Transcript
Curare and Related Compounds
George Hsiao
2008
Therapeutic uses of anti-ChE agents
(1) Paralytic Ileus and Atony of the Urinary Bladder: Neostigmine is used for the relief of abdominal distension and acute colonic pseudoobstruction from a variety of medical and surgical causes.
(2) Glaucoma and Other Ophthalmologic Indication
(3) Myasthenia Gravis
(4) Prophylaxis in Cholinesterase Inhibitor Poisoning (nerve gas: pyridostigmine)
(5) Intoxication by Anticholinergic Drugs (atropine: CNS effects: physostigmine)
(6) Alzheimer’s Disease (tacrine, donepezil)
Myasthenia Gravis vs Normal Condition
Neurofibrillary Tangles and Senile Plaques
Cholinergic Innervation
Therapeutics on Alzheimer’s disease • Cholinergic drugs• Ach E inhibitors• Tacrine• Donepezil• Rivastigmine• Galantamine
Terrorism !!!
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