Robert H. Wiltrout Director, CCR Director’s Address.
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Robert H. WiltroutDirector, CCR
Director’s Address
DirectorRobert H. Wiltrout
Center for Cancer Research
Scientific Director for Clinical Science
Lee Helman
15 Clinical Branches
Deputy DirectorMark Udey
Scientific Director for Basic Science
Robert H. Wiltrout
38 Basic Science Laboratories and
Branches
Deputy DirectorsDouglas LowyJeff Strathern
Larry Samelson
Associate Director for Science
L. Michelle Bennett
Clinical Infrastructure
CCR Budget Relative to the NCI BudgetCCR Budget Relative to the NCI Budget
In 1995 the CCR budget was approximately 10% of the NCI budgetIn 2005 the CCR budget was approximately 7.7% of the NCI budget
NCI
0
500,000
1,000,000
1,500,000
2,000,000
2,500,000
3,000,000
3,500,000
4,000,000
4,500,000
5,000,000
1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006
CCR
CCR Budget Relative to the NCI BudgetCCR Budget Relative to the NCI Budget
In 1995 the CCR budget was approximately 10% of the NCI budgetIn 2005 the CCR budget was approximately 7.7% of the NCI budget
NCI
0
500,000
1,000,000
1,500,000
2,000,000
2,500,000
3,000,000
3,500,000
4,000,000
4,500,000
5,000,000
1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006
CCR
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NCI CCR
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Mission of the Center for Cancer Mission of the Center for Cancer Research, NCIResearch, NCI
Eliminate Death and Suffering from Cancer by:
- Integrating basic discovery with cutting edge technologies to create novel approaches for prevention and treatment of cancer
– Providing leadership and innovation in clinical trial development and performance
– Providing a distinctive venue for training the next generation of interdisciplinary basic and clinical researchers
– Establishing innovative partnerships with extramural organizations and private enterprise to accelerate the translation of new discoveries and technologies to clinical application.
Unique Identity of the NCI’s IRPUnique Identity of the NCI’s IRP
• Distinctive critical mass and unique programmatic integration of basic, clinical and epidemiologic scientists within a unified environment
• Review and reward structure that allows long-term, high-risk basic and clinical research
• Allows and encourages rapid changes in direction and response to new opportunities and national priorities
• Ability to fuse basic science with the newest technologies for novel clinical trials within the state of the art Clinical Research Center
• Ability to recruit diverse cohorts of patients to perform science-driven, concept-based clinical trials
• Distinctive and highly acclaimed interdisciplinary training programs for the next generation of biomedical scientists
• Mandate and freedom to collaborate widely and provide leadership for new basic and clinical research paradigms
• Higher stringency for avoidance of conflicts of interest than many other research institutions
Distinctive Qualities of CCRDistinctive Qualities of CCR
• Critical mass of basic and clinical scientists solving complex scientific problems
• Can quickly redeploy resources to address:(a) NCI mission goals
(b) Urgent public need
(c) New opportunities
• Access to NIH Clinical Center
The Center for Cancer Research:The Center for Cancer Research:A Comprehensive Translational Research ProgramA Comprehensive Translational Research Program
Molecular Targets and Molecular Oncology
Cancer Biology
and Etiology
Immunology, Immunotherapy, and Immunoprophylaxis
Genetics Genetics and and
GenomicsGenomicsHIV/AIDS HIV/AIDS ResearchResearch
Imaging and
Biomarkers
Advanced Biomedical
Technologies
Clinical Infrastructure and Support
CCR Infrastructure
Discovery Research
Clinical Research
Translational Research
HIV/AIDS Research
Training
Molecular Targets
Cancer Biology
Immunology
Genetics
HIV/AIDS
Imaging/Biomarkers
Advanced Technology
Clinical Infrastructure
CCR Infrastructure
CCR Major Theme AreasCCR Major Theme Areas
Training Faculty COE
Drug
Dev Imaging
Programs/
Initiatives Cores HIV/AIDS Epi
Molecular Targets
Cancer Biology
Immunology
Genetics
HIV/AIDS
Imaging/Biomarkers
Advanced Technology
Clinical Infrastructure
CCR Infrastructure
Infrastructure to Support Translational Multidisciplinary Research
Centers of Excellence: Focal Points for Centers of Excellence: Focal Points for Bench to Bedside TranslationBench to Bedside Translation
These Centers of Excellence serve to support the IRPs dedication to long-term, high-risk, innovative basic, clinical, and epidemiologic research.
Immunology
Chromosome Biology
Advanced Biomedical Technology
Molecular Epidemiology
Molecular Oncology
How Reengineering is Reshaping How Reengineering is Reshaping Interactions in the CCRInteractions in the CCR
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ReengineeringReengineering
andand
RedeploymentRedeployment
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* - Clinical Research
- Outside of NCI+ - Other NCI entities
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Before After
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* - Basic Research
Mark O. Hatfield Clinical Research Center
Warren Grant Magnuson Clinical Center
NIH Clinical Center
The NCI Intramural Clinical The NCI Intramural Clinical Research ProgramResearch Program
• The NCI intramural clinical program is not a large volume, full-service cancer center
• The NCI intramural clinical program is the largest cancer-focused clinical research center (CRC) in the world, capable of performing patient-intensive clinical research focused on developing new approaches for prevention, diagnosis, and treatment of cancer.
• The NCI intramural clinical program is an important component of the nation’s overall cancer program
Clinical Molecular Profiling CoreClinical Molecular Profiling Core
All CCR Clinical ProtocolsAll CCR Clinical Protocols
Biospecimen Procurement and Processing FacilityBiospecimen Procurement and Processing FacilityLCM, AnnotationLCM, Annotation
Clinical Molecular Profiling CoreClinical Molecular Profiling Core
Genomic AnalysisGenomic Analysis-Array CGH-Array CGH
- Kinome - Kinome resequencingresequencing-SNP analysis-SNP analysis
- etc- etc
Tissue Tissue ProteomicsProteomics
DevelopmentDevelopmentExpression Expression ProfilingProfiling
Tissue ArrayTissue ArrayIHCIHCEtcEtc
Vision for the FutureVision for the Future
• Focus on testing new science-based hypotheses interrogating a disease or disease process
• Maximize our understanding of how to intervene in the disease process by interrogating the cancer network using genetic, proteomic, and imaging tools
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