Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| Dr. CN Ramchand CEO, Saksin lifesciences Pvt. Ltd Chennai.

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com

Dr. CN RamchandCEO,

Saksin lifesciences Pvt. Ltd

Chennai & San Francisco

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 2

My experien

ces

Funding and development of biotech start-

upsOverview-India

& in Kerala

General outline

Vice President & Head of New Drug Discovery

Director & World Wide executive member

Chief Scientific Officer

President and CEO

President & CEO Advisor Advisor

Education

Early days

Semi-

Entrepreneur

Entrepreneur

Scientific publications= > 150

Patents => 60Conferences organized => 8

Nanoparticles for biological applications

Curcumin based products The Fish oil story

Value added basic research

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 5

Major players in the country

Advantage IndiaSkilled manpower

Large consumer base

Government funding/Venture funding

Good IT support

English proficiency Raw materials aplenty

Ancient knowledge

Ecological /Cultural diversity Agricultural base strong

Indian biotech in global contextLeadership vacuum

Publications and Patents still less

Research in Industry not significant yet

No dialogue between academics and industries

Less number of startups

Academia not ready to take risk for a venture

Less number of R&D Institutes & Universities

Shortage on mentors, advisors

Lack of awareness about opportunities

One mentionable pointUniversity’s role in supporting Innovation & Entrepreneurship

Spun off from Oxford University in 1993

Spun off from Oxford University in 1959

Spun off from Cavendish Laboratory at

the University of Cambridge in 2000

Spun off from Carnegie Mellon

University in 1994

Country Period No. Spinouts

US 1980-2003

4543

Canada 1962-2003

1100

France 1984-2005

1230

Netherlands 1980-1990s

300

Australia 1984-1999

97

UK 1981-2003

1650

Columbia University- >100 spin offs

Roadmap to success

Learning by example

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 15

Reverse pharmacology

Conventional drug discovery

Associated issues

Strategy

Curcumin

Capsaicin

6-Gingerol

Lycopene

Resvertrol

Diallyl sulphide

Indole-3-carbinol

Source SourceActive Phytochemical Active PhytochemicalApplication Application

Caffeic acid phenethyl ester

Anti-inflammatory, antioxidant, antiamyloid,antiarthritic.

Long-term analgesic,

anti-inflammary, anti-psoriasis.

Antitumor,anti-carcenogenic,

antiarthritic.

Strong antioxidant, Anti-inflammatory,

anti-HIV.

Anti-ageing, antioxidant, antidiabetic.

Neuroprotective,Cardioprotective

antidiabetic, antiviral.

Inhibits H. pylori, anticarcinogenic.

Anticarcinogenic, antioxidant,

antiatherogenic.

Antimicrobial, antioxidant.

Anti-inflammatory, antimitogenic,

antifungal.

Sulphoraphane

Epicatechin gallate

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 19

Development of Novel biologics at Saksin Lifesciences

Wet AMD

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com

Age related AMD

Dry, or Atrophic or Non-neovascular macular degeneration

Wet or Exudative or Neovascular macular degeneration

Abnormal blood vessels begin to grow underneath the retina

Blood vessels may leak fluid or blood, blurring or distorting central vision.

Macula

Optic disc

Wet AMD Dry AMD

Fovea centralis

Disease causing factor

Receptor in eyesDisease causing factor Disease complex formed

AMD

Anti-VEGF Fab

Disease causing factor

No AMD

No complex formed

Mechanism of the novel drug

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com

DNA extraction using magnetic nanoparticles

Magnetic nanoparticles

DNA extractionMagnetic

nanoparticles

using

Applicable to various biological systems

Quick and robust

Can be performed without using sophisticated instruments

High yield and purity Easy to use for large number of samples

Patent application number5676/CHE/2014

UK patent application GB 2455780.

Patent application number1067/MUM/2006

GM crops, Micro-propagation, Bio-fertilizers & Bio-pesticides, Animal Improvement

r-DNA Products, Vaccines & Diagnostics, Monoclonal Antibodies, Stem Cells, Tissue Specific delivery methods

Enzymes , Fermentation based Products & Food, Biotech Instruments & Equipment, Bio-energy & Bio-fuel,

Bioinformatics, Bio-mining

Soil & Water remediation, Bio-safety & GMOs

Viable applications

Healthcare

Agriculture

Environment

Industry

Technology development funds Technology in-licensing funds

Market entry funds Funds for patent protection

Technology scale-up/validation/de-risking funds

Expansion funds

Funding

Government of

India/Kerala

Venture capitalist

For more information visit :http://

www.venturecenter.co.in/funding

Department of Scientific & Industrial Research (DSIR)

Ministry of Micro Small Medium Enterprises (MoMSME)

Department of Science and Technology (DST)

National Innovation Foundation (NIF)

Kerala Venture Capital Fund

National Research Development Corporation (NRDC)

Department of Bio-Technology (DBT)

World Bank & ICICI Bank collaboration

Bill and Melinda Gates Foundation

Amrita Vishwa Vidhyapeetham- TBI

Major funding sources

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 32

Biotechnology in India/Kerala-Thrust areas

Module No:306, 3rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com 33

Advantage Kerala

Prebiotics & Probiotics Agri-foods

Pharmaco-genomics

and Nutri-

genomics

FCR enhancers

Regional Research Laboratory, Thiruvananthapuram

Kerala Forest Research Institute, Peechi

Kerala Agricultural University, Vellayani

Central Tuber Crops Research Institute,

Thiruvananthapuram

Central Institute of Fisheries Technology,

Ernakulam

Rubber Research Institute of India,

Kottayam

Central Coir Research Institute,

Kalavoor, Alappuzha

Central Marine Fisheries Research Institute, Ernakulam

National Research Center for Oil Palm (Regional Center), Palode,

Thiruvananthapuram

Indian Cardamom Research Institute,

Myladumpara, Idukki

Indian Institute of Spices Research, Kozhikode

Central Plantation Crops Research

Institute, Kasargod

Regional Cancer Center,

Thiruvananthapuram

Center for Water Resources Development and Management,

Kunnamangalam, Kozhikode

Major research institutes in

Kerala