Clinical Use of Blood and Blood Components Policy

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1

Clinical

Use of Blood and Blood Components Policy

Policy Manager Dr Catriona Connelly Eleanor Hazra

Policy Group Hospital Transfusion Committee

Policy Established

Policy Review PeriodExpiry October 2014

Last Updated

September 2013

UNCONTROLLED WHEN PRINTED

Item 613 Appendix

2

Version Control

Version Number

PurposeChange Author Date

10

Version Control was introduced in July 2011 and the previous versions of this policy prior to this date are available in the Electronic Document Store

Catriona Connelly Eleanor Hazra

August 2011

20 Changes made following review of principal policy areas bull Amendment to Appendix 2 NHS Tayside Maximum Blood 0rdering Schedule(MSBOS) bull Amendment to Appendix 3a Transfusion Reaction Flowchart

bull Removal of Six Step Guide

Dr Catriona Connolly Eleanor Hazra

September 2013

3

CONTENTS 1 PURPOSE AND SCOPE

2 STATEMENT OF POLICY 3 RESPONSIBILITIES 4 ORGANISATIONAL ARRANGEMENTS 5 PROCEDURAL GUIDANCE amp MANAGEMENT RISK 6 KEY CONTACTS amp LINKS TO LABORATORY USER HANDBOO KS 7 REFERENCES amp OTHER USEFUL LINKS 8 APPENDICES Appendix 1 NHS Tayside Adult Transfusion guideline

Appendix 2

Ninewells Hospital amp Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) Appendix 3a Flow-chart for management of a transfusion reaction

Appendix 3b Procedural document for management of a transfusion reaction

Appendix 4 UK Blood Safety and Quality Regulations (2005)

Appendix 5a Jehovah Witness Consent

Appendix 5b Decision to Transfuse

Appendix 6 Requesting Transfusion Support

Appendix 7 Authorisation ndash Prescription of Transfusion Support

Appendix 8 Taking the Blood Sample

Appendix 9 Collection and Delivery of Blood and Blood Components

Appendix 10 Administration of Red Cells Appendix 11

Administration of other Blood Components FFP Cryoprecipitate Platelets PCC and Anti-D

Appendix 12 Other Components available from ESBTC Transfusion Laboratory Ninewells

4

Appendix 13 Monitoring during a Transfusion of Blood or Blood Components

Appendix 14 Paediatric - Neonatal considerations

Appendix 15 SBAR posters for Emergency Obstetric and Neonatal Transfusion Support

Appendix 15a - Mother Appendix 15b ndash Baby Appendix 16 Transfusion Record Document v 04 9 RAPID IMPACT CHECKLIST

5

1 PURPOSE AND SCOPE

11 This policy has been developed in response to the identified need to raise awareness in the management of patients receiving blood components or blood products Blood transfusion by definition is the introduction of prepared compatible donor blood components or blood products into the circulation of a recipient patient

12 Since 2005 all blood components have been excluded from the UK Medicines Act (1968) and therefore supplied as unlicensed non-medicinal products The term ldquoauthorisationrdquo rather than ldquoprescriptionrdquo should be used

13 It is imperative that any member of staff involved in the transfusion process adheres to this policy in particular

bull Phlebotomy staff who have a critical duty to carry out required identity checks before taking blood

transfusion samples from the patient bull Nursing and Midwifery staff who have a critical duty to carry out required checks before taking

blood transfusion samples collection and delivery of blood components administering the component and observation of the patient during and after the transfusion

bull Portering staff who are involved the safe collection and transport of blood components

bull Medical staff and advanced neonatal nurse practitioners who have undergone appropriate training who assess the patient take blood transfusion samples authorise and order transfusion support

2 STATEMENT OF POLICY 21 The aim of the policy is to ensure the correct componentproduct is given at the correct time in

the appropriate way to the correct patient

22 Any member of staff involved in the transfusion process should be conversant with the sections of this document that pertain to their role and have access to appropriate education training and support in its implementation NHS Quality Improvement Scotland Blood Transfusion Standards (2006) recommend that only staff who have completed an appropriate education programme appropriate to their role can participate in the transfusion process

23 The administration of blood and blood components must only be carried out by suitably trained practitioners Only staff that have completed transfusion training can collect and deliver blood transfusion products and components

This policy should be read in conjunction with the following documents (Please click on the links below to access)

bull British Committee for Standards in Haematology(BCSH) Guideline on the Administration of Blood Components (2009)

httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf

bull National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusion aspx

bull NHS Tayside Establishing Patient Identity Policy

httpedstaysidescotnhsukNHSTaysideDocsgroupscorporatedocumentsdocumentsprod_162299pdf

bull NHS Tayside Informed Consent Policy

httpedstaysidescotnhsukNHSTaysideDocsgroupsworking_safelydocumentsdocumentsdocs_016304pdf

6

3 RESPONSIBILITIES

Indications for Blood Transfusion 31 An infusion of blood components may be given to bull Manage acute blood loss bull Replace a deficiency of specific blood components such as erythrocytes platelets or clotting factors bull Increase the oxygen carrying capacity of the blood The final decision to transfuse rests with the clinician in charge of the patientrsquos care 32 An NHS Tayside Adult Blood Transfusion Guideline (Appendix 1 ) provides guidance on when

blood transfusion is likely to beneficial 33 The Ninewells and PRI Maximum Surgical Blood Ordering Schedule (Appendix 2 ) provides

further guidance on the recommended amount of red cells to order for different surgical procedures

Both of these guidelines are available electronically and copies should be available in all clinical areas Additional copies are available from Transfusion Practitionersthe hospital transfusion laboratory 4 ORGANISATIONAL ARRANGEMENTS

41 Hospital Transfusion Laboratory Contact Information

bull East of Scotland Blood Transfusion Centre Hospital Transfusion Laboratory

Ninewells - Extension 32953 Remit covers all clinical areas medical centres and community hospitals in Dundee and Angus

bull Perth Royal Infirmary Hospital Transfusion Laborato ry

PRI- Extension 13338 or Pager 5122

Remit covers all clinical areas medical centres and community hospitals in Perth and Kinross

42 Blood supply in an emergency situation

Communication with the local Hospital Transfusion Laboratory (HTL) is key to allowing the department to provide the highest standard of care Under normal circumstances red cells are only issued from the Hospital Transfusion laboratory after full compatibility testing However in the presence of a life-threatening situation in which there is insufficient time to complete these tests clinician responsible for the care of the patient may decide that the situation warrants the use of un-cross matched blood

When this occurs it is preferable to give blood of the patients own ABO and Rh D group If the urgency of the situation makes this impossible Group O Rh D negative blood may be used Supplies of un-cross matched group specific or Group O Rh D Negative blood are obtainable from the local Hospital Transfusion Laboratory

In Ninewells Emergency Group O Rh D negative blood is held in

bull Main Theatre Blood Fridge ndash 2 units

7

bull Accident and Emergency Blood Fridge ndash 6 units

bull Transfusion Laboratory Fridges 4 units

In Perth Royal Infirmary Group O Rh D negative bloo d is held in bull Main Theatre Blood Fridge ndash 2 units bull Transfusion Laboratory- 2 units

It is imperative that when these supplies are accessed the Hospital Transfusion Laboratory is informed immediately so that arrangements can be made to replenish stocks

Supplies of Group O Rh D Negative blood for emergen cy use are also available in

bull Arbroath Infirmary Blood Fridge ndash 2 units bull Stracathro Hospital Blood Fridge ndash 4 units bull Fernbrae BMI Hospital Blood Fridge- 2 units

Stracathro Hospital has 4 units of O Rh D negative blood for emergency use for inpatients or theatre cases If the emergency blood is used on a patient in Stracathro then the Hospital Transfusion Laboratory in Ninewells must be informed immediately and elective surgery suspended until replacement emergency blood is in place at the hospital

It must be remembered that when using un-cross matched blood there is an increased risk of a severe haemolytic transfusion reaction as the patient may have antibodies that react with one of the other blood groups Appendix 3a and 3b contain further information about transfusion reactions and their management Appendix 4 is the UK Blood Safety and Quality Regulations guidance on reporting serious adverse events and reactions Massive Haemorrhage Protocol

NHS Tayside Guide to Massive Transfusion Blood Loss httpedstaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsprod_174661pdf

5 PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK

There are several key considerations when administering blood products or components

bull The patient receives an appropriate and safe transfusion of blood or blood products bull The patients risk of transfusion reactioncomplications is minimised bull Changes in the patients condition are detected at an early stage bull Adverse events are reported to the hospital transfusion laboratory in a timely manner 51 Decision to Transfuse The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual needs A checklist with additional information for doctors gaining consent from Jehovah Witnesses on blood products that they may accept can be found at appendix 5a

8

The decision process leading to transfusion should be documented in the patientrsquos clinical record

Links to guidance on transfusion issues issued by the British Committee for Standards in Haematology (BCSH) can be found in appendix 5b - Procedural document on decision to transfuse 52 Requesting Transfusion Support

The request for transfusion support for patients under the care of NHS Tayside should be in accordance with BCSH guidelines

The procedure for requesting transfusion support can be found in appendix 6 of this document and includes details on consent and documentation availability of patient information leaflets and additional information that is required by the transfusion laboratory before blood is prepared for transfusion

Appendix 6 also contains indications for Irradiated Blood

53 Written authorisation (formerly known as prescr iption) of Transfusion Support

Section130 of the 1968 Medicines Act has been amended by regulation 25 of the Blood Safety and Quality Regulations 2005 (SI 2005 no 50) Blood components are now excluded from the act and the term prescription does not apply as they are not medicinal products the term authorisation should be used

The authorisation must be signed by the responsible clinician or advanced neonatal nurse practitioner It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009) Blood and blood components must always be authorised prescribed prior to commencement of treatment The procedure is outlined in appendix 7

54 Taking the blood sample

The blood sample should be taken in accordance with BCSH guideline on administration of blood components (2009) which takes into account the Blood Safety and Quality Regulations (BSQR (2005) Statutory Instrument 200550 as amended) the National Patient Safety Agency (NPSA) Safer Practice Notices SHOT recommendations and the NHS Quality Improvement Scotland (QIS) 2006 Clinical Standards for Blood Transfusion

Both the East of Scotland Blood Transfusion Centre and Perth Royal Infirmary Blood Transfusion Laboratory have a zero-tolerance policy in place for incorrectly or inadequately labelled sample request forms and sample bottles The procedure for taking a blood sample is detailed in appendix 8

55 Collection and Delivery of Blood and Blood Comp onents Collection and delivery of blood and components must be in accordance with BCSH guideline on administration of blood components (2009)

All staff involved in the collection and delivery of blood components from the storage area to the clinical area should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) and BSQR (SI 2005 No50 as amended) standards The procedure for collecting and delivering blood components is described in appendix 9 56 Administration of Red Cells Blood components must be administered by a registered healthcare professional

9

As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

512 Management of Transfusion Reactions

In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

10

Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

6 KEY CONTACTS

Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

11

7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

12

httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

13

Appendix 1 Adult Blood Transfusion Guideline

ADULT BLOOD TRANSFUSION GUIDELINE

bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

Remember

bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

consider the cause

References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

Haemoglobin Less than 8 gdl

Haemoglobin 8 to 10 gdl

Haemoglobin Greater than 10gdl

Yes Possibly if No

14

Appendix 2

Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

Tariff for Elective Procedures

2013-09-26 NW amp PRI MSBOS V30

Procedure

Tariff

Procedure

Tariff

Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

excision GampS

AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

If surgery for malignancy and pre-op Hblt120 L gdL

If pre-op Hbgt 120L gdL

2

GampS

Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

2 Nephrectomy - OPEN 2

Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

Colposuspension) GampS

Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

GampS Pyeloplasty GampS

Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

GampS Total Proctocolectomy 2

Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

15

Appendix 3a Flowchart Management of a Transfusion Reaction

Symptoms Signs of Acute Transfusion Reaction

Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

Stop the transfusion and call a doctor

Measure temperature pulse blood pressure respiratory rate amp O2 saturation

Check identity of the recipient with the details on the unit and compatibility label or tag

Any discrepancy noted call the transfusion laboratory

Febrile non-haemolytic transfusion

reaction

If temperature rise less than

20˚C the observations are stable

and the patient is otherwise well

give paracetamol

Restart infusion at slower rate

and observe more frequently

Mild allergic reaction

Give Chlopheniramine 10mg

slowly iv and restart the

transfusion at a slower rate and

observe more frequently

Reaction

involves mild

fever or

urticarial

rash only

Mild fever

Urticaria

ABO incompatibility

Stop transfusion

Remove unit keeping IV giving set

attached and c lamped off for return

to Blood Transfusion Laboratory

Commence iv saline infusion through

a NEW IV administration set

Monitor blood pressure pulse urine

output (catheterise) frequently Seek

help from experts in management of

shock where appropriate

Treat any DIC with appropriate blood

components

Inform Hospital Transfusion

Laboratory immediately

Suspected ABO

incompatibility

No

Haemolytic reaction bacterial

infection of unit

Stop transfusion

Take down unit and giving set

Return intact to blood bank with all

other usedunused units

Take blood cultures repeat blood

group crossmatch FBC coagulation

screen biochemistry urinalysis

Monitor urine output

Commence broad spectrum

antibiotics if suspected bacterial

infection

Commence oxygen and fluid support

Seek haematological and intensive

Severe allergic reaction

Other haemolytic reaction bacterial

contamination

Severe allergic reaction

Bronchospasm angioedema

abdominal pain hypotension

Stop transfusion Call for help

Maintain airway give 100 O2

If severe hypotension lie patient flat

with legs elevated Give adrenaline

(05ml of 1 in 1000 intramuscular )

NEVER give undiluted epinephrine

intravascularly

Paediatric doses depend on the age of

the child Intramuscular 1 in 1000

epinephrine should be administered as

follows

12 years

05 milligrams (05 ml)

6-12 years

025 milligrams (025ml)

gt6 months to 6 years 012

milligrams( 012 ml)

lt6 months 005 milligrams

( 005ml)

Take down unit and giving set

Start infusion of crystalloid or colloid

through a new iv fluid administration

set

Secondary therapy

Chlopheniramine 10mg slow iv

Salbutamol nebuliser

Corticosteroids 100-500mg

Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

Fluid overload

Give oxygen

Diuretic iv

TRALI

Clinical features of acute LVF with

fever and chills

Discontinue transfusion

Give 100 Oxygen

Treat as ARDS ndash ventilate if hypoxia

indicates

Acute dyspnoea

hypotension

Monitor blood gases

Perform CXR

Measure CVP

Pulmonary capillary

pressure

Raised

CVP

Normal

CVP

No

Yes

Yes

Yes

No

No

16

Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

17

The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

The component unit and any remaining contents with the clamped off IV giving set attached

should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

Any empty used unit packs from this transfusion episode or unused units of blood issued for

the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

Completed Transfusion Reaction form should be returned to the hospital transfusion

laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

18

Appendix 4

20

21

22

23

24

25

Appendix 5a Jehovah Witness Consent

CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

WILLING TO HAVE IF REQUIRED

REFUSE UNDER ANY CIRCUMSTANCES

Blood Components Red cells Platelets

Fresh frozen plasma Cryoprecipitate

Cell Salvage

Cell saver- Standard set up

Cell saver- set up in continuity only

Blood Products Octaplas (Prothrombin complex

Concentrate)

Anti-D Immunoglobulin Albumin

Factor VIII concentrate Factor IX concentrate

Fibrinogen Concentrate Recombinant Products

Erythropoietin Factor VIIa

I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

26

expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

27

Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

(2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

28

Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

- It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

29

- Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

30

bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

31

Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

Practitioner

bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

32

Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

33

If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

34

bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

identity band bull Match all other identifying information

35

Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

is to take place

36

If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

37

Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

38

bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

Blood Safety and Quality Regulations (2005)

39

bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

40

Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

41

bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

42

Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

43

Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

44

Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

45

Appendix 15A

46

Appendix 15B

47

Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

Please use a new document for each transfusion event

PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

HospitalUnit Affix label here or write patient details Forename

Surname

Gender

Date of birth

CHI

WardDept

Consultant

Authorisation Prescription

bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

Consent for Transfusion

bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

after reading the PIL Yes No bull Does this patient guardian agree to have a blood

transfusion No Yes bull Is an advanced directive (refusal of transfusion)

document in place Yes No Please delete patientguardian as appropriate

Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

48

THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

Patient Name Date of birthCHI

UN

IT 1

Blood component

Unit Pool mls

Special Requirements Instructions (please tick)

Affix completed pink portion of compatibility label here

Irradiated CMV negative Blood warmer Other medication

Reason for transfusion

Date Duration Authoriser Prescriber signature

Reassess before you progress (Venflon site and observations)

UN

IT 2

Blood component

Unit Pool mls

Special Requirements Instructions (please tick)

Affix completed pink portion of compatibility label here

Irradiated CMV negative Blood warmer Other medication

Reason for transfusion

Date Duration Authoriser Prescriber signature

Reassess before you progress (Venflon site and observations)

UN

IT 3

Blood component

Unit Pool mls

Special Requirements Instructions (please tick)

Affix completed pink portion of compatibility label here

Irradiated CMV negative Blood warmer Other medication

Reason for transfusion

Date Duration Authoriser Prescriber signature

Reassess before you progress (Venflon site and observations)

UN

IT 4

Blood component

Unit Pool mls

Special Requirements Instructions (please tick)

Affix completed pink portion of compatibility label here

Irradiated CMV negative Blood warmer Other medication

Reason for transfusion

Date Duration Authoriser Prescriber signature

THB(MR) 020 V40 May 2013

THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

Patient Na me Date of birthCHI

Transfusion Checklist - Please initial each box as checks are completed

PRE-

COLLECTION

Checks below should be completed before collection of component from temperature

controlled storage is undertaken

PRE-

ADMINISTRATION

AT BEDSIDE

Only remove clear outer wrap

bag immediately prior to commencing transfusion and

only when all positive identification checks have been

completed

POST

TRANSFUSION

Unit No

1

helliphelliphelliphelliphelliphelliphelliphelliphellip

helliphelliphelliphelliphelliphelliphellip

2

helliphelliphelliphelliphelliphelliphelliphelliphellip

helliphelliphelliphelliphelliphelliphellip

3

helliphelliphelliphelliphelliphelliphelliphelliphellip

helliphelliphelliphelliphelliphellip

4

helliphelliphelliphelliphelliphelliphelliphelliphellip

helliphelliphelliphelliphelliphelliphellip

THB(MR) 020 V40 - May 2013

Identification band insitu amp details verified and correct

Patent IV access

(Patient safety bundle adhered to)

Blood authorised

prescribed

Check for special

requirements amp consent

Verbal identification

at the bedside

(if applicable)

Identification band details are verified

and correct amp match details

on Traceability ldquobagamp tagrdquo

label

DateTime Transfusion completed

Traceability Tag signed with starting time amp date of transfusion recorded

Inspect bag

(condition amp expiry

date)

DateTime blood removed from

cold temperature

storage

Baseline Observations recorded on SEWS chart

(Temperature Pulse

Oxygen sats Respiration rate

amp BP)

Completion of Observations

Noted on the SEWS chart

(Temperature Pulse

Oxygen Sats Respiration rate

50

Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

recorded and concerns escalated to the medical team according to the SEWS

Adverse Events

bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

Post Transfusion

bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

Resources

Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

THB(MR)020 v 40 May 2013

Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

51

9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

Why has this policy been developed

Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

Has a risk control plan been developed and who is the owner of the risk If not why not

Who has been involvedconsulted in the development of the policy

Has the policy been assessed for Equality and Diversity in relation to-

Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

Please indicate YesNo for the following YES

Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

Please indicate Ye sNo for the following YES

Does the policy contain evidence of the Equality amp

Diversity Impact Assessment Process

Is there an implementation plan

Which officers are responsible for implementation

When will the policy take effect

Who must comply with the policystrategy

How will they be informed of their responsibilities

Is any training required

If yes has any been arranged

Are there any cost implications

NO

If yes please detail costs and note source of funding

Who is responsible for auditing the implementation of the policy

What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

2

POLICY MANAGER________________________ DATE______ _____________________

  • Blood supply in an emergency situation
  • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
  • Administration of Platelets
    • Appendix 1 Adult Blood Transfusion Guideline
      • ADULT BLOOD TRANSFUSION GUIDELINE
        • Remember
          • References
            • Appendix 3a Flowchart Management of a Transfusion Reaction
              • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                • Consent for Transfusion
                • THB(MR) 020 V40 May 2013
                  • PRE- COLLECTION
                  • PRE-ADMINISTRATION

    2

    Version Control

    Version Number

    PurposeChange Author Date

    10

    Version Control was introduced in July 2011 and the previous versions of this policy prior to this date are available in the Electronic Document Store

