D'Cosmix

Dr. Priti Vaidyanathan Sabinsa Europe GmbH

16 April 2015 In-Cosmetics 2015

What is D’Cosmix™?

D’Cosmix™ is the outcome of over 2 decades of unrivalled competence of the Sabinsa research team to pioneer and innovate, novel dermaceuticals from natural sources.

D’Cosmix™ is an intelligent fusion of science and performance. D’Cosmix™ caters to the broad palette of applications in the Cosmeceutical and Personal care range.

Why D’Cosmix™ ? Provides innovative solutions to create unique formulations. Helps unravel multiple facets with the “powerhouse” of

synergistic naturals. Brings balance to your search of novelty in formulations. Offers solutions to the boundless challenges that your

formulations face. Helps your products stand out in the fiercely competitive

market. Positively influences the ease of formulations. Uplifts the spirit of formulations…Naturally !

Skin firming Skin regeneration

Skin hydration Skin protection

Skin calming Skin nourishing Skin energizing

D’Cosmix™ – Application Focus.

Skin lightening Skin brightening Skin conditioning

Skin de-stress Hair growth

Hair fall control Hair conditioning

D’Cosmix™ Range

D’Cosmix Range Blend Broad range of application

1 AgeLess Complex DCx Skin firming, Skin regeneration

2 AcNil DCx Anti-acne, Skin protection, Skin calming

3 CosmeVit DCx Skin conditioning, Skin energizing, Skin lightening and Skin de-stress

4 DermaSoothe DCx Skin conditioning, Skin calming

5 DerMoist DCx Skin hydration, Skin nourishing

6 D’Heal DCx Skin protection, Skin calming

7 KeraCon DCx Hair growth, Hair fall control

8 MelaLite DCx Skin lightening, Skin brightening

AgeLess Complex DCx

1. AgeLess Complex DCx

AgeLess Complex DCx effective ingredients that offer pro-active protection against time and environmental aggression and synergistically help to repair, rejuvenate and condition the skin naturally!!

Ageless Complex DCx Ingredient Rationale

Barley Beta Glucans - Recognized for their role in maintaining collagen balance, it helps protect the integrity of the skin matrix

Niacinamide - Clinically validated to balance skin moisture and manage hyperpigmentation. It inhibits melanosome transfer to keratinocytes

N-Acetyl Glucosamine – Maintains the natural reserve of skin moisture

pTeroWhite® - Known for its melanogensis inhibition potential

Tocopheryl Acetate- Cell membrane protectant and potent antioxidant

Cosmoperine® - Patented and proven dermal penetration enhancer

Cosmoperine® U.S Patent No. 6,849,645. Japanese Patent No. JP4098985. Great Britain Patent No. GB2380675

Ageless Complex DCx In vitro study

Activity Result

Anti-collagenase activity 13.56% inhibition at 1000 µg/ml

Anti-elastase activity 11.5% inhibition at 1000 µg/ml

Efficient control of wrinkles Increase collagen formation Enhance elasticity of the skin Promote evenness of skin tone

AgeLess Complex DCx - Deliverables

Range Dosage Form Dose Anti aging Cream 1-3 %

Translucent Serum 1-3% Anti Wrinkle Cream 0.5-2% After Suncare Cream, Lotion 1-2%

AgeLess Complex DCx - Suggested Usage and Dosage

AcNil DCx

2. AcNil DCx

AcNil DCx provides an effective nutrient composite offering a multi-pronged approach to acne management by addressing different skin concerns such as P acne activity, inflammation, irritation and increase sebum secretion.

Some of the common causes of acne • Growth and multiplication of acne causing

bacterium Propionibacterium acnes. • Higher levels of the hormone

Dihydrotestosterone by the activity of the enzyme 5-alpha reductase.

• Increase in androgens during puberty and adolescence which in turn, triggers an enlargement of the sebaceous glands.

Causes of acne

AcNil DCx Ingredient Rationale

Monolaurin - A produce from Cocus nucifera with proven antiacne benefits

Olive oil – Contains natural squalene and affords skin soothing benefits

Aloe vera – Clinically validated to promote wound healing and soothing

Niacinamide - Clinically validated to manage depigmentation and acne breakouts. It inhibits melanosome transfer to keratinocytes

Zinc Monomethionine – Improves skin immunity

Policosanol – Clinically evaluated to reduce sebum production

Coleus Oil – Potent antimicrobial

Ginger SCFE 20%- Anti-inflammtory, Antimicrobial

Mandelic acid- Mild exfoliate and anti acne

Policosanol U.S Patent No. 7,217,546. Indian Patent No. IN229695.

