MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F Nahum Sonenberg et al. Science, September 2007 Presentation.
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MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the
Cap-Binding Complex eIF4FNahum Sonenberg et al.
Science, September 2007
Presentation byAnsuman sahoo
Advanced Mol. Bio Class07.10.14
Fig. 1. Repression of protein synthesis by let-7 miRNA in an ascites extract.
G Mathonnet et al. Science 2007;317:1764-1767
Published by AAAS
Fig. 2. let-7 miRNA inhibits translation without affecting mRNA stability in an ascites extract.
G Mathonnet et al. Science 2007;317:1764-1767
Published by AAAS
Fig. 3. let-7 miRNA inhibits ribosome binding.
G Mathonnet et al. Science 2007;317:1764-1767
Published by AAAS
Fig. 4. let-7 miRNA inhibits cap-dependent, but not cap-independent, translation in an ascites extract.
G Mathonnet et al. Science 2007;317:1764-1767
Published by AAAS
Figure : Possible Mechanisms of miRISC-Mediated Repression Nonrepressed mRNAs recruit initiation factors and ribosomal subunits and form circularized structures that enhance translation (top). When miRISCs bind to mRNAs, they can repress initiation at the...
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Cell, Volume 136, Issue 4, 2009, 642 - 655
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