Patient-Reported Outcomes Quality of Life (PROQOL) How can the patient’s individual perspective of well-being augment the real-time clinical monitoring.

Patient-Reported Outcomes Patient-Reported Outcomes

Quality of Life (PROQOL)Quality of Life (PROQOL)

How can the patient’s individual perspective of well-being augment the real-time clinical monitoring

enabled by BEACON?

March 22, 2012Dr. Jeff Sloan, Mayo Clinic

• Describe Beacon PROQOL pilot

• Present training video

• Answer logistics questions

• Discuss site-specific information needed– Identify champion(s)– List of users– Site-specific clinical pathways

Today’s GoalsToday’s Goals

Beacon Pilot ProjectBeacon Pilot Project

• Overall Goal: Integrate patient-reported outcomes consistently and efficiently into the BEACON network with minimum burden to the patient, clinicians, and affiliated systems to improve clinical outcomes.

BackgroundBackground

Beacon Patient-Reported Outcomes (PRO) Pilot Validation Pilot Project

Background: The SE Minnesota Beacon has produced a brief patient-reported outcome (PRO) assessment for patients with diabetes. The assessment is available in both paper and computer-driven formats and we are presently in beta-testing of the measure at sites in SE Minnesota. We would like to work with other Beacon sites on a national basis to test the PRO measures.

Goal: We are seeking further sites across the national Beacon network to gain further feedback and validation data in different settings and with diverse populations.

General RequestGeneral Request

Request: We are asking that you would consider:

1.Working with our group to customize the information and logistics to implement the PRO assessment at one or more sites within your Beacon network. It would be optimal to have just one physician champion at each site within your network so as to reduce practice variability and the associated effort of rolling this out in your network.

2.Test the system for one month to gather validation data on 30 or more patients by June 30, 2012.

SystemSystem

System Description: The system is intended to be self-administered via paper or computer before an office visit, either in-clinic or at home. We have prepared a 4-minute training video for staff and patients.

Each site will decide whether to implement the paper and/or computer version of the Patient-Reported Outcomes Quality of Life (PROQOL) tool based on local logistics.

SystemSystem

The PRO system asks the patients three things:

1.To identify their “single biggest concern” at the moment.2.To check their concerns.3.To answer six general QOL questions and three diabetes-specific QOL questions.

The PRO data collection system takes no more than 5 minutes whether it is administered by paper or computer. It produces a summary of present and longitudinal patient data in a report for the provider and patient.

• The goal of the project is to facilitate communication between the patient and the clinical team as well as identify resources within the community beyond the care team.

• Customizing the clinical pathways in the program for a given site, a comprehensive list of community resources, clinical team members, and contact information is constructed and available across the institution.

• Bringing this information together as to whom to contact for financial help, what state programs are available, how to get in touch with a support group, which local firms supply meal services and so on, represent a potential savings in staff time as well as improving the communication flow among the key stakeholders.

Benefits to Pilot ParticipantsBenefits to Pilot Participants

• Connecting the patient to the appropriate clinical personnel beyond the physician will alleviate time pressure to deliver aspects of care that physicians may feel ill-equipped to address or beyond their purview.

• Specific benefits to the pilot participants will include:– Co-authorship on a manuscript detailing the experience that will be

targeted to Diabetes Care. – Upon completion of the pilot to gather the community representatives

together in a series of telecommunications to plan for future collaborations. We hence think of this as a continuing opportunity to learn and support each other as we try to facilitate diabetes care.

– Participate in a planned national webinar on the PROQOL pilot

Benefits to Pilot ParticipantsBenefits to Pilot Participants

• Agree to roll pilot out to a minimum of one physician

• Select a paper or electronic format

• Willingness to collaborate with SE MN Beacon on customizing the tool for your community

• Collect validation data on a minimum of thirty diabetic patients

• Comply with data feedback requirements

• Participate in check-in calls with SE MN PROQOL lead throughout pilot period

Pilot ExpectationsPilot Expectations

• Confirm community, Beacon staff and provider interest/bandwidth to participate in the pilot

• Submit letter of intent from your program director to Amanda Misiti (amanda.misiti@hhs.gov) and Dr. Jeff Sloan (jsloan@mayo.edu) that confirms your participation by 3/29/2012

Next StepsNext Steps

PatientClinical profile

Patient-reported QOL-related assessment

intake

Prophylactic interventions for PRO QOL-related domains

Real-time Monitoring of PRO QOL-related domains

Treatment

Triggered supportive care or treatment modification

Improved quality of lifeImproved survivalReduced emergent care

The Vision: QOL PROs as an The Vision: QOL PROs as an Integrated Vital SignIntegrated Vital Sign

Median Survival (Months)

Median (95% CI)

Log-rankP-value

BMA+ 16.8 (16.1, 17.4)0.0001

BMA- 9.2 (8.1, 10.6)

Survival Time (Years)

BMA+

BMA-

Biomaker Assay (BMA) Positive versus NegativeBiomaker Assay (BMA) Positive versus Negative23 Trials (3,704 patients)23 Trials (3,704 patients)

Directions: Please circle the number (0-10) best reflecting your response to the following that describes your feelings during the past week, including today. How would you describe: 1. your overall Quality of Life? 0 1 2 3 4 5 6 7 8 9 10 As bad as As good as it can be it can be

This is a reliable and valid measure for cancer patient populations

(Sloan, MCP, 2002; Huschka, Cancer, 2005; Locke, JPSM,2007)

cut-off validation: Butt, JPSM,2008; Sloan, Value in Health, 2007; Temel, J Thorac Oncol, 2006

BMA- = A Score of 5 or LessBMA- = A Score of 5 or Lessin Patient-Reported QOL on a 0-10 Scalein Patient-Reported QOL on a 0-10 Scale

• Find PRO-related problems

• Uncover otherwise unknown problems

• Modify treatment

PROs in Clinic Can be Used to:PROs in Clinic Can be Used to:

• 8 year cancer survivor annual clinic visit

• Rated QOL as a 2 out of 10

• Initiated conversation

• Insomnia

• “Stupid thoughts”

• Suicidal ideation

Case Study #1Case Study #1

• Psych referral

• Anti-depressant

• 1 month later QOL was 7

Case Study #1Case Study #1

• Item bank of diabetes PROs

• Discussion Groups with stakeholders

• Logistics realities

• Beta testing of PROQOL system

Beacon PROQOL GenesisBeacon PROQOL Genesis

• Thousands of items

• Research-orientated

• Group comparison orientated

• Not intended for individual patient management

Item Bank of Diabetes PROsItem Bank of Diabetes PROs

• To get initial feedback and validation on the key issues facing patients with diabetes and identify key domains for data collection

• Constrain the number of items

Discussion GroupsDiscussion Groups

• Identify the most pressing/urgent/first mentioned needs of the patient and produce a clinical pathway system to:

1. clarify the issue with further probative items (minimalist)

2. identify the actions that the clinician and patient could take

3. engage appropriate referral/supportive services both clinical and community

4. track and feedback this information for future visits and further needs assessment

5. combine with other BEACON data

PROQOL System ParametersPROQOL System Parameters

• Paper version available

• Computer version revised (March 1)

• Testing at Winona, OMC, Olmsted Public Health, Mayo

• Other Beacon sites interested in testing

• Meeting with sites for implementation

Submit

UpdateUpdate

Clinical Flow ChartClinical Flow Chart