AcNil DCx In vitro Antimicrobial activity

Inhibitory activity against P acnes bacteria – Minimal Inhibitory Concentration – 500 µg/ml

Reduce sebum production Inhibit P. acnes proliferation Minimize recurrence of acne break outs Reduce inflammation Diminish acne scars

AcNil DCx - Deliverables

Range Dosage Form Dose Anti-Acne Cream 2-5%

Gel (Spot applicator) 4-6% Creamy Face Wash 2-4% Face pack 2-3%

AcNil DCx - Suggested Usage and Dosage

CosmeVit DCx

3. CosmeVit DCx

CosmeVit DCx is a power house of skin nutrients that supports a healthy and glowing skin with a multifaceted approach to skin lightening, skin moisturizing and skin protection.

CosmeVit DCx is generally recommended for

use in combination with core actives intended for the specific application.

CosmeVit DCx - Ingredient Rationale

Retinol / Vitamin A - Effective as an antioxidant, skin-cell regulator and helps skin repair

Vitamin E acetate - Stable form of Vitamin E, acts as a cell membrane protectant

Niacinamide / Vitamin B3 – Clinically validated to manage hyper pigmentation and moisture balance. It inhibits melanosome transfer to keratinocytes

Vitamin F - Linoleic acid and Linolenic acids well recognized to promote skin vitality

Ascorbyl glucoside - Stabilized form of Vitamin C with antioxidant benefits

Nourishes skin with vital nutrients to make it bright and radiant Protects skin against harmful UV radiation

production Visibly lightens complexion Evens out skin tone

CosmeVit DCx - Deliverables

Range Dosage Form Dose Skin lightening Cream, Lotion, Translucent Serum 0.5-1% Depigmentation Cream 1-2% Anti-aging Cream, Translucent Serum 1-2% Anti-Wrinkle Cream 0.5-2% Anti-acne Cream, Face Wash 0.5-1% After Sun-care Creams and Lotions 0.5-1% Hair Care Creams 0.3-0.5%

CosmeVit DCx - Suggested Usage and Dosage

CosmeVit DCx used in commercial formulation – Johara® PhytoBright™ Skin Lightening Range

DermaSoothe DCx

4. DermaSoothe DCx

Dermasoothe DCx is a composite of potent ingredients to replenish the skin’s natural moisture reserves and placate the skin naturally.

DermaSoothe DCx - Ingredient Rationale

Allantoin – A proven moisturizing, healing, anti-irritating, soothing nutrient

N-Acetyl Glucosamine – Helps preserve the natural moisture reserves of the skin

CovaFresh IV - Water soluble Menthyl lactate to offer cooling effects

Chamomile extract – Proven anti-irritant phytonutrients

Olive oil – Skin soothing oil

Soothe and calm the skin Moisturizes to restore visibly healthier skin Helps calm minor skin itch / irritations

DermaSoothe DCx - Deliverables

Range Dosage Form Dose After Suncare Lotion, cream 1-3% Soothing - Calamine Lotion 1-3% Skin Care Shave and After shave cream or

Translucent Gel 2-3%

Hair Care Leave on Hair cream 2-3%

DermaSoothe DCx - Usage and Dosage

DermaSoothe DCx used in commercial formulation – Glenmark’s Elosmooth™

DerMoist DCx

5. DerMoist DCx

DerMoist DCx is a balanced composite of proven nutrients that help to gently calm sensitive skin while keeping it moist, nourished and healthy.

DerMoist DCx - Ingredient Rationale

Cococin™ CG - Supports skin hydration and rejuvenation

Dexapanthenol – Helps maintain hydration balance

Hyaluronic acid- Potent moisturizer and humectant for dry skin

Zinc Gluconate – Boosts skin immunity

Jojoba Oil - Affords a protective sheath to the skin

Cococin™ U.S Patent No. 7,300,682 & 8,247,003. European Patent No. EP1341547. New Zealand Patent No. NZ598630. and NZ600307. Eurasian Patent No. EA20368

DerMoist DCx – Human User Study

*After using DerMoist DCx 3% Moisturizing Cream for 4 weeks by 20 volunteers (6 men and 14 women), during a study conducted by an independent agency

Affords hydration of skin Moderate and modulate sebum production Improve skin immunity Support skin rejuvenation

DerMoist DCx - Deliverables

Range Dosage Form Dose Anti-acne Cream, Face Wash 5-15% Anti-aging Cream, Serum 5-10% Day Care Creams, Lotions 3-5% Skin conditioning Creams, Lotions 2-5%

DerMoist DCx - Usage and Dosage

D’Heal DCx

6. D’Heal DCx

D’Heal DCx is a scientifically validated composite of natural nutrients that provide a healing touch and soothe the skin while protecting it from microbial infections.

