Feb 02, 2016
(aplastic anemia,AA),
1 1
2
23X4
5SLE6Fanconi
7PNHPNH20%-30%PNH15%PNH8
/TNKE2
2
3TT4/T8T8CFU-C/CFU-E
, T ,
-(1),(2);(3)(,);(4);(5)()()
(1),;(2);(3),,,(),,;(4),
1PNH 2MDS 34
: PNHPNH
MDSFABMDSMDSMDS
.
-
:
,,23,()2-4mg31-20.4-0.8g3
CAA (EPOGM-CSF)TT35
(CsA)(),CsA,CsACsA
AAATT-2(IL-2R)-2(IL-2)TIL-2T(CFU-GM)2
1 ()(SAA)()SAA8010%70%
(ATG) / ALGA(CsA) ALGATG,,,IgG
ALGATGSAA1ATG,2ATG,2,3,
ALGATG: ,,1540mg/Kg/, 100200mg/,5%500,45,710,.
ALGATG,60%710(),(1//)4,3% AML10,13%PNH9.6%MDS6.6%
(CsA(CsA(SAA),ATGALG
(CsACSF-CCsA, ,200400ng/L,36,1,47/, 12/
(CsA,,,,,,,
5001000/,4,40/,4,44ATGALG,2030
(G-CSF) (GM- CSF)() 11(-11),
G-CSF(GM-CSF)150300 /,Epo150 / Kg,IL-12.525 /Kg,,12G-CSFCsA>1,
CTXCTX50//X4CTX
CTXCTX682654.41%1524,84%,73%,5065%,
,,70,,
90G-CSF,GM-CSF),,,
,,,G-CSF,
G-CSF,,510g/,2G-CSF,34+3,56
CD34+1%,(CD34+ CD71- CD45RA-)CD34+(25%)(5%-20%)
CFU-GM16,9(HPP-CSF)8,5CD34+ CD38-,38.2%5.9%,
,1,HLA
:,,
(1),CsA;(2)ATGCsA, ;(3);(4),,
,:,:,
-,,,
(),,,,,
,,,,,,,,
, 4:
+ +
- , ();,,();,
,
-5:(1);(2);(3)();
-(4)(); (5)
80,(),;,92.5%
()30,2,24,86.60%
()CAA 30,22,73.33%
7()427,131,120,130,89.23%,
(),6,1,5,10,
()36,9,7,11,75.00%
, ,
1() , T ()
1 62 , NKa T NKaCD3CD4CD4/CD8 NK , T
1(:) , CD4CD8 CD4/CD8
1(
2 / ,
2 118 () ,/;
3 , , 100% , ,CFU-F , ,
3 , , , , , ,
: (1) , , (2) ,
AA,,,,,,,
3611.2G/L60g/L8.0G/L
() 150mg 2/ 2mg 3/ 33.5 G/L90g/L45.050G/L