static-content.springer.com10.1007... · Web viewSupporting information for New T etrazoloquinolinyl Methoxy P henyl 4-Thiazolidinones: Synthesis and Antihyperglycemic Evaluation

Supporting information for

New Tetrazoloquinolinyl Methoxy Phenyl 4-Thiazolidinones: Synthesis and

Antihyperglycemic Evaluation

Amarsinh R. Deshmukh1, Manisha R. Bhosle1, Lalit D. Khillare1, Sambhaji T. Dhumal1, Akansha

Mishra2, Arvind K. Srivastava2, Ramrao A. Mane1*

1Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (MS)

431004, India2Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow-226031, India

*Corresponding author E-mail: manera2011@gmail.com

This includes spectral characterization data of the intermediates and title compounds

Tetrazolo[1,5-a]quinolin-4-ylmethyl methanesulfonate (4)1H NMR

1

NN N

N

O SO

O

4-(Tetrazolo[1,5-a]quinolin-4-ylmethoxy)benzaldehyde (5)1H NMR

13C-NMR

2

HRMS

3

3-Phenyl-2-(4-(tetrazolo[1,5-a]quinolin-4-ylmethoxy)phenyl)thiazolidin-4-one (8a)1H NMR

13C-NMR

4

HRMS

3-(4-Chlorophenyl)-2-(4-(tetrazolo[1,5-a]quinolin-4-ylmethoxy)phenyl)thiazolidin-4-one (8b)1H NMR

13C-NMR

5

13C-NMR (Expansion)

HRMS

6

3-(4-Ethoxyphenyl)-2-(4-(tetrazolo[1,5-a]quinolin-4-ylmethoxy)phenyl)thiazolidin-4-one (8c)

7

1H NMR

13C-NMR

13C-NMR (Expansion)

8

HRMS

2-(4-(Tetrazolo[1,5-a]quinolin-4-ylmethoxy)phenyl)-3-(p-tolyl)thiazolidin-4-one (8d)1H NMR

9

13C-NMR

13C-NMR (Expansion)

10

HRMS

3-(4-Methoxyphenyl)-2-(4-(tetrazolo[1,5-a]quinolin-4-ylmethoxy)phenyl)thiazolidin-4-one (8g)1H NMR

11

13C-NMR

HRMS

12

13