Lisa Grohskopf, MD, MPH Medical Officer Influenza Division Centers for Disease Control and Prevention U.S. Influenza Surveillance National Center for Immunization.
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Lisa Grohskopf, MD, MPHMedical Officer
Influenza DivisionCenters for Disease Control and Prevention
U.S. Influenza Surveillance
National Center for Immunization & Respiratory Diseases
Influenza Division
VRBPAC MeetingFebruary 25, 2011
Characteristics of Recent Influenza Viruses Tested at CDC
Of 644 U.S. viruses antigenically characterized at CDC since October 1, 2010:
85 (13%) Influenza A (H1N1) 85 (100%) A/California/7/2009-like
348 (54%) Influenza A (H3N2) 345 (99%) A/Perth/16/2009-like
211 (33%) Influenza B 199 (94%) Victoria lineage; 198 (99%) B/Brisbane/60/2008-like 12 (6%) Yamagata lineage
High level resistance to adamantanes persists among Influenza A isolates; A(H1N1), A(H3N2) and B virus isolates tested remain susceptible to neuraminidase inhibitors
Percentage of Visits for Influenza-like Illness (ILI) Reported by
the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet), Weekly National Summary,
September 30, 2007 – February 12, 2011
Influenza Positive Tests Reported to CDC by U.S. WHO/NREVSS Collaborating Laboratories, National Summary, 2010-11
Per
cent
Pos
itive
Num
ber
of P
ositi
ve S
peci
men
s
Epidemic Threshold
Seasonal Baseline
Pneumonia and Influenza Mortalityfor 122 U.S. CitiesWeek Ending 02/12/2011
2007 20082006 2009 2010 2011
0
5
10
15
20
25
30
35
402
00
7-4
0
20
07
-46
20
07
-52
20
08
-06
20
08
-12
20
08
-18
20
08
-24
20
08
-30
20
08
-36
20
08
-42
20
08
-48
20
09
-01
20
09
-07
20
09
-13
20
09
-19
20
09
-25
20
09
-31
20
09
-37
20
09
-43
20
09
-49
20
10
-03
20
10
-09
20
10
-15
20
10
-21
20
10
-27
20
10
-33
20
10
-39
20
10
-45
20
10
-51
20
11-0
5
Nu
mb
er
of
de
ath
s
Week of Death
2007-08
Number of Deaths Reported = 88
2008-09
Number of Deaths Reported = 133
2009-10
Number of Deaths Reported = 282
Deaths Reported Current WeekDeaths Reported Previous Week
2010-11
Number of Deaths Reported = 35
Number of Influenza-Associated Pediatric Deaths by Week of Death: 2007-08 season to present
Key Points
Influenza A(H3N2), A(H1N1), and B strains continue to co-circulate in the U.S.
Recently characterized strains appear to be well-matched to the recommended 2010-2011 seasonal vaccine
Recently circulating viruses remain susceptible to neuraminidase inhibitors
In the U.S., influenza activity remains high in recent weeks
Increase in proportion of influenza A viruses identified as A(H1N1) since the beginning of the U.S. season
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