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Contents
Elsevier
What is and What we can get from Reaxys
How to use Reaxys
Your question
The world’s leading provider of Science and Technology information, Medical since 1880. HQ in Amsterdam .
Serving >30 million scientists, students and health and information professions. 76% of Top 1000 R&D
companies using Elsevier solutions.
Elsevier has been part of the local Chinese scientific research landscape for more than 20 years. More than 60%
of all full-text usage in China comes from Elsevier Journals.
Physics
Mathematics & Computer Science
Social Sciences
Earth Sciences
Environmental Science
Life Sciences
Materials Science & Engineering
Chemistry & Chemical Engineering
ELS 26%
Polymer • Neuroscience • The Lancet • Catalysis Today
Bioorganic & Medicinal Chemistry Letters
#1 Global Provider Publish 26% of world’s
journal articles
Sales in 180+ countries
$3.3 billion in revenue (2011)
2,200 journals yearly
Global team 74 offices in 24 countries
7,000 Journal Editors
70,000 Editorial Board Members
600,000 authors
Scientific Research Articles Published Multi-disciplinary content
Introduction of Elsevier
DISCOVERY
PRE-CLINICAL
CLINICAL POST-
MARKET
OUR PORTFOLIO ADDRESSES KEY CHALLENGES ACROSS THE PHARMA R&D VALUE CHAIN
SERVING THE LIFE SCIENCES SPACE
Search full-text, peer-
reviewed journal
articles
Database for access to
abstract & citation
Characterize
targets & analyze
disease pathways
Characterize & discover
molecules
Identify & confirm lead
compounds
Translate preclinical
data in humans
(Translational)
Monitor drug
adverse events &
real-world evidence
data in literature
Integrate the world of
data & solutions
Drug Candidate Selection
Go-No Go Decision Preclinical
Data Validation
Managing risk
4
Text Mining & Data Integration
Broader full-text indexing of
biomedical content
Workflow-Specific Solutions:
Broad-Based Solutions:
Contents
Elsevier
What is and What we can get from Reaxys
How to use Reaxys
Your question
Acknowledgement
Reaxys
What is reaxys?
What we can get from Reaxys?
7
WHAT’S IN A TYPICAL CHEMISTRY DOCUMENT (PUBLICATION OR PATENT)?
Scientific topic, author Chemical reactions
Chemical spectra
Experimental procedures
Substances and their
physicochemical properties
Cannot be searched by
text terms in full text
Cannot be searched by
text terms in full text
Can be searched in full
text, but you don’t want
to read the whole paper
in you are interested
only by this section!
Cannot be searched by
text terms in full text
Cannot be searched by
text terms in full text
Can be searched in full
text, but difficult to find
the right search term
Chemical structure
DR. OLIVIER BARBERAN | 2014| ELSEVIER
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A Bibliographic Database
>46 million records
(from ~16,000 journal titles plus records from key patent organisations)
A Substance Database
> 78 million substances (total)
~ 57 million substances (unique)
A Chemical Reaction Database
> 36 million reactions
A Property Database
> 500 million experimental properties
in > 500 fields in > 130 subject areas
Reaxys 2014
Reaxys (Many TYPES of databases all in one)
INTEGRATED
DATABASES
INTEROPERABILITY WITH
Reaxys (We are becoming more and more powerful~)
0
10
20
30
40
50
60
Total Unique Substances
(millions)
30
32
34
36
38
40
Total Reactions
(millions)
0
10
20
30
40
50
Total Bibliographic Records
(millions)
0
5000
10000
15000
20000
Total Journal
Titles
0
2
4
6
8
10
12
Major Functions
REAXYS 2012 REAXYS 2014
Reaxys (We are becoming more and more powerful~)
~57.0 Million unique Substances
~36.6 Million Reactions
~500 Million experimental properties
~16,000 Journal Titles
(Life Science, Chemistry&Engineering,
Pharmacology, Enviromental Science, Books, Conference
proceedings, Editorials etc. )
~46 Million Bibliographic Records
> 500 Search fields(through querylet)
Contents
Elsevier
What is and What we can get from Reaxys
How to use Reaxys
Your question
How to Use Reaxys (http://www.reaxys.com)
How to Use Reaxys (http://www.reaxys.com)
How to Use Reaxys (http://www.reaxys.com)
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How to Use Reaxys (http://www.reaxys.com)
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How to Use Reaxys (http://www.reaxys.com)
Current 19
Reactions Selected
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All yield >90%!
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Filter by
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Without de-protection list!
