Transcript
METAGONIMIASIS
Metagonimiasis is an infectious parasitic disease that is associated with eating undercooked fish. It is found mostly in the Far East, but also in Siberia, Manchuria, the Balkan states, Israel and Spain.
a disease caused by an intestinal trematode, most commonly Metagonimus yokagawai, but sometimes by M. takashii or M. miyatai. The metagonimiasis causing flukes are one of two minute flukes called the heterophyids. Metagonimiasis was described by Katsurasa in 1911-1913 when he first observed eggs of M. yokagawai in feces
ETIOLOGIC AGENT Metagonimus yokagawai,
also called the Japanese fluke. Much more rarely, metagonimiasis can arise from infection with M. takahashii or M. miyatia. Recent studies analyzing the DNA of the three agents causing Metagonimiasis found that DNA sequencing supports M. yokagawai and M. takahashii be placed in the same clade, and phylogenic tree analysis supports their genetic similarity. M. miyatia.
MODE OF TRANSMISSION
vector BORNE
SIGNS
AND
SYMPTOMS
PERPHERAL EOSINOPHILIA
DIARRHEA“BOGRATOR”
NAUSEA
ABDOMINAL PAIN
LETHARGY
ANOREXIA
FATIGUE
CHAIN OF
INFECTION
VECTOR BORNE
m.yokogawii
reservoir
Portal of exit
G.I tract
human
DIAGNOSTIC TEST
stool TESTELISA TEST
TREATMENTPRAZIQUANTEL BITHIONOLOL
NICOLOSAMIDE
MANAGEMENT There is a studies in rats and rabbits
have shown the drug to increase abortion rates and to have teratogenic effects when given in doses that exceed the recommended human dose. In addition, Praziquantel is excreted in breast milk, and so should not be used while a mother is breastfeeding.
It is administered orally, and does not require heavy dosage. Its potential applications for mass therapy are promising.
Prophylactic treatment should also be coupled with therapy to address secondary clinical symptoms.
With heavy infections, rehydration and electrolyte therapy should be administered to counter fluid and salt losses due to diarrhea.
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