    Catriona Connelly Eleanor Hazra

    August 2011

    20 Changes made following review of principal policy areas bull Amendment to Appendix 2 NHS Tayside Maximum Blood 0rdering Schedule(MSBOS) bull Amendment to Appendix 3a Transfusion Reaction Flowchart

    bull Removal of Six Step Guide

    Dr Catriona Connolly Eleanor Hazra

    September 2013

    3

    CONTENTS 1 PURPOSE AND SCOPE

    2 STATEMENT OF POLICY 3 RESPONSIBILITIES 4 ORGANISATIONAL ARRANGEMENTS 5 PROCEDURAL GUIDANCE amp MANAGEMENT RISK 6 KEY CONTACTS amp LINKS TO LABORATORY USER HANDBOO KS 7 REFERENCES amp OTHER USEFUL LINKS 8 APPENDICES Appendix 1 NHS Tayside Adult Transfusion guideline

    Appendix 2

    Ninewells Hospital amp Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) Appendix 3a Flow-chart for management of a transfusion reaction

    Appendix 3b Procedural document for management of a transfusion reaction

    Appendix 4 UK Blood Safety and Quality Regulations (2005)

    Appendix 5a Jehovah Witness Consent

    Appendix 5b Decision to Transfuse

    Appendix 6 Requesting Transfusion Support

    Appendix 7 Authorisation ndash Prescription of Transfusion Support

    Appendix 8 Taking the Blood Sample

    Appendix 9 Collection and Delivery of Blood and Blood Components

    Appendix 10 Administration of Red Cells Appendix 11

    Administration of other Blood Components FFP Cryoprecipitate Platelets PCC and Anti-D

    Appendix 12 Other Components available from ESBTC Transfusion Laboratory Ninewells

    4

    Appendix 13 Monitoring during a Transfusion of Blood or Blood Components

    Appendix 14 Paediatric - Neonatal considerations

    Appendix 15 SBAR posters for Emergency Obstetric and Neonatal Transfusion Support

    Appendix 15a - Mother Appendix 15b ndash Baby Appendix 16 Transfusion Record Document v 04 9 RAPID IMPACT CHECKLIST

    5

    1 PURPOSE AND SCOPE

    11 This policy has been developed in response to the identified need to raise awareness in the management of patients receiving blood components or blood products Blood transfusion by definition is the introduction of prepared compatible donor blood components or blood products into the circulation of a recipient patient

    12 Since 2005 all blood components have been excluded from the UK Medicines Act (1968) and therefore supplied as unlicensed non-medicinal products The term ldquoauthorisationrdquo rather than ldquoprescriptionrdquo should be used

    13 It is imperative that any member of staff involved in the transfusion process adheres to this policy in particular

    bull Phlebotomy staff who have a critical duty to carry out required identity checks before taking blood

    transfusion samples from the patient bull Nursing and Midwifery staff who have a critical duty to carry out required checks before taking

    blood transfusion samples collection and delivery of blood components administering the component and observation of the patient during and after the transfusion

    bull Portering staff who are involved the safe collection and transport of blood components

    bull Medical staff and advanced neonatal nurse practitioners who have undergone appropriate training who assess the patient take blood transfusion samples authorise and order transfusion support

    2 STATEMENT OF POLICY 21 The aim of the policy is to ensure the correct componentproduct is given at the correct time in

    the appropriate way to the correct patient

    22 Any member of staff involved in the transfusion process should be conversant with the sections of this document that pertain to their role and have access to appropriate education training and support in its implementation NHS Quality Improvement Scotland Blood Transfusion Standards (2006) recommend that only staff who have completed an appropriate education programme appropriate to their role can participate in the transfusion process

    23 The administration of blood and blood components must only be carried out by suitably trained practitioners Only staff that have completed transfusion training can collect and deliver blood transfusion products and components

    This policy should be read in conjunction with the following documents (Please click on the links below to access)

    bull British Committee for Standards in Haematology(BCSH) Guideline on the Administration of Blood Components (2009)

    httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf

    bull National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusion aspx

    bull NHS Tayside Establishing Patient Identity Policy

    httpedstaysidescotnhsukNHSTaysideDocsgroupscorporatedocumentsdocumentsprod_162299pdf

    bull NHS Tayside Informed Consent Policy

    httpedstaysidescotnhsukNHSTaysideDocsgroupsworking_safelydocumentsdocumentsdocs_016304pdf

    6

    3 RESPONSIBILITIES

    Indications for Blood Transfusion 31 An infusion of blood components may be given to bull Manage acute blood loss bull Replace a deficiency of specific blood components such as erythrocytes platelets or clotting factors bull Increase the oxygen carrying capacity of the blood The final decision to transfuse rests with the clinician in charge of the patientrsquos care 32 An NHS Tayside Adult Blood Transfusion Guideline (Appendix 1 ) provides guidance on when

    blood transfusion is likely to beneficial 33 The Ninewells and PRI Maximum Surgical Blood Ordering Schedule (Appendix 2 ) provides

    further guidance on the recommended amount of red cells to order for different surgical procedures

    Both of these guidelines are available electronically and copies should be available in all clinical areas Additional copies are available from Transfusion Practitionersthe hospital transfusion laboratory 4 ORGANISATIONAL ARRANGEMENTS

    41 Hospital Transfusion Laboratory Contact Information

    bull East of Scotland Blood Transfusion Centre Hospital Transfusion Laboratory

    Ninewells - Extension 32953 Remit covers all clinical areas medical centres and community hospitals in Dundee and Angus

    bull Perth Royal Infirmary Hospital Transfusion Laborato ry

    PRI- Extension 13338 or Pager 5122

    Remit covers all clinical areas medical centres and community hospitals in Perth and Kinross

    42 Blood supply in an emergency situation

    Communication with the local Hospital Transfusion Laboratory (HTL) is key to allowing the department to provide the highest standard of care Under normal circumstances red cells are only issued from the Hospital Transfusion laboratory after full compatibility testing However in the presence of a life-threatening situation in which there is insufficient time to complete these tests clinician responsible for the care of the patient may decide that the situation warrants the use of un-cross matched blood

    When this occurs it is preferable to give blood of the patients own ABO and Rh D group If the urgency of the situation makes this impossible Group O Rh D negative blood may be used Supplies of un-cross matched group specific or Group O Rh D Negative blood are obtainable from the local Hospital Transfusion Laboratory

    In Ninewells Emergency Group O Rh D negative blood is held in

    bull Main Theatre Blood Fridge ndash 2 units

    7

    bull Accident and Emergency Blood Fridge ndash 6 units

    bull Transfusion Laboratory Fridges 4 units

    In Perth Royal Infirmary Group O Rh D negative bloo d is held in bull Main Theatre Blood Fridge ndash 2 units bull Transfusion Laboratory- 2 units

    It is imperative that when these supplies are accessed the Hospital Transfusion Laboratory is informed immediately so that arrangements can be made to replenish stocks

    Supplies of Group O Rh D Negative blood for emergen cy use are also available in

    bull Arbroath Infirmary Blood Fridge ndash 2 units bull Stracathro Hospital Blood Fridge ndash 4 units bull Fernbrae BMI Hospital Blood Fridge- 2 units

    Stracathro Hospital has 4 units of O Rh D negative blood for emergency use for inpatients or theatre cases If the emergency blood is used on a patient in Stracathro then the Hospital Transfusion Laboratory in Ninewells must be informed immediately and elective surgery suspended until replacement emergency blood is in place at the hospital

    It must be remembered that when using un-cross matched blood there is an increased risk of a severe haemolytic transfusion reaction as the patient may have antibodies that react with one of the other blood groups Appendix 3a and 3b contain further information about transfusion reactions and their management Appendix 4 is the UK Blood Safety and Quality Regulations guidance on reporting serious adverse events and reactions Massive Haemorrhage Protocol

    NHS Tayside Guide to Massive Transfusion Blood Loss httpedstaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsprod_174661pdf

    5 PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK

    There are several key considerations when administering blood products or components

    bull The patient receives an appropriate and safe transfusion of blood or blood products bull The patients risk of transfusion reactioncomplications is minimised bull Changes in the patients condition are detected at an early stage bull Adverse events are reported to the hospital transfusion laboratory in a timely manner 51 Decision to Transfuse The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual needs A checklist with additional information for doctors gaining consent from Jehovah Witnesses on blood products that they may accept can be found at appendix 5a

    8

    The decision process leading to transfusion should be documented in the patientrsquos clinical record

    Links to guidance on transfusion issues issued by the British Committee for Standards in Haematology (BCSH) can be found in appendix 5b - Procedural document on decision to transfuse 52 Requesting Transfusion Support

    The request for transfusion support for patients under the care of NHS Tayside should be in accordance with BCSH guidelines

    The procedure for requesting transfusion support can be found in appendix 6 of this document and includes details on consent and documentation availability of patient information leaflets and additional information that is required by the transfusion laboratory before blood is prepared for transfusion

    Appendix 6 also contains indications for Irradiated Blood

    53 Written authorisation (formerly known as prescr iption) of Transfusion Support

    Section130 of the 1968 Medicines Act has been amended by regulation 25 of the Blood Safety and Quality Regulations 2005 (SI 2005 no 50) Blood components are now excluded from the act and the term prescription does not apply as they are not medicinal products the term authorisation should be used

    The authorisation must be signed by the responsible clinician or advanced neonatal nurse practitioner It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009) Blood and blood components must always be authorised prescribed prior to commencement of treatment The procedure is outlined in appendix 7

    54 Taking the blood sample

    The blood sample should be taken in accordance with BCSH guideline on administration of blood components (2009) which takes into account the Blood Safety and Quality Regulations (BSQR (2005) Statutory Instrument 200550 as amended) the National Patient Safety Agency (NPSA) Safer Practice Notices SHOT recommendations and the NHS Quality Improvement Scotland (QIS) 2006 Clinical Standards for Blood Transfusion

    Both the East of Scotland Blood Transfusion Centre and Perth Royal Infirmary Blood Transfusion Laboratory have a zero-tolerance policy in place for incorrectly or inadequately labelled sample request forms and sample bottles The procedure for taking a blood sample is detailed in appendix 8

    55 Collection and Delivery of Blood and Blood Comp onents Collection and delivery of blood and components must be in accordance with BCSH guideline on administration of blood components (2009)

    All staff involved in the collection and delivery of blood components from the storage area to the clinical area should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) and BSQR (SI 2005 No50 as amended) standards The procedure for collecting and delivering blood components is described in appendix 9 56 Administration of Red Cells Blood components must be administered by a registered healthcare professional

    9

    As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

    a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

    The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

    58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

    59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

    510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

    511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

    512 Management of Transfusion Reactions

    In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

    Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

    10

    Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

    513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

    6 KEY CONTACTS

    Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

    Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

    NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

    11

    7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

    12

    httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

    13

    Appendix 1 Adult Blood Transfusion Guideline

    ADULT BLOOD TRANSFUSION GUIDELINE

    bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

    Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

    Remember

    bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

    consider the cause

    References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

    BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

    Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

    This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

    Haemoglobin Less than 8 gdl

    Haemoglobin 8 to 10 gdl

    Haemoglobin Greater than 10gdl

    Yes Possibly if No

    14

    Appendix 2

    Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

    Tariff for Elective Procedures

    2013-09-26 NW amp PRI MSBOS V30

    Procedure

    Tariff

    Procedure

    Tariff

    Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

    excision GampS

    AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

    If surgery for malignancy and pre-op Hblt120 L gdL

    If pre-op Hbgt 120L gdL

    2

    GampS

    Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

    2 Nephrectomy - OPEN 2

    Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

    Colposuspension) GampS

    Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

    GampS Pyeloplasty GampS

    Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

    GampS Total Proctocolectomy 2

    Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

    15

    Appendix 3a Flowchart Management of a Transfusion Reaction

    Symptoms Signs of Acute Transfusion Reaction

    Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

    chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

    Stop the transfusion and call a doctor

    Measure temperature pulse blood pressure respiratory rate amp O2 saturation

    Check identity of the recipient with the details on the unit and compatibility label or tag

    Any discrepancy noted call the transfusion laboratory

    Febrile non-haemolytic transfusion

    reaction

    If temperature rise less than

    20˚C the observations are stable

    and the patient is otherwise well

    give paracetamol

    Restart infusion at slower rate

    and observe more frequently

    Mild allergic reaction

    Give Chlopheniramine 10mg

    slowly iv and restart the

    transfusion at a slower rate and

    observe more frequently

    Reaction

    involves mild

    fever or

    urticarial

    rash only

    Mild fever

    Urticaria

    ABO incompatibility

    Stop transfusion

    Remove unit keeping IV giving set

    attached and c lamped off for return

    to Blood Transfusion Laboratory

    Commence iv saline infusion through

    a NEW IV administration set

    Monitor blood pressure pulse urine

    output (catheterise) frequently Seek

    help from experts in management of

    shock where appropriate

    Treat any DIC with appropriate blood

    components

    Inform Hospital Transfusion

    Laboratory immediately

    Suspected ABO

    incompatibility

    No

    Haemolytic reaction bacterial

    infection of unit

    Stop transfusion

    Take down unit and giving set

    Return intact to blood bank with all

    other usedunused units

    Take blood cultures repeat blood

    group crossmatch FBC coagulation

    screen biochemistry urinalysis

    Monitor urine output

    Commence broad spectrum

    antibiotics if suspected bacterial

    infection

    Commence oxygen and fluid support

    Seek haematological and intensive

    Severe allergic reaction

    Other haemolytic reaction bacterial

    contamination

    Severe allergic reaction

    Bronchospasm angioedema

    abdominal pain hypotension

    Stop transfusion Call for help

    Maintain airway give 100 O2

    If severe hypotension lie patient flat

    with legs elevated Give adrenaline

    (05ml of 1 in 1000 intramuscular )

    NEVER give undiluted epinephrine

    intravascularly

    Paediatric doses depend on the age of

    the child Intramuscular 1 in 1000

    epinephrine should be administered as

    follows

    12 years

    05 milligrams (05 ml)

    6-12 years

    025 milligrams (025ml)

    gt6 months to 6 years 012

    milligrams( 012 ml)

    lt6 months 005 milligrams

    ( 005ml)

    Take down unit and giving set

    Start infusion of crystalloid or colloid

    through a new iv fluid administration

    set

    Secondary therapy

    Chlopheniramine 10mg slow iv

    Salbutamol nebuliser

    Corticosteroids 100-500mg

    Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

    Fluid overload

    Give oxygen

    Diuretic iv

    TRALI

    Clinical features of acute LVF with

    fever and chills

    Discontinue transfusion

    Give 100 Oxygen

    Treat as ARDS ndash ventilate if hypoxia

    indicates

    Acute dyspnoea

    hypotension

    Monitor blood gases

    Perform CXR

    Measure CVP

    Pulmonary capillary

    pressure

    Raised

    CVP

    Normal

    CVP

    No

    Yes

    Yes

    Yes

    No

    No

    16

    Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

    bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

    Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

    bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

    site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

    17

    The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

    The component unit and any remaining contents with the clamped off IV giving set attached

    should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

    Any empty used unit packs from this transfusion episode or unused units of blood issued for

    the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

    Completed Transfusion Reaction form should be returned to the hospital transfusion

    laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

    o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

    Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

    Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

    bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

    bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

    receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

    18

    Appendix 4

    20

    21

    22

    23

    24

    25

    Appendix 5a Jehovah Witness Consent

    CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

    WILLING TO HAVE IF REQUIRED

    REFUSE UNDER ANY CIRCUMSTANCES

    Blood Components Red cells Platelets

    Fresh frozen plasma Cryoprecipitate

    Cell Salvage

    Cell saver- Standard set up

    Cell saver- set up in continuity only

    Blood Products Octaplas (Prothrombin complex

    Concentrate)

    Anti-D Immunoglobulin Albumin

    Factor VIII concentrate Factor IX concentrate

    Fibrinogen Concentrate Recombinant Products

    Erythropoietin Factor VIIa

    I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

    26

    expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

    DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

    27

    Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

    needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

    to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

    bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

    Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

    bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

    transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

    bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

    must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

    (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

    28

    Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

    units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

    desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

    bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

    SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

    requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

    Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

    Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

    - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

    29

    - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

    Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

    bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

    taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

    Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

    unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

    the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

    Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

    date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

    Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

    30

    bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

    The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

    31

    Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

    Practitioner

    bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

    bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

    32

    Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

    Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

    alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

    patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

    Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

    or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

    33

    If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

    if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

    the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

    from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

    the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

    34

    bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

    identity band bull Match all other identifying information

    35

    Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

    been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

    had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

    the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

    bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

    Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

    alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

    you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

    bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

    form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

    bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

    is to take place

    36

    If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

    inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

    delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

    37

    Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

    unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

    are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

    storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

    no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

    transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

    available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

    correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

    for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

    38

    bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

    wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

    blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

    band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

    component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

    checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

    bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

    infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

    2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

    infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

    transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

    Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

    commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

    receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

    blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

    bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

    container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

    Blood Safety and Quality Regulations (2005)

    39

    bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

    bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

    a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

    40

    Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

    inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

    bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

    Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

    depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

    substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

    or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

    urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

    41

    bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

    haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

    42

    Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

    bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

    bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

    bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

    43

    Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

    Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

    Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

    regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

    44

    Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

    negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

    45

    Appendix 15A

    46

    Appendix 15B

    47

    Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

    Please use a new document for each transfusion event

    PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

    HospitalUnit Affix label here or write patient details Forename

    Surname

    Gender

    Date of birth

    CHI

    WardDept

    Consultant

    Authorisation Prescription

    bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

    transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

    chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

    Consent for Transfusion

    bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

    Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

    after reading the PIL Yes No bull Does this patient guardian agree to have a blood

    transfusion No Yes bull Is an advanced directive (refusal of transfusion)

    document in place Yes No Please delete patientguardian as appropriate

    Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

    I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

    Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

    48

    THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

    Patient Name Date of birthCHI

    UN

    IT 1

    Blood component

    Unit Pool mls

    Special Requirements Instructions (please tick)

    Affix completed pink portion of compatibility label here

    Irradiated CMV negative Blood warmer Other medication

    Reason for transfusion

    Date Duration Authoriser Prescriber signature

    Reassess before you progress (Venflon site and observations)

    UN

    IT 2

    Blood component

    Unit Pool mls

    Special Requirements Instructions (please tick)

    Affix completed pink portion of compatibility label here

    Irradiated CMV negative Blood warmer Other medication

    Reason for transfusion

    Date Duration Authoriser Prescriber signature

    Reassess before you progress (Venflon site and observations)

    UN

    IT 3

    Blood component

    Unit Pool mls

    Special Requirements Instructions (please tick)

    Affix completed pink portion of compatibility label here

    Irradiated CMV negative Blood warmer Other medication

    Reason for transfusion

    Date Duration Authoriser Prescriber signature

    Reassess before you progress (Venflon site and observations)

    UN

    IT 4

    Blood component

    Unit Pool mls

    Special Requirements Instructions (please tick)

    Affix completed pink portion of compatibility label here

    Irradiated CMV negative Blood warmer Other medication

    Reason for transfusion

    Date Duration Authoriser Prescriber signature

    THB(MR) 020 V40 May 2013

    THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

    Patient Na me Date of birthCHI

    Transfusion Checklist - Please initial each box as checks are completed

    PRE-

    COLLECTION

    Checks below should be completed before collection of component from temperature

    controlled storage is undertaken

    PRE-

    ADMINISTRATION

    AT BEDSIDE

    Only remove clear outer wrap

    bag immediately prior to commencing transfusion and

    only when all positive identification checks have been

    completed

    POST

    TRANSFUSION

    Unit No

    1

    helliphelliphelliphelliphelliphelliphelliphelliphellip

    helliphelliphelliphelliphelliphelliphellip

    2

    helliphelliphelliphelliphelliphelliphelliphelliphellip

    helliphelliphelliphelliphelliphelliphellip

    3

    helliphelliphelliphelliphelliphelliphelliphelliphellip

    helliphelliphelliphelliphelliphellip

    4

    helliphelliphelliphelliphelliphelliphelliphelliphellip

    helliphelliphelliphelliphelliphelliphellip

    THB(MR) 020 V40 - May 2013

    Identification band insitu amp details verified and correct

    Patent IV access

    (Patient safety bundle adhered to)

    Blood authorised

    prescribed

    Check for special

    requirements amp consent

    Verbal identification

    at the bedside

    (if applicable)

    Identification band details are verified

    and correct amp match details

    on Traceability ldquobagamp tagrdquo

    label

    DateTime Transfusion completed

    Traceability Tag signed with starting time amp date of transfusion recorded

    Inspect bag

    (condition amp expiry

    date)

