Transcript
Protein and disease networks
Lars Juhl Jensen
three parts
temporal networks
association networks
disease networks
Part 1temporal networks
protein interactions
Jensen & Bork, Science, 2008
Jeong et al., Nature, 2001
static view
cell cycle
Nobel Prize press release, 2001
temporal expression
dynamic nodes
a single number
circular layout
G1
S
M
G2
distorts statistics
de Lichtenberg, Jensen et al., Science, 2005
color scale
relax the network
static nodes
de Lichtenberg, Jensen et al., Science, 2005
no general solution
Part 2association networks
STRING
large-scale data mining
interactive network
drill down
text mining
co-expression
customization
external payload
pretty networks
Part 3disease networks
national discharge registry
6.2 million individuals
119 million diagnoses
correlated diseases
heatmap
too many nodes
significance filter
network
too many edges
clustering
hyper-cluster visualization
global overview
sufficient detail
not simple
Acknowledgments
Temporal networks
Ulrik de Lichtenberg
Søren Brunak
Peer Bork
Disease networks
Anders Boeck Jensen
Søren Brunak
Interactive networks
Damian Szklarczyk
Andrea Franceschini
Michael Kuhn
Milan Simonovic
Alexander Roth
Pablo Minguez
Tobias Doerks
Manuel Stark
Jean Muller
Peer Bork
Christian von Mering
larsjuhljensen
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