Joe Pekny, Professor Chemical Engineering Director, e-Enterprise Center Discovery Park Marietta Harrison, Professor Medicinal Chemistry & Molecular Pharmacology.

Joe Pekny, Professor Chemical Engineering Director, e-Enterprise Center Discovery Park

Marietta Harrison, Professor Medicinal Chemistry & Molecular Pharmacology Director Oncological Sciences Center Discovery Park

Cancer Care Engineering

An Interdisciplinary

A Multidisciplinary

A Transdisciplinary

MEGA ProjectThe Grand Societal Challenge of…..

CANCER

Discovery Park Addresses GRAND CHALLENGES

Cancer Care EngineeringCollaboration between…

Collaboration between…

Discovery Park is home to Large Scale Interdisciplinary Projects

Cancer Care Engineering Goal: To dramatically increase the success of cancer treatment and the effectiveness of cancer care using Indiana as a model for the nation

How: Create an engineering “Systems Analysis” model for cancer detection, treatment and care delivery

CCE Strategy

Indiana Cancer Care

UnderstandGoal Oriented Improvement

Model, Analyze, Communicate

System Awareness

Decision Support Tools

CCE Hub

Animal Models

The Integrated Pillars

Mathematical Models

Patient OMIC Analysis

Health Services Research

Cancer as a Managed Disease

Cancer Care System Projects

The Integrated Hierarchy

Cancer Care Best Practice Projects

Physician Tools Projects

OMICS Projects

Modeling the Indiana Cancer Care System: A What-If Tool for the Big Picture

Regulatory Agents

Organizational & Regulatory Agents

Patient Agents

CRC Care System

Indiana Cancer Care SystemIndiana Cancer Care Model

What If Questions

validate

data

What is the impact of screening rate improvement?

Caregiver Agents

What is the best strategy for using OMICS advances?

What is the best strategy for colonoscopy

screening?

How can all patients with colonoscopy orders to follow-up get them? What resources

are required?

Patient Blood

• Genomic Analysis

• Lipidomic

• Metabolomic

• Glycoproteomic

Colon Cancer Predictive Molecular Signatures

Cancer Care Engineering Model: integrated “omics” analysis

No Disease Cancer

BLOOD

Genomics

Proteomics

Metabolomics

Predictive Molecular SignatureLipidomics

• CCE Integrates Faculty, Schools, and Organizations To Accelerate Effective Solutions to Treating Cancer and, Ultimately Preventing Cancer

• Targeted Research – Aim Research at Barriers to Success

• Vanguard Project for Personalized Medicine

• Cancer Care Engineering Would Not Exist Without Discovery Park