MEDICAL PRESENTATION HYPERBARIC MEDICINEmedical presentation hyperbaric medicine. hyperbaric chamber medical device used in hbot, to ... • fibromyalgia ... presentation of cases
Post on 25-Jun-2020
17 Views
Preview:
Transcript
MEDICAL PRESENTATION
HYPERBARICMEDICINE
HYPERBARIC CHAMBERMedical device used in HBOT, to administer oxygen (O2) at high pressure, above atmospheric (1 ATM).
HYPERBARIC OXYGEN THERAPY
Hermetic Cabin: It is pressurized in a stable manner (Treatment Pressure), where the patient remains during the session.
Compressors Cabinet: It enters filtered air into the cabin to reach the treatment pressure by venting in a safe manner.
Oxygen external source:It may be by hub or tank, it supplies high-concentration of O2 to the patient.
COMPONENTS
Increasing the concentration of O2 that we breathe
Increasing the pressure of the air we breathe (environment ≥1.45 ATM) *
O2 100% HYPERBARIA
O2 dissolved in blood: HYPEROXIA reaching very poorly
irrigated tissues and producing other physiological effects
TREATMENT
HYPERBARIC OXYGENATION (HBOT)
*Undersea and Hyperbaric Medicine Society >>>1.4 ATA
DALTON'S LAW
The pressure of a mixture of
gases is equal to the sum of
partial pressures (Pp) of each of
the gases that compose it.
HENRY'S LAW
Gases dissolve in liquids
when under pressure.
PHYSIOLOGY OF OXYGENPHYSICOCHEMICAL FUNDAMENTALS
PHYSIOLOGY OF OXYGENAnalogy with a Sparkling Wather bottle
You can see no bubbles in a closed sparklingwater bottle. When you open it, bubblesappear. This is due to the physical laws statingthat gasses dilute in liquid when they are underpressure.
The same physical laws apply to our body.When O2 is breathed in a pressurized cabin, theO2 dilutes in blood plasma, which is 50% water.
PHYSIOLOGY OF OXYGEN
Normobaria (Air at sea level):
Atmospheric pressure: 760 mmHg (1 ATA)
Partial concentration of O2: 21%
Pp O2: 0.21 x 760 mmHg = 160 mmHg
Hyperbaria: 1.45 ATA
Partial concentration of O2: 21%
Pp O2: 0.21 x (1.45 x760 mmHg) = 231 mmHg
FiO2: (Fraction Inspired by O2 - NV: 0.21)
VH20: 47 mmHg (internal humidity - Water)
PACO2: 40 mmHg (Alveolar Pressure CO2)
CR = 0.8 (respiratory coefficient between CO2 and O2)
Alveolar pressure of the O2
PAO2 = (760 - 47) x 0.21 - 40 / 0.8 = 100 mmHg
100% O2 to 1.45 ATA: PAO2 = (760 * 1.45 - 47) x 1 - 40 / 0.8 = 950 mmHg
INCREASING
THE PRESSURE
IN THE
ALVEOLO
INCREASES THE
DISSEMINATION
TO THE PLASMA
VH20 PACO2 CR
PHYSIOLOGY OF OXYGEN
CONTENT OF
O2 IN THE BLOOD
The hyperbaric effect on dissolved oxygen:
1. Normobaric air (21% O2 1 ATA 97% Hb): 0.3ml / dl dissolved oxygen2. Hyperbaric oxygen (100% 1.45 ATA 100% Hb): 3.0 ml / dl dissolved oxygen
Hyperoxia:
Increases 10 times the amount of dissolved oxygen (independent of Hemoglobin) O2 is immediately and completely available for cells.
