IMMUNOLOGY Doc. dr Dušan Popadić Doc. dr Miloš Marković Ass. dr Emina Savić Prof. dr Vera Pravica imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija.
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IMMUNOLOGY
Doc. dr Dušan PopadićDoc. dr Miloš Marković
Ass. dr Emina SavićProf. dr Vera Pravica
imunologija@med.bg.ac.rs
Tel. 3643-236Facebook: Antitelija Limfocitic
Welcome to Immunology Course
Advice
• for successful learning• and passing the exam
Immunology Course (40 hours)
Lectures(12 hrs)
Practice(Seminars and Labs 28 hrs)
Seminars and Labs during first 14 weeks
Lectures during first 12 weeks
Seminars, Labs and Lectures are integral parts of the course
Student are allowed to be absent on seminar or lab twiceduring the semester
In addition to these 40 hrs to prepare the exam you will need
60 hours of effective work
Preparation for lectures and practice (15 hrs)
Preparation of colloquium and final exam (45 hrs)
Lectures(12 hrs)
Practise (seminars and labs 28 hrs)
References
Basic Immunology: Functions and Disorders of the Immune System- Authors: Abbas AK, Lichtman AH.- Publisher: Elsevier- 3rd edition updated, 2011
.ppt presentations and authorised supplementary material (available on web site)
activities on the course (seminars, labs and lectures) – through activity points
Continuous assessment
colloquium – partial, after every 4 weeks (5th, 9th and 13th week)
presence on lectures noted separately
Threshold for a pass is 31 points, max 60 points
Test (multiple choice – 1 correct answer out of 4)
- first: in the 5th week- second: in the 9th week- third: in the 13th week
Colloquium
15 minutes per mini test
It consists of 30 questions in total (divided into 3 mini tests)
1 point for each answer, max 30 points
Final exam
Final test with combined multiple choice and short answer questions
Colloquium score(30%)
Final exam mark (60%)
Activity on seminars and labs (7%)Regularity
of course attendance (3%)
Final mark in Immunology
Final mark in Immunology (25%)February session→
Final mark in Microbiology (75%)June session→
Final mark in Microbiology and Immunology
Pass in Immunology is a condition for starting the exam in Microbiology
Introduction to immune system
• Innate and adaptive immunity• Types of adaptive immunity• Properties and phases of adaptive
immune response• Central and peripheral lymphoid organs• Lymphocyte recirculation
IMMUNITY
INNATE
(Natural)
(Native)
ADAPTIVE
(Aquired)
Principle mechanisms of innate and adaptive immunity
Principle mechanisms of innate and adaptive immunity
The most important cells of the immune system
Chain of events in infection
Pathogen(s) enter(s) tissue
Pathogen(s) enter(s) tissue
Pathogen(s) enter(s) tissue
Macrophages recognize (and eliminate) pathogens
Macrophages recognize (and eliminate) pathogens
Macrophages recognize (and eliminate) pathogens
Inflammation is induced and PMNs attracted
Inflammation is induced and PMNs attracted
Antigen-presenting cells (APCs) capture antigen(s)
Antigen-presenting cells (APCs) capture antigen(s)
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
T cells are activated by APCs
T cells are activated by APCs
T cells are activated by APCs
B cell are activated (helped by T cells)
B cell are activated (helped by T cells)
B cell are activated (helped by T cells)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated T cells and Abs leave lymph node...
... enter blood stream and...
... enter blood stream and...
... migrate to site of infection
... migrate to site of infection
... migrate to site of infection
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
http://instruction.cvhs.okstate.edu/vmed5253/immunobiology.swf
Pathogen is eliminated
Principle mechanisms of innate and adaptive immunity
Mechanisms of adaptive immunity
- acquired throughout a lifetime of an individual
- result of previous contact with pathogen
- present in vertebrates
Properties of adaptive immunity
- diversity and specificity
- memory
- clonal expansion
- autotolerance
- specialization
- stimulation of mechanisms of innate immunity
Types of adaptive immunity
Phases of adaptive immune response
Types of lymphocytes
Lymphoid organs
Lymph node structure
Lymph node structure
Recirculation of T lymphocytes
The morphology of the spleen
Introduction to immune system
• Innate and adaptive immunity• Types of adaptive immunity• Properties and phases of adaptive
immune response• Central and peripheral lymphoid organs• Lymphocyte recirculation
lymph nodes, spleen and MALTj.Primary adaptive immune response begins in
10.
peripheral lymphoid organsi.Human peripheral (secondary) lymphoid organs are
9.
epithelial barriersh.Human central (primary) lymphoid organs are
8.
early defence against infectious agents
g.Important properties of adaptive immune cells are
7.
bone marrow and thymusf.Types of adaptive immunity are6.
diversity, specificity and memorye.Cells of adaptive immunity are5.
natural or native immunityd.Cells of innate immunity are4.
B and T lymphocytes c.First line of defence of innate immunity is provided by
3.
humoral and cellular immunityb.Mechanisms of innate immunity mediate
2.
phagocytes and NK cellsa.Innate immunity is also called1.
1._____ 2._____ 3._____ 4._____ 5._____ 6._____ 7._____ 8._____ 9._____ 10.____d. g. h. a. c. b. e. f. j. i.
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