    DateTime blood removed from

    cold temperature

    storage

    Baseline Observations recorded on SEWS chart

    (Temperature Pulse

    Oxygen sats Respiration rate

    amp BP)

    Completion of Observations

    Noted on the SEWS chart

    (Temperature Pulse

    Oxygen Sats Respiration rate

    50

    Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

    be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

    Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

    be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

    recorded and concerns escalated to the medical team according to the SEWS

    Adverse Events

    bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

    more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

    hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

    Post Transfusion

    bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

    patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

    bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

    Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

    transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

    patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

    Resources

    Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

    THB(MR)020 v 40 May 2013

    Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

    PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

    51

    9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

    This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

    POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

    Why has this policy been developed

    Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

    Has a risk control plan been developed and who is the owner of the risk If not why not

    Who has been involvedconsulted in the development of the policy

    Has the policy been assessed for Equality and Diversity in relation to-

    Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

    RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

    Please indicate YesNo for the following YES

    Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

    Please indicate Ye sNo for the following YES

    Does the policy contain evidence of the Equality amp

    Diversity Impact Assessment Process

    Is there an implementation plan

    Which officers are responsible for implementation

    When will the policy take effect

    Who must comply with the policystrategy

    How will they be informed of their responsibilities

    Is any training required

    If yes has any been arranged

    Are there any cost implications

    NO

    If yes please detail costs and note source of funding

    Who is responsible for auditing the implementation of the policy

    What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

    2

    POLICY MANAGER________________________ DATE______ _____________________

    • Blood supply in an emergency situation
    • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
    • Administration of Platelets
      • Appendix 1 Adult Blood Transfusion Guideline
        • ADULT BLOOD TRANSFUSION GUIDELINE
          • Remember
            • References
              • Appendix 3a Flowchart Management of a Transfusion Reaction
                • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                  • Consent for Transfusion
                  • THB(MR) 020 V40 May 2013
                    • PRE- COLLECTION
                    • PRE-ADMINISTRATION

      3

      CONTENTS 1 PURPOSE AND SCOPE

      2 STATEMENT OF POLICY 3 RESPONSIBILITIES 4 ORGANISATIONAL ARRANGEMENTS 5 PROCEDURAL GUIDANCE amp MANAGEMENT RISK 6 KEY CONTACTS amp LINKS TO LABORATORY USER HANDBOO KS 7 REFERENCES amp OTHER USEFUL LINKS 8 APPENDICES Appendix 1 NHS Tayside Adult Transfusion guideline

      Appendix 2

      Ninewells Hospital amp Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) Appendix 3a Flow-chart for management of a transfusion reaction

      Appendix 3b Procedural document for management of a transfusion reaction

      Appendix 4 UK Blood Safety and Quality Regulations (2005)

      Appendix 5a Jehovah Witness Consent

      Appendix 5b Decision to Transfuse

      Appendix 6 Requesting Transfusion Support

      Appendix 7 Authorisation ndash Prescription of Transfusion Support

      Appendix 8 Taking the Blood Sample

      Appendix 9 Collection and Delivery of Blood and Blood Components

      Appendix 10 Administration of Red Cells Appendix 11

      Administration of other Blood Components FFP Cryoprecipitate Platelets PCC and Anti-D

      Appendix 12 Other Components available from ESBTC Transfusion Laboratory Ninewells

      4

      Appendix 13 Monitoring during a Transfusion of Blood or Blood Components

      Appendix 14 Paediatric - Neonatal considerations

      Appendix 15 SBAR posters for Emergency Obstetric and Neonatal Transfusion Support

      Appendix 15a - Mother Appendix 15b ndash Baby Appendix 16 Transfusion Record Document v 04 9 RAPID IMPACT CHECKLIST

      5

      1 PURPOSE AND SCOPE

      11 This policy has been developed in response to the identified need to raise awareness in the management of patients receiving blood components or blood products Blood transfusion by definition is the introduction of prepared compatible donor blood components or blood products into the circulation of a recipient patient

      12 Since 2005 all blood components have been excluded from the UK Medicines Act (1968) and therefore supplied as unlicensed non-medicinal products The term ldquoauthorisationrdquo rather than ldquoprescriptionrdquo should be used

      13 It is imperative that any member of staff involved in the transfusion process adheres to this policy in particular

      bull Phlebotomy staff who have a critical duty to carry out required identity checks before taking blood

      transfusion samples from the patient bull Nursing and Midwifery staff who have a critical duty to carry out required checks before taking

      blood transfusion samples collection and delivery of blood components administering the component and observation of the patient during and after the transfusion

      bull Portering staff who are involved the safe collection and transport of blood components

      bull Medical staff and advanced neonatal nurse practitioners who have undergone appropriate training who assess the patient take blood transfusion samples authorise and order transfusion support

      2 STATEMENT OF POLICY 21 The aim of the policy is to ensure the correct componentproduct is given at the correct time in

      the appropriate way to the correct patient

      22 Any member of staff involved in the transfusion process should be conversant with the sections of this document that pertain to their role and have access to appropriate education training and support in its implementation NHS Quality Improvement Scotland Blood Transfusion Standards (2006) recommend that only staff who have completed an appropriate education programme appropriate to their role can participate in the transfusion process

      23 The administration of blood and blood components must only be carried out by suitably trained practitioners Only staff that have completed transfusion training can collect and deliver blood transfusion products and components

      This policy should be read in conjunction with the following documents (Please click on the links below to access)

      bull British Committee for Standards in Haematology(BCSH) Guideline on the Administration of Blood Components (2009)

      httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf

      bull National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusion aspx

      bull NHS Tayside Establishing Patient Identity Policy

      httpedstaysidescotnhsukNHSTaysideDocsgroupscorporatedocumentsdocumentsprod_162299pdf

      bull NHS Tayside Informed Consent Policy

      httpedstaysidescotnhsukNHSTaysideDocsgroupsworking_safelydocumentsdocumentsdocs_016304pdf

      6

      3 RESPONSIBILITIES

      Indications for Blood Transfusion 31 An infusion of blood components may be given to bull Manage acute blood loss bull Replace a deficiency of specific blood components such as erythrocytes platelets or clotting factors bull Increase the oxygen carrying capacity of the blood The final decision to transfuse rests with the clinician in charge of the patientrsquos care 32 An NHS Tayside Adult Blood Transfusion Guideline (Appendix 1 ) provides guidance on when

      blood transfusion is likely to beneficial 33 The Ninewells and PRI Maximum Surgical Blood Ordering Schedule (Appendix 2 ) provides

      further guidance on the recommended amount of red cells to order for different surgical procedures

      Both of these guidelines are available electronically and copies should be available in all clinical areas Additional copies are available from Transfusion Practitionersthe hospital transfusion laboratory 4 ORGANISATIONAL ARRANGEMENTS

      41 Hospital Transfusion Laboratory Contact Information

      bull East of Scotland Blood Transfusion Centre Hospital Transfusion Laboratory

      Ninewells - Extension 32953 Remit covers all clinical areas medical centres and community hospitals in Dundee and Angus

      bull Perth Royal Infirmary Hospital Transfusion Laborato ry

      PRI- Extension 13338 or Pager 5122

      Remit covers all clinical areas medical centres and community hospitals in Perth and Kinross

      42 Blood supply in an emergency situation

      Communication with the local Hospital Transfusion Laboratory (HTL) is key to allowing the department to provide the highest standard of care Under normal circumstances red cells are only issued from the Hospital Transfusion laboratory after full compatibility testing However in the presence of a life-threatening situation in which there is insufficient time to complete these tests clinician responsible for the care of the patient may decide that the situation warrants the use of un-cross matched blood

      When this occurs it is preferable to give blood of the patients own ABO and Rh D group If the urgency of the situation makes this impossible Group O Rh D negative blood may be used Supplies of un-cross matched group specific or Group O Rh D Negative blood are obtainable from the local Hospital Transfusion Laboratory

      In Ninewells Emergency Group O Rh D negative blood is held in

      bull Main Theatre Blood Fridge ndash 2 units

      7

      bull Accident and Emergency Blood Fridge ndash 6 units

      bull Transfusion Laboratory Fridges 4 units

      In Perth Royal Infirmary Group O Rh D negative bloo d is held in bull Main Theatre Blood Fridge ndash 2 units bull Transfusion Laboratory- 2 units

      It is imperative that when these supplies are accessed the Hospital Transfusion Laboratory is informed immediately so that arrangements can be made to replenish stocks

      Supplies of Group O Rh D Negative blood for emergen cy use are also available in

      bull Arbroath Infirmary Blood Fridge ndash 2 units bull Stracathro Hospital Blood Fridge ndash 4 units bull Fernbrae BMI Hospital Blood Fridge- 2 units

      Stracathro Hospital has 4 units of O Rh D negative blood for emergency use for inpatients or theatre cases If the emergency blood is used on a patient in Stracathro then the Hospital Transfusion Laboratory in Ninewells must be informed immediately and elective surgery suspended until replacement emergency blood is in place at the hospital

      It must be remembered that when using un-cross matched blood there is an increased risk of a severe haemolytic transfusion reaction as the patient may have antibodies that react with one of the other blood groups Appendix 3a and 3b contain further information about transfusion reactions and their management Appendix 4 is the UK Blood Safety and Quality Regulations guidance on reporting serious adverse events and reactions Massive Haemorrhage Protocol

      NHS Tayside Guide to Massive Transfusion Blood Loss httpedstaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsprod_174661pdf

      5 PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK

      There are several key considerations when administering blood products or components

      bull The patient receives an appropriate and safe transfusion of blood or blood products bull The patients risk of transfusion reactioncomplications is minimised bull Changes in the patients condition are detected at an early stage bull Adverse events are reported to the hospital transfusion laboratory in a timely manner 51 Decision to Transfuse The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual needs A checklist with additional information for doctors gaining consent from Jehovah Witnesses on blood products that they may accept can be found at appendix 5a

      8

      The decision process leading to transfusion should be documented in the patientrsquos clinical record

      Links to guidance on transfusion issues issued by the British Committee for Standards in Haematology (BCSH) can be found in appendix 5b - Procedural document on decision to transfuse 52 Requesting Transfusion Support

      The request for transfusion support for patients under the care of NHS Tayside should be in accordance with BCSH guidelines

      The procedure for requesting transfusion support can be found in appendix 6 of this document and includes details on consent and documentation availability of patient information leaflets and additional information that is required by the transfusion laboratory before blood is prepared for transfusion

      Appendix 6 also contains indications for Irradiated Blood

      53 Written authorisation (formerly known as prescr iption) of Transfusion Support

      Section130 of the 1968 Medicines Act has been amended by regulation 25 of the Blood Safety and Quality Regulations 2005 (SI 2005 no 50) Blood components are now excluded from the act and the term prescription does not apply as they are not medicinal products the term authorisation should be used

      The authorisation must be signed by the responsible clinician or advanced neonatal nurse practitioner It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009) Blood and blood components must always be authorised prescribed prior to commencement of treatment The procedure is outlined in appendix 7

      54 Taking the blood sample

      The blood sample should be taken in accordance with BCSH guideline on administration of blood components (2009) which takes into account the Blood Safety and Quality Regulations (BSQR (2005) Statutory Instrument 200550 as amended) the National Patient Safety Agency (NPSA) Safer Practice Notices SHOT recommendations and the NHS Quality Improvement Scotland (QIS) 2006 Clinical Standards for Blood Transfusion

      Both the East of Scotland Blood Transfusion Centre and Perth Royal Infirmary Blood Transfusion Laboratory have a zero-tolerance policy in place for incorrectly or inadequately labelled sample request forms and sample bottles The procedure for taking a blood sample is detailed in appendix 8

      55 Collection and Delivery of Blood and Blood Comp onents Collection and delivery of blood and components must be in accordance with BCSH guideline on administration of blood components (2009)

      All staff involved in the collection and delivery of blood components from the storage area to the clinical area should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) and BSQR (SI 2005 No50 as amended) standards The procedure for collecting and delivering blood components is described in appendix 9 56 Administration of Red Cells Blood components must be administered by a registered healthcare professional

      9

      As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

      a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

      The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

      58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

      59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

      510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

      511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

      512 Management of Transfusion Reactions

      In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

      Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

      10

      Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

      513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

      6 KEY CONTACTS

      Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

      Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

      NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

      11

      7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

      12

      httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

      13

      Appendix 1 Adult Blood Transfusion Guideline

      ADULT BLOOD TRANSFUSION GUIDELINE

      bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

      Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

      Remember

      bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

      consider the cause

      References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

      BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

      Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

      This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

      Haemoglobin Less than 8 gdl

      Haemoglobin 8 to 10 gdl

      Haemoglobin Greater than 10gdl

      Yes Possibly if No

      14

      Appendix 2

      Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

      Tariff for Elective Procedures

      2013-09-26 NW amp PRI MSBOS V30

      Procedure

      Tariff

      Procedure

      Tariff

      Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

      excision GampS

      AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

      If surgery for malignancy and pre-op Hblt120 L gdL

      If pre-op Hbgt 120L gdL

      2

      GampS

      Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

      2 Nephrectomy - OPEN 2

      Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

      Colposuspension) GampS

      Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

      GampS Pyeloplasty GampS

      Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

      GampS Total Proctocolectomy 2

      Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

      15

      Appendix 3a Flowchart Management of a Transfusion Reaction

      Symptoms Signs of Acute Transfusion Reaction

      Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

      chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

      Stop the transfusion and call a doctor

      Measure temperature pulse blood pressure respiratory rate amp O2 saturation

      Check identity of the recipient with the details on the unit and compatibility label or tag

      Any discrepancy noted call the transfusion laboratory

      Febrile non-haemolytic transfusion

      reaction

      If temperature rise less than

      20˚C the observations are stable

      and the patient is otherwise well

      give paracetamol

      Restart infusion at slower rate

      and observe more frequently

      Mild allergic reaction

      Give Chlopheniramine 10mg

      slowly iv and restart the

      transfusion at a slower rate and

      observe more frequently

      Reaction

      involves mild

      fever or

      urticarial

      rash only

      Mild fever

      Urticaria

      ABO incompatibility

      Stop transfusion

      Remove unit keeping IV giving set

      attached and c lamped off for return

      to Blood Transfusion Laboratory

      Commence iv saline infusion through

      a NEW IV administration set

      Monitor blood pressure pulse urine

      output (catheterise) frequently Seek

      help from experts in management of

      shock where appropriate

      Treat any DIC with appropriate blood

      components

      Inform Hospital Transfusion

      Laboratory immediately

      Suspected ABO

      incompatibility

      No

      Haemolytic reaction bacterial

      infection of unit

      Stop transfusion

      Take down unit and giving set

      Return intact to blood bank with all

      other usedunused units

      Take blood cultures repeat blood

      group crossmatch FBC coagulation

      screen biochemistry urinalysis

      Monitor urine output

      Commence broad spectrum

      antibiotics if suspected bacterial

      infection

      Commence oxygen and fluid support

      Seek haematological and intensive

      Severe allergic reaction

      Other haemolytic reaction bacterial

      contamination

      Severe allergic reaction

      Bronchospasm angioedema

      abdominal pain hypotension

      Stop transfusion Call for help

      Maintain airway give 100 O2

      If severe hypotension lie patient flat

      with legs elevated Give adrenaline

      (05ml of 1 in 1000 intramuscular )

      NEVER give undiluted epinephrine

      intravascularly

      Paediatric doses depend on the age of

      the child Intramuscular 1 in 1000

      epinephrine should be administered as

      follows

      12 years

      05 milligrams (05 ml)

      6-12 years

      025 milligrams (025ml)

      gt6 months to 6 years 012

      milligrams( 012 ml)

      lt6 months 005 milligrams

      ( 005ml)

      Take down unit and giving set

      Start infusion of crystalloid or colloid

      through a new iv fluid administration

      set

      Secondary therapy

      Chlopheniramine 10mg slow iv

      Salbutamol nebuliser

      Corticosteroids 100-500mg

      Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

      Fluid overload

      Give oxygen

      Diuretic iv

      TRALI

      Clinical features of acute LVF with

      fever and chills

      Discontinue transfusion

      Give 100 Oxygen

      Treat as ARDS ndash ventilate if hypoxia

      indicates

      Acute dyspnoea

      hypotension

      Monitor blood gases

      Perform CXR

      Measure CVP

      Pulmonary capillary

      pressure

      Raised

      CVP

      Normal

      CVP

      No

      Yes

      Yes

      Yes

      No

      No

      16

      Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

      bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

      Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

      bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

      site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

      17

      The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

      The component unit and any remaining contents with the clamped off IV giving set attached

      should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

      Any empty used unit packs from this transfusion episode or unused units of blood issued for

      the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

      Completed Transfusion Reaction form should be returned to the hospital transfusion

      laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

      o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

      Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

      Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

      bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

      bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

      receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

      18

      Appendix 4

      20

      21

      22

      23

      24

      25

      Appendix 5a Jehovah Witness Consent

      CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

      WILLING TO HAVE IF REQUIRED

      REFUSE UNDER ANY CIRCUMSTANCES

      Blood Components Red cells Platelets

      Fresh frozen plasma Cryoprecipitate

      Cell Salvage

      Cell saver- Standard set up

      Cell saver- set up in continuity only

      Blood Products Octaplas (Prothrombin complex

      Concentrate)

      Anti-D Immunoglobulin Albumin

      Factor VIII concentrate Factor IX concentrate

      Fibrinogen Concentrate Recombinant Products

      Erythropoietin Factor VIIa

      I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

      26

      expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

      DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

      27

      Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

      needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

      to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

      bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

      Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

      bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

      transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

      bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

      must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

      (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

      28

      Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

      units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

      desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

      bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

      SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

      requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

      Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

      Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

      - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

      29

      - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

      Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

      bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

      taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

      Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

      unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

      the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

      Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

      date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

      Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

      30

      bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

      The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

      31

      Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

      Practitioner

      bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

      bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

      32

      Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

      Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

      alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

      patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

      Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

      or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

      33

      If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

      if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

      the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

      from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

      the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

      34

      bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

      identity band bull Match all other identifying information

      35

      Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

      been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

      had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

      the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

      bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

      Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

      alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

      you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

      bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

      form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

      bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

      is to take place

      36

      If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

      inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

      delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

      37

      Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

      unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

      are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

      storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

      no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

      transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

      available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

      correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

      for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

      38

      bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

      wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

      blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

      band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

      component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

      checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

      bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

      infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

      2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

      infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

      transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

      Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

      commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

      receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

      blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

      bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

      container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

      Blood Safety and Quality Regulations (2005)

      39

      bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

      bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

      a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

      40

      Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

      inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

      bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

      Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

      depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

      substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

      or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

      urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

      41

      bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

      haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

      42

      Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

      bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

      bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

      bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

      43

      Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

      Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

      Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

      regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

      44

      Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

      negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

      45

      Appendix 15A

      46

      Appendix 15B

      47

      Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

      Please use a new document for each transfusion event

      PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

      HospitalUnit Affix label here or write patient details Forename

      Surname

      Gender

      Date of birth

      CHI

      WardDept

      Consultant

      Authorisation Prescription

      bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

      transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

      chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

      Consent for Transfusion

      bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

      Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

      after reading the PIL Yes No bull Does this patient guardian agree to have a blood

      transfusion No Yes bull Is an advanced directive (refusal of transfusion)

      document in place Yes No Please delete patientguardian as appropriate

      Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

      I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

      Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

      48

      THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

      Patient Name Date of birthCHI

      UN

      IT 1

      Blood component

      Unit Pool mls

      Special Requirements Instructions (please tick)

      Affix completed pink portion of compatibility label here

      Irradiated CMV negative Blood warmer Other medication

      Reason for transfusion

      Date Duration Authoriser Prescriber signature

      Reassess before you progress (Venflon site and observations)

      UN

      IT 2

      Blood component

      Unit Pool mls

      Special Requirements Instructions (please tick)

      Affix completed pink portion of compatibility label here

      Irradiated CMV negative Blood warmer Other medication

      Reason for transfusion

      Date Duration Authoriser Prescriber signature

      Reassess before you progress (Venflon site and observations)

      UN

      IT 3

      Blood component

      Unit Pool mls

      Special Requirements Instructions (please tick)

      Affix completed pink portion of compatibility label here

      Irradiated CMV negative Blood warmer Other medication

      Reason for transfusion

      Date Duration Authoriser Prescriber signature

      Reassess before you progress (Venflon site and observations)

      UN

      IT 4

      Blood component

      Unit Pool mls

      Special Requirements Instructions (please tick)