TREATMENT
HYPERBARIC OXYGENATIONEssential effect of Hyperbaric Oxygenation
Oxygenate the tissues
The average density of capillaries varies in tissues (~ 600 / mm3)• 2500-3000 / mm3 (brain, kidneys, liver, myocardium);• 300-400 / mm3 (skeletal muscles);• <100 / mm3 (bones, adipose tissue, connective tissue)
Average separation of ~ 40μm between adjacent capillaries
Distance capillary cells in living tissues: ~ 1-3 cells
Source: Robert A. Freitas Jr., Nanomedicine, Volume I: Basic Capabilities, Landes Bioscience, Georgetown, TX, 1999
Describes radial gradients of PO2 in a tissue cylinder
of radius R. The model considers the O2 consumption,
the solubility, the diffusion coefficient of O2 and the
non-linear fall of PO2 from the arterial to the venous
end of the capillary.
It allows calculating the PO2 at any point r, where c is
the radius of the capillary and r is the distance from
the center of the capillary inside the tissue cylinder.
The penetration of O2 into tissues is a function of PO2
BLOOD END
VENOUS END
a.radial
L
L
DISSEMINATION OF O2:
KROGH MODEL
DISSEMINATION OF O2:
KROGH MODELO2 Penetration to tissues:
Pressure in hyperbaric chamber = 1.45 ATA
generates PO2arterial = 950mmHg
Minimum effective PO2, tissue = 20mmHg
Penetration radius ~ 75μm (diameter ~ 150 μm)
Under these conditions, the penetration of O2 into
all tissue cells is guaranteed
950mmHg
PHYSIOLOGICAL EFFECTS
O2 gradient between the alveolus and pulmonary capillary
O2 diffusion and availability in tissues
Blood pressure of O2 and amount of dissolved O2:
HYPEROXIA (independent of hemoglobin)
AEROBIC METABOLISM
Through HBOT, O2 is administered as an active ingredient, seeking to maximize the oxygenation of
tissues to fulfill cellular and metabolic functions.
Molecular oxygen (O2) is an essential element for the cell: its main "mechanism of action" is to
participate as fuel in the energy supply of the cell.
O2
Energy production
ATP
FREE RADICALSFree radicals (FR) are chemical species with
an unpaired electron in their outer orbit. The
FR seek to match that electron, so they are
highly reactive. Oxygen is also present in the
form of FR (ROS) used by our body for
multiple functions:
• Inflammatory and immunological
response (against viruses and / or
bacteria)
• Proliferation and cell division
• Apoptosis
ROS
OXIDATIVE STRESSANTIOXIDANT DEFENSE
BALANCE OF THE OXIDIZING SYSTEM - ANTIOXIDANT
DISBALANCE: DISEASE
(H₂O₂ -0₂ -OH NO NOO-)
antioxidant
Free radical
electron
MECHANISM OF ACTION - HOBT
HYPEROXIA
ROS production
Improves the antioxidant system
Objective: to guarantee the arrival of O2 to tissues to fulfill
biochemical, metabolic and physiological functions
InglésInglésInglés
HYPERBARIC OXYGEN
GENERATES A STRONG HYPEROXIA
BENEFICIAL PHYSIOLOGICAL EFFECTS
HYPEROXIA - PHYSIOLOGICAL EFFECTS
NON-HYPOXEMIC
VASOCONSTRICTION
ANGIOGENESIS
OSTEOGÉNESIS
CELLULAR IMMUNITY
PERIPHERAL AXONAL
REGENERATION
COLLAGEN SYNTHESIS
OXIDATIVE STRESS AND
INFLAMMATORY RESPONSE
PROLIFERATION AND STIMULATION
OF MOTHER CELLS
NEURONAL FUNCTION
AND NEUROPROTECTION
BACTERICIDAL ACTIVITY
OXYGEN DOSEThe therapeutic effect of hyperoxia is
determined by the dose of oxygen.
The dose of oxygen depends on 5 variables:
• % of O2
• Pressure of the camera
• Duration of the session
• Session frequency
• Total number of sessions
5 weekly sessions
4 weekly sessions
3 weekly sessions
2 weekly sessions
1 weekly session
INDICATION OF THE TREATMENTSessions
Generally, a minimum of 10-20 sessions are indicated, according to the pathology of each patient.
