Transcript
Fish Oil Omega-3 Health Benefits
Neurologist
Ophthalmologist
Cardiologist
Dermatologist
Rheumatologist
Immunologist
Gastroenterologist
Hematologist
Perinatologist
Omega-3 EPA/DHA Happy Mothers
• Depressed mothers have lower O-3 levels.
• Increased O-3 in 3rd trimester: less PPD
• Theory of PPD: O-3 deficiency
• Baby drains mother.
• Psychoneuroendrocrinology
Lin, J Clin Psychiatry 2007, 68:1056
Omega-3 EPA/DHA During Pregnancy - Babies
• Improved cognitive abilities,
age 4 years
• Improved visual acuity
• Less allergies, eczema
• Slightly increased birth size
and weight
Helland, Pediatrics 2003;111
Pediatric Research 2005;57
Brain Most Affected by Nutrition
• Brain grows most during pregnancy and first year.
• Brain 60% Fat
• 20% DHA
• Omega-3 is to brain like calcium is to bone.
• Brain cell membrane fluidity
• Myelin development
• “Fathead”
DHA Dietary Deficiency Impairs Synapse Development
DHA 6.6 ± 0.7% 0.5 ± 0.1%
DPAn-6 0.4 ± 0.1% 4.7 ± 0.1%Hippocampal
Fatty Acids
Cao et al. J. Neurochem. 2009
Adequate Deficient
30 µm
Mother mice fed adequate or deficient diets, embryo neurons harvested day 18
Synapes in
Hippocampal
Neurons
Omega-3 EPA/DHA: The Membrane Molecule
• Omega-3 EPA/DHA –
a “cell conditioner”,
like hair conditioner
makes hair soft and
flexible.
• Optimal cell signaling
Epidemic of Ds: Seafood is School Food
• ADD, ADHD, OCD, BPD, ASD
• 78% of children 4-8 years old are omega-3 deficient
• Improved attention and learning with O-3 supplementation
• Dosage: 1000 mg of EPA/DHA/day
• D’s = deficiency of neurohormones: serotonin, dopamine
• ADHD children: lower blood levels of DHA
• Children with highest blood omega-3, better attention, learning
• Dyslexia improvement
• Less aggressive behavior
• Improvement with omega-3 more effective, safer than Rx
The Omega-3 Effect, Sears
How Omega-3s EPA/DHA Help School Children
Before supplements
Richardson, AP and P. Montgomery Pediatrics, 2005. 115(5): p. 1360-6.
Oxford-Durham Study
1 month after EPA 558mg/DHA174mg
Improved: Reading, Spelling, Writing
8-year-old Joe: “My head feels clear.”
Teens: What Science Says
• Lower risk of metabolic syndrome
• Lower BMI’s (seafood, not only
supplements), high satiety factor
• Less mood disorders
• PDAY study: 20% of 15-19 y/o have fatty
streaks in aorta
• Omega-3s lower BP in overweight teens
Daisy Study: Omega-3s Lessen Diabetic Risk
• Diabetes Autoimmunity Study in the Young
• 1700 children at risk for diabetes
• Highest RBC omega-3 level, least type I
diabetes
• CDC: 1:3 children destined to diabetes
How Much Omega-3 EPA/DHA?
• Pregnancy and lactation: 1000 mg/day EPA/DHA
• Infants and toddlers: 300 mg/day EPA/DHA
• Children and Teens: 500-1000 mg/day EPA/DHA
• Omega-3s from seafood better than from flax
• 6oz wild Salmon twice a week: 600 mg/day
• Neurological disorders: 2-5 grams
• Cardiovascular disease: 1-4 grams
• “itis” illnesses: 3-4 grams, 3 months
Dosage for Pregnant Mother: 1000 mg/day
• Average: only 150 mg/day
• Recommended: 500 mg EPA/DHA minimum
• Baby’s growing brain: 70-200 mg DHA/day
• Mother’s blood volume increases 40%: 100mg
• Extra maternal tissue growth and healing:
200mg
• No safety issues with 1000mg.
Supplements: EPA + DHA or DHA Only?
• Science supports both EPA and DHA
• Trust Nature:
– Breast milk contains both EPA and DHA,
approximately 1:2 depending on mother’s diet
– Salmon 1:1.4 EPA/DHA
• DHA and EPA complementary
• DHA for cell structure; EPA for cell maintenance
Measuring Omega-3s in Medical Practice
RBC Omega-3 Index vs
Daily Omega-3 Intake
0
200
400
600
800
1000
1200
0 2 4 6 8 10 12
RBC Omega-3 Index (%)
Daily O
meg
a-3
In
take .
(m
g/d
ay)
Don’t Be an i-Bod; Change Your Oil
• Inflammatory
balance
• More oils:
fish, flax, olive,
coconut
• Less oils:
hydrogenated,
saturated, meat
Science Says: Go Fish!
Inflammation-balancing effects of omega-3s
• Brain: Improves learning and behavior in kids,
mellows moods, prevents Alzheimer’s, improves
thinking, helps heal neurodegenerative diseases,
lessens stroke
• Eyes: Improves vision, moistens dry eyes, delays
age-related macular degeneration
• Ears: Delays age-related hearing loss
• Gums: Helps gingivitis
• Gut: Lessens colitis and irritable bowel syndrome
• Immune System: Lessens auto-immune disease
Science Says: Go Fish!
Inflammation-balancing effects of omega-3s
• Heart: Steadies irregular heartbeat, lessens clots in
vessels, balances high blood pressure, softens
atherosclerosis
• Lungs: Alleviates asthma, bronchitis
• Skin: Heals dermatitis
• Joints: Alleviates arthritis
• Penis: Enhances blood vessel health for erectile
function
The Healing Power of Omega-3s
Nutritional Armor for the Warfighter. 2009.
http://videocast.nih.gov/summary.asp?File=15352
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