      Affix completed pink portion of compatibility label here

      Irradiated CMV negative Blood warmer Other medication

      Reason for transfusion

      Date Duration Authoriser Prescriber signature

      THB(MR) 020 V40 May 2013

      THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

      Patient Na me Date of birthCHI

      Transfusion Checklist - Please initial each box as checks are completed

      PRE-

      COLLECTION

      Checks below should be completed before collection of component from temperature

      controlled storage is undertaken

      PRE-

      ADMINISTRATION

      AT BEDSIDE

      Only remove clear outer wrap

      bag immediately prior to commencing transfusion and

      only when all positive identification checks have been

      completed

      POST

      TRANSFUSION

      Unit No

      1

      helliphelliphelliphelliphelliphelliphelliphelliphellip

      helliphelliphelliphelliphelliphelliphellip

      2

      helliphelliphelliphelliphelliphelliphelliphelliphellip

      helliphelliphelliphelliphelliphelliphellip

      3

      helliphelliphelliphelliphelliphelliphelliphelliphellip

      helliphelliphelliphelliphelliphellip

      4

      helliphelliphelliphelliphelliphelliphelliphelliphellip

      helliphelliphelliphelliphelliphelliphellip

      THB(MR) 020 V40 - May 2013

      Identification band insitu amp details verified and correct

      Patent IV access

      (Patient safety bundle adhered to)

      Blood authorised

      prescribed

      Check for special

      requirements amp consent

      Verbal identification

      at the bedside

      (if applicable)

      Identification band details are verified

      and correct amp match details

      on Traceability ldquobagamp tagrdquo

      label

      DateTime Transfusion completed

      Traceability Tag signed with starting time amp date of transfusion recorded

      Inspect bag

      (condition amp expiry

      date)

      DateTime blood removed from

      cold temperature

      storage

      Baseline Observations recorded on SEWS chart

      (Temperature Pulse

      Oxygen sats Respiration rate

      amp BP)

      Completion of Observations

      Noted on the SEWS chart

      (Temperature Pulse

      Oxygen Sats Respiration rate

      50

      Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

      be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

      Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

      be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

      recorded and concerns escalated to the medical team according to the SEWS

      Adverse Events

      bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

      more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

      hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

      Post Transfusion

      bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

      patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

      bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

      Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

      transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

      patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

      Resources

      Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

      THB(MR)020 v 40 May 2013

      Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

      PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

      51

      9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

      This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

      POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

      Why has this policy been developed

      Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

      Has a risk control plan been developed and who is the owner of the risk If not why not

      Who has been involvedconsulted in the development of the policy

      Has the policy been assessed for Equality and Diversity in relation to-

      Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

      RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

      Please indicate YesNo for the following YES

      Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

      Please indicate Ye sNo for the following YES

      Does the policy contain evidence of the Equality amp

      Diversity Impact Assessment Process

      Is there an implementation plan

      Which officers are responsible for implementation

      When will the policy take effect

      Who must comply with the policystrategy

      How will they be informed of their responsibilities

      Is any training required

      If yes has any been arranged

      Are there any cost implications

      NO

      If yes please detail costs and note source of funding

      Who is responsible for auditing the implementation of the policy

      What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

      2

      POLICY MANAGER________________________ DATE______ _____________________

      • Blood supply in an emergency situation
      • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
      • Administration of Platelets
        • Appendix 1 Adult Blood Transfusion Guideline
          • ADULT BLOOD TRANSFUSION GUIDELINE
            • Remember
              • References
                • Appendix 3a Flowchart Management of a Transfusion Reaction
                  • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                    • Consent for Transfusion
                    • THB(MR) 020 V40 May 2013
                      • PRE- COLLECTION
                      • PRE-ADMINISTRATION

        4

        Appendix 13 Monitoring during a Transfusion of Blood or Blood Components

        Appendix 14 Paediatric - Neonatal considerations

        Appendix 15 SBAR posters for Emergency Obstetric and Neonatal Transfusion Support

        Appendix 15a - Mother Appendix 15b ndash Baby Appendix 16 Transfusion Record Document v 04 9 RAPID IMPACT CHECKLIST

        5

        1 PURPOSE AND SCOPE

        11 This policy has been developed in response to the identified need to raise awareness in the management of patients receiving blood components or blood products Blood transfusion by definition is the introduction of prepared compatible donor blood components or blood products into the circulation of a recipient patient

        12 Since 2005 all blood components have been excluded from the UK Medicines Act (1968) and therefore supplied as unlicensed non-medicinal products The term ldquoauthorisationrdquo rather than ldquoprescriptionrdquo should be used

        13 It is imperative that any member of staff involved in the transfusion process adheres to this policy in particular

        bull Phlebotomy staff who have a critical duty to carry out required identity checks before taking blood

        transfusion samples from the patient bull Nursing and Midwifery staff who have a critical duty to carry out required checks before taking

        blood transfusion samples collection and delivery of blood components administering the component and observation of the patient during and after the transfusion

        bull Portering staff who are involved the safe collection and transport of blood components

        bull Medical staff and advanced neonatal nurse practitioners who have undergone appropriate training who assess the patient take blood transfusion samples authorise and order transfusion support

        2 STATEMENT OF POLICY 21 The aim of the policy is to ensure the correct componentproduct is given at the correct time in

        the appropriate way to the correct patient

        22 Any member of staff involved in the transfusion process should be conversant with the sections of this document that pertain to their role and have access to appropriate education training and support in its implementation NHS Quality Improvement Scotland Blood Transfusion Standards (2006) recommend that only staff who have completed an appropriate education programme appropriate to their role can participate in the transfusion process

        23 The administration of blood and blood components must only be carried out by suitably trained practitioners Only staff that have completed transfusion training can collect and deliver blood transfusion products and components

        This policy should be read in conjunction with the following documents (Please click on the links below to access)

        bull British Committee for Standards in Haematology(BCSH) Guideline on the Administration of Blood Components (2009)

        httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf

        bull National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusion aspx

        bull NHS Tayside Establishing Patient Identity Policy

        httpedstaysidescotnhsukNHSTaysideDocsgroupscorporatedocumentsdocumentsprod_162299pdf

        bull NHS Tayside Informed Consent Policy

        httpedstaysidescotnhsukNHSTaysideDocsgroupsworking_safelydocumentsdocumentsdocs_016304pdf

        6

        3 RESPONSIBILITIES

        Indications for Blood Transfusion 31 An infusion of blood components may be given to bull Manage acute blood loss bull Replace a deficiency of specific blood components such as erythrocytes platelets or clotting factors bull Increase the oxygen carrying capacity of the blood The final decision to transfuse rests with the clinician in charge of the patientrsquos care 32 An NHS Tayside Adult Blood Transfusion Guideline (Appendix 1 ) provides guidance on when

        blood transfusion is likely to beneficial 33 The Ninewells and PRI Maximum Surgical Blood Ordering Schedule (Appendix 2 ) provides

        further guidance on the recommended amount of red cells to order for different surgical procedures

        Both of these guidelines are available electronically and copies should be available in all clinical areas Additional copies are available from Transfusion Practitionersthe hospital transfusion laboratory 4 ORGANISATIONAL ARRANGEMENTS

        41 Hospital Transfusion Laboratory Contact Information

        bull East of Scotland Blood Transfusion Centre Hospital Transfusion Laboratory

        Ninewells - Extension 32953 Remit covers all clinical areas medical centres and community hospitals in Dundee and Angus

        bull Perth Royal Infirmary Hospital Transfusion Laborato ry

        PRI- Extension 13338 or Pager 5122

        Remit covers all clinical areas medical centres and community hospitals in Perth and Kinross

        42 Blood supply in an emergency situation

        Communication with the local Hospital Transfusion Laboratory (HTL) is key to allowing the department to provide the highest standard of care Under normal circumstances red cells are only issued from the Hospital Transfusion laboratory after full compatibility testing However in the presence of a life-threatening situation in which there is insufficient time to complete these tests clinician responsible for the care of the patient may decide that the situation warrants the use of un-cross matched blood

        When this occurs it is preferable to give blood of the patients own ABO and Rh D group If the urgency of the situation makes this impossible Group O Rh D negative blood may be used Supplies of un-cross matched group specific or Group O Rh D Negative blood are obtainable from the local Hospital Transfusion Laboratory

        In Ninewells Emergency Group O Rh D negative blood is held in

        bull Main Theatre Blood Fridge ndash 2 units

        7

        bull Accident and Emergency Blood Fridge ndash 6 units

        bull Transfusion Laboratory Fridges 4 units

        In Perth Royal Infirmary Group O Rh D negative bloo d is held in bull Main Theatre Blood Fridge ndash 2 units bull Transfusion Laboratory- 2 units

        It is imperative that when these supplies are accessed the Hospital Transfusion Laboratory is informed immediately so that arrangements can be made to replenish stocks

        Supplies of Group O Rh D Negative blood for emergen cy use are also available in

        bull Arbroath Infirmary Blood Fridge ndash 2 units bull Stracathro Hospital Blood Fridge ndash 4 units bull Fernbrae BMI Hospital Blood Fridge- 2 units

        Stracathro Hospital has 4 units of O Rh D negative blood for emergency use for inpatients or theatre cases If the emergency blood is used on a patient in Stracathro then the Hospital Transfusion Laboratory in Ninewells must be informed immediately and elective surgery suspended until replacement emergency blood is in place at the hospital

        It must be remembered that when using un-cross matched blood there is an increased risk of a severe haemolytic transfusion reaction as the patient may have antibodies that react with one of the other blood groups Appendix 3a and 3b contain further information about transfusion reactions and their management Appendix 4 is the UK Blood Safety and Quality Regulations guidance on reporting serious adverse events and reactions Massive Haemorrhage Protocol

        NHS Tayside Guide to Massive Transfusion Blood Loss httpedstaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsprod_174661pdf

        5 PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK

        There are several key considerations when administering blood products or components

        bull The patient receives an appropriate and safe transfusion of blood or blood products bull The patients risk of transfusion reactioncomplications is minimised bull Changes in the patients condition are detected at an early stage bull Adverse events are reported to the hospital transfusion laboratory in a timely manner 51 Decision to Transfuse The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual needs A checklist with additional information for doctors gaining consent from Jehovah Witnesses on blood products that they may accept can be found at appendix 5a

        8

        The decision process leading to transfusion should be documented in the patientrsquos clinical record

        Links to guidance on transfusion issues issued by the British Committee for Standards in Haematology (BCSH) can be found in appendix 5b - Procedural document on decision to transfuse 52 Requesting Transfusion Support

        The request for transfusion support for patients under the care of NHS Tayside should be in accordance with BCSH guidelines

        The procedure for requesting transfusion support can be found in appendix 6 of this document and includes details on consent and documentation availability of patient information leaflets and additional information that is required by the transfusion laboratory before blood is prepared for transfusion

        Appendix 6 also contains indications for Irradiated Blood

        53 Written authorisation (formerly known as prescr iption) of Transfusion Support

        Section130 of the 1968 Medicines Act has been amended by regulation 25 of the Blood Safety and Quality Regulations 2005 (SI 2005 no 50) Blood components are now excluded from the act and the term prescription does not apply as they are not medicinal products the term authorisation should be used

        The authorisation must be signed by the responsible clinician or advanced neonatal nurse practitioner It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009) Blood and blood components must always be authorised prescribed prior to commencement of treatment The procedure is outlined in appendix 7

        54 Taking the blood sample

        The blood sample should be taken in accordance with BCSH guideline on administration of blood components (2009) which takes into account the Blood Safety and Quality Regulations (BSQR (2005) Statutory Instrument 200550 as amended) the National Patient Safety Agency (NPSA) Safer Practice Notices SHOT recommendations and the NHS Quality Improvement Scotland (QIS) 2006 Clinical Standards for Blood Transfusion

        Both the East of Scotland Blood Transfusion Centre and Perth Royal Infirmary Blood Transfusion Laboratory have a zero-tolerance policy in place for incorrectly or inadequately labelled sample request forms and sample bottles The procedure for taking a blood sample is detailed in appendix 8

        55 Collection and Delivery of Blood and Blood Comp onents Collection and delivery of blood and components must be in accordance with BCSH guideline on administration of blood components (2009)

        All staff involved in the collection and delivery of blood components from the storage area to the clinical area should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) and BSQR (SI 2005 No50 as amended) standards The procedure for collecting and delivering blood components is described in appendix 9 56 Administration of Red Cells Blood components must be administered by a registered healthcare professional

        9

        As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

        a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

        The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

        58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

        59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

        510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

        511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

        512 Management of Transfusion Reactions

        In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

        Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

        10

        Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

        513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

        6 KEY CONTACTS

        Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

        Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

        NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

        11

        7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

        12

        httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

        13

        Appendix 1 Adult Blood Transfusion Guideline

        ADULT BLOOD TRANSFUSION GUIDELINE

        bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

        Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

        Remember

        bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

        consider the cause

        References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

        BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

        Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

        This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

        Haemoglobin Less than 8 gdl

        Haemoglobin 8 to 10 gdl

        Haemoglobin Greater than 10gdl

        Yes Possibly if No

        14

        Appendix 2

        Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

        Tariff for Elective Procedures

        2013-09-26 NW amp PRI MSBOS V30

        Procedure

        Tariff

        Procedure

        Tariff

        Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

        excision GampS

        AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

        If surgery for malignancy and pre-op Hblt120 L gdL

        If pre-op Hbgt 120L gdL

        2

        GampS

        Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

        2 Nephrectomy - OPEN 2

        Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

        Colposuspension) GampS

        Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

        GampS Pyeloplasty GampS

        Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

        GampS Total Proctocolectomy 2

        Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

        15

        Appendix 3a Flowchart Management of a Transfusion Reaction

        Symptoms Signs of Acute Transfusion Reaction

        Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

        chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

        Stop the transfusion and call a doctor

        Measure temperature pulse blood pressure respiratory rate amp O2 saturation

        Check identity of the recipient with the details on the unit and compatibility label or tag

        Any discrepancy noted call the transfusion laboratory

        Febrile non-haemolytic transfusion

        reaction

        If temperature rise less than

        20˚C the observations are stable

        and the patient is otherwise well

        give paracetamol

        Restart infusion at slower rate

        and observe more frequently

        Mild allergic reaction

        Give Chlopheniramine 10mg

        slowly iv and restart the

        transfusion at a slower rate and

        observe more frequently

        Reaction

        involves mild

        fever or

        urticarial

        rash only

        Mild fever

        Urticaria

        ABO incompatibility

        Stop transfusion

        Remove unit keeping IV giving set

        attached and c lamped off for return

        to Blood Transfusion Laboratory

        Commence iv saline infusion through

        a NEW IV administration set

        Monitor blood pressure pulse urine

        output (catheterise) frequently Seek

        help from experts in management of

        shock where appropriate

        Treat any DIC with appropriate blood

        components

        Inform Hospital Transfusion

        Laboratory immediately

        Suspected ABO

        incompatibility

        No

        Haemolytic reaction bacterial

        infection of unit

        Stop transfusion

        Take down unit and giving set

        Return intact to blood bank with all

        other usedunused units

        Take blood cultures repeat blood

        group crossmatch FBC coagulation

        screen biochemistry urinalysis

        Monitor urine output

        Commence broad spectrum

        antibiotics if suspected bacterial

        infection

        Commence oxygen and fluid support

        Seek haematological and intensive

        Severe allergic reaction

        Other haemolytic reaction bacterial

        contamination

        Severe allergic reaction

        Bronchospasm angioedema

        abdominal pain hypotension

        Stop transfusion Call for help

        Maintain airway give 100 O2

        If severe hypotension lie patient flat

        with legs elevated Give adrenaline

        (05ml of 1 in 1000 intramuscular )

        NEVER give undiluted epinephrine

        intravascularly

        Paediatric doses depend on the age of

        the child Intramuscular 1 in 1000

        epinephrine should be administered as

        follows

        12 years

        05 milligrams (05 ml)

        6-12 years

        025 milligrams (025ml)

        gt6 months to 6 years 012

        milligrams( 012 ml)

        lt6 months 005 milligrams

        ( 005ml)

        Take down unit and giving set

        Start infusion of crystalloid or colloid

        through a new iv fluid administration

        set

        Secondary therapy

        Chlopheniramine 10mg slow iv

        Salbutamol nebuliser

        Corticosteroids 100-500mg

        Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

        Fluid overload

        Give oxygen

        Diuretic iv

        TRALI

        Clinical features of acute LVF with

        fever and chills

        Discontinue transfusion

        Give 100 Oxygen

        Treat as ARDS ndash ventilate if hypoxia

        indicates

        Acute dyspnoea

        hypotension

        Monitor blood gases

        Perform CXR

        Measure CVP

        Pulmonary capillary

        pressure

        Raised

        CVP

        Normal

        CVP

        No

        Yes

        Yes

        Yes

        No

        No

        16

        Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

        bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

        Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

        bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

        site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

        17

        The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

        The component unit and any remaining contents with the clamped off IV giving set attached

        should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

        Any empty used unit packs from this transfusion episode or unused units of blood issued for

        the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

        Completed Transfusion Reaction form should be returned to the hospital transfusion

        laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

        o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

        Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

        Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

        bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

        bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

        receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

        18

        Appendix 4

        20

        21

        22

        23

        24

        25

        Appendix 5a Jehovah Witness Consent

        CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

        WILLING TO HAVE IF REQUIRED

        REFUSE UNDER ANY CIRCUMSTANCES

        Blood Components Red cells Platelets

        Fresh frozen plasma Cryoprecipitate

        Cell Salvage

        Cell saver- Standard set up

        Cell saver- set up in continuity only

        Blood Products Octaplas (Prothrombin complex

        Concentrate)

        Anti-D Immunoglobulin Albumin

        Factor VIII concentrate Factor IX concentrate

        Fibrinogen Concentrate Recombinant Products

        Erythropoietin Factor VIIa

        I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

        26

        expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

        DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

        27

        Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

        needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

        to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

        bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

        Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

        bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

        transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

        bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

        must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

        (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

        28

        Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

        units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

        desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

        bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

        SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

        requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

        Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

        Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

        - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

        29

        - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

        Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

        bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

        taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

        Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

        unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

        the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

        Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

        date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

        Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

        30

        bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

        The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

        31

        Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

        Practitioner

        bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

        bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

        32

        Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

        Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

        alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

        patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

        Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

        or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

        33

        If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

        if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

        the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

        from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

        the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

        34

        bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

        identity band bull Match all other identifying information

        35

        Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

        been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

        had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

        the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

        bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

        Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

        alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

        you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

        bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

        form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

        bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

        is to take place

        36

        If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

        inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

        delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

        37

        Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

        unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

        are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

        storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

        no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

        transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

        available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

        correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

        for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

        38

        bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

        wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

        blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

        band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

        component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

        checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

        bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

        infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

        2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

        infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

        transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

        Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

        commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

        receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

        blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

        bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

        container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

        Blood Safety and Quality Regulations (2005)

        39

        bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

        bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

        a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

        40

        Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

        inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

        bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

        Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

        depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

        substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

        or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

        urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

        41

        bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

        haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

        42

        Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

        bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

        bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

        bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

        43

        Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

        Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

        Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

        regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

        44

        Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

        negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

        45

        Appendix 15A

        46

        Appendix 15B

        47

        Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

        Please use a new document for each transfusion event

        PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

        HospitalUnit Affix label here or write patient details Forename

        Surname

        Gender

        Date of birth

        CHI

        WardDept

        Consultant

        Authorisation Prescription

        bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

        transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

        chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

        Consent for Transfusion

        bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

        Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

        after reading the PIL Yes No bull Does this patient guardian agree to have a blood

        transfusion No Yes bull Is an advanced directive (refusal of transfusion)

        document in place Yes No Please delete patientguardian as appropriate

        Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

        I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

        Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

        48

        THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

        Patient Name Date of birthCHI

        UN

        IT 1

        Blood component

        Unit Pool mls

        Special Requirements Instructions (please tick)

        Affix completed pink portion of compatibility label here

        Irradiated CMV negative Blood warmer Other medication

        Reason for transfusion

        Date Duration Authoriser Prescriber signature

        Reassess before you progress (Venflon site and observations)

        UN

        IT 2

        Blood component

        Unit Pool mls

        Special Requirements Instructions (please tick)

        Affix completed pink portion of compatibility label here

        Irradiated CMV negative Blood warmer Other medication

        Reason for transfusion

        Date Duration Authoriser Prescriber signature

        Reassess before you progress (Venflon site and observations)

        UN

        IT 3

        Blood component

        Unit Pool mls

        Special Requirements Instructions (please tick)

        Affix completed pink portion of compatibility label here

        Irradiated CMV negative Blood warmer Other medication

        Reason for transfusion

        Date Duration Authoriser Prescriber signature

        Reassess before you progress (Venflon site and observations)

        UN

        IT 4

        Blood component

        Unit Pool mls

        Special Requirements Instructions (please tick)

