Liver transplant news

BYBYOmer Mohammed Saleh Omer Mohammed Saleh

Assistant lecturer of Tropical Medicine and Gastroenterology Assistant lecturer of Tropical Medicine and Gastroenterology

Hadramout University College of Medicine, Hadramout University College of Medicine, Yemen Yemen

LIVER TRANSPLANT NEWS

Hepatocyte-derived MicroRNAs as SerumBiomarkers of Hepatic Injury and Rejection

after Liver Transplantation

liver injury is associated with the release of HDmiRs into the circulation which now considered as a promising, early, stable, and sensitive biomarkers of rejection after liver transplantation.

Farid W, et al, Liver Transpl, 2012.

Diagnosing Cirrhosis from Recurrent Hepatitis C Accurately With Ultrasound Technology

Ultrasound-based transient elastography provides excellent diagnostic accuracy (98 % sensitivity and 83 % specificity) in recurrent HCV related cirrhosis in post-LTx.

Adebbajo C, et al, Liver Transpl , 2012.

A 7-Gene Signature of the Recipient Predicts theProgression of Fibrosis After Liver

Transplantationfor Hepatitis C Virus Infection

The genetic signature of the recipient predicts the likelihood of severe liver fibrosis in the graft after HCV recurrence.

Nicole T, et al, Liver Transpl, 2012.

A Novel Model for Evaluating the Risk of A Novel Model for Evaluating the Risk of Hepatitis B Recurrence After Liver Hepatitis B Recurrence After Liver

TransplantationTransplantation

Pre-transplant HBV DNA, presence of HCC, AVT status and post-transplant viral mutation are the major risk factors associated with HBV recurrence after LTx.

Xiao Xu, et al, Liver International, 2012.

Effect of Maintenance Therapy With Low –dose Effect of Maintenance Therapy With Low –dose Peginterferon for Recurrent Hepatitis C After Peginterferon for Recurrent Hepatitis C After

Living Donor Liver TransplantationLiving Donor Liver Transplantation

Continuing long-term maintenance therapy with peg-interferon prevented histological progression of hepatitis C in patients who had undergone LDLT.

Ueda Y, et al, J viral Hepat. 2012.

Prevention of Hepatitis B Recurrence in Liver Prevention of Hepatitis B Recurrence in Liver Transplant Patients Using oral antivrial therapy Transplant Patients Using oral antivrial therapy without long term hepatitis B immunoglobulinwithout long term hepatitis B immunoglobulin

Nucleos(t)ide analogue therapy with short term or no HBIG was efficacious and safe in preventing post-LT HBV.

Ahn J and Martin S, Hepat Mon. 2011.

Hepatitis B Virus Infection Has no Significant role on

Lymphoproliferative Disorders Post Liver Transplantation

HBV infection has no significant impact on inducing PTLD and represents no survival effect in PTLD setting.

Izadi M and Taheri S, Annals of Hepatology, 2011.

العماره --- فن بحضرموت شبام العماره --- مدينة فن بحضرموت شبام مدينةالطينيةالطينية

Sorafenib for Hepatocellular Carcinoma Patients Beyond Milan Criteria after

Orthotopic Liver Transplantation: A Case Control Study

Adjuvant sorafenib could possibly extend both disease-free and overall survival for HCC patients beyond Milan criteria after OLT.

Chieh-Lin Teng, et al, World J Surg oncol 2012.

Living Donor Liver Transplantation VersusDeceased Donor Liver Transplantation for

Hepatocellular Carcinoma: ComparableSurvival and Recurrence

in well-matched cohorts of LDLT and DDLTrecipients, LDLT and DDLT provide similarly low

recurrence rates and high survival rates for the treatment of HCC.

Sandhu L, et al, Liver Transpl, 2012.

Prognostic Factors for Late Mortality after Liver Transplantation for Benign End-stage Liver

Disease

The major causes of late mortality were infection, biliary complications and Hepatitis B virus recurrence/reinfection.

Five variables (Age, ABO blood group, cold ischemia time, infection, and biliary complications) had significant impacts on patient survival.

ZHANG Ying-cai, Chinese Medical Journal 2011.

Safety and Efficacy of ERCPin Patients with Post-Liver Transplant Biliary

Complications: Results of aCohort Study with Long-Term Follow-Up

ERCP is safe and effective for the treatment of post-OLT biliary complications, has a low rate of pancreatitis and results in a durable effect.

Sanna C, et al, Gut and Liver, 2011.

Liver Transplantation for Autoimmune Hepatitis Liver Transplantation for Autoimmune Hepatitis in Peru: Outcomes and Recurrencein Peru: Outcomes and Recurrence

Rejection and recurrence were commonly associated with AIH, but did not affect patient survival .

Rapid progression to cirrhosis should be considered in severe recurrences.

Padilla M, et al, Annals of hepatology, 2012.

ومباني --- شاهقة جبال الوادي ومباني --- حضرموت شاهقة جبال الوادي حضرموتنظيفة . وبيئة اثريه نظيفة .طينية وبيئة اثريه طينية

Pregnancy Outcomes in Liver Transplant Pregnancy Outcomes in Liver Transplant Recipients: A Systematic Review and Meta-Recipients: A Systematic Review and Meta-

analysisanalysis

Post-LTx miscarriage rate (15.6%) , Pre-eclampsia (21.9%), Cesarean section (44.6%), and preterm delivery (39.4%).

Deshpande NA, et al, Liver Transpl, 2012.

Quality of Life and Psychological Outcome of Donors after Living Donor Liver Transplantation

No major impact on HRQOL and psychological outcomes in living liver transplant donors after donation.

Guang S, et al, World j Gastroenterol, 2012.

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