Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes Coordinator: Prof. Martin Hrabé de Angelis Project Office:
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InfrafrontierThe European infrastructure for phenotypingand archiving of model mammalian genomes
Coordinator: Prof. Martin Hrabé de AngelisProject Office: Dr. Michael Raess, Dr. Ana de CastroHelmholtz Zentrum München
www.infrafrontier.eu
European Strategy Forum on Research Infrastructures
www.infrafrontier.eu
ESFRI roadmap
• BBMRI – biobanking• EATRIS – translational research• ECRIN – clinical trials• ELIXIR – bioinformatics
• Infrafrontier – animal disease models
• INSTRUCT – structural biology
• EU-OPENSCREEN – chemical biology• BLS4 – high security labs• Euro-BioImaging - bioimaging• EMBRC – marine biology
First roadmapin 2006
First roadmapin 2006
First roadmapin 2006
35projects
Update inDec2008Update inDec2008Update inDec2008
+ 10projects
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Grand Challenges
- Understand genetic and environmental impact on human health
- Develop novel strategies for diagnosis, prevention and therapies
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Current Biology
Why mouse?
• Mouse genome fully sequenced
• 95% similarity of the genes of mice and men
• Easy to breed and handle in captivity
• Extensive toolbox for manipulating the mouse genome
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Why mouse?
Mouse models achieve high impact
Publications on ‘Mouse Models’
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Shortage on capacities and access:
Phenotyping (characterising mouse models)• Mouse ClinicsEUMODIC, Infrafrontier
Archiving and Dissemination of mice and data • RepositoriesEMMA, Infrafrontier
The challenge
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Required capacities
European Phenotyping Capacities
'00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13
Mouse Lines / year
0
250
500
750
1000
1250
1500
1750
•Archiving and distribution
•Phenotyping
EMMA Submissions (total)
'02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13
Mouse Lines
0
1000
2000
3000
4000
5000
6000
7000
1500 p.a.
420 p.a.
EMMA Requests (total)
'02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13
Mouse Lines
0
1000
2000
3000
4000
5000
6000
7000
1500 p.a.
350 p.a.
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Access to phenotyping data and mouse models
Infrafrontier
Phenomefrontier Archivefrontier
+ emerging centres + emerging centres
Infrafrontier: two main parts
SystemicPhenotyping
Archivefrontier/EMMAArchiving /Distribution
Access to phenotyping services, data and mouse models
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Capacity building required!
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Osteogenesis imperfectaA group of genetic bone disorders ...
Noted People with OI• Jazz pianist Michel Petrucciani• Actor writer and ethicist Peter Radke...
In the mouse model:
Bisphosphonate treatment
… reverses bone phenotype
… but does not lower mortality
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The German Mouse Clinic
www.mouseclinic.deNature Methods 2005, Nature Genetics 2005, Nature Genetics 2008, Cell 2009
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- Mutation in collagen I
Bone phenotype• Mineralisation defect• Bone deformity• fractures • Beaded ribs• Reduced Bone mineral content &
decreased bone mineral density
Systemic• Lung phenotype • Heart phenotype• Reduced fat mass & increased lean
mass• Metabolic alterations
Mouse model for Osteogenesis imperfecta
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12 European Countries + Canada
Research Institutions + Funding Agencies
Infrafrontier partners
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Infrafrontier partners
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InfrastructureLarge Project
Smaller Project
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Very large Project:
International Mouse Phenotyping Consortium (IMPC)
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Infrafrontier and IMPCKeep in mind:•Infrafrontier is a BMS research infrastructure, NOT a single project•Infrafrontier has a different and broader portfolio than IMPC (infrastructure for bottom-up and top-down projects)•State of the art research infrastructures are highly dynamic entities
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Official start: 01 March 200836 months until: 28 February 2011
4.5 Mio € funding by the European Commission
Infrafrontier preparatory phase
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Infrafrontier implementation
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Infrafrontier implementation
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Access to mouse resources and data
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Operation Costs
Cohort Breeding23,000 – 30,000 € per line
Cohort Breeding23,000 – 30,000 € per line
Phenotyping15,000 – 20,000 € per line
Phenotyping15,000 – 20,000 € per line
Mouse Archiving3,500 – 4,400 € per line
Mouse Archiving3,500 – 4,400 € per line
Mouse Distribution1,100 – 2,100 € per line
Mouse Distribution1,100 – 2,100 € per line
ES Cell Distribution? € per line
ES Cell Distribution? € per line
User Fees1,100 – 1,700 €
User Fees1,100 – 1,700 €
User Fees500 –700 €
User Fees500 –700 €
User Feesto be developed
User Feesto be developed
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New mouse clinics and EMMA nodes
Established facilities
New facilities
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Physical Infrastructure
Personnel
Operation
Technology Development
Integration of national & European funds
Nationalinfrastructure
funds
Nat
ion
al a
nd
Eu
rop
ean
Pro
ject
s
Funding Strategy
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MS
MS
MS
MS
MS
EuropeanCommission
CentralCoordinationMS
MS = Member State
Decentralised funding model
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Governance Infrafrontier ERIC (Boards)
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Governance Infrafrontier ERIC (Tasks)
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More Information ….