        Affix completed pink portion of compatibility label here

        Irradiated CMV negative Blood warmer Other medication

        Reason for transfusion

        Date Duration Authoriser Prescriber signature

        THB(MR) 020 V40 May 2013

        THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

        Patient Na me Date of birthCHI

        Transfusion Checklist - Please initial each box as checks are completed

        PRE-

        COLLECTION

        Checks below should be completed before collection of component from temperature

        controlled storage is undertaken

        PRE-

        ADMINISTRATION

        AT BEDSIDE

        Only remove clear outer wrap

        bag immediately prior to commencing transfusion and

        only when all positive identification checks have been

        completed

        POST

        TRANSFUSION

        Unit No

        1

        helliphelliphelliphelliphelliphelliphelliphelliphellip

        helliphelliphelliphelliphelliphelliphellip

        2

        helliphelliphelliphelliphelliphelliphelliphelliphellip

        helliphelliphelliphelliphelliphelliphellip

        3

        helliphelliphelliphelliphelliphelliphelliphelliphellip

        helliphelliphelliphelliphelliphellip

        4

        helliphelliphelliphelliphelliphelliphelliphelliphellip

        helliphelliphelliphelliphelliphelliphellip

        THB(MR) 020 V40 - May 2013

        Identification band insitu amp details verified and correct

        Patent IV access

        (Patient safety bundle adhered to)

        Blood authorised

        prescribed

        Check for special

        requirements amp consent

        Verbal identification

        at the bedside

        (if applicable)

        Identification band details are verified

        and correct amp match details

        on Traceability ldquobagamp tagrdquo

        label

        DateTime Transfusion completed

        Traceability Tag signed with starting time amp date of transfusion recorded

        Inspect bag

        (condition amp expiry

        date)

        DateTime blood removed from

        cold temperature

        storage

        Baseline Observations recorded on SEWS chart

        (Temperature Pulse

        Oxygen sats Respiration rate

        amp BP)

        Completion of Observations

        Noted on the SEWS chart

        (Temperature Pulse

        Oxygen Sats Respiration rate

        50

        Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

        be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

        Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

        be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

        recorded and concerns escalated to the medical team according to the SEWS

        Adverse Events

        bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

        more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

        hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

        Post Transfusion

        bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

        patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

        bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

        Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

        transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

        patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

        Resources

        Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

        THB(MR)020 v 40 May 2013

        Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

        PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

        51

        9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

        This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

        POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

        Why has this policy been developed

        Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

        Has a risk control plan been developed and who is the owner of the risk If not why not

        Who has been involvedconsulted in the development of the policy

        Has the policy been assessed for Equality and Diversity in relation to-

        Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

        RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

        Please indicate YesNo for the following YES

        Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

        Please indicate Ye sNo for the following YES

        Does the policy contain evidence of the Equality amp

        Diversity Impact Assessment Process

        Is there an implementation plan

        Which officers are responsible for implementation

        When will the policy take effect

        Who must comply with the policystrategy

        How will they be informed of their responsibilities

        Is any training required

        If yes has any been arranged

        Are there any cost implications

        NO

        If yes please detail costs and note source of funding

        Who is responsible for auditing the implementation of the policy

        What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

        2

        POLICY MANAGER________________________ DATE______ _____________________

        • Blood supply in an emergency situation
        • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
        • Administration of Platelets
          • Appendix 1 Adult Blood Transfusion Guideline
            • ADULT BLOOD TRANSFUSION GUIDELINE
              • Remember
                • References
                  • Appendix 3a Flowchart Management of a Transfusion Reaction
                    • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                      • Consent for Transfusion
                      • THB(MR) 020 V40 May 2013
                        • PRE- COLLECTION
                        • PRE-ADMINISTRATION

          5

          1 PURPOSE AND SCOPE

          11 This policy has been developed in response to the identified need to raise awareness in the management of patients receiving blood components or blood products Blood transfusion by definition is the introduction of prepared compatible donor blood components or blood products into the circulation of a recipient patient

          12 Since 2005 all blood components have been excluded from the UK Medicines Act (1968) and therefore supplied as unlicensed non-medicinal products The term ldquoauthorisationrdquo rather than ldquoprescriptionrdquo should be used

          13 It is imperative that any member of staff involved in the transfusion process adheres to this policy in particular

          bull Phlebotomy staff who have a critical duty to carry out required identity checks before taking blood

          transfusion samples from the patient bull Nursing and Midwifery staff who have a critical duty to carry out required checks before taking

          blood transfusion samples collection and delivery of blood components administering the component and observation of the patient during and after the transfusion

          bull Portering staff who are involved the safe collection and transport of blood components

          bull Medical staff and advanced neonatal nurse practitioners who have undergone appropriate training who assess the patient take blood transfusion samples authorise and order transfusion support

          2 STATEMENT OF POLICY 21 The aim of the policy is to ensure the correct componentproduct is given at the correct time in

          the appropriate way to the correct patient

          22 Any member of staff involved in the transfusion process should be conversant with the sections of this document that pertain to their role and have access to appropriate education training and support in its implementation NHS Quality Improvement Scotland Blood Transfusion Standards (2006) recommend that only staff who have completed an appropriate education programme appropriate to their role can participate in the transfusion process

          23 The administration of blood and blood components must only be carried out by suitably trained practitioners Only staff that have completed transfusion training can collect and deliver blood transfusion products and components

          This policy should be read in conjunction with the following documents (Please click on the links below to access)

          bull British Committee for Standards in Haematology(BCSH) Guideline on the Administration of Blood Components (2009)

          httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf

          bull National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusion aspx

          bull NHS Tayside Establishing Patient Identity Policy

          httpedstaysidescotnhsukNHSTaysideDocsgroupscorporatedocumentsdocumentsprod_162299pdf

          bull NHS Tayside Informed Consent Policy

          httpedstaysidescotnhsukNHSTaysideDocsgroupsworking_safelydocumentsdocumentsdocs_016304pdf

          6

          3 RESPONSIBILITIES

          Indications for Blood Transfusion 31 An infusion of blood components may be given to bull Manage acute blood loss bull Replace a deficiency of specific blood components such as erythrocytes platelets or clotting factors bull Increase the oxygen carrying capacity of the blood The final decision to transfuse rests with the clinician in charge of the patientrsquos care 32 An NHS Tayside Adult Blood Transfusion Guideline (Appendix 1 ) provides guidance on when

          blood transfusion is likely to beneficial 33 The Ninewells and PRI Maximum Surgical Blood Ordering Schedule (Appendix 2 ) provides

          further guidance on the recommended amount of red cells to order for different surgical procedures

          Both of these guidelines are available electronically and copies should be available in all clinical areas Additional copies are available from Transfusion Practitionersthe hospital transfusion laboratory 4 ORGANISATIONAL ARRANGEMENTS

          41 Hospital Transfusion Laboratory Contact Information

          bull East of Scotland Blood Transfusion Centre Hospital Transfusion Laboratory

          Ninewells - Extension 32953 Remit covers all clinical areas medical centres and community hospitals in Dundee and Angus

          bull Perth Royal Infirmary Hospital Transfusion Laborato ry

          PRI- Extension 13338 or Pager 5122

          Remit covers all clinical areas medical centres and community hospitals in Perth and Kinross

          42 Blood supply in an emergency situation

          Communication with the local Hospital Transfusion Laboratory (HTL) is key to allowing the department to provide the highest standard of care Under normal circumstances red cells are only issued from the Hospital Transfusion laboratory after full compatibility testing However in the presence of a life-threatening situation in which there is insufficient time to complete these tests clinician responsible for the care of the patient may decide that the situation warrants the use of un-cross matched blood

          When this occurs it is preferable to give blood of the patients own ABO and Rh D group If the urgency of the situation makes this impossible Group O Rh D negative blood may be used Supplies of un-cross matched group specific or Group O Rh D Negative blood are obtainable from the local Hospital Transfusion Laboratory

          In Ninewells Emergency Group O Rh D negative blood is held in

          bull Main Theatre Blood Fridge ndash 2 units

          7

          bull Accident and Emergency Blood Fridge ndash 6 units

          bull Transfusion Laboratory Fridges 4 units

          In Perth Royal Infirmary Group O Rh D negative bloo d is held in bull Main Theatre Blood Fridge ndash 2 units bull Transfusion Laboratory- 2 units

          It is imperative that when these supplies are accessed the Hospital Transfusion Laboratory is informed immediately so that arrangements can be made to replenish stocks

          Supplies of Group O Rh D Negative blood for emergen cy use are also available in

          bull Arbroath Infirmary Blood Fridge ndash 2 units bull Stracathro Hospital Blood Fridge ndash 4 units bull Fernbrae BMI Hospital Blood Fridge- 2 units

          Stracathro Hospital has 4 units of O Rh D negative blood for emergency use for inpatients or theatre cases If the emergency blood is used on a patient in Stracathro then the Hospital Transfusion Laboratory in Ninewells must be informed immediately and elective surgery suspended until replacement emergency blood is in place at the hospital

          It must be remembered that when using un-cross matched blood there is an increased risk of a severe haemolytic transfusion reaction as the patient may have antibodies that react with one of the other blood groups Appendix 3a and 3b contain further information about transfusion reactions and their management Appendix 4 is the UK Blood Safety and Quality Regulations guidance on reporting serious adverse events and reactions Massive Haemorrhage Protocol

          NHS Tayside Guide to Massive Transfusion Blood Loss httpedstaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsprod_174661pdf

          5 PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK

          There are several key considerations when administering blood products or components

          bull The patient receives an appropriate and safe transfusion of blood or blood products bull The patients risk of transfusion reactioncomplications is minimised bull Changes in the patients condition are detected at an early stage bull Adverse events are reported to the hospital transfusion laboratory in a timely manner 51 Decision to Transfuse The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual needs A checklist with additional information for doctors gaining consent from Jehovah Witnesses on blood products that they may accept can be found at appendix 5a

          8

          The decision process leading to transfusion should be documented in the patientrsquos clinical record

          Links to guidance on transfusion issues issued by the British Committee for Standards in Haematology (BCSH) can be found in appendix 5b - Procedural document on decision to transfuse 52 Requesting Transfusion Support

          The request for transfusion support for patients under the care of NHS Tayside should be in accordance with BCSH guidelines

          The procedure for requesting transfusion support can be found in appendix 6 of this document and includes details on consent and documentation availability of patient information leaflets and additional information that is required by the transfusion laboratory before blood is prepared for transfusion

          Appendix 6 also contains indications for Irradiated Blood

          53 Written authorisation (formerly known as prescr iption) of Transfusion Support

          Section130 of the 1968 Medicines Act has been amended by regulation 25 of the Blood Safety and Quality Regulations 2005 (SI 2005 no 50) Blood components are now excluded from the act and the term prescription does not apply as they are not medicinal products the term authorisation should be used

          The authorisation must be signed by the responsible clinician or advanced neonatal nurse practitioner It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009) Blood and blood components must always be authorised prescribed prior to commencement of treatment The procedure is outlined in appendix 7

          54 Taking the blood sample

          The blood sample should be taken in accordance with BCSH guideline on administration of blood components (2009) which takes into account the Blood Safety and Quality Regulations (BSQR (2005) Statutory Instrument 200550 as amended) the National Patient Safety Agency (NPSA) Safer Practice Notices SHOT recommendations and the NHS Quality Improvement Scotland (QIS) 2006 Clinical Standards for Blood Transfusion

          Both the East of Scotland Blood Transfusion Centre and Perth Royal Infirmary Blood Transfusion Laboratory have a zero-tolerance policy in place for incorrectly or inadequately labelled sample request forms and sample bottles The procedure for taking a blood sample is detailed in appendix 8

          55 Collection and Delivery of Blood and Blood Comp onents Collection and delivery of blood and components must be in accordance with BCSH guideline on administration of blood components (2009)

          All staff involved in the collection and delivery of blood components from the storage area to the clinical area should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) and BSQR (SI 2005 No50 as amended) standards The procedure for collecting and delivering blood components is described in appendix 9 56 Administration of Red Cells Blood components must be administered by a registered healthcare professional

          9

          As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

          a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

          The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

          58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

          59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

          510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

          511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

          512 Management of Transfusion Reactions

          In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

          Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

          10

          Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

          513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

          6 KEY CONTACTS

          Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

          Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

          NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

          11

          7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

          12

          httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

          13

          Appendix 1 Adult Blood Transfusion Guideline

          ADULT BLOOD TRANSFUSION GUIDELINE

          bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

          Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

          Remember

          bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

          consider the cause

          References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

          BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

          Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

          This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

          Haemoglobin Less than 8 gdl

          Haemoglobin 8 to 10 gdl

          Haemoglobin Greater than 10gdl

          Yes Possibly if No

          14

          Appendix 2

          Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

          Tariff for Elective Procedures

          2013-09-26 NW amp PRI MSBOS V30

          Procedure

          Tariff

          Procedure

          Tariff

          Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

          excision GampS

          AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

          If surgery for malignancy and pre-op Hblt120 L gdL

          If pre-op Hbgt 120L gdL

          2

          GampS

          Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

          2 Nephrectomy - OPEN 2

          Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

          Colposuspension) GampS

          Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

          GampS Pyeloplasty GampS

          Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

          GampS Total Proctocolectomy 2

          Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

          15

          Appendix 3a Flowchart Management of a Transfusion Reaction

          Symptoms Signs of Acute Transfusion Reaction

          Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

          chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

          Stop the transfusion and call a doctor

          Measure temperature pulse blood pressure respiratory rate amp O2 saturation

          Check identity of the recipient with the details on the unit and compatibility label or tag

          Any discrepancy noted call the transfusion laboratory

          Febrile non-haemolytic transfusion

          reaction

          If temperature rise less than

          20˚C the observations are stable

          and the patient is otherwise well

          give paracetamol

          Restart infusion at slower rate

          and observe more frequently

          Mild allergic reaction

          Give Chlopheniramine 10mg

          slowly iv and restart the

          transfusion at a slower rate and

          observe more frequently

          Reaction

          involves mild

          fever or

          urticarial

          rash only

          Mild fever

          Urticaria

          ABO incompatibility

          Stop transfusion

          Remove unit keeping IV giving set

          attached and c lamped off for return

          to Blood Transfusion Laboratory

          Commence iv saline infusion through

          a NEW IV administration set

          Monitor blood pressure pulse urine

          output (catheterise) frequently Seek

          help from experts in management of

          shock where appropriate

          Treat any DIC with appropriate blood

          components

          Inform Hospital Transfusion

          Laboratory immediately

          Suspected ABO

          incompatibility

          No

          Haemolytic reaction bacterial

          infection of unit

          Stop transfusion

          Take down unit and giving set

          Return intact to blood bank with all

          other usedunused units

          Take blood cultures repeat blood

          group crossmatch FBC coagulation

          screen biochemistry urinalysis

          Monitor urine output

          Commence broad spectrum

          antibiotics if suspected bacterial

          infection

          Commence oxygen and fluid support

          Seek haematological and intensive

          Severe allergic reaction

          Other haemolytic reaction bacterial

          contamination

          Severe allergic reaction

          Bronchospasm angioedema

          abdominal pain hypotension

          Stop transfusion Call for help

          Maintain airway give 100 O2

          If severe hypotension lie patient flat

          with legs elevated Give adrenaline

          (05ml of 1 in 1000 intramuscular )

          NEVER give undiluted epinephrine

          intravascularly

          Paediatric doses depend on the age of

          the child Intramuscular 1 in 1000

          epinephrine should be administered as

          follows

          12 years

          05 milligrams (05 ml)

          6-12 years

          025 milligrams (025ml)

          gt6 months to 6 years 012

          milligrams( 012 ml)

          lt6 months 005 milligrams

          ( 005ml)

          Take down unit and giving set

          Start infusion of crystalloid or colloid

          through a new iv fluid administration

          set

          Secondary therapy

          Chlopheniramine 10mg slow iv

          Salbutamol nebuliser

          Corticosteroids 100-500mg

          Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

          Fluid overload

          Give oxygen

          Diuretic iv

          TRALI

          Clinical features of acute LVF with

          fever and chills

          Discontinue transfusion

          Give 100 Oxygen

          Treat as ARDS ndash ventilate if hypoxia

          indicates

          Acute dyspnoea

          hypotension

          Monitor blood gases

          Perform CXR

          Measure CVP

          Pulmonary capillary

          pressure

          Raised

          CVP

          Normal

          CVP

          No

          Yes

          Yes

          Yes

          No

          No

          16

          Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

          bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

          Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

          bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

          site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

          17

          The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

          The component unit and any remaining contents with the clamped off IV giving set attached

          should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

          Any empty used unit packs from this transfusion episode or unused units of blood issued for

          the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

          Completed Transfusion Reaction form should be returned to the hospital transfusion

          laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

          o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

          Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

          Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

          bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

          bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

          receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

          18

          Appendix 4

          20

          21

          22

          23

          24

          25

          Appendix 5a Jehovah Witness Consent

          CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

          WILLING TO HAVE IF REQUIRED

          REFUSE UNDER ANY CIRCUMSTANCES

          Blood Components Red cells Platelets

          Fresh frozen plasma Cryoprecipitate

          Cell Salvage

          Cell saver- Standard set up

          Cell saver- set up in continuity only

          Blood Products Octaplas (Prothrombin complex

          Concentrate)

          Anti-D Immunoglobulin Albumin

          Factor VIII concentrate Factor IX concentrate

          Fibrinogen Concentrate Recombinant Products

          Erythropoietin Factor VIIa

          I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

          26

          expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

          DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

          27

          Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

          needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

          to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

          bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

          Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

          bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

          transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

          bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

          must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

          (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

          28

          Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

          units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

          desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

          bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

          SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

          requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

          Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

          Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

          - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

          29

          - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

          Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

          bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

          taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

          Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

          unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

          the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

          Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

          date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

          Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

          30

          bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

          The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

          31

          Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

          Practitioner

          bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

          bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

          32

          Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

          Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

          alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

          patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

          Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

          or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

          33

          If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

          if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

          the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

          from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

          the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

          34

          bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

          identity band bull Match all other identifying information

          35

          Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

          been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

          had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

          the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

          bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

          Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

          alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

          you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

          bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

          form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

          bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

          is to take place

          36

          If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

          inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

          delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

          37

          Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

          unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

          are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

          storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

          no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

          transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

          available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

          correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

          for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

          38

          bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

          wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

          blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

          band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

          component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

          checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

          bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

          infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

          2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

          infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

          transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

          Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

          commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

          receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

          blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

          bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

          container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

          Blood Safety and Quality Regulations (2005)

          39

          bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

          bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

          a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

          40

          Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

          inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

          bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

          Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

          depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

          substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

          or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

          urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

          41

          bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

          haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

          42

          Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

          bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

          bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

          bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

          43

          Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

          Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

          Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

          regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

          44

          Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

          negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

          45

          Appendix 15A

          46

          Appendix 15B

          47

          Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

          Please use a new document for each transfusion event

          PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

          HospitalUnit Affix label here or write patient details Forename

          Surname

          Gender

          Date of birth

          CHI

          WardDept

          Consultant

          Authorisation Prescription

          bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

          transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

          chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

          Consent for Transfusion

          bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

          Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

          after reading the PIL Yes No bull Does this patient guardian agree to have a blood

          transfusion No Yes bull Is an advanced directive (refusal of transfusion)

          document in place Yes No Please delete patientguardian as appropriate

          Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

          I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

          Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

          48

          THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

          Patient Name Date of birthCHI

          UN

          IT 1

          Blood component

          Unit Pool mls

          Special Requirements Instructions (please tick)

          Affix completed pink portion of compatibility label here

          Irradiated CMV negative Blood warmer Other medication

          Reason for transfusion

          Date Duration Authoriser Prescriber signature

          Reassess before you progress (Venflon site and observations)

          UN

          IT 2

          Blood component

          Unit Pool mls

          Special Requirements Instructions (please tick)

          Affix completed pink portion of compatibility label here

          Irradiated CMV negative Blood warmer Other medication

          Reason for transfusion

          Date Duration Authoriser Prescriber signature

          Reassess before you progress (Venflon site and observations)

          UN

          IT 3

          Blood component

          Unit Pool mls

          Special Requirements Instructions (please tick)

          Affix completed pink portion of compatibility label here

          Irradiated CMV negative Blood warmer Other medication

          Reason for transfusion

          Date Duration Authoriser Prescriber signature

          Reassess before you progress (Venflon site and observations)

          UN

          IT 4

          Blood component

          Unit Pool mls

          Special Requirements Instructions (please tick)

