Meeting of the Working Group on TB Drug Development Why you need to be engaged? Marcos Espinal Executive Secretary Stop TB Partnership 29 October 2004.
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Meeting of the Working Group Meeting of the Working Group on on
TB Drug DevelopmentTB Drug Development
Why you need to be engaged?Why you need to be engaged?
Marcos EspinalMarcos EspinalExecutive SecretaryExecutive SecretaryStop TB PartnershipStop TB Partnership
29 October 200429 October 2004Paris, FranceParis, France
I am pleased to let you know that… tuberculosis I am pleased to let you know that… tuberculosis control has progressed to the point where virtual control has progressed to the point where virtual elimination of the disease as a public health elimination of the disease as a public health problem appears to be within reach…problem appears to be within reach…
So Maria, Peter, Giorgio, Rick, Ken, Lee, and all of you So Maria, Peter, Giorgio, Rick, Ken, Lee, and all of you please go home, relax, and look for a more exciting job…please go home, relax, and look for a more exciting job…
November 1959, The Arden House Conference on Tuberculosis. November 1959, The Arden House Conference on Tuberculosis. New YorkNew York
The Arden House Conference on Tuberculosis. U.S. Department of Health, Education, The Arden House Conference on Tuberculosis. U.S. Department of Health, Education, and Welfare, Public Health Service No. 784. Washington, DC:US Government Printing and Welfare, Public Health Service No. 784. Washington, DC:US Government Printing Office; 1961. Office; 1961.
Stop TB GoalsStop TB Goals
By 2005By 2005– 70% Case detection under DOTS70% Case detection under DOTS– 85% Cure rate85% Cure rate
By 2015: Millennium Development GoalsBy 2015: Millennium Development Goals– 50% reduction in prevalence and deaths by 201550% reduction in prevalence and deaths by 2015
By 2050:By 2050:The global incidence of TB The global incidence of TB disease will be less than 1 per million disease will be less than 1 per million populationpopulation
New tools will take us thereNew tools will take us there
ChallengesChallenges
Additional resources for health and poverty reduction– Workforce crisis: more & better human
resources
– Better harmonized and more effective aid– Strengthened health systems: primary
care– Improved performance monitoring
Consolidate, sustain and advance achievements– Mobilise communities, the private sector,
and enhance political commitment– Accelerate response to HIV/AIDS
emergency– Invest in research & dev't to shape
the future Source: 2nd Ad-hoc committee, September 2003
Partnership towards Partnership towards Stop TB TargetsStop TB Targets
Partners Forum
Coordinating Board
Secretariat/GDF
Goals & Targets
DOTS Expansion
WG
TB/HIVWG
DOTS-PlusMDRTB WG
New Drugs WG
TB DiagnosticsWG
New VaccinesWG
Communication/Advocacy WG
WG MissionWG Mission
You need to deliver faster and You need to deliver faster and affordable TB medicinesaffordable TB medicines
– Simplification / shortening TB treatmentSimplification / shortening TB treatment– Improve latent TB treatmentImprove latent TB treatment– Effective against MDR-TBEffective against MDR-TB– Be easily adoptable in the fieldBe easily adoptable in the field
Why is important for the Why is important for the R & D community to keep R & D community to keep engaged through the WG…engaged through the WG…
Current tools are not sufficient Current tools are not sufficient and and
being away and isolated is not the solutionbeing away and isolated is not the solution
MGIT …. About 15-20 years….MGIT …. About 15-20 years….
PortfolioPortfolio Shared responsibilityShared responsibility
– Novartis donation to GDF – Eli Lilly discount to the GLCNovartis donation to GDF – Eli Lilly discount to the GLC
NetworkingNetworking– Learning from others – duplicationLearning from others – duplication
Forum for a common agenda on new tools issues Forum for a common agenda on new tools issues – economics, regulatory requirements, trial site register, economics, regulatory requirements, trial site register,
immunological issues, market introduction, advocacy and immunological issues, market introduction, advocacy and communication communication
Get new tools into TB control in poor countriesGet new tools into TB control in poor countries– Cross fertilization with other WGs Cross fertilization with other WGs
Global Plan to Stop TBGlobal Plan to Stop TB
DOTS Expansion Working DOTS Expansion Working Group: Group: 180 countries implementing DOTS
Working Group on Working Group on TB/HIV: TB/HIV: Policy for TB/HIV collaborative activies
Working Group on DOTS-Working Group on DOTS-Plus for MDR-TB: Plus for MDR-TB: Treatment for MDR-TB in more than 10 countries
The Global Plan to The Global Plan to Stop TB Stop TB (and 2003 (and 2003 update)update)
Working Group on New Working Group on New Diagnostics: Diagnostics: Enabling environment for commercial tool development
Working Group on New TB Drugs: Working Group on New TB Drugs: Pipeline of promising compounds
Working Group on Working Group on New Vaccines: New Vaccines: Two vaccine candidates entering phase I clinical trials
Partnership Governance:Partnership Governance:Coordinating BoardCoordinating Board
High TB burden countries (4): High TB burden countries (4): China, India, Brazil, DR China, India, Brazil, DR CongoCongo
Regional representatives (6)Regional representatives (6) WHO, World Bank, UNAIDS, GFATMWHO, World Bank, UNAIDS, GFATM Working Group Chairpersons (7)Working Group Chairpersons (7) Financial donors (4): Financial donors (4): CIDA, Japan, Euro (NL), USAIDCIDA, Japan, Euro (NL), USAID Foundations (1): Foundations (1): Gates FoundationGates Foundation NGOs and technical agencies (3):NGOs and technical agencies (3): IUATLD, CDC, IFRC IUATLD, CDC, IFRC Communities affected by TB (1): Communities affected by TB (1): Under selectionUnder selection Chair of the WHO STAG: Chair of the WHO STAG: Mexico vice MOHMexico vice MOH Corporate business sector: Corporate business sector: Heineken Heineken
I am pleased to let you know that… I am pleased to let you know that… tuberculosis control tuberculosis control will progresswill progress to the to the point where elimination of the disease as a point where elimination of the disease as a public health problem public health problem will bewill be within within reach…reach…
So Maria, Peter, Giorgio, Rick, Ken, Lee, and all of So Maria, Peter, Giorgio, Rick, Ken, Lee, and all of you please you please keep working hard because the keep working hard because the quest is not yet overquest is not yet over……
Thank you…
…for your contributions, and your continued collaboration in the Stop TB
Partnership!
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