Tackling AMR Developing new ways of working · Tackling AMR –Developing new ways of working Dr Ghada Zoubiane Medical Research Council - UK AMR intergovernmental workshop - November
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Tackling AMR – Developing new ways of working
Dr Ghada Zoubiane
Medical Research Council - UK
AMR intergovernmental workshop - November 2015
Research Councils
NIHR
Defra/VMD
Patientsand carers
UK Government Departments
OSCHR
Medical charities
ParliamentariansPolicy-makers
Industry
International
Public
Research community
Universities
NHS
Learned societies
The UK: A rich network of funders and researchers
InnovateUK
UK 5 year AMR Strategy
• DH and DEFRA: 2013 -2018
• Seven key areas of action
Improving infection prevention and control practices
Optimising prescribing practice, stewardship
Improving professional education, training and public engagement
Developing new drugs, treatments and diagnostics
Better access to and use of surveillance data
Better identification and prioritisation of AMR research needs
Strengthened international collaboration
UK spend on AMR (2007-2013)
£163m£56m
£16.8m
£16.6m
£0.49m£21.7mTherapeutics
Diagnostics
Surveillance
Transmission
Environment
Interventions
Total funding: £275m (<1% research budget)
UnderpinningAlternativesOptimisationLead compounds
What is needed?
• Collaborative working
• Coordination of key disciplines
• Coordinating research funding – government and other research funders including industry
• Ensuring integration with human/animal healthcare
UK AMR Funders’ Forum
AMR Funders’ Forum (AMRFF)
• Made up of representatives from the research councils, governmental bodies and charities
• Led and managed by the MRC
• Has a common vision for AMR research and its implementation
• Will add value to existing programmes
• Will coordinate and/or support the initiation of funding and delivery programmes
• Will raise the profile of the AMR research base in the UK and internationally
AMRFF current membership
• The Arts and Humanities Research Councils (AHRC)
• The Biotechnology and Biological Sciences Research Council (BBSRC)
• Defra, the Veterinary Medicines Directorate
• Department for International Development (DFID)
• The Department of Health
• Defence Science and Technology Laboratory (Dstl)
• The Economic and Social Research Council (ESRC)
• The Engineering and Physical Sciences Research Council (EPSRC)
• The Food Standards Agency (FSA)
• HSC R&D Division, Public Health Agency, Northern Ireland
• Innovate UK
• *The Medical Research Council (MRC)
• National Institute of Health Research (NIHR)
• The Natural Environment Research Council (NERC)
• Public Health England
• The Science and Technology Facilities Research Council (STFC)
• The Wellcome Trust
• The Welsh Government
UK Research Councils
• The research councils: broad remits; support AMR across the whole of the research spectrum
Research Councils portfolio: ~£25m per year on AMR
AMR Cross-council Initiative
• Launched June 2014
• All Research Councils – led by MRC
• Bacterial resistance in the first instance
• 4 themes to tackle AMR
Steering Group
Herman Goossens (Chair) – University of Antwerp, Belgium
Sharon Peacock – University of Cambridge/Bloomsbury Institute, UK
Duncan Maskell – University of Cambridge, UK
Rachel McKendry – University College London, UK
Richard Smith- London School of Hygiene and Tropical Medicine, UK
Elizabeth Wellington – Warwick University, UK
David Payne – GlaxoSmithKline
Jared Silverman – VL32 (Ex-Cubist pharmaceuticals)
Antimicrobial Resistance –a thematic approach
Understanding resistant bacteria
Accelerating therapeutic
and diagnostic development
Understanding real world
interactions
Behaviour within an beyond the health care setting
Funding
• Multidisciplinary research
• Themed calls
• Mixed funding models
• Kick start with £36m
• Scalable approach
• Networking preceding final submissions
• Priority at next CSR
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