          Affix completed pink portion of compatibility label here

          Irradiated CMV negative Blood warmer Other medication

          Reason for transfusion

          Date Duration Authoriser Prescriber signature

          THB(MR) 020 V40 May 2013

          THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

          Patient Na me Date of birthCHI

          Transfusion Checklist - Please initial each box as checks are completed

          PRE-

          COLLECTION

          Checks below should be completed before collection of component from temperature

          controlled storage is undertaken

          PRE-

          ADMINISTRATION

          AT BEDSIDE

          Only remove clear outer wrap

          bag immediately prior to commencing transfusion and

          only when all positive identification checks have been

          completed

          POST

          TRANSFUSION

          Unit No

          1

          helliphelliphelliphelliphelliphelliphelliphelliphellip

          helliphelliphelliphelliphelliphelliphellip

          2

          helliphelliphelliphelliphelliphelliphelliphelliphellip

          helliphelliphelliphelliphelliphelliphellip

          3

          helliphelliphelliphelliphelliphelliphelliphelliphellip

          helliphelliphelliphelliphelliphellip

          4

          helliphelliphelliphelliphelliphelliphelliphelliphellip

          helliphelliphelliphelliphelliphelliphellip

          THB(MR) 020 V40 - May 2013

          Identification band insitu amp details verified and correct

          Patent IV access

          (Patient safety bundle adhered to)

          Blood authorised

          prescribed

          Check for special

          requirements amp consent

          Verbal identification

          at the bedside

          (if applicable)

          Identification band details are verified

          and correct amp match details

          on Traceability ldquobagamp tagrdquo

          label

          DateTime Transfusion completed

          Traceability Tag signed with starting time amp date of transfusion recorded

          Inspect bag

          (condition amp expiry

          date)

          DateTime blood removed from

          cold temperature

          storage

          Baseline Observations recorded on SEWS chart

          (Temperature Pulse

          Oxygen sats Respiration rate

          amp BP)

          Completion of Observations

          Noted on the SEWS chart

          (Temperature Pulse

          Oxygen Sats Respiration rate

          50

          Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

          be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

          Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

          be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

          recorded and concerns escalated to the medical team according to the SEWS

          Adverse Events

          bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

          more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

          hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

          Post Transfusion

          bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

          patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

          bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

          Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

          transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

          patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

          Resources

          Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

          THB(MR)020 v 40 May 2013

          Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

          PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

          51

          9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

          This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

          POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

          Why has this policy been developed

          Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

          Has a risk control plan been developed and who is the owner of the risk If not why not

          Who has been involvedconsulted in the development of the policy

          Has the policy been assessed for Equality and Diversity in relation to-

          Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

          RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

          Please indicate YesNo for the following YES

          Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

          Please indicate Ye sNo for the following YES

          Does the policy contain evidence of the Equality amp

          Diversity Impact Assessment Process

          Is there an implementation plan

          Which officers are responsible for implementation

          When will the policy take effect

          Who must comply with the policystrategy

          How will they be informed of their responsibilities

          Is any training required

          If yes has any been arranged

          Are there any cost implications

          NO

          If yes please detail costs and note source of funding

          Who is responsible for auditing the implementation of the policy

          What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

          2

          POLICY MANAGER________________________ DATE______ _____________________

          • Blood supply in an emergency situation
          • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
          • Administration of Platelets
            • Appendix 1 Adult Blood Transfusion Guideline
              • ADULT BLOOD TRANSFUSION GUIDELINE
                • Remember
                  • References
                    • Appendix 3a Flowchart Management of a Transfusion Reaction
                      • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                        • Consent for Transfusion
                        • THB(MR) 020 V40 May 2013
                          • PRE- COLLECTION
                          • PRE-ADMINISTRATION

            6

            3 RESPONSIBILITIES

            Indications for Blood Transfusion 31 An infusion of blood components may be given to bull Manage acute blood loss bull Replace a deficiency of specific blood components such as erythrocytes platelets or clotting factors bull Increase the oxygen carrying capacity of the blood The final decision to transfuse rests with the clinician in charge of the patientrsquos care 32 An NHS Tayside Adult Blood Transfusion Guideline (Appendix 1 ) provides guidance on when

            blood transfusion is likely to beneficial 33 The Ninewells and PRI Maximum Surgical Blood Ordering Schedule (Appendix 2 ) provides

            further guidance on the recommended amount of red cells to order for different surgical procedures

            Both of these guidelines are available electronically and copies should be available in all clinical areas Additional copies are available from Transfusion Practitionersthe hospital transfusion laboratory 4 ORGANISATIONAL ARRANGEMENTS

            41 Hospital Transfusion Laboratory Contact Information

            bull East of Scotland Blood Transfusion Centre Hospital Transfusion Laboratory

            Ninewells - Extension 32953 Remit covers all clinical areas medical centres and community hospitals in Dundee and Angus

            bull Perth Royal Infirmary Hospital Transfusion Laborato ry

            PRI- Extension 13338 or Pager 5122

            Remit covers all clinical areas medical centres and community hospitals in Perth and Kinross

            42 Blood supply in an emergency situation

            Communication with the local Hospital Transfusion Laboratory (HTL) is key to allowing the department to provide the highest standard of care Under normal circumstances red cells are only issued from the Hospital Transfusion laboratory after full compatibility testing However in the presence of a life-threatening situation in which there is insufficient time to complete these tests clinician responsible for the care of the patient may decide that the situation warrants the use of un-cross matched blood

            When this occurs it is preferable to give blood of the patients own ABO and Rh D group If the urgency of the situation makes this impossible Group O Rh D negative blood may be used Supplies of un-cross matched group specific or Group O Rh D Negative blood are obtainable from the local Hospital Transfusion Laboratory

            In Ninewells Emergency Group O Rh D negative blood is held in

            bull Main Theatre Blood Fridge ndash 2 units

            7

            bull Accident and Emergency Blood Fridge ndash 6 units

            bull Transfusion Laboratory Fridges 4 units

            In Perth Royal Infirmary Group O Rh D negative bloo d is held in bull Main Theatre Blood Fridge ndash 2 units bull Transfusion Laboratory- 2 units

            It is imperative that when these supplies are accessed the Hospital Transfusion Laboratory is informed immediately so that arrangements can be made to replenish stocks

            Supplies of Group O Rh D Negative blood for emergen cy use are also available in

            bull Arbroath Infirmary Blood Fridge ndash 2 units bull Stracathro Hospital Blood Fridge ndash 4 units bull Fernbrae BMI Hospital Blood Fridge- 2 units

            Stracathro Hospital has 4 units of O Rh D negative blood for emergency use for inpatients or theatre cases If the emergency blood is used on a patient in Stracathro then the Hospital Transfusion Laboratory in Ninewells must be informed immediately and elective surgery suspended until replacement emergency blood is in place at the hospital

            It must be remembered that when using un-cross matched blood there is an increased risk of a severe haemolytic transfusion reaction as the patient may have antibodies that react with one of the other blood groups Appendix 3a and 3b contain further information about transfusion reactions and their management Appendix 4 is the UK Blood Safety and Quality Regulations guidance on reporting serious adverse events and reactions Massive Haemorrhage Protocol

            NHS Tayside Guide to Massive Transfusion Blood Loss httpedstaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsprod_174661pdf

            5 PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK

            There are several key considerations when administering blood products or components

            bull The patient receives an appropriate and safe transfusion of blood or blood products bull The patients risk of transfusion reactioncomplications is minimised bull Changes in the patients condition are detected at an early stage bull Adverse events are reported to the hospital transfusion laboratory in a timely manner 51 Decision to Transfuse The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual needs A checklist with additional information for doctors gaining consent from Jehovah Witnesses on blood products that they may accept can be found at appendix 5a

            8

            The decision process leading to transfusion should be documented in the patientrsquos clinical record

            Links to guidance on transfusion issues issued by the British Committee for Standards in Haematology (BCSH) can be found in appendix 5b - Procedural document on decision to transfuse 52 Requesting Transfusion Support

            The request for transfusion support for patients under the care of NHS Tayside should be in accordance with BCSH guidelines

            The procedure for requesting transfusion support can be found in appendix 6 of this document and includes details on consent and documentation availability of patient information leaflets and additional information that is required by the transfusion laboratory before blood is prepared for transfusion

            Appendix 6 also contains indications for Irradiated Blood

            53 Written authorisation (formerly known as prescr iption) of Transfusion Support

            Section130 of the 1968 Medicines Act has been amended by regulation 25 of the Blood Safety and Quality Regulations 2005 (SI 2005 no 50) Blood components are now excluded from the act and the term prescription does not apply as they are not medicinal products the term authorisation should be used

            The authorisation must be signed by the responsible clinician or advanced neonatal nurse practitioner It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009) Blood and blood components must always be authorised prescribed prior to commencement of treatment The procedure is outlined in appendix 7

            54 Taking the blood sample

            The blood sample should be taken in accordance with BCSH guideline on administration of blood components (2009) which takes into account the Blood Safety and Quality Regulations (BSQR (2005) Statutory Instrument 200550 as amended) the National Patient Safety Agency (NPSA) Safer Practice Notices SHOT recommendations and the NHS Quality Improvement Scotland (QIS) 2006 Clinical Standards for Blood Transfusion

            Both the East of Scotland Blood Transfusion Centre and Perth Royal Infirmary Blood Transfusion Laboratory have a zero-tolerance policy in place for incorrectly or inadequately labelled sample request forms and sample bottles The procedure for taking a blood sample is detailed in appendix 8

            55 Collection and Delivery of Blood and Blood Comp onents Collection and delivery of blood and components must be in accordance with BCSH guideline on administration of blood components (2009)

            All staff involved in the collection and delivery of blood components from the storage area to the clinical area should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) and BSQR (SI 2005 No50 as amended) standards The procedure for collecting and delivering blood components is described in appendix 9 56 Administration of Red Cells Blood components must be administered by a registered healthcare professional

            9

            As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

            a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

            The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

            58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

            59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

            510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

            511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

            512 Management of Transfusion Reactions

            In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

            Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

            10

            Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

            513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

            6 KEY CONTACTS

            Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

            Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

            NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

            11

            7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

            12

            httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

            13

            Appendix 1 Adult Blood Transfusion Guideline

            ADULT BLOOD TRANSFUSION GUIDELINE

            bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

            Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

            Remember

            bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

            consider the cause

            References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

            BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

            Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

            This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

            Haemoglobin Less than 8 gdl

            Haemoglobin 8 to 10 gdl

            Haemoglobin Greater than 10gdl

            Yes Possibly if No

            14

            Appendix 2

            Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

            Tariff for Elective Procedures

            2013-09-26 NW amp PRI MSBOS V30

            Procedure

            Tariff

            Procedure

            Tariff

            Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

            excision GampS

            AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

            If surgery for malignancy and pre-op Hblt120 L gdL

            If pre-op Hbgt 120L gdL

            2

            GampS

            Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

            2 Nephrectomy - OPEN 2

            Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

            Colposuspension) GampS

            Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

            GampS Pyeloplasty GampS

            Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

            GampS Total Proctocolectomy 2

            Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

            15

            Appendix 3a Flowchart Management of a Transfusion Reaction

            Symptoms Signs of Acute Transfusion Reaction

            Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

            chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

            Stop the transfusion and call a doctor

            Measure temperature pulse blood pressure respiratory rate amp O2 saturation

            Check identity of the recipient with the details on the unit and compatibility label or tag

            Any discrepancy noted call the transfusion laboratory

            Febrile non-haemolytic transfusion

            reaction

            If temperature rise less than

            20˚C the observations are stable

            and the patient is otherwise well

            give paracetamol

            Restart infusion at slower rate

            and observe more frequently

            Mild allergic reaction

            Give Chlopheniramine 10mg

            slowly iv and restart the

            transfusion at a slower rate and

            observe more frequently

            Reaction

            involves mild

            fever or

            urticarial

            rash only

            Mild fever

            Urticaria

            ABO incompatibility

            Stop transfusion

            Remove unit keeping IV giving set

            attached and c lamped off for return

            to Blood Transfusion Laboratory

            Commence iv saline infusion through

            a NEW IV administration set

            Monitor blood pressure pulse urine

            output (catheterise) frequently Seek

            help from experts in management of

            shock where appropriate

            Treat any DIC with appropriate blood

            components

            Inform Hospital Transfusion

            Laboratory immediately

            Suspected ABO

            incompatibility

            No

            Haemolytic reaction bacterial

            infection of unit

            Stop transfusion

            Take down unit and giving set

            Return intact to blood bank with all

            other usedunused units

            Take blood cultures repeat blood

            group crossmatch FBC coagulation

            screen biochemistry urinalysis

            Monitor urine output

            Commence broad spectrum

            antibiotics if suspected bacterial

            infection

            Commence oxygen and fluid support

            Seek haematological and intensive

            Severe allergic reaction

            Other haemolytic reaction bacterial

            contamination

            Severe allergic reaction

            Bronchospasm angioedema

            abdominal pain hypotension

            Stop transfusion Call for help

            Maintain airway give 100 O2

            If severe hypotension lie patient flat

            with legs elevated Give adrenaline

            (05ml of 1 in 1000 intramuscular )

            NEVER give undiluted epinephrine

            intravascularly

            Paediatric doses depend on the age of

            the child Intramuscular 1 in 1000

            epinephrine should be administered as

            follows

            12 years

            05 milligrams (05 ml)

            6-12 years

            025 milligrams (025ml)

            gt6 months to 6 years 012

            milligrams( 012 ml)

            lt6 months 005 milligrams

            ( 005ml)

            Take down unit and giving set

            Start infusion of crystalloid or colloid

            through a new iv fluid administration

            set

            Secondary therapy

            Chlopheniramine 10mg slow iv

            Salbutamol nebuliser

            Corticosteroids 100-500mg

            Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

            Fluid overload

            Give oxygen

            Diuretic iv

            TRALI

            Clinical features of acute LVF with

            fever and chills

            Discontinue transfusion

            Give 100 Oxygen

            Treat as ARDS ndash ventilate if hypoxia

            indicates

            Acute dyspnoea

            hypotension

            Monitor blood gases

            Perform CXR

            Measure CVP

            Pulmonary capillary

            pressure

            Raised

            CVP

            Normal

            CVP

            No

            Yes

            Yes

            Yes

            No

            No

            16

            Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

            bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

            Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

            bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

            site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

            17

            The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

            The component unit and any remaining contents with the clamped off IV giving set attached

            should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

            Any empty used unit packs from this transfusion episode or unused units of blood issued for

            the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

            Completed Transfusion Reaction form should be returned to the hospital transfusion

            laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

            o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

            Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

            Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

            bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

            bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

            receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

            18

            Appendix 4

            20

            21

            22

            23

            24

            25

            Appendix 5a Jehovah Witness Consent

            CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

            WILLING TO HAVE IF REQUIRED

            REFUSE UNDER ANY CIRCUMSTANCES

            Blood Components Red cells Platelets

            Fresh frozen plasma Cryoprecipitate

            Cell Salvage

            Cell saver- Standard set up

            Cell saver- set up in continuity only

            Blood Products Octaplas (Prothrombin complex

            Concentrate)

            Anti-D Immunoglobulin Albumin

            Factor VIII concentrate Factor IX concentrate

            Fibrinogen Concentrate Recombinant Products

            Erythropoietin Factor VIIa

            I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

            26

            expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

            DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

            27

            Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

            needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

            to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

            bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

            Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

            bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

            transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

            bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

            must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

            (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

            28

            Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

            units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

            desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

            bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

            SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

            requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

            Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

            Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

            - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

            29

            - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

            Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

            bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

            taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

            Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

            unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

            the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

            Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

            date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

            Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

            30

            bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

            The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

            31

            Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

            Practitioner

            bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

            bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

            32

            Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

            Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

            alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

            patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

            Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

            or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

            33

            If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

            if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

            the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

            from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

            the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

            34

            bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

            identity band bull Match all other identifying information

            35

            Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

            been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

            had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

            the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

            bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

            Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

            alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

            you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

            bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

            form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

            bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

            is to take place

            36

            If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

            inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

            delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

            37

            Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

            unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

            are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

            storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

            no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

            transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

            available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

            correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

            for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

            38

            bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

            wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

            blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

            band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

            component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

            checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

            bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

            infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

            2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

            infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

            transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

            Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

            commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

            receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

            blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

            bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

            container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

            Blood Safety and Quality Regulations (2005)

            39

            bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

            bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

            a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

            40

            Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

            inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

            bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

            Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

            depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

            substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

            or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

            urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

            41

            bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

            haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

            42

            Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

            bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

            bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

            bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

            43

            Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

            Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

            Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

            regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

            44

            Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

            negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

            45

            Appendix 15A

            46

            Appendix 15B

            47

            Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

            Please use a new document for each transfusion event

            PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

            HospitalUnit Affix label here or write patient details Forename

            Surname

            Gender

            Date of birth

            CHI

            WardDept

            Consultant

            Authorisation Prescription

            bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

            transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

            chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

            Consent for Transfusion

            bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

            Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

            after reading the PIL Yes No bull Does this patient guardian agree to have a blood

            transfusion No Yes bull Is an advanced directive (refusal of transfusion)

            document in place Yes No Please delete patientguardian as appropriate

            Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

            I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

            Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

            48

            THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

            Patient Name Date of birthCHI

            UN

            IT 1

            Blood component

            Unit Pool mls

            Special Requirements Instructions (please tick)

            Affix completed pink portion of compatibility label here

            Irradiated CMV negative Blood warmer Other medication

            Reason for transfusion

            Date Duration Authoriser Prescriber signature

            Reassess before you progress (Venflon site and observations)

            UN

            IT 2

            Blood component

            Unit Pool mls

            Special Requirements Instructions (please tick)

            Affix completed pink portion of compatibility label here

            Irradiated CMV negative Blood warmer Other medication

            Reason for transfusion

            Date Duration Authoriser Prescriber signature

            Reassess before you progress (Venflon site and observations)

            UN

            IT 3

            Blood component

            Unit Pool mls

            Special Requirements Instructions (please tick)

            Affix completed pink portion of compatibility label here

            Irradiated CMV negative Blood warmer Other medication

            Reason for transfusion

            Date Duration Authoriser Prescriber signature

            Reassess before you progress (Venflon site and observations)

            UN

            IT 4

            Blood component

            Unit Pool mls

            Special Requirements Instructions (please tick)

            Affix completed pink portion of compatibility label here

            Irradiated CMV negative Blood warmer Other medication

            Reason for transfusion

            Date Duration Authoriser Prescriber signature

            THB(MR) 020 V40 May 2013

            THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

            Patient Na me Date of birthCHI

            Transfusion Checklist - Please initial each box as checks are completed

            PRE-

            COLLECTION

            Checks below should be completed before collection of component from temperature

            controlled storage is undertaken

            PRE-

            ADMINISTRATION

            AT BEDSIDE

            Only remove clear outer wrap

            bag immediately prior to commencing transfusion and

            only when all positive identification checks have been

            completed

            POST

            TRANSFUSION

            Unit No

            1

            helliphelliphelliphelliphelliphelliphelliphelliphellip

            helliphelliphelliphelliphelliphelliphellip

            2

            helliphelliphelliphelliphelliphelliphelliphelliphellip

            helliphelliphelliphelliphelliphelliphellip

            3

            helliphelliphelliphelliphelliphelliphelliphelliphellip

            helliphelliphelliphelliphelliphellip

            4

            helliphelliphelliphelliphelliphelliphelliphelliphellip

            helliphelliphelliphelliphelliphelliphellip

            THB(MR) 020 V40 - May 2013

            Identification band insitu amp details verified and correct

            Patent IV access

            (Patient safety bundle adhered to)

            Blood authorised

            prescribed

            Check for special

            requirements amp consent

            Verbal identification

            at the bedside

            (if applicable)

            Identification band details are verified

            and correct amp match details

            on Traceability ldquobagamp tagrdquo

            label

            DateTime Transfusion completed

            Traceability Tag signed with starting time amp date of transfusion recorded

            Inspect bag

            (condition amp expiry

            date)

            DateTime blood removed from

            cold temperature

            storage

            Baseline Observations recorded on SEWS chart

            (Temperature Pulse

            Oxygen sats Respiration rate

            amp BP)

            Completion of Observations

            Noted on the SEWS chart

            (Temperature Pulse

            Oxygen Sats Respiration rate

            50

            Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

            be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

            Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

            be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

            recorded and concerns escalated to the medical team according to the SEWS

            Adverse Events

            bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

            more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

            hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

            Post Transfusion

            bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

            patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

            bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

            Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

            transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

            patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

            Resources

            Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

            THB(MR)020 v 40 May 2013

            Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

            PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

            51

            9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

            This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

            POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

            Why has this policy been developed

            Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

            Has a risk control plan been developed and who is the owner of the risk If not why not