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Position&Stereo isomers Widest
(http://www.reaxys.com) How to Use Reaxys Reactions– Tautomers
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1: only 8 reactions compare
to the 13 before.
2: No anymore!
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G: Any groups
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Atom mapping
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The same as before!
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That’ not what we need!!
(http://www.reaxys.com) How to Use Reaxys Reactions– Make bond as reaction center
How to Use Reaxys (http://www.reaxys.com)
(http://www.reaxys.com) How to Use Reaxys Reactions-Rentention/Inversion
(http://www.reaxys.com) How to Use Reaxys Reactions-Rentention/Inversion
(http://www.reaxys.com) How to Use Reaxys Reactions-Rentention/Inversion
Inversion
(http://www.reaxys.com) How to Use Reaxys Reactions-Rentention/Inversion
(http://www.reaxys.com) How to Use Reaxys Reactions-Rentention/Inversion
(http://www.reaxys.com) How to Use Reaxys Reactions-Rentention/Inversion
(http://www.reaxys.com) How to Use Reaxys Advance Search
(http://www.reaxys.com) How to Use Reaxys Advance Search
(http://www.reaxys.com) How to Use Reaxys Advance Search
How to Use Reaxys (http://www.reaxys.com)
We will get: 1, Substructures on all atoms, 2: No ring closure
3: Yield>70%, 4: NMR exits
(http://www.reaxys.com) How to Use Reaxys Substances
(http://www.reaxys.com) How to Use Reaxys Substances
(http://www.reaxys.com) How to Use Reaxys
Single Structure
Salt
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(http://www.reaxys.com) How to Use Reaxys Substances—Position Variation Bond
What we need
1. Pyridin with only one X substitute. 2. The position of X was not certain
(http://www.reaxys.com)
Substances—Position Variation Bond
What we need
1. Pyridin with only one X substitute. 2. The position of X was not certain
How to Use Reaxys
(http://www.reaxys.com)
Substances—Position Variation Bond
What we need
1. Pyridin with only one X substitute. 2. The position of X was not certain
How to Use Reaxys
How to Use Reaxys (http://www.reaxys.com)
(http://www.reaxys.com)
Substances
How to Use Reaxys
How to Use Reaxys (http://www.reaxys.com)
How to make a synthetic plan
1: Tafinlar (GSK)
2: Approved by FDA in 2013
3: mutation-positive
How to Use Reaxys (http://www.reaxys.com)
How to Use Reaxys (http://www.reaxys.com)
2 synthetic routes designed by Reaxys
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Literature
How to Use Reaxys (http://www.reaxys.com)
How to Use Reaxys (http://www.reaxys.com)
Update in Reaxys
OUR GOAL: MAKE CONTENT MORE DISCOVERABLE, MORE EASILY!
1
0
1
Ask Reaxys Reaxys Tree
Ask Reaxys provides new
user experience for text
searching: content better
discoverable, answers more
immediately available
ReaxysTree lets users
“browse” the database by
taxonomies: helps with
search precision and answer
comprehension
Formula Builder improves
the searchability of
substances through
molecular formulas: easy
way to find substances right
across the Periodic Table
Formula Builder
(http://www.reaxys.com)
Ask Reaxys –A question relating to literature
How to Use Reaxys
(http://www.reaxys.com) How to Use Reaxys Ask Reaxys –Search for substances by name
(http://www.reaxys.com) How to Use Reaxys Ask Reaxys –Text querys relating to reactions
How to Use Reaxys (http://www.reaxys.com)
(http://www.reaxys.com) How to Use Reaxys Reaxystree–Find any term search box
(http://www.reaxys.com) How to Use Reaxys Reaxystree–Find any term search box
(http://www.reaxys.com) How to Use Reaxys Reaxystree–Find any term search box
(http://www.reaxys.com) How to Use Reaxys Reaxystree–Find any term search box
(http://www.reaxys.com) How to Use Reaxys Reaxystree–Chemical reaction classes
Display all reactions and all
substances
(http://www.reaxys.com) How to Use Reaxys Reaxystree–Named Reaction
Sep
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, 20
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lide 1
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(http://www.reaxys.com) How to Use Reaxys
Formular Builder
(http://www.reaxys.com) Your questions
GuoBao Victor Ren, Ph.D
Life Science Solution Customer Consutant, China
Tel: +86 21 61333055
Mobile: +86 13816752637
Email: [email protected]
Other introduction of Reaxys functions
will be continued~~! Thanks for your
questions and suggestion!