /tg/lOO cc) !1*:.5,;t. 1=it:!.. t::j' , v. t:. jajt4i;li:!: Lt lt, az l, :,'{'F ' F!i5<jiji \0 <. jj*;:: !;!v* :. lF ;., Ti&1?: ti: :ly'X '\!1gto t:ll 1= 1*:,@> !:'*<;iii < ;5: ,, < L *,,$. 7, < 1; ,, 11ey L < ;:: 6 : !;!7!* ! . t v . Z, j : , ijl; t'Lt V. ; ,, ; 1 1= 1 !: A. , !:'0:!i'6 i$k L ly, ; :;iti@> f @>i @>;1 !, 0 jt9i ;, i;, t= ld:Jt\@>lj

!1: .: .;9:*> b gEil; t: v. o i=1 ; : :. j; g L t v. 7::. jj:

B 't' '< lt:, Z< i!tt 1 : ;iE (Minesota MultiphasicPersonality Tnventry7!* , 1ilB 4;1! 1{ E*:i;T U /::M. K. A. 1. ) 1= ,s ly*'c , j , jjtjt j , :.;\<';', ':5{ 25 :i3 ,1, 6 :t;v. i:: C }: 'C';!;,. , (*j' ld: 14 :t5rl, 0 ). L*. L, C @>5,jjj :-j": *5 i= {z u :,. @>! ql!1.1j\ ~ .6, c !: !* !lj;je ;;: v. !: , : ' , lt: b . t, 3 0 , iiid, '12 P >'i i !: 1!!1 !!'!'.5, '@>{ O

i7i!L ,,::7fy, o t:. Kinnigkeit (1962) @>{z P >' : i!,1: iS* .$, T*!$@>{ ! :;;''$:' lg!. 1. L t: l 3 :!C ,k Z, }: , 624 rj, 35 4{,@>{ *j75*m;itj :.;t ., jjrj= {,; *

. tj:j jt4 ;U:7, * j, o jt: 32). 9 :j@>j : :: -j= id:, $ j ;; !: ' '$":"" ';f 75<jy!; *'L, {tt!@>At!'!*. E'@> J: 5 ;5:; 4f:1*: *L :*7, '.-? 7t:. . ' . 0 trl, .tt V :, i&1 1d 0.007-0.05 mg/m' t3i, o t:. CO:;i, lt. i !;!1;t, . '@>;! 1 0 MAC O. l mg/m'l. Jbl L < {, j v. . d i::, im , .!iiy,, t: b >'i8!1!:!= 1tt; l*:1, :i 0 7i{ji!, 4, *t. t: c !: t> *ltj . Ltv*;5 . ji j c jo i!it:!=ti: it 1 1 t @>/::">1=5;' f{ *'i ;; n9*: \> 0'@i v. !: ;i> b , :jt:;jjrj, 4g p >, j jg:!:jm , ,!\iq. -b u > j t!: 0>fi\yE!:;, i:*> L v*6j. j{j @>t:&>t:'35 , 5 !: t> ; *LtV. 6, Glover (1967, 1970) 1*. 1z P :,!i,iitt;: i !! E ~; , Ti!.@>{ ;! : '0> 200-300 Al=ov"'C . 4. >z P >'@>t;FjjL g:. jja, !e L /:: "" d . {z p > j= i !jg::;$ *'L .5, grinder l;U 1!@>{ *::;i'@> rl. .tz , > 1t 0.25-0.43 mg/L ti't*, o t::5'.lz P >, 1 ,;;;6t;:: V *{ ;! ; '@> fi !:tl*;, 0.1 mg/L i;LT i' d5o it: . Grinder j!q i!!! @> 1& j 'C' @> 5ijr1. 4z L, ;, iR:!;E 13: 3.6mg/m' t;', {lUO*!tiJi'C'1* 0.2 ~ 0.4 mg/m' 'C'85 0 /::. , Cltt {z P > iR!1!!: : 0. i mg/m'i;!T l=ji, i, 1';~ .6 : ,jjirj. {z L, . > !t O. l mg/L i;\T1= ;9: 6 C ;: 7!tT& 2; *'L, $j$ll"{z P >'i !!E O. l mg/L IC*R; ',$, t, 1, {z P :, iE!":1* 0. lmg/m' 'C'3ji. 6, !: gi; . ;, f'Li::. Dudley l selenium oxy-chloride l. J: o C l= } ! ::li\ 1. 3 1 0*1<1 :' *5 C ' !: *Rf! c t: " '. Glover !,, selenium dioxide > t 1;1;* 1=* i 1t' !:'

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'1:!:1j, ;; '\:. il; C .4' !: *jj; , L i!: "d'. d: i!: selenium diox-ide **1t\T, \}.,$, !: ; ;iti4i: $:' . L /:: b , B !=}. b fql ;! :'it . L, z!: ty liB*$. J t= allergy i . 1 \> *? *L. .&g i!tj;!B :, 0* j!jC 22