D’Heal DCx - Ingredient Rationale

Cococin™ CG - Supports skin hydration and promotes wound healing

Centellin® CG – Wound and scar management

Aloe vera – Clinically validated to promote wound healing and soothing

Allantoin – A proven moisturizing, healing, anti-irritating, soothing nutrient

Betaine Monohydrate - Helps strengthen skin barrier and maintain water-balance of the skin

1,2 Diols – Antimicrobial, hydration support

Chamomile extract – Proven anti-irritant phytonutrients

D’Heal DCx - In vitro study

Activity Result

MTT cell proliferation assay 24.15% cell proliferation at 50 µg/ml

SRB cell proliferation assay 21.50% cell proliferation at 50 µg/ml

Promotes cell renewal and restores skin vitality Helps reduce inflammation Stimulates collagen production Prevents microbial infection Provides antioxidant support Gently nourishes the skin

D’Heal DCx - Deliverables

Range Dosage Form Dose Cuts/Burns & Wounds Cream 3-5% Cleansers Face wash 2-4%

Hand wash 3-5% Skin conditioning Creams, Lotions 2-5%

D’Heal DCx - Usage and Dosage

KeraCon DCx

7. KeraCon DCx

KeraCon DCx is composed of ingredients which helps to strengthen hair, promote hair growth and keeps the hair healthy and soft.

KeraCon DCx - Ingredient Rationale

Barley Beta Glucans - Helps to improve the hair vitality and protect it from environmental stressors

Caffeine – A phosphodiesterase inhibitor, helps prevent hair loss and also promotes hair growth

Betaine Monohydrate - Increase the moisture content of the hair, protects the scalp and produces brighter hair gloss

Trehalose – Moisture retention property

Cococin™ CG - Helps promote hair growth while moisturizing the scalp

KeraCon DCx - In vitro study

Activity Result

MTT cell proliferation assay 22.35% cell proliferation at 50 µg/ml

SRB cell proliferation assay 26.00% cell proliferation at 50 µg/ml

Strengthens hair shaft Protects from hair shaft damage Protects hair from environmental stressors

KeraCon DCx - Deliverables

Range Dosage Form Dose Hair care Hair conditioner 5-8%

Shampoo 2-5% Conditioning Creams 1-2% Gels 1-2%

KeraCon DCx - Usage and Dosage

MelaLite DCx

8. MelaLite DCx

MelaLite DCx is a natural composite of melanin suppressors that helps to lighten the skin tone and eliminate pigmentation problems.

MelaLite DCx - Ingredient Rationale

pTeroWhite® - Potent melanogenesis inhibitor, UV protectant

Licorice Extract 40% CA – Potential tyrosinase and melanogenesis inhibitor

SabiWhite® - Clinically proven to be a safe and effective alternative to Hydroquinone for its skin lightening property

Tetrahydrocurcuminoids (SabiWhite®) U.S Patent No. 6,653,327. European Patent No. EP1171144 & EP1328263. New Zealand Patent No. NZ514884. Australian Patent No. AU2006235807

MelaLite DCx - In vitro study

Tyrosinase inhibition Melanogenesis inhibition

3.62 10.19 7

Skin lightening potential of MelaLite DCx vs Kojic acid

MelaLite DCx Kojic Acid

Lower the IC50 value, higher the activity

MelaLite DCx – Human User Study

*After using MelaLite DCx 1% Skin Lightening Cream for 4 weeks by 20 volunteers (10 men and 10 women), during a study conducted by an independent agency

Users also reported an improvement in skin clarity, skin tone and glow on using MelaLite DCx cream.

MelaLite DCx - Deliverables

Improves fairness to the skin Supports an even skin tone Nourishes skin to make it bright and radiant Protects skin against harmful UV radiation

MelaLite DCx - Usage and Dosage

Range Dosage Form Dose Skin lightening Cream,Lotion,Serum 3-5% Depigmentation Cream 5-8% Anti-aging Cream, Serum 1-3% Sun care Cream, Lotions 1-2% After suncare Cream, Lotion 3-5%

Application Focus D’Cosmix™ Skin firming AgeLess Complex DCx Skin regeneration AgeLess Complex DCx Skin conditioning CosmeVit DCx, DermaSoothe DCx Skin hydration DerMoist DCx Skin protection AcNil DCx, D’Heal DCx Skin calming DermaSoothe DCx, D’Heal DCx, AcNil DCx Skin nourishing DerMoist DCx

D’Cosmix™ – Application Areas.

Contd.,

Application Focus D’Cosmix™ Skin energizing CosmeVit DCx Skin lightening MelaLite DCx, CosmeVit DCx Skin brightening MelaLite DCx Skin de-stress CosmeVit DCx Hair growth KeraCon DCx Hair fall control KeraCon DCx

D’Cosmix™ – Application Areas.

D’Cosmix™ D’Cosmix is an intelligent integration of science and performance. D’Cosmix is suitable for use in a broad range of dosage forms that include creams, lotions, gels, serums, tonics and more.

D’Cosmix – The formulator’s choice

THANK YOU www.sabinsa.com participating members of:

D'Cosmix

skin energizing

cosmevit dcx skin conditioning

dheal dcx skin protection

melalite dcx skin lightening

dermoist dcx skin hydration

skin matrix niacinamide

keracon dcx hair growth

sabinsa research team

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