One Health in Action Dr. Ralph Richardson Dean, College of Veterinary Medicine Kansas State University Dr. Neil Olson Dean, College of Veterinary Medicine.
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One Health in ActionDr. Ralph Richardson
Dean, College of Veterinary MedicineKansas State University
Dr. Neil OlsonDean, College of Veterinary Medicine
University of Missouri
Cooperation between human and veterinary medicine in selected endeavors, working locally, nationally and globally.
Building on common pool of knowledge in physiology, pathology, epidemiology, etc.
Simultaneous study of environmental and zoonotic diseases in people, domestic and wild animals.
What is one health?
One Health MovementThe Convergence of…
Human Health
Animal Health
Environmental Health
Ref: JAVMA One Health, July 15, 2008
60% OF THE 1,462 KNOWN INFECTIOUS ILLNESSES ARE CAUSED BY AGENTS WHICH ARE MULTI-HOST
PATHOGENS AND MOVE ACROSS SPECIES LINES.
IN THE LAST 30 YEARS, 70% OF THE NEW HUMAN INFECTIONS HAVE BEEN ZOONOTIC.
Emerging infectious disease
Spinach outbreak 200 people, 26 states, 3 dead
Food-as-foe
"I never thought you could die from E.coli. Never. I had heard of E.coli and I just thought it was food poisoning" she said."I never ever thought Mason would die from it.”
-- Family’s call for E. coli lessons01.nov.05
BBC News
Mason Jones Dec. 24, 1999 - Oct. 6,
2005
Similar appearance of fully cooked and uncooked breaded products
Product packaging of fully cooked vs. uncooked products
Cause for consumer confusion?
“Between animal and human medicine there is no dividing line – nor should there be. The object is different but the experience obtained constitutes the basis of all medicine.” - Rudolf Virchow (1821-1902)
NEW YORK TIMES, SEPTEMBER 10, 2012“Vets and Physicians Find Research Parallels”
“One reason is a growing frustration with the inefficiency of using the rodent model in lab research, which often fails to translate to human subjects…this type of research model has led to a host of collaborative research projects aimed at speeding the journey from lab to human clinical trials, and in the end, producing a result that can be applied to human and animal patients alike.”
Comparative Neurology Program
Diseases of the Nervous System
Epilepsy & movement disorders
Meningitis & encephalitis
Brain tumors
Stroke & head injury
Spinal injury & herniated disks
Muscular dystrophy & other muscle diseases
Comparative Neurology
Program
What do these two have in common?
http://en.wikipedia.org/wiki/Lou_Gehrig
From lab to clinic
Identification of new genes
Development of new therapies
Canine genome map provided the tools
Cancer in Animals
50% of animals that live beyond 10 years of age will develop cancer
Improved methods of diagnosis
Increased demand for care
Cancer Incidence by Species(Age-adjusted Incidence)
381 cases/100,000 dogs per year
264 cases/100,000 cats per year
300 cases/100,000 people each year
Why are animal cancer models useful?
Shorter life span
Why are animal cancer models useful?
Sharedenvironment
Why are animal cancer models useful?
Controllable factors
Lifestyle choices
Diet
Hormonal status
Placebo effect
Why are animal cancer models useful?
Pedigree may be known
The Quadramet Story at MU
One Health in Action
Samarium 153 developed at MU (1980s)
Osteosarcoma
Clinical trials in dogs (1990s)
Critical data for FDA to conduct human clinical trials
The Quadramet Story at MU
Springer Spaniel owned by St. Louis couple in early 2000s
Wife’s father developed metastatic tumor in spine (2005)
Treated with Quadramet
2012 couple bequested $5M ofestate to MU CVM
Ongoing clinical trials with next generation drug (cyclosam)
Cooperation between human and veterinary medicine in selected endeavors, working locally, nationally and globally
Building on common pools of knowledge in physiology, pathology, epidemiology, etc.
Simultaneous study of environmental and zoonotic diseases in people, domestic and wild animals
Assurance of scientific rigor
Identifying mutual benefit for animals and humans
How will programs be built?
The Greater Kansas City Community Foundation“A Time to Get it Right” and “Staying Competitive in the New Economy”
“It is essential that faculty members and researchers in Kansas City’s key 4 life sciences organizations, e.g., universities, the Stowers Institute, area medical centers and life sciences businesses, be strongly encouraged to work together. Every effort should be made by organizations to remove those factors that hinder such intellectual collaboration.”
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