Final Propject Part 1 Presentation..................

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Effect of Hardness on Disintegration Time –A Study on Marketed Antacid Tablets

A Dissertation Submitted to the Department of Pharmacy State University of Bangladesh in partial

fulfillment of the requirement for the degree of Bachelor of Pharmacy (Hons.)

ID # UG 08-14(B)-09-097   

Pharmacy Research LaboratoryDepartment of Pharmacy

State University of Bangladesh

Introduction

Purpose of the Project workMeasuring tablet hardness (breaking force) plays a vital role in defining dosage form with optimum physical characteristics and testing whether produced dosage form meets the defined specifications in manufacturing. Testing tablet hardness is more than ensuring the mechanical integrity of produced tablets during subsequent processes. Because the hardness of a tablet directly relates to all other physical parameters, it is a fast and efficient test that indicates whether specifications such as disintegration time and friability will be met.

Hardness Test of Chewable Tablets

Features of Hardness

Importance of hardness test

Measurement of Hardness

Factors Affecting Strength (hardness) of Chewable Tablet

Hardness Variation

Chewable Tablet Disintegration

Disintegration Apparatus

Determination of DisintegrationTime of Tablet

Stopwatch

Serial no Hardness (kg/cm2) Disintegration Time(Min)Individual Average

1. 17.2

16.71 35 min 2.5 sec.

2. 16.2

3. 17.2

4. 16.1

5. 16.4

6. 17.0

7. 17.2

8. 16.4

9 16.2

10. 17.2

Hardness and Disintegration Time test of Sample A01

Serial no Hardness (kg/cm2) Disintegration Time(Min)Individual Average

1. 14.2

13.05 25 min 26.5 sec.

2. 12.1

3. 14.0

4. 13.4

5. 11.0

6. 13.4

7. 13.0

8. 12.2

9 14.0

10. 13.2

Hardness and Disintegration Time test of Sample A02

Serial no Hardness (kg/cm2) Disintegration Time

(Min)Individual Average

1. 11.0

11.78 32 min 11 sec.

2. 13.0

3. 11.0

4. 12.4

5. 10.6

6. 11.0

7. 12.4

8. 13.0

9 11.2

10. 12.2

Hardness and Disintegration Time test of Sample A09

Sample Code Average Hardness (kg/cm2) Disintegration Time (Min)

A01 16.71 35 min 2.5 sec.A02 13.05 25 min 26.5 sec

A03 14.72 30 min 41.5 sec

A04 11.88 40 min 40.5 sec

A05 12.76 35 min 28 sec

A06 16.52 27 min 38 sec

A07 14.85 28 min 17 sec

A08 09.50 26 min 22.5 sec

A09 11.78 32 min 11 sec

A10 14.72 33 min 23 sec

Overall Hardness and Disintegration Time test of Collected 10 Antacid Samples

From the above table it was revealed that no such relation can establish between hardness and disintegration time. Sample A01 had 16.71 kg/cm2 hardness and DT was 35 min 2.5 sec. Again in sample A09 had 11.78 kg/cm2 hardness and DT was 32 min 11 sec. So no relation can be established between two parameters.

Conclusion

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