Duration of the session
The average time used is 60 minutes. In acute patients, sessions of 90 minutes up to 2 times a day
are performed.
Session cycle
Number of sessions to be done indicating: total number, daily amount, weekly periodicity (1 to 6)
and duration of the session.
Intercycle period
Rest indicated between cycles.
HBOT: INDICATIONS
MEDICAL CLINIC
• Fibromyalgia
• Chronic fatigue
• Migraines and headaches
• Tinnitus
• Geriatrics
• Apneas of sleep
• Crohn's disease
Adjuvant treatment that reduces inflammation and edema, relieves pain, improves tissue perfusion, energy efficiency and quality of life.
Inglés
• Trauma
• Pre and post-surgical
• Progressive bacterial gangrene
• Acute traumatic ischemia
• Ligament injuries
• Osteomyelitis
Adjuvant treatment accelerates recovery and healing, reduces inflammation and edema, relieves pain, reduces the risk of infection and amputation and improves quality of life.
HBOT: INDICATIONS
TRAUMATOLOGY
Adjuvant treatment prepares athletes during training, improves energy efficiency, shortens recovery, prevents fatigue and improves injury rehabilitation.
• Training
• Muscle and tendon injuries
• Post-exercise recovery
• Chronic Fatigue Syndrome
HBOT: INDICATIONS
SPORT MEDICINE
• ACV
• Parkinson's disease
• Multiple sclerosis
• Alzheimer disease
Adjuvant treatment reduces edema, redistributes blood flow and improves cerebral oxygenation, reduces spasticity and tremors, improves cognitive function, neuroprotection and quality of life.
PEDIATRIC PATIENT:
• Autism
• PDD (Pervasive Developmental Disorder)
• Cerebral palsy
• Detoxification
HBOT: INDICATIONS
NEUROLOGY
• Wounds
• Ulcers - Diabetic foot
• Venous ulcers
• Post-surgical injuries
• Burns
• Grafts and implants
The treatment of hyperbaric oxygenation accelerates healing, favors angiogenesis, reduces
inflammation and edema, stimulates collagen synthesis, triggers the immune response and
improves perfusion.
HBOT: INDICATIONS
WOUNDS
Fibromyalgia
Rheumatoid arthritis
Osteoarthritis
Bone edema
Bone necrosis
Osteomyelitis
Adjuvant treatment to accelerate recovery, relieve pain, reduce inflammation and edema, reduce the risk of infection and improve quality of life.
HBOT: INDICATIONS
REUMATOLOGY
• Tumors
• Radio-necrosis and radiotherapy
Adjuvant treatment to improve sensitivity to radio and chemotherapy, control tumor growth, relieve
pain, prevent and recover radio-necrosis and improve quality of life
HBOT: INDICATIONS
ONCOLOGY
EVIDENCE ANDPRESENTATION OF CASES
VARIOUS ESSAYS, SERIES AND CASE REPORTS
RAISE THE EFFECTIVENESS OF HBOT AS A
SUCCESSFUL TREATMENT FOR DIFFERENT
DISEASES.
Hyperbaric Oxygen Induces Late Neuroplasticity
in Post Stroke Patients - Randomized,
Prospective Trial
Shai Efrati1,2,3*, Gregori Fishlev1, Yair Bechor1,
Olga Volkov3,4, Jacob Bergan1, Kostantin
Kliakhandler5,
Izhak Kamiager3,6, Nachum Gal1, Mony
Friedman1, Eshel Ben-Jacob2,5,7, Haim Golan3,4
Hyperbaric Oxygen Induces Late Neuroplasticity in PostStroke Patients -Randomized, Prospective Trial
A normal and healthy adult brain
should be seen primarily yellow in
the SPECT scanner. Green
indicates lower blood flow and
oxygen. Blue and violet represent
a significant reduction of blood
flow in the brain.
