Transcript
Diffusion Spectrum Imaging: New ways of reconstructing
long-range connections in the brain
Presented by Sophia Larriva with work by Alex Asturias, Viktoriya Babenko, Matt Cieslak, Celine Mol, and Scott Grafton, PhD.
What is all this?• Brain has many overlapping connections
• Neurons• White matter
• Different connections are different!
Split Brain: Corpus Callosum
Left Lateral Occipital to Left Inferior Temporal
• Diffusion MRI looks at water movement
• Constrained by axon bundles
• Maps out connections (speech, visual pathways, etc.)
• Clinical uses for strokes and certain types of injuries
Right Superior Parietal to Brain
Stem
Some Background
Recent InnovationsDTI scan
2007 DSI scan 2015 DSI scan• Scan time=
under 20 minutes• Can determine
directions for crossing fiber tracts
• Multi-band imaging protocols
• Scan time= 6 minutes
• Cannot resolve crossing fibers
• More variability in results interpretations
• Scan time= 1 hour
• Determine directions for crossing fiber tracts
• Single-band imaging protocols
A Comparison of Scans• Center for Magnetic Resonance Research at University of
Minnesota (CMRR)• Siemens Corporation
• Examined differences in signal quality
ResultsCMRR Wins! (almost outright)
Neuronal fiber tracts (axons) where Siemens appeared better were statistically insignificant/not real
Right Paracentral Gyrus to Left Paracentral Gyrus
Right Entorhinal Cortex to Brain Stem
What Now?Potential Clinical Uses
• Surgery• Monitoring Fetal Development• Stroke Patients
References
-http://definingsolutions.ca/wp-content/uploads/2013/10/split-brain.gif-http://www.cguy.net/wireless_networking_guide/images/p2p%20connection.jpg-http://www.humanconnectome.org/img/art/pulse-sequences-fig3.png-http://upload.wikimedia.org/wikipedia/commons/3/36/MCA-Stroke-Brain-Human-2.JPG-http://www.h3dwallpapers.com/wp-content/uploads/2014/10/Cute_baby_pics.jpg-http://www.the-scientist.com/Nov2014/whitematter2.jpg
Thank You!
top related