Pistoia Alliance Sequence Services Programme Phase 2

Sequence Services Programme

Phase 2

Simon Thornber

22nd July 2011

1

Agenda

• The Sequence Services Vision.

• Phase 1 results.

• Phase 2 overview.

• Process & TimeLines.

• Q&A

2

Pre-Competitive services (from the perspective of the Life Science industry).

Common use cases.

IT partners to develop, deploy & support these services long term.

• IT Services (e.g. security, authentication)

• Platform Services (Hosting services)

• Data Services (e.g. Genome data)

• Training & Support

Security built-in from the beginning

Easy collaboration

Huge scalability

Economies of scale deliver

decreased total cost of ownership

Public / Private / Commercial data all in one interface

The Vision

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Rome Wasn‟t built in a day.

Break the challenge down into 1 year phases.

Phase 1 POC: 2010 – 2011 (completed)

• Proof of concept.

• Focus on non-functional Requirements.

• Basic Functional Requirements.

Phase 2 Pilot: 2011 -2012 (just starting)

• Building on the success of phase 1.

• Focus on Functional Requirements. (NGS)

• Mainly open source tools.

Phase 3 Production: 2012-2013

• Addition of commercial tools / algorithms.

• Increasing sophistication of services.

• Vibrant marketplace – user choices available.

4

Phase 1 – „Proof of Concept‟

• 4 Successful POCs.

• All security tested

by AT&T.

• Further discussions

about production

deployment.

5

Ethical

Hack

• Building on Phase 1

• Broadening the functional requirements - NGS

• We are inviting service providers to provide a system for the

analysis and storage of NGS data.

– This will demonstrate their ability to support scientists‟ needs for

sequence analysis and in so doing demonstrate (to users and suppliers)

the feasibility of moving such systems from inside companies to an

external, shared, service provider.

• Phase 2 therefore requires “near production” systems capable of

being used on real data by regular users.

Phase 2 „Pilot‟– Overview

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Phase 2

Data Loading

Data Management

Simple Analysis pipelines

Expert user modifications / loading of new algorithms

Full RFP description on the Pistoia.org website.7

Core Functionality

Phase 2 – System Use Cases

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• Proposals to be ready by CoB UK time, Friday

23rd September 2011.

• Proposals to receive funding will be notified in

October 2011.

• Security / functional testing to be run in second

half of March 2012.

• Pilots to be presented to the Pistoia Alliance at a

conference in April 2012.

Timelines

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• Proposals to take the form of:

– a written response to the RFP

– A short presentation to be given to the Sequence

Services team via TC / Web-ex.

• It is anticipated that to meet the full RFP in the

time frame will be a challenge, but a pilot:-

– should clearly demonstrate core functionality

– show ability to expand to meet the whole RFP where

any functionality is missing.

Proposal Format (1/2)

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• All pilots must provide a clear rationale / business

model that demonstrates a commitment to on-

going support and development.

• Note:

– Price information is NOT to be shared with the Pistoia

Alliance.

– Price information may only be discussed - as part of

individual, confidential, contract negotiations - with

individual service consumers.

Proposal Format (2/2)

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• The Pistoia Alliance is prepared to provide

up to (US) $50,000 towards development

costs for a limited number of proposals.

Shared Risk Funding

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• Detailed requirements specification– http://www.pistoiaalliance.org/images/stories/pdfs/sequenceservicesphase2requir

ements.pdf

• Project contacts

– Project Lead: sequenceservices@pistoiaalliance.org

– Analyst: Giles.Ratcliffe@pathforwards.com

• Pistoia website and Basecamp

https://pistoia.basecamphq.com/projects/4354635/log

http://www.pistoiaalliance.org/

Phase 2: Further Information

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Q&A

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