Patient: male
Age: 60 years
Number of sessions: 40Diagnosis: Ischemic ulcer - rheumatoid arthritis
EVIDENCE ANDPRESENTATION OF CASES
Patient: male
Age: 27 years
Number of sessions: 34
Diagnosis: Arteriovenous fistula
Patient: male
Age: 27 years
Number of sessions: 34
Diagnosis: Arteriovenous fistula
Patient: male
Age: 60 years
Number of sessions: 35
Diagnosis: Post-heart surgery
Patient: male
Age: 60 years
Number of sessions: 20
Diagnosis: lower limb, Necrosis, circulatory failure
Patient: male
Age: 5 years
Number of sessions: 70
Diagnosis: Arteriovenous malformation
Patient: male
Age: 70 years
Number of sessions: 70
Diagnosis: Diabetic ulcer
Patient: female
Age: 90 years
Number of sessions: 35
Diagnosis: Gluteal scapula
Patient: female
Age: 60 years.
Number of sessions: 40
Diagnosis: Pyoderma gangrenosum
Patient: female
Age: 11 years
Number of sessions: 40
Diagnosis: Trauma
Patient: female
Age: 70 years
Number of sessions: 20
Diagnosis: Lip melanoma
Patient: male
Age: 90 years
Number of sessions: 20
Diagnosis: Venous insufficiency
Patient: male
Age: 90 years
Number of sessions: 20
Diagnosis: Venous insufficiency
Patient: baby
Age: 3 days
Number of sessions: 3Diagnosis: Penicillin reaction
Patient: baby
Age: 3 Weeks
Number of sessions: 10
Diagnosis: Fasciitis Necrotizing
Patient: female
Age: 40 years
Number of sessions: 40
Diagnosis: Necrotizing Fasciitis
Patient: male
Number of sessions: 30
(Lesion in evolution for 4 years)
Diagnosis: Buruli ulcer
Courtesy Dr. AmousaBioBarica Headquarters
Gabon - Africa
Number of sessions: 18
Upper and left floor gangrene
Diagnosis: Diabetic Foot
Diagnosis: Sickle cell ulcer Number of sessions: 20
Courtesy Dr. AmousaBioBarica Headquarters
Gabon - Africa
Diagnosis: Dry gangrene of the fingers
Significant risk of amputation Improvement of the vascular
bed and conservation of the
fingers
Courtesy Dr. AmousaBioBarica Headquarters
Gabon - Africa
Diagnosis: Diabetic leg and foot gangrene
After surgical debridement Leg waiting for skin graft
Courtesy Dr. AmousaBioBarica Headquarters
Gabon - Africa
AbsolutePneumothorax not treatedBulla Pulmonar
RelativeTympanic perforationCancer treatment (Bleomycin, Cisplatin, Doxorubicin, Disulfiram)Pacemaker
Special caresMild hypoglycemic and Hypertensive.Congestion or catarrhClaustrophobiaPathology of VAS and COPD
CONTRAINDICATIONS
HYPERBARIC TREATMENT WITHREVITALAIR 430 CHAMBERS
Verification protocol in healthy patients:
It concludes:
Treatment at 1.45 ATA does not modify the biochemical parameters of acute phase
inflammation and oxidative stress in healthy volunteers.
Significant increase in antioxidant enzyme suggests the effect of hyperoxia in healthy
The biochemical parameters at 10 and 20 sessions are kept within the values of reference.
The treatment is safe and well tolerated, without adverse effects
CONCLUSION
The strong HYPEROXIA increases the volume of dissolvedoxygen in the blood plasma. This increase in O2 diffusionreaches less irrigated tissues.
Hyperoxia produces a broad chain of PHYSIOLOGICAL BENEFITS in the body.
HYPERBARIC TREATMENT: The patient breathes high doses of O2 in a hyperbaric environment.
SYSTEMIC PERFORMANCE IN PATHOLOGIES.
top related