Secondary analyses of HSE data and linked health outcomes - an overview of work in progress Dr Jennifer Mindell, UCL (University College London)

Secondary analyses of HSE data and linked health outcomes - an overview of work in progress

Dr Jennifer Mindell,

UCL (University College London)

Linked HSE mortality data (2008)

• In 2008, some mortality data provided by ONS:oHSE 1994 – 2004oDeaths to March 2008

• Will not be archived or publicised until regular updates organised

• Released to a few named researchers by NatCen after detailed review by their Data Release Panel

Published studies include:

Hamer M, Ingle L, Carroll S, Stamatakis E.

Physical Activity and Cardiovascular Mortality Risk: Possible Protective Mechanisms?

Med Sci Sports Exerc. 2011 Jun 8. [Epub ahead of print]

o HSE + SHeS datao average follow up 7.0y ± 3.1yo 446 deaths (213 CVD)

Body mass index, waist circumference and waist-hip ratio: which is the better discriminator of cardiovascular disease mortality risk?

• Czernichow S, Kengne AP, Stamatakis E, Hamer M, Batty GD. Obes Rev. 2011 Apr 27. doi: 10.1111/j.1467-789X.2011.00879.x. [Epub ahead of print]

Physical activity behaviour and coronary heart disease mortality among South Asian people in the UK: an observational longitudinal study.

Williams ED, Stamatakis E, Chandola T, Hamer M.

Heart. 2011;97(8):655-9. • HSE 1999 & 2004

Adjusted HRs (with 95% CIs) for ethnicity on coronary heart disease mortality

The combined influence of hypertension and common mental disorder on all-cause and cardiovascular disease mortality

Hamer M, Batty GD, Stamatakis E, Kivimaki M.

J Hypertens. 2010;28(12):2401-6.• HSE data• Hypertension has a stronger association with

total and CVD mortality in people with a GHQ-12 score of ≥ 4

Linked HSE mortality data (2011)

• NatCen has just received the latest update of Mortality records from ONS, though some delay in IC implementing new procedures that will increase automated matching

• Some data will / may / probably be archived later in 2011

• More detailed data may be available from NatCen via their Data Release Panel

HSE linked Hospital Episodes Statistics

• NatCen is in discussion with the NHS Information Centre about HES data:o what we can haveo how we will link thiso what we can or can't do with the data etc

• What will be available on the archive, what will be available from NatCen, what won’t be available - still being negotiated

Linkage of multiple databases

Hamer M, Stamatakis E. Physical activity and mortality in men and women with diagnosed cardiovascular disease. Eur J Cardiovasc Prev Rehabil. 2009;16(2):156-60.

• Scottish Health Surveys (1995, 1998, 2003) • Linked to patient-based database of CVD hospital

admissions and deaths o 837 adults with clinically confirmed CVD at baselineo 175 diedo follow-up average 5.6y +/-3.1y

Linkage of multiple databases

• Men and women with existing CVD who participate in moderate-to-vigorous activity for at least 20 min pw showed the lowest risks of all-cause mortality:o fully adjusted hazard ratio=0.32 (95% CI 0.16-0.65) for sporto fully adjusted hazard ratio=0.74 (0.53-1.04) for walking

• Similar associations observed for CVD mortality. • The physically active also showed

o ↓inflammatory risk markers o ↑ HDL cholesterol.

Cancer data

• Cancer mortality• Incident cancer

Diabetes, hyperglycaemia and cancer incidence and mortalityVanessa Gordon-Dseagu

Preliminary results: Cancer among the HSE and SHeS cohort at baseline

Cancer among diabetic (%)

Cancer non-diabetic (%)

HSE 3.1 2.0SHeS 2.4 1.1

Total 3.0 (n=261)

1.8 (n=3,458)

How do I access HSE mortality data?

• If people are interested in accessing this data they should contact Susan Nunn, the HSE Data Manager (susan.nunn@natcen.ac.uk) who will oversee their application process.

• The application would ordinarily be:o reviewed by NatCen’s internal Data Release Panel,o probably by the NHS Information Centre o - and quite possibly ONS too.