Page 3 Introduction
• The complement system is one of the major effector mechanisms of
humoral immunity
• Is an important effector mechanism of innate immunity.
• Jules Bordet 1919
• The complement system consists of serum and cell surface proteins
• Activation of complement involves the sequential proteolysis
• zymogens
Page 5 Complement nomenclature
•C3
C3a
ConvertaseC3b
Page 6 The classical pathway of complement activation
Page 8 The classical pathway of
complement activation
Page 9 The classical pathway
of complem
ent activatio
n
Page 10 The alternative pathway
Page 12 The alternative
pathway
• The alternative-
pathway C3 and C5
convertases are both
stabilized by
properdin (factor P)
Page 15 Lectin Pathway of
Complement
Activation
Ficolin
Page 17 MAC formation
late steps of complement activation and formation of the MAC
Page 19 Regulator of complement activation
Page 20 Regulator of complement activation
Page 21 Inhibition of the formation of C3 convertases
Page 22 Factor I-mediated cleavage of C3b
Regulator of complement activation
Page 23 Regulation of formation of the MAC
Page 28 Functions of complement
Page 30 Receptors for Fragments of C3
Page 31 Inflammatory effects of complement
Page 33 C3 deficiency
•Sever recurrent infection with encapsulated bacteria
•Begain shortly after birth
Page 34 MAC (C5-C9) deficiency
•Susceptible to N. meningitidis infection
Page 36 Complement deficiency
Page 38 C1q, C2 and C4 deficiency
•Associated with the development of SLE.
Page 40 PNH
Deficiency in
DAF or CD 59
Page 41 fetal loss in antiphospholipid syndrome.
Page 42 Examples of pathological conditions involving the complement system.
Page 44 Clinical effects of complement deficiency