Transcript
THE ROLE OF THE ROLE OF PEGYLATED PEGYLATED
INTERFERONS IN THE INTERFERONS IN THE MANAGEMENT OF HCV MANAGEMENT OF HCV
INFECTIONINFECTION Dr Nasir Khokhar MD FACP FACGDr Nasir Khokhar MD FACP FACG
Professor of Medicine and Professor of Medicine and Director, Division of Director, Division of
GastroenterologyGastroenterologyShifa International Hospital, Shifa International Hospital,
IslamabadIslamabad
16-Wk vs 24-Wk Therapy 16-Wk vs 24-Wk Therapy for Genotypes 2/3for Genotypes 2/3
Peginterferon alfa-2a (180 g/wk) + Ribavirin
800-1200 mg/day
Untreated ptswith HCV
genotype 2 or 3 (N = 153)
16-wktreatment(n = 71)
24-wktreatment(n = 69)
24-wktreatment(n = 13)
HCV RNA (+)
EOT SVR
94% 79%
85% 75%
71% 29%
Randomized, multicenter study [1]
1. von Wagner M, et al. AASLD 2004. Abstract LB-02.2. Dalgard O, et al. AASLD 2004. Abstract 197.
Wk 4 HCV RNA (-)
THANK YOU FOR THANK YOU FOR YOUR ATTENTIONYOUR ATTENTION
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