2012 Pearson Education, Inc. Nervous system •All organisms must sense and react to their environment •Hydra – simplest nervous system with a nerve net •Arthropods and annelids – ganglia •We have neurons •Neurons consist of a cell body, dendrites and axon
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•All organisms must sense and react to their environment•Hydra – simplest nervous system with a nerve net•Arthropods and annelids – ganglia•We have neurons•Neurons consist of a cell body, dendrites and axon
Resting membrane is polarized. In the resting state, theexternal face of the membrane is slightly positive; its internalface is slightly negative. The chief extracellular ion is sodium(Na+), whereas the chief intracellular ion is potassium (K+).The membrane is relatively impermeable to both ions.
2 Stimulus initiates local depolarization. A stimuluschanges the permeability of a local "patch" of the membrane,and sodium ions diffuse rapidly into the cell. This changes thepolarity of the membrane (the inside becomes more positive;the outside becomes more negative) at that site.
3 Depolarization and generation of an action potential.If the stimulus is strong enough, depolarization causesmembrane polarity to be completely reversed and an actionpotential is initiated.
Propagation of the action potential. Depolarization ofthe first membrane patch causes permeability changes in theadjacent membrane, and the events described in step arerepeated. Thus, the action potential propagates rapidly alongthe entire length of the membrane.
Repolarization. Potassium ions diffuse out of the cell asthe membrane permeability changes again, restoring thenegative charge on the inside of the membrane and thepositive charge on the outside surface. Repolarization occursin the same direction as depolarization.
Initial ionic conditions restored. The ionic conditionsof the resting state are restored later by the activity of thesodium-potassium pump. Three sodium ions are ejected forevery two potassium ions carried back into the cell.
• If enough neurotransmitter is released, graded potential will be generated• Inhibitory or excitatory•Eventually an action potential (nerve impulse) will occur in the neuron beyond the synapse
•Neurotransmitter that is released from the axon as a result of Ca2+ entering the axon terminal•Stimulates muscle contraction•Active in parasympathetic nervous system•Norepinephrine and GABA are other neurotransmitters
ACh binds and channels openthat allow simultaneous passageof Na+ into the muscle fiber and K+ out of the muscle fiber. MoreNa+ ions enter than K+ ions leaveand this produces a local changein the electrical conditions of themembrane (depolarization), whicheventually leads to an actionpotential.
1. Increased heart rate2. Increased blood pressure3. Liver converts glycogen to glucose and releases glucose to blood4. Dilation of bronchioles5. Changes in blood flow patterns, leading to increased alertness and decreased digestive and kidney activity6. Increased metabolic rate
1. Retention of sodium and water by kidneys2. Increased blood volume and blood pressure
1. Proteins and fats converted to glucose or broken down for energy2. Increased blood sugar3. Suppression of immune system
In a relaxed muscle cell, the regulatory proteins formingpart of the actin myofilaments prevent myosin binding(see a). When an action potential (AP) sweeps along itssarcolemma and a muscle cell is excited, calcium ions(Ca2+) are released from intracellular storage areas (thesacs of the sarcoplasmic reticulum).
The flood of calcium acts as the final trigger forcontraction, because as calcium binds to the regulatoryproteins on the actin filaments, the proteins undergo a change in both their shape and their position on the thinfilaments. This action exposes myosin-binding sites onthe actin, to which the myosin heads can attach (see b),and the myosin heads immediately begin seeking out binding sites.