) !: ig: j! jj != , ;;e!- n;j!. j*:. jz p >, 7!tl= 1* 7:'3.*'A, ' !' t C ' E; 7!* ;:: ,* !: j'Lt v * ,$, 36. 37i.jtl!Ejt/\1=*SV. 'C sodium selenate :' 15 ppm @>i&1;:'t;' i'te:Et !: { ! 3, FMl i Lt: $ ., llT; 0 , E 13:1075A !ii!: b 41.9 A*, , 27.5 A, \i;&,!? L t: "5. flU@>1 1@> !;tlGAustralia: 0.2 mg/m' ({z P > !: L C hydrogen

selenide ; !1 < ), 1990Sweden: 0. i mg/m' ({z u > !: L 'C hydrogenselenide ' : < ). 1990Unite Kindom: 0.1 mg/m' (. tz P > !: L'C, hydrogenselenide '$:'1 < ), 1991USA (ACGTH): 0.2 mg/m' (+tP> i: Lt, hydrogenselenide ' '1 < ), 19926. 3j* ;F !1 0t :; >z P >' 'ti**'lru@>i:e* *';; fi : !:'1=i j j*~.6 -tz p >

Lj, i !t, ' :'C' J: < ll , *Lt V .,5,. !:*1$'C ld;, = >' =- ,' ! , lt;1!1:, 1 !: J: ;1; :i 1=** ~z,"ify t; 0, j}:75t b *'L. 5, 7it Et:!**ft{ . *Ltv. ;::v*. = >, = ';;!!t:{ ;!i@>gE{1:, 0 b -tt u ;, @>{ ;all=,:sl*. , ftii ti:j ji 75< : < : 0 'C, *Z, C }: ': <'$'!: :i '; . C, *'L;$,. L it:*'0 'C>2 P >@> '%Fi&1! 1d:, i :!! 1":, 1 :. L 1; tittl=*t ' . "ij t:: !fli 4}: :.t <' C. !: !: !: {> !. , .= :, = ? !; 7!tj.!t L ;:: v. J:

:i5'! '< !: :5'; . , *L6 . !tt'i@>i?i' i:il$1! 0.1 ing/m'lt, = *'L , :' WiV. :'V . , !: :g:; ;. 1:, *'L;5 . {2 P > !t:! fi;j7i.:;, t>j}!ljt *'L, $,. :1 !j, :b. 1 j!{un( *L , {z P >'Ol tc-- B5 ttlJ: 0.4 mg (ii A@>5F j{*ilt ' 55 kg !: '!~. ,) !:

*'L, . Ol , 1ibrj, .!z P :, i!! EE1**;1 0.2 mg/L }: *Rf!i' *Lt v * z, 39. d'). 4;y!= l@:; J ::,! , 4@> ti: V. 1, 1. @>1ii ij. .lr U7i 1!E!3: 0.02 ~ 0.2 mg/L t:'di, ,6 . . ' L'C, lli&*!}@> tll.{z P :,'ie!1;E O. l mg/m' 1*!tirj, .t: , >8 1!E O. l mg/L l=*R !i' ' .5, :: '; . 1;, *L t . L i 7!to 'C , _1:. : 0 8': j& :'C,+r P >iit'!~,*<'C, !tlX *'L. , !: , !:, inn' @> EDl' '1= P>' t!!"$. ft*< . V. ;!! i. != 1t , tit:fc- B ;; fttt > , 0.4mg (!iill. .tr , ;'i !;:;6* 0.2 mg/L) :'ili!.; . ,. L ii. L ,c 0>; ;:5 !ti*f@; B @>! . j , j=,:s!*6 j;\!gjm !=bj::. , ft!: Lt: ' . 1 *Lt*5 1, , 3t ':: ' * ' . C A, 'C ,; 0'C,_L;! @?3+ i!i1 :'C*, 'ljJ :.*{ C ' iTft 1 !d:j V. !: '

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,:C l) WHO Environmental Healih Criteria 58: 1987; Geneva.Selenium.

2) Griffiths NM. Stewart RHD. Robinson MF. The metabo.lism of t75Sel selenomethionine in four women. Br j Nuir1976; 35: 373-382.

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5) Seko Y, lmura N. Active oxygen generation as a possi-

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ble mechanism of se!enium toxiciiy. Biomed Environ Sci

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mice. Effects on growth, survival. and tumors. ArcliEnviron Hea1 1972; 24: 66-71.

21) 1nternational Agency for Research on Cancer lARCMonographs on the evaluations of carcinogenic risk ofchemicals to man. v01. 9. Some Aziridines. N-. S-. 0-mus-

tards and selenium. Lyon. Prance: lARC 1975: 245-260.22) National Cancer lnstitute. Bioassay of selenium sulfide(gavage) for possible carcinogenicity. NCI Technicalreporr series N0. 194. DHHS (NIHj Pub. N0. 80-1750;

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