www.infraf
rontier.eu
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Resource Sharing Policy
The Rome Agenda:•“Funding organizations should … cover the costs of deposition of materials arising from projects as part of the project budget.”•“Funding agencies should … ensure appropriate data-sharing plans at the outset of projects …”
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More Information ….
Coordinator:Prof. Dr. Martin Hrabé de Angelishrabe@helmholtz-muenchen.de
Project Office:Dr. Michael RaessDr. Ana de Castroinfrafrontier@helmholtz-muenchen.de
Helmholtz Zentrum MünchenInstitute of Experimental GeneticsIngolstädter Landstrasse 185764 Neuherberg
InfrafrontierThe European infrastructure for phenotypingand archiving of model mammalian genomes
Coordinator: Prof. Martin Hrabé de AngelisProject Office: Dr. Michael Raess, Dr. Ana de CastroHelmholtz Zentrum München
www.infrafrontier.eu
Scope of Activities
www.infrafrontier.eu
Constructing Required Capacities
Mouse Clinics
Initial Investment (100 mouse lines):~ 15,000,000 € for Construction
~ 5,000,000 € for Equipment
Adding capacities for 100 lines~ 6,500,000 €
Mouse Clinics
Initial Investment (100 mouse lines):~ 15,000,000 € for Construction
~ 5,000,000 € for Equipment
Adding capacities for 100 lines~ 6,500,000 €
EMMA Repository
Initial Investment (100 mouse lines):~ 6,600,000 € for Construction~ 2,000,000 € for Equipment
Adding capacities for 100 lines~ 1,300,000 €
EMMA Repository
Initial Investment (100 mouse lines):~ 6,600,000 € for Construction~ 2,000,000 € for Equipment
Adding capacities for 100 lines~ 1,300,000 €
www.infrafrontier.eu
Maintaining Capacities
Mouse Clinics
Maintaining and Updating Equipment~ 20% of Purchasing Price per year
Mouse Clinics
Maintaining and Updating Equipment~ 20% of Purchasing Price per year
EMMA Repository
Cryo-Archive (100 mouse lines):~ 10,000 € per year
Maintaining and Updating Equipment~ 10% of Purchasing Price per year
EMMA Repository
Cryo-Archive (100 mouse lines):~ 10,000 € per year
Maintaining and Updating Equipment~ 10% of Purchasing Price per year
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Infrafrontier project – key objectives
• Preparation to meet increasing demands for phenotyping and archiving – capacity building
• Developing a business plan based on a sustainable funding concept
• Identification of the most suitable legal form
• Providing a strategic plan for the construction phase
• Reaching a legal agreement between all partners
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Implementation
Preparatory Phase
Key deliverables
• WP2 – Strategy and Governance• WP3 – Legal Work• WP4 – Financial Work & Funding
2008 2009 2010 2011
WP2
WP3 Legal Work
MoU
Strategic PlanDraft Strategic Plan
WP4 FinanceBusiness Plan
Legal status
Update
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