-
( , , )
13 ) : . (,
, , ) : ,
,
-
-
. ,
. , 4.5-5 . . :
. 6-9 :TDF Testicular Determining
Factor & SRY: Sex determining Region of the Y chromosome. A & & .
-
- : 1. (
: & ).
2. ( )
-
& .
. :) :
, ) ) . 6m :
, , .
-
: 1. Sertoli
/
2. .
:
1. Leydig - ()
-
, , ,250 . : - . -: 1-4 & ( Leydig).
-
- 50-70cm/.0,12-0,30mm. - 20-30
-
6 .
& Sertoli.
.
-
MIS/AMH (Mullerian Inhibiting Substance- Muller Wolff: , , .
Sertoli . & : , , . .
-
. . & : - & FSH - , & FSH (Androgen Binding Protein) & .
-
H ( LEYDIG)
(, , , , ) Leydig .
, , , , , , Golgi. .
-
.
4
. 10-12 .
() ( ) , ( ) ( -)
-
3 -75 . 1.
. & . .
-
2.
(). ( 46=44++).
1 -: ()
2 : ( 23=22+/)
-
3. .
Sertoli & . & FSH.
-
.
:
.
.
-
.
:
. . 26 , 40 ,
74 .
-
: 2-3C , .(2-5 +/)
& & .
250R(Roentgen) . 500-600R
Vasectomy- -reversal.
-
- -
- . WHO
. 1.5ml 95%
. p 7.2 15-250x106/ml. :
100x106/ml. (5% . ) 40% 50% 4%
-
pH
-
: , 15 x 106 /ml 39 x 106 . : ( 1 ), 40% , 32%
-
: ( Kruger) 4 %. : , .
-
& & .
-
-
-
: ,
& ::
. : 40-50 &
. ( ), ( ), & .
-
.
(Catsper proteins).
-
. Leydig
LH. : DHEA,
&
DHT, , .
17- ( & ) & . .
-
98%
. 1. TeBG - (Testosterone Binding Globulin)
65%. 2. 33% 3. . . 25-30
.
-
Leydig
(, { }, -DHEA{ } & -DHT) ( & )
Sertoli , ABP.
-
& & .
-
.
, , .
: ( Kallman
Syndrome/ ) (/ .)
-
1. . 2. . 3. . 4. . 5. . 6. . 7. .
-
. : 1. Wolff
& . 2. Muller. 3.
4. &
. : 1. ,
, , , & .
-
.
.
( , , )
-
&
& .
& .
-
1. . 2. . 3. .
-
. , , & .
-
& .
& .
.
-
&
& .
.
-
.
.
-
, (Libido).
-
DHT 5- /
. , .
DHT.
= DHT. .
5- ( ) DHT .
= Wolff & LH.
-
DHT
DHTA & & .
5- - . (46, +, ,, + + .
- LH, T .
-
ANA- -
Sertoli & - .
& FSH & GnRH .
.
-
& -- .
Luteinising Hormone (LH) & Follicle Stimulating Hormone (FSH)
-
LH & FSH.
LH & FSH & .
-
LH & FSH. LH Leydig
. FSH Sertoli ABP,
, . Leydig
Sertoli.
LH. FSH.
-
/ Sertoli/Leydig (,,) , / , , , , .
Slide Number 3 - - Slide Number 8 & . , , ,250 . : - .-: 1-4 & ( Leydig). Slide Number 12 MIS/AMH (Mullerian Inhibiting Substance- Muller Wolff: , , . . . & :- & FSH- , & FSH (Androgen Binding Protein) & .H ( LEYDIG)Slide Number 21 . : .: Slide Number 26Slide Number 27Slide Number 28Slide Number 29 Slide Number 36 . & DHT DHTANA- - Slide Number 56