            Who has been involvedconsulted in the development of the policy

            Has the policy been assessed for Equality and Diversity in relation to-

            Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

            RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

            Please indicate YesNo for the following YES

            Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

            Please indicate Ye sNo for the following YES

            Does the policy contain evidence of the Equality amp

            Diversity Impact Assessment Process

            Is there an implementation plan

            Which officers are responsible for implementation

            When will the policy take effect

            Who must comply with the policystrategy

            How will they be informed of their responsibilities

            Is any training required

            If yes has any been arranged

            Are there any cost implications

            NO

            If yes please detail costs and note source of funding

            Who is responsible for auditing the implementation of the policy

            What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

            2

            POLICY MANAGER________________________ DATE______ _____________________

            • Blood supply in an emergency situation
            • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
            • Administration of Platelets
              • Appendix 1 Adult Blood Transfusion Guideline
                • ADULT BLOOD TRANSFUSION GUIDELINE
                  • Remember
                    • References
                      • Appendix 3a Flowchart Management of a Transfusion Reaction
                        • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                          • Consent for Transfusion
                          • THB(MR) 020 V40 May 2013
                            • PRE- COLLECTION
                            • PRE-ADMINISTRATION

              7

              bull Accident and Emergency Blood Fridge ndash 6 units

              bull Transfusion Laboratory Fridges 4 units

              In Perth Royal Infirmary Group O Rh D negative bloo d is held in bull Main Theatre Blood Fridge ndash 2 units bull Transfusion Laboratory- 2 units

              It is imperative that when these supplies are accessed the Hospital Transfusion Laboratory is informed immediately so that arrangements can be made to replenish stocks

              Supplies of Group O Rh D Negative blood for emergen cy use are also available in

              bull Arbroath Infirmary Blood Fridge ndash 2 units bull Stracathro Hospital Blood Fridge ndash 4 units bull Fernbrae BMI Hospital Blood Fridge- 2 units

              Stracathro Hospital has 4 units of O Rh D negative blood for emergency use for inpatients or theatre cases If the emergency blood is used on a patient in Stracathro then the Hospital Transfusion Laboratory in Ninewells must be informed immediately and elective surgery suspended until replacement emergency blood is in place at the hospital

              It must be remembered that when using un-cross matched blood there is an increased risk of a severe haemolytic transfusion reaction as the patient may have antibodies that react with one of the other blood groups Appendix 3a and 3b contain further information about transfusion reactions and their management Appendix 4 is the UK Blood Safety and Quality Regulations guidance on reporting serious adverse events and reactions Massive Haemorrhage Protocol

              NHS Tayside Guide to Massive Transfusion Blood Loss httpedstaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsprod_174661pdf

              5 PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK

              There are several key considerations when administering blood products or components

              bull The patient receives an appropriate and safe transfusion of blood or blood products bull The patients risk of transfusion reactioncomplications is minimised bull Changes in the patients condition are detected at an early stage bull Adverse events are reported to the hospital transfusion laboratory in a timely manner 51 Decision to Transfuse The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual needs A checklist with additional information for doctors gaining consent from Jehovah Witnesses on blood products that they may accept can be found at appendix 5a

              8

              The decision process leading to transfusion should be documented in the patientrsquos clinical record

              Links to guidance on transfusion issues issued by the British Committee for Standards in Haematology (BCSH) can be found in appendix 5b - Procedural document on decision to transfuse 52 Requesting Transfusion Support

              The request for transfusion support for patients under the care of NHS Tayside should be in accordance with BCSH guidelines

              The procedure for requesting transfusion support can be found in appendix 6 of this document and includes details on consent and documentation availability of patient information leaflets and additional information that is required by the transfusion laboratory before blood is prepared for transfusion

              Appendix 6 also contains indications for Irradiated Blood

              53 Written authorisation (formerly known as prescr iption) of Transfusion Support

              Section130 of the 1968 Medicines Act has been amended by regulation 25 of the Blood Safety and Quality Regulations 2005 (SI 2005 no 50) Blood components are now excluded from the act and the term prescription does not apply as they are not medicinal products the term authorisation should be used

              The authorisation must be signed by the responsible clinician or advanced neonatal nurse practitioner It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009) Blood and blood components must always be authorised prescribed prior to commencement of treatment The procedure is outlined in appendix 7

              54 Taking the blood sample

              The blood sample should be taken in accordance with BCSH guideline on administration of blood components (2009) which takes into account the Blood Safety and Quality Regulations (BSQR (2005) Statutory Instrument 200550 as amended) the National Patient Safety Agency (NPSA) Safer Practice Notices SHOT recommendations and the NHS Quality Improvement Scotland (QIS) 2006 Clinical Standards for Blood Transfusion

              Both the East of Scotland Blood Transfusion Centre and Perth Royal Infirmary Blood Transfusion Laboratory have a zero-tolerance policy in place for incorrectly or inadequately labelled sample request forms and sample bottles The procedure for taking a blood sample is detailed in appendix 8

              55 Collection and Delivery of Blood and Blood Comp onents Collection and delivery of blood and components must be in accordance with BCSH guideline on administration of blood components (2009)

              All staff involved in the collection and delivery of blood components from the storage area to the clinical area should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) and BSQR (SI 2005 No50 as amended) standards The procedure for collecting and delivering blood components is described in appendix 9 56 Administration of Red Cells Blood components must be administered by a registered healthcare professional

              9

              As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

              a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

              The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

              58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

              59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

              510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

              511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

              512 Management of Transfusion Reactions

              In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

              Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

              10

              Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

              513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

              6 KEY CONTACTS

              Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

              Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

              NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

              11

              7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

              12

              httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

              13

              Appendix 1 Adult Blood Transfusion Guideline

              ADULT BLOOD TRANSFUSION GUIDELINE

              bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

              Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

              Remember

              bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

              consider the cause

              References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

              BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

              Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

              This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

              Haemoglobin Less than 8 gdl

              Haemoglobin 8 to 10 gdl

              Haemoglobin Greater than 10gdl

              Yes Possibly if No

              14

              Appendix 2

              Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

              Tariff for Elective Procedures

              2013-09-26 NW amp PRI MSBOS V30

              Procedure

              Tariff

              Procedure

              Tariff

              Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

              excision GampS

              AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

              If surgery for malignancy and pre-op Hblt120 L gdL

              If pre-op Hbgt 120L gdL

              2

              GampS

              Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

              2 Nephrectomy - OPEN 2

              Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

              Colposuspension) GampS

              Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

              GampS Pyeloplasty GampS

              Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

              GampS Total Proctocolectomy 2

              Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

              15

              Appendix 3a Flowchart Management of a Transfusion Reaction

              Symptoms Signs of Acute Transfusion Reaction

              Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

              chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

              Stop the transfusion and call a doctor

              Measure temperature pulse blood pressure respiratory rate amp O2 saturation

              Check identity of the recipient with the details on the unit and compatibility label or tag

              Any discrepancy noted call the transfusion laboratory

              Febrile non-haemolytic transfusion

              reaction

              If temperature rise less than

              20˚C the observations are stable

              and the patient is otherwise well

              give paracetamol

              Restart infusion at slower rate

              and observe more frequently

              Mild allergic reaction

              Give Chlopheniramine 10mg

              slowly iv and restart the

              transfusion at a slower rate and

              observe more frequently

              Reaction

              involves mild

              fever or

              urticarial

              rash only

              Mild fever

              Urticaria

              ABO incompatibility

              Stop transfusion

              Remove unit keeping IV giving set

              attached and c lamped off for return

              to Blood Transfusion Laboratory

              Commence iv saline infusion through

              a NEW IV administration set

              Monitor blood pressure pulse urine

              output (catheterise) frequently Seek

              help from experts in management of

              shock where appropriate

              Treat any DIC with appropriate blood

              components

              Inform Hospital Transfusion

              Laboratory immediately

              Suspected ABO

              incompatibility

              No

              Haemolytic reaction bacterial

              infection of unit

              Stop transfusion

              Take down unit and giving set

              Return intact to blood bank with all

              other usedunused units

              Take blood cultures repeat blood

              group crossmatch FBC coagulation

              screen biochemistry urinalysis

              Monitor urine output

              Commence broad spectrum

              antibiotics if suspected bacterial

              infection

              Commence oxygen and fluid support

              Seek haematological and intensive

              Severe allergic reaction

              Other haemolytic reaction bacterial

              contamination

              Severe allergic reaction

              Bronchospasm angioedema

              abdominal pain hypotension

              Stop transfusion Call for help

              Maintain airway give 100 O2

              If severe hypotension lie patient flat

              with legs elevated Give adrenaline

              (05ml of 1 in 1000 intramuscular )

              NEVER give undiluted epinephrine

              intravascularly

              Paediatric doses depend on the age of

              the child Intramuscular 1 in 1000

              epinephrine should be administered as

              follows

              12 years

              05 milligrams (05 ml)

              6-12 years

              025 milligrams (025ml)

              gt6 months to 6 years 012

              milligrams( 012 ml)

              lt6 months 005 milligrams

              ( 005ml)

              Take down unit and giving set

              Start infusion of crystalloid or colloid

              through a new iv fluid administration

              set

              Secondary therapy

              Chlopheniramine 10mg slow iv

              Salbutamol nebuliser

              Corticosteroids 100-500mg

              Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

              Fluid overload

              Give oxygen

              Diuretic iv

              TRALI

              Clinical features of acute LVF with

              fever and chills

              Discontinue transfusion

              Give 100 Oxygen

              Treat as ARDS ndash ventilate if hypoxia

              indicates

              Acute dyspnoea

              hypotension

              Monitor blood gases

              Perform CXR

              Measure CVP

              Pulmonary capillary

              pressure

              Raised

              CVP

              Normal

              CVP

              No

              Yes

              Yes

              Yes

              No

              No

              16

              Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

              bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

              Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

              bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

              site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

              17

              The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

              The component unit and any remaining contents with the clamped off IV giving set attached

              should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

              Any empty used unit packs from this transfusion episode or unused units of blood issued for

              the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

              Completed Transfusion Reaction form should be returned to the hospital transfusion

              laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

              o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

              Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

              Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

              bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

              bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

              receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

              18

              Appendix 4

              20

              21

              22

              23

              24

              25

              Appendix 5a Jehovah Witness Consent

              CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

              WILLING TO HAVE IF REQUIRED

              REFUSE UNDER ANY CIRCUMSTANCES

              Blood Components Red cells Platelets

              Fresh frozen plasma Cryoprecipitate

              Cell Salvage

              Cell saver- Standard set up

              Cell saver- set up in continuity only

              Blood Products Octaplas (Prothrombin complex

              Concentrate)

              Anti-D Immunoglobulin Albumin

              Factor VIII concentrate Factor IX concentrate

              Fibrinogen Concentrate Recombinant Products

              Erythropoietin Factor VIIa

              I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

              26

              expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

              DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

              27

              Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

              needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

              to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

              bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

              Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

              bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

              transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

              bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

              must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

              (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

              28

              Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

              units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

              desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

              bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

              SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

              requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

              Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

              Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

              - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

              29

              - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

              Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

              bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

              taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

              Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

              unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

              the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

              Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

              date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

              Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

              30

              bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

              The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

              31

              Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

              Practitioner

              bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

              bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

              32

              Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

              Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

              alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

              patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

              Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

              or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

              33

              If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

              if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

              the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

              from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

              the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

              34

              bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

              identity band bull Match all other identifying information

              35

              Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

              been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

              had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

              the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

              bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

              Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

              alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

              you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

              bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

              form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

              bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

              is to take place

              36

              If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

              inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

              delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

              37

              Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

              unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

              are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

              storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

              no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

              transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

              available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

              correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

              for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

              38

              bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

              wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

              blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

              band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

              component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

              checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

              bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

              infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

              2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

              infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

              transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

              Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

              commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

              receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

              blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

              bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

              container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

              Blood Safety and Quality Regulations (2005)

              39

              bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

              bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

              a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

              40

              Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

              inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

              bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

              Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

              depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

              substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

              or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

              urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

              41

              bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

              haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

              42

              Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

              bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

              bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

              bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

              43

              Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

              Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

              Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

              regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

              44

              Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

              negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

              45

              Appendix 15A

              46

              Appendix 15B

              47

              Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

              Please use a new document for each transfusion event

              PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

              HospitalUnit Affix label here or write patient details Forename

              Surname

              Gender

              Date of birth

              CHI

              WardDept

              Consultant

              Authorisation Prescription

              bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

              transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

              chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

              Consent for Transfusion

              bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

              Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

              after reading the PIL Yes No bull Does this patient guardian agree to have a blood

              transfusion No Yes bull Is an advanced directive (refusal of transfusion)

              document in place Yes No Please delete patientguardian as appropriate

              Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

              I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

              Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

              48

              THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

              Patient Name Date of birthCHI

              UN

              IT 1

              Blood component

              Unit Pool mls

              Special Requirements Instructions (please tick)

              Affix completed pink portion of compatibility label here

              Irradiated CMV negative Blood warmer Other medication

              Reason for transfusion

              Date Duration Authoriser Prescriber signature

              Reassess before you progress (Venflon site and observations)

              UN

              IT 2

              Blood component

              Unit Pool mls

              Special Requirements Instructions (please tick)

              Affix completed pink portion of compatibility label here

              Irradiated CMV negative Blood warmer Other medication

              Reason for transfusion

              Date Duration Authoriser Prescriber signature

              Reassess before you progress (Venflon site and observations)

              UN

              IT 3

              Blood component

              Unit Pool mls

              Special Requirements Instructions (please tick)

              Affix completed pink portion of compatibility label here

              Irradiated CMV negative Blood warmer Other medication

              Reason for transfusion

              Date Duration Authoriser Prescriber signature

              Reassess before you progress (Venflon site and observations)

              UN

              IT 4

              Blood component

              Unit Pool mls

              Special Requirements Instructions (please tick)

              Affix completed pink portion of compatibility label here

              Irradiated CMV negative Blood warmer Other medication

              Reason for transfusion

              Date Duration Authoriser Prescriber signature

              THB(MR) 020 V40 May 2013

              THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

              Patient Na me Date of birthCHI

              Transfusion Checklist - Please initial each box as checks are completed

              PRE-

              COLLECTION

              Checks below should be completed before collection of component from temperature

              controlled storage is undertaken

              PRE-

              ADMINISTRATION

              AT BEDSIDE

              Only remove clear outer wrap

              bag immediately prior to commencing transfusion and

              only when all positive identification checks have been

              completed

              POST

              TRANSFUSION

              Unit No

              1

              helliphelliphelliphelliphelliphelliphelliphelliphellip

              helliphelliphelliphelliphelliphelliphellip

              2

              helliphelliphelliphelliphelliphelliphelliphelliphellip

              helliphelliphelliphelliphelliphelliphellip

              3

              helliphelliphelliphelliphelliphelliphelliphelliphellip

              helliphelliphelliphelliphelliphellip

              4

              helliphelliphelliphelliphelliphelliphelliphelliphellip

              helliphelliphelliphelliphelliphelliphellip

              THB(MR) 020 V40 - May 2013

              Identification band insitu amp details verified and correct

              Patent IV access

              (Patient safety bundle adhered to)

              Blood authorised

              prescribed

              Check for special

              requirements amp consent

              Verbal identification

              at the bedside

              (if applicable)

              Identification band details are verified

              and correct amp match details

              on Traceability ldquobagamp tagrdquo

              label

              DateTime Transfusion completed

              Traceability Tag signed with starting time amp date of transfusion recorded

              Inspect bag

              (condition amp expiry

              date)

              DateTime blood removed from

              cold temperature

              storage

              Baseline Observations recorded on SEWS chart

              (Temperature Pulse

              Oxygen sats Respiration rate

              amp BP)

              Completion of Observations

              Noted on the SEWS chart

              (Temperature Pulse

              Oxygen Sats Respiration rate

              50

              Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

              be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

              Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

              be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

              recorded and concerns escalated to the medical team according to the SEWS

              Adverse Events

              bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

              more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

              hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

              Post Transfusion

              bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

              patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

              bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

              Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

              transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

              patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

              Resources

              Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

              THB(MR)020 v 40 May 2013

              Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

              PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

              51

              9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

              This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

              POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

              Why has this policy been developed

              Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

              Has a risk control plan been developed and who is the owner of the risk If not why not

              Who has been involvedconsulted in the development of the policy

              Has the policy been assessed for Equality and Diversity in relation to-

              Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

              RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

              Please indicate YesNo for the following YES

              Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

              Please indicate Ye sNo for the following YES

              Does the policy contain evidence of the Equality amp

              Diversity Impact Assessment Process

              Is there an implementation plan

              Which officers are responsible for implementation

              When will the policy take effect

              Who must comply with the policystrategy

              How will they be informed of their responsibilities

              Is any training required

              If yes has any been arranged

              Are there any cost implications

              NO

              If yes please detail costs and note source of funding

              Who is responsible for auditing the implementation of the policy

              What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

              2

              POLICY MANAGER________________________ DATE______ _____________________

              • Blood supply in an emergency situation
              • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
              • Administration of Platelets
                • Appendix 1 Adult Blood Transfusion Guideline
                  • ADULT BLOOD TRANSFUSION GUIDELINE
                    • Remember
                      • References
                        • Appendix 3a Flowchart Management of a Transfusion Reaction
                          • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                            • Consent for Transfusion
                            • THB(MR) 020 V40 May 2013
                              • PRE- COLLECTION
                              • PRE-ADMINISTRATION

                8

                The decision process leading to transfusion should be documented in the patientrsquos clinical record

                Links to guidance on transfusion issues issued by the British Committee for Standards in Haematology (BCSH) can be found in appendix 5b - Procedural document on decision to transfuse 52 Requesting Transfusion Support

                The request for transfusion support for patients under the care of NHS Tayside should be in accordance with BCSH guidelines

                The procedure for requesting transfusion support can be found in appendix 6 of this document and includes details on consent and documentation availability of patient information leaflets and additional information that is required by the transfusion laboratory before blood is prepared for transfusion

                Appendix 6 also contains indications for Irradiated Blood

                53 Written authorisation (formerly known as prescr iption) of Transfusion Support

                Section130 of the 1968 Medicines Act has been amended by regulation 25 of the Blood Safety and Quality Regulations 2005 (SI 2005 no 50) Blood components are now excluded from the act and the term prescription does not apply as they are not medicinal products the term authorisation should be used

                The authorisation must be signed by the responsible clinician or advanced neonatal nurse practitioner It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009) Blood and blood components must always be authorised prescribed prior to commencement of treatment The procedure is outlined in appendix 7

                54 Taking the blood sample

                The blood sample should be taken in accordance with BCSH guideline on administration of blood components (2009) which takes into account the Blood Safety and Quality Regulations (BSQR (2005) Statutory Instrument 200550 as amended) the National Patient Safety Agency (NPSA) Safer Practice Notices SHOT recommendations and the NHS Quality Improvement Scotland (QIS) 2006 Clinical Standards for Blood Transfusion

                Both the East of Scotland Blood Transfusion Centre and Perth Royal Infirmary Blood Transfusion Laboratory have a zero-tolerance policy in place for incorrectly or inadequately labelled sample request forms and sample bottles The procedure for taking a blood sample is detailed in appendix 8

                55 Collection and Delivery of Blood and Blood Comp onents Collection and delivery of blood and components must be in accordance with BCSH guideline on administration of blood components (2009)

                All staff involved in the collection and delivery of blood components from the storage area to the clinical area should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) and BSQR (SI 2005 No50 as amended) standards The procedure for collecting and delivering blood components is described in appendix 9 56 Administration of Red Cells Blood components must be administered by a registered healthcare professional

                9

                As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

                a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

                The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

                58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

                59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

                510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

                511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

                512 Management of Transfusion Reactions

                In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

                Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

                10

                Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

                513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

                6 KEY CONTACTS

                Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

                Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

                NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

                11

                7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

                12

                httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

                13

                Appendix 1 Adult Blood Transfusion Guideline

                ADULT BLOOD TRANSFUSION GUIDELINE

                bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

                Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

                Remember

                bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

                consider the cause

                References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

                BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

                Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

                This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

                Haemoglobin Less than 8 gdl

                Haemoglobin 8 to 10 gdl

                Haemoglobin Greater than 10gdl

                Yes Possibly if No

                14

                Appendix 2

                Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

                Tariff for Elective Procedures

                2013-09-26 NW amp PRI MSBOS V30

                Procedure

                Tariff

                Procedure

                Tariff

                Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

                excision GampS

                AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

                If surgery for malignancy and pre-op Hblt120 L gdL

                If pre-op Hbgt 120L gdL

                2

                GampS

                Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

                2 Nephrectomy - OPEN 2

                Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

                Colposuspension) GampS

                Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

                GampS Pyeloplasty GampS

                Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

                GampS Total Proctocolectomy 2

                Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

                15

                Appendix 3a Flowchart Management of a Transfusion Reaction

                Symptoms Signs of Acute Transfusion Reaction

                Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

                chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

                Stop the transfusion and call a doctor

                Measure temperature pulse blood pressure respiratory rate amp O2 saturation

                Check identity of the recipient with the details on the unit and compatibility label or tag

