Cosmetics and Natural Products Research Center

Cosmetics and Natural Products Research Center

(CosNat)

สถานวจยเครองสาอางและผลตภณฑธรรมชาต

Assoc. Prof. Neti Waranuch, Ph.D. Faculty of Pharmaceutical Sciences

Naresuan University

Cosmetics and Natural Products Research Center

Founded in October 2003

Cosmetics and Natural Products Research Center

Cosmetics and Natural Products Research Center

Cosmetics and Natural Products Research Center

Cosmetics and Natural Products Research Center

Cosmetics and Natural Products Research Center

Researchers

• Assoc. Prof. Neti Waranuch, B.Sc.(Pharm), Ph.D. (Pharmaceutical scientist) • Assoc. Prof. Jarupa Viyoch, B.Sc.(Pharm), Ph.D. (Medico-Pharmaceutical scientist) • Assoc. Prof. Waree Tiyaboonchai, B.Sc.(Pharm), Ph.D.

(Pharmaceutical chemist) • Assoc. Prof. Tasana Pitaksuteepong, B.Sc.(Pharm), Ph.D.

(Pharmaceutical technologist) • Assoc. Prof. Kornanok Ingkaninun, B.Sc.(Pharm), Ph.D.

(Phytochemist) • Asst. Prof. Soravoot Rujivipat, B.Sc.(Pharm), Ph.D. (Pharmaceutical processing scientist)

Researchers

• Supaporn Lamlertthon, B.Sc.(Pharm), Ph.D. (Microbiologist) • Assoc. Prof. Sutatip Pongcharoen, M.D., Ph.D. (Immunologist) • Asst. Prof. Prateep Wornnissorn, M.D., Ph.D. (Dermatologist) • Panlop Chakkavittumrong, M.D. (Dermatologist) • Non Sowanna, M.D. (Family medicine doctor) • Asst. Prof. Katechan Jampachaisri, Ph.D. (Statistician)

Services

• Pharmacological Screening • Cosmetic Formulations Development • Chemical-analytical Research • Microbiology Test • Efficacy and Safety Tests • Consumer Preferences Test • Marketing Survey

Efficacy Tests

• Moisterization (Corneometer) • Transepidermal water loss (Tewameter) • Skin elasticity (Cutometer) • Skin roughness (Visiometer, Visioscan) • Skin oiliness (Sebumeter) • Skin pH measurement (Skin pH Meter) • Skin color (Maxameter)

Efficacy Tests

• Anti-perspirant (Gravimetric Test)

• Deodorant (Sniffing Test) • Home use test • etc.

Safety Tests

• Simple 48 hours patch test • Human repeated Insult patch test • Antecubital wash test • Repeated open application test • Stinging test

Involving Parties in Clinical Evaluation

Trial

Project manager Sponsor(s)

Principal investigator(s)

Site coordinator(s)

Institutional Review Board

FDA

Operator(s)

Subjects

Eight Steps in the Clinical Evaluation

Literature review

Study design

Ethic protocol submission

Volunteers selection

Placebo run-in

Panel study

Data analysis

Report

Wrinkle scales

1 2 3

4 5

16

Instruments

Cutometer for skin elasticity Tewameter for skin irritation

Instruments

Mexameter for skin darkness

Skin-pH meter, Sebumeter, Corneometer

Instruments

Rotameter for hair friction

Instron for hair tensile

Instruments

Instruments

Skin irritation test

Rodamine Red in Chitosan Microparticles

ระบบนาสง

Green Tea in Chitosan Microparticles

21.53

35.66

6.97

63.8

0

21.84

0.35 1.360

10

20

30

40

50

60

70

80

Green tea Solution Green tea loaded chitosanmicroparticle

% o

f app

lied

dose

EGC

EC

EGCG

ECG

Skin absorption

Anti-wrinkle testing

Before After

Turmeric extract in solid lipid nano-particles

Turmeric extract in solid lipid nano-particles

0

10

20

30

40

Before 1 mo ( sun) 1mo( sunprotect) 3 mo (sun) 3 mo (sun protect)

* b

Cream containing curcuminoids SLNs Curcuminoids cream

Color stability

Chemical stability Curcumin

0

20

40

60

80

100

1 mo (sun) 3mo (sun) 1 mo(sunprotect)

3 mo(sunprotect)

% c

urcu

min

cream containingcurcuminoids SLNscurcuminoids cream

Keep at room temperature

Bisdemethoxycurcumin

0

20

40

60

80

100

1 month (sun) 3 month (sun) 1 month (sunprotected)

3 month (sunprotected)

% b

isd

em

eth

oxycu

rcu

min

Demethoxycurcumin

0

20

40

60

80

100

1 month (sun) 3 month (sun) 1month (sunprotected)

3 month (sunprotected)

% d

emet

ho

xycu

rcu

min

Anti-wrinkle testing

Baseline 5 Weeks

Skin images evaluation

Baseline 8 Weeks

Skin product development

Anti-wrinkle testing

Baseline week 12

Anti-wrinkle testing

Baseline week 12

Hair product development

Baseline 4 Months

Hair growth evaluation

Hair growth evaluation

Baseline 4 Months

Under-arm product development

Baseline 11 Weeks

Hair growth suppression

Anti-cellulite product development

Anti-cellulite evaluation

Anti-cellulite evaluation

Our clients

Our clients

- บรษท ทโอลน คอสเมตค จากด

- Complexsion science - บรษท สกนเนกซ จากด

- บรษท ไบรทเซส กรป จากด - บรษท โยนโส จากด

- บรษท กรนบราเธอรส โปรดส จากด

Our clients