奈米科技的領導者 皕發國際奈米生物科技 股份有限公司

(CEO)

-

(Antrodia camphorata)(Cinnamomun kanehirai hay)(2000()20012002()2003)(2004)

(polysaccharides)(sesquiterpenes)(triterpenes)(steroids)(Chiang et al., 1995;Cherng et al., 1995; Cherng et al., 1996; Yang et al., 1996)B(2001)(Lee et al., 2002)

29 5

-D- B

Triterpenoids Superoxide Dismutase SOD Adenosine - D- - D-glucan Immunity Protein B Vitamin-B Ergosterol Nucleic Acid Amino Acid Lectin Lignin Antrodia Acid : Calcium Phosphorous Germanium (Triterpenoids) 1~3% 15~45% Angiotensin Converting Enzyme(ACE) polysaccharides -D- (-D-glucan) -D- (-D-glucan) -D-glucan T B Mizuno,1995 -D-glucan -D-glucan - 1-3 - 1-6 X-ray -1,3 D-Glucan (SOD:Superoxide Dismutase) (ROS:Reactive Oxygen Species ) DNA (SOD)

Nucleic Acid (Adenosine) Nucleic Acid (Adenosine) (RNA) (Adenine) (Uracil)

-D-

7~14 200~500

(2),,

4~6()1000~5000

,

1 8000~30000

317~14200~50024~61000~500031~28000~30000()HPLC ,

HPLCHPLCHPLC254nmHPLC

HPLC

HPLC:15100

30-100

100%!

NCBI: Antrodia camphorata 100%

FDA

FDAFDA

FDA39.87

74.46DNAmg/g()DNA*()DNA*100%()39.87%(-FDA)7.02%352.33mg/g11100%()5.98(-FDA)1.08%32.56mg/g1/18.211011821/18.211011828()1/18.214.91900.41%12.54mg/g1/661291191428()2.18%63.53mg/g1/6011.41841/60151300FKS100%()99%()1.86%55.8mg/g1/53161318VBC13.937%()3.08/%92.4mg/g1/4112.81114.81/4113.81155.8(7.35)

3-5 (Dr. Mary Ruth Swope)P.01(2005P.04)

C B

()

2% ( ) DNA indole lanostane Angiotensin converting enzyme ACE Cytotoxic Histamine Angiotensin converting enzyme ACE -D-glucan

glucan ergosterol D D

()

()1. (peripheral bloodmononuclear cells, PBMCs)U937 U93755.3 % (2003)2. HL-60 (Hseu et al., 2002)3. PBMCsU937U937Sarcoma 180ICR(2002)()1. (lipopolysaccharride, LPS)IL-2INF(2002)2. Th1IL-2Th2IL-4(2002)3. PBMCsU937U937(2002)4. C57BL/6BALB/c()60%48%TNF-INF-IL-2(2001)Th1

29 5

/(%)%%(w/w)(SGS) mg/g (g)(mg)1100050mg/g 1g50mg50/10005%36mg/g 1.2%30

7%63%4.4%

10%()(SGS)(..etc)() 1. 2. ()3.

XinWang()

() ,

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!! . . !!

()()(+)!!

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(HPLC)()()!! () , !!5 !!