Lect19-376F09(DevNeuro1) - University of San Diegohome.sandiego.edu/~cloer/bio376f09/376f09_lectures/Lect... · 2009. 10. 23. · MNs Dorsalin mRNA Nkx6.1 mRNA Pax6 over-lap: MNs

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Like the entomologist in search of brightly colored butterflies, my attention hunted, in the garden of gray matter, cells with delicate and elegant forms, the mysterious butterflies of the soul.

Santiago Ramón y Cajal (1937)

Purkinje cell of the cerebellum

Dorsal-Ventral Pattern in the Vertebrate Spinal Cord

Figure 12.13 Cascade of Inductions Initiated by Notochord in Ventral Neural Tube

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Figure 12.12(1) Dorsal-Ventral Specification of the Neural Tube

Figure 12.12(2) Dorsal-Ventral Specification of the Neural Tube

Figure 12.12

Shh

Pax7 mRNA

MNs

Dorsalin mRNA

Nkx6.1 mRNA

Pax6

over-lap:MNs

D

V

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Figure 12.12 (E)

Shh (and BMPʼs)gradient determinesTF expression, specifying cell types

D

V

Figure 12.13(2) Cascade of Inductions Initiated by Notochord in Ventral Neural Tube