                Any discrepancy noted call the transfusion laboratory

                Febrile non-haemolytic transfusion

                reaction

                If temperature rise less than

                20˚C the observations are stable

                and the patient is otherwise well

                give paracetamol

                Restart infusion at slower rate

                and observe more frequently

                Mild allergic reaction

                Give Chlopheniramine 10mg

                slowly iv and restart the

                transfusion at a slower rate and

                observe more frequently

                Reaction

                involves mild

                fever or

                urticarial

                rash only

                Mild fever

                Urticaria

                ABO incompatibility

                Stop transfusion

                Remove unit keeping IV giving set

                attached and c lamped off for return

                to Blood Transfusion Laboratory

                Commence iv saline infusion through

                a NEW IV administration set

                Monitor blood pressure pulse urine

                output (catheterise) frequently Seek

                help from experts in management of

                shock where appropriate

                Treat any DIC with appropriate blood

                components

                Inform Hospital Transfusion

                Laboratory immediately

                Suspected ABO

                incompatibility

                No

                Haemolytic reaction bacterial

                infection of unit

                Stop transfusion

                Take down unit and giving set

                Return intact to blood bank with all

                other usedunused units

                Take blood cultures repeat blood

                group crossmatch FBC coagulation

                screen biochemistry urinalysis

                Monitor urine output

                Commence broad spectrum

                antibiotics if suspected bacterial

                infection

                Commence oxygen and fluid support

                Seek haematological and intensive

                Severe allergic reaction

                Other haemolytic reaction bacterial

                contamination

                Severe allergic reaction

                Bronchospasm angioedema

                abdominal pain hypotension

                Stop transfusion Call for help

                Maintain airway give 100 O2

                If severe hypotension lie patient flat

                with legs elevated Give adrenaline

                (05ml of 1 in 1000 intramuscular )

                NEVER give undiluted epinephrine

                intravascularly

                Paediatric doses depend on the age of

                the child Intramuscular 1 in 1000

                epinephrine should be administered as

                follows

                12 years

                05 milligrams (05 ml)

                6-12 years

                025 milligrams (025ml)

                gt6 months to 6 years 012

                milligrams( 012 ml)

                lt6 months 005 milligrams

                ( 005ml)

                Take down unit and giving set

                Start infusion of crystalloid or colloid

                through a new iv fluid administration

                set

                Secondary therapy

                Chlopheniramine 10mg slow iv

                Salbutamol nebuliser

                Corticosteroids 100-500mg

                Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

                Fluid overload

                Give oxygen

                Diuretic iv

                TRALI

                Clinical features of acute LVF with

                fever and chills

                Discontinue transfusion

                Give 100 Oxygen

                Treat as ARDS ndash ventilate if hypoxia

                indicates

                Acute dyspnoea

                hypotension

                Monitor blood gases

                Perform CXR

                Measure CVP

                Pulmonary capillary

                pressure

                Raised

                CVP

                Normal

                CVP

                No

                Yes

                Yes

                Yes

                No

                No

                16

                Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                17

                The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                The component unit and any remaining contents with the clamped off IV giving set attached

                should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                Any empty used unit packs from this transfusion episode or unused units of blood issued for

                the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                Completed Transfusion Reaction form should be returned to the hospital transfusion

                laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                18

                Appendix 4

                20

                21

                22

                23

                24

                25

                Appendix 5a Jehovah Witness Consent

                CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                WILLING TO HAVE IF REQUIRED

                REFUSE UNDER ANY CIRCUMSTANCES

                Blood Components Red cells Platelets

                Fresh frozen plasma Cryoprecipitate

                Cell Salvage

                Cell saver- Standard set up

                Cell saver- set up in continuity only

                Blood Products Octaplas (Prothrombin complex

                Concentrate)

                Anti-D Immunoglobulin Albumin

                Factor VIII concentrate Factor IX concentrate

                Fibrinogen Concentrate Recombinant Products

                Erythropoietin Factor VIIa

                I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                26

                expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                27

                Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                28

                Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                29

                - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                30

                bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                31

                Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                Practitioner

                bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                32

                Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                33

                If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                34

                bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                identity band bull Match all other identifying information

                35

                Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                is to take place

                36

                If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                37

                Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                38

                bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                Blood Safety and Quality Regulations (2005)

                39

                bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                40

                Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                41

                bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                42

                Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                43

                Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                44

                Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                45

                Appendix 15A

                46

                Appendix 15B

                47

                Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                Please use a new document for each transfusion event

                PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                HospitalUnit Affix label here or write patient details Forename

                Surname

                Gender

                Date of birth

                CHI

                WardDept

                Consultant

                Authorisation Prescription

                bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                Consent for Transfusion

                bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                document in place Yes No Please delete patientguardian as appropriate

                Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                48

                THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                Patient Name Date of birthCHI

                UN

                IT 1

                Blood component

                Unit Pool mls

                Special Requirements Instructions (please tick)

                Affix completed pink portion of compatibility label here

                Irradiated CMV negative Blood warmer Other medication

                Reason for transfusion

                Date Duration Authoriser Prescriber signature

                Reassess before you progress (Venflon site and observations)

                UN

                IT 2

                Blood component

                Unit Pool mls

                Special Requirements Instructions (please tick)

                Affix completed pink portion of compatibility label here

                Irradiated CMV negative Blood warmer Other medication

                Reason for transfusion

                Date Duration Authoriser Prescriber signature

                Reassess before you progress (Venflon site and observations)

                UN

                IT 3

                Blood component

                Unit Pool mls

                Special Requirements Instructions (please tick)

                Affix completed pink portion of compatibility label here

                Irradiated CMV negative Blood warmer Other medication

                Reason for transfusion

                Date Duration Authoriser Prescriber signature

                Reassess before you progress (Venflon site and observations)

                UN

                IT 4

                Blood component

                Unit Pool mls

                Special Requirements Instructions (please tick)

                Affix completed pink portion of compatibility label here

                Irradiated CMV negative Blood warmer Other medication

                Reason for transfusion

                Date Duration Authoriser Prescriber signature

                THB(MR) 020 V40 May 2013

                THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                Patient Na me Date of birthCHI

                Transfusion Checklist - Please initial each box as checks are completed

                PRE-

                COLLECTION

                Checks below should be completed before collection of component from temperature

                controlled storage is undertaken

                PRE-

                ADMINISTRATION

                AT BEDSIDE

                Only remove clear outer wrap

                bag immediately prior to commencing transfusion and

                only when all positive identification checks have been

                completed

                POST

                TRANSFUSION

                Unit No

                1

                helliphelliphelliphelliphelliphelliphelliphelliphellip

                helliphelliphelliphelliphelliphelliphellip

                2

                helliphelliphelliphelliphelliphelliphelliphelliphellip

                helliphelliphelliphelliphelliphelliphellip

                3

                helliphelliphelliphelliphelliphelliphelliphelliphellip

                helliphelliphelliphelliphelliphellip

                4

                helliphelliphelliphelliphelliphelliphelliphelliphellip

                helliphelliphelliphelliphelliphelliphellip

                THB(MR) 020 V40 - May 2013

                Identification band insitu amp details verified and correct

                Patent IV access

                (Patient safety bundle adhered to)

                Blood authorised

                prescribed

                Check for special

                requirements amp consent

                Verbal identification

                at the bedside

                (if applicable)

                Identification band details are verified

                and correct amp match details

                on Traceability ldquobagamp tagrdquo

                label

                DateTime Transfusion completed

                Traceability Tag signed with starting time amp date of transfusion recorded

                Inspect bag

                (condition amp expiry

                date)

                DateTime blood removed from

                cold temperature

                storage

                Baseline Observations recorded on SEWS chart

                (Temperature Pulse

                Oxygen sats Respiration rate

                amp BP)

                Completion of Observations

                Noted on the SEWS chart

                (Temperature Pulse

                Oxygen Sats Respiration rate

                50

                Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                recorded and concerns escalated to the medical team according to the SEWS

                Adverse Events

                bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                Post Transfusion

                bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                Resources

                Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                THB(MR)020 v 40 May 2013

                Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                51

                9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                Why has this policy been developed

                Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                Has a risk control plan been developed and who is the owner of the risk If not why not

                Who has been involvedconsulted in the development of the policy

                Has the policy been assessed for Equality and Diversity in relation to-

                Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                Please indicate YesNo for the following YES

                Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                Please indicate Ye sNo for the following YES

                Does the policy contain evidence of the Equality amp

                Diversity Impact Assessment Process

                Is there an implementation plan

                Which officers are responsible for implementation

                When will the policy take effect

                Who must comply with the policystrategy

                How will they be informed of their responsibilities

                Is any training required

                If yes has any been arranged

                Are there any cost implications

                NO

                If yes please detail costs and note source of funding

                Who is responsible for auditing the implementation of the policy

                What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                2

                POLICY MANAGER________________________ DATE______ _____________________

                • Blood supply in an emergency situation
                • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                • Administration of Platelets
                  • Appendix 1 Adult Blood Transfusion Guideline
                    • ADULT BLOOD TRANSFUSION GUIDELINE
                      • Remember
                        • References
                          • Appendix 3a Flowchart Management of a Transfusion Reaction
                            • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                              • Consent for Transfusion
                              • THB(MR) 020 V40 May 2013
                                • PRE- COLLECTION
                                • PRE-ADMINISTRATION

                  9

                  As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (NHS QIS 2006) Staff involved in administration of blood should be competency assessed to NPSA SPN 14 (2006) or NHS QIS (2006) standards (see section 9) Transfusion must only take place when there are enough staff available to monitor the patient and when the patient can be readily observed Overnight transfusions should be avoided unless clinically essential The procedure for administration of red cells is attached in appendix 10 57 Use of Blood Warmers The use of a CE -marked commercial blood warmer may be indicated

                  a In adults receiving a blood transfusion at a rate greater than 50mlkghour or 100mlmin b In infants undergoing an exchange transfusion c In some cases of severe cold agglutinins disease

                  The initials CE do not stand for any specific words but are a declaration by the manufacturer that his product meets the requirements of the applicable European Directive(s) Blood warmers must be serviced and used according to the manufacturers instructions The warming of blood by other methods is potentially dangerous and is strictly prohibited

                  58 Administration of Fresh Frozen Plasma (FFP) FFP should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

                  59 Administration of Cryoprecipitate Cryoprecipitate should be administered in accordance with BCSH guideline (2004) and amendments (2007) The details of the procedure are contained in appendix 11

                  510 Administration of Platelets Platelets should be stored and administered in accordance with BCSH guideline on the use of platelet transfusions 2003 The procedure for platelet transfusion is contained in appendix 11 of this document

                  511 Monitoring All patients must be monitored appropriately throughout transfusion therapy Details of minimum required monitoring for each component transfused is contained in appendix 13

                  512 Management of Transfusion Reactions

                  In the event that the patient becomes unwell the transfusion must be stopped and appropriate treatment commenced

                  Appendix 3a and 3b provide information on the management of transfusion reactions including the procedure of returning the blood to the transfusion laboratory

                  10

                  Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

                  513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

                  6 KEY CONTACTS

                  Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

                  Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

                  NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

                  11

                  7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

                  12

                  httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

                  13

                  Appendix 1 Adult Blood Transfusion Guideline

                  ADULT BLOOD TRANSFUSION GUIDELINE

                  bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

                  Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

                  Remember

                  bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

                  consider the cause

                  References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

                  BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

                  Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

                  This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

                  Haemoglobin Less than 8 gdl

                  Haemoglobin 8 to 10 gdl

                  Haemoglobin Greater than 10gdl

                  Yes Possibly if No

                  14

                  Appendix 2

                  Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

                  Tariff for Elective Procedures

                  2013-09-26 NW amp PRI MSBOS V30

                  Procedure

                  Tariff

                  Procedure

                  Tariff

                  Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

                  excision GampS

                  AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

                  If surgery for malignancy and pre-op Hblt120 L gdL

                  If pre-op Hbgt 120L gdL

                  2

                  GampS

                  Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

                  2 Nephrectomy - OPEN 2

                  Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

                  Colposuspension) GampS

                  Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

                  GampS Pyeloplasty GampS

                  Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

                  GampS Total Proctocolectomy 2

                  Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

                  15

                  Appendix 3a Flowchart Management of a Transfusion Reaction

                  Symptoms Signs of Acute Transfusion Reaction

                  Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

                  chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

                  Stop the transfusion and call a doctor

                  Measure temperature pulse blood pressure respiratory rate amp O2 saturation

                  Check identity of the recipient with the details on the unit and compatibility label or tag

                  Any discrepancy noted call the transfusion laboratory

                  Febrile non-haemolytic transfusion

                  reaction

                  If temperature rise less than

                  20˚C the observations are stable

                  and the patient is otherwise well

                  give paracetamol

                  Restart infusion at slower rate

                  and observe more frequently

                  Mild allergic reaction

                  Give Chlopheniramine 10mg

                  slowly iv and restart the

                  transfusion at a slower rate and

                  observe more frequently

                  Reaction

                  involves mild

                  fever or

                  urticarial

                  rash only

                  Mild fever

                  Urticaria

                  ABO incompatibility

                  Stop transfusion

                  Remove unit keeping IV giving set

                  attached and c lamped off for return

                  to Blood Transfusion Laboratory

                  Commence iv saline infusion through

                  a NEW IV administration set

                  Monitor blood pressure pulse urine

                  output (catheterise) frequently Seek

                  help from experts in management of

                  shock where appropriate

                  Treat any DIC with appropriate blood

                  components

                  Inform Hospital Transfusion

                  Laboratory immediately

                  Suspected ABO

                  incompatibility

                  No

                  Haemolytic reaction bacterial

                  infection of unit

                  Stop transfusion

                  Take down unit and giving set

                  Return intact to blood bank with all

                  other usedunused units

                  Take blood cultures repeat blood

                  group crossmatch FBC coagulation

                  screen biochemistry urinalysis

                  Monitor urine output

                  Commence broad spectrum

                  antibiotics if suspected bacterial

                  infection

                  Commence oxygen and fluid support

                  Seek haematological and intensive

                  Severe allergic reaction

                  Other haemolytic reaction bacterial

                  contamination

                  Severe allergic reaction

                  Bronchospasm angioedema

                  abdominal pain hypotension

                  Stop transfusion Call for help

                  Maintain airway give 100 O2

                  If severe hypotension lie patient flat

                  with legs elevated Give adrenaline

                  (05ml of 1 in 1000 intramuscular )

                  NEVER give undiluted epinephrine

                  intravascularly

                  Paediatric doses depend on the age of

                  the child Intramuscular 1 in 1000

                  epinephrine should be administered as

                  follows

                  12 years

                  05 milligrams (05 ml)

                  6-12 years

                  025 milligrams (025ml)

                  gt6 months to 6 years 012

                  milligrams( 012 ml)

                  lt6 months 005 milligrams

                  ( 005ml)

                  Take down unit and giving set

                  Start infusion of crystalloid or colloid

                  through a new iv fluid administration

                  set

                  Secondary therapy

                  Chlopheniramine 10mg slow iv

                  Salbutamol nebuliser

                  Corticosteroids 100-500mg

                  Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

                  Fluid overload

                  Give oxygen

                  Diuretic iv

                  TRALI

                  Clinical features of acute LVF with

                  fever and chills

                  Discontinue transfusion

                  Give 100 Oxygen

                  Treat as ARDS ndash ventilate if hypoxia

                  indicates

                  Acute dyspnoea

                  hypotension

                  Monitor blood gases

                  Perform CXR

                  Measure CVP

                  Pulmonary capillary

                  pressure

                  Raised

                  CVP

                  Normal

                  CVP

                  No

                  Yes

                  Yes

                  Yes

                  No

                  No

                  16

                  Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                  bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                  Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                  bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                  site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                  17

                  The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                  The component unit and any remaining contents with the clamped off IV giving set attached

                  should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                  Any empty used unit packs from this transfusion episode or unused units of blood issued for

                  the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                  Completed Transfusion Reaction form should be returned to the hospital transfusion

                  laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                  o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                  Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                  Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                  bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                  bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                  receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                  18

                  Appendix 4

                  20

                  21

                  22

                  23

                  24

                  25

                  Appendix 5a Jehovah Witness Consent

                  CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                  WILLING TO HAVE IF REQUIRED

                  REFUSE UNDER ANY CIRCUMSTANCES

                  Blood Components Red cells Platelets

                  Fresh frozen plasma Cryoprecipitate

                  Cell Salvage

                  Cell saver- Standard set up

                  Cell saver- set up in continuity only

                  Blood Products Octaplas (Prothrombin complex

                  Concentrate)

                  Anti-D Immunoglobulin Albumin

                  Factor VIII concentrate Factor IX concentrate

                  Fibrinogen Concentrate Recombinant Products

                  Erythropoietin Factor VIIa

                  I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                  26

                  expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                  DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                  27

                  Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                  needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                  to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                  bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                  Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                  bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                  transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                  bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                  must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                  (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                  28

                  Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                  units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                  desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                  bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                  SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                  requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                  Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                  Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                  - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                  29

                  - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                  Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                  bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                  taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                  Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                  unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                  the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                  Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                  date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                  Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                  30

                  bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                  The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                  31

                  Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                  Practitioner

                  bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                  bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                  32

                  Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                  Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                  alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                  patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                  Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                  or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                  33

                  If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                  if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                  the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                  from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                  the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                  34

                  bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                  identity band bull Match all other identifying information

                  35

                  Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                  been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                  had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                  the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                  bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                  Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                  alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                  you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                  bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                  form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                  bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                  is to take place

                  36

                  If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                  inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                  delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                  37

                  Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                  unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                  are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                  storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                  no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                  transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                  available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                  correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                  for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                  38

                  bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                  wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                  blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                  band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                  component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                  checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                  bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                  infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                  2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                  infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                  transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                  Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                  commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                  receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                  blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                  bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                  container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                  Blood Safety and Quality Regulations (2005)

                  39

                  bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                  bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                  a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                  40

                  Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                  inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                  bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                  Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                  depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                  substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                  or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                  urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                  41

                  bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                  haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                  42

                  Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                  bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                  bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                  bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                  43

                  Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                  Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                  Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                  regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                  44

                  Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                  negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                  45

                  Appendix 15A

                  46

                  Appendix 15B

                  47

                  Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                  Please use a new document for each transfusion event

                  PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                  HospitalUnit Affix label here or write patient details Forename

                  Surname

                  Gender

                  Date of birth

                  CHI

                  WardDept

                  Consultant

                  Authorisation Prescription

                  bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                  transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                  chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                  Consent for Transfusion

                  bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                  Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                  after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                  transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                  document in place Yes No Please delete patientguardian as appropriate

                  Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                  I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                  Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                  48

                  THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                  Patient Name Date of birthCHI

                  UN

                  IT 1

                  Blood component

                  Unit Pool mls

                  Special Requirements Instructions (please tick)

                  Affix completed pink portion of compatibility label here

                  Irradiated CMV negative Blood warmer Other medication

                  Reason for transfusion

                  Date Duration Authoriser Prescriber signature

                  Reassess before you progress (Venflon site and observations)

                  UN

                  IT 2

                  Blood component

                  Unit Pool mls

                  Special Requirements Instructions (please tick)

                  Affix completed pink portion of compatibility label here

                  Irradiated CMV negative Blood warmer Other medication

                  Reason for transfusion

                  Date Duration Authoriser Prescriber signature

                  Reassess before you progress (Venflon site and observations)

                  UN

                  IT 3

                  Blood component

                  Unit Pool mls

                  Special Requirements Instructions (please tick)

                  Affix completed pink portion of compatibility label here

                  Irradiated CMV negative Blood warmer Other medication

                  Reason for transfusion

                  Date Duration Authoriser Prescriber signature

                  Reassess before you progress (Venflon site and observations)

                  UN

                  IT 4

                  Blood component

                  Unit Pool mls

                  Special Requirements Instructions (please tick)

                  Affix completed pink portion of compatibility label here

                  Irradiated CMV negative Blood warmer Other medication

                  Reason for transfusion

                  Date Duration Authoriser Prescriber signature

                  THB(MR) 020 V40 May 2013

                  THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                  Patient Na me Date of birthCHI

                  Transfusion Checklist - Please initial each box as checks are completed

                  PRE-

                  COLLECTION

                  Checks below should be completed before collection of component from temperature

                  controlled storage is undertaken

                  PRE-

                  ADMINISTRATION

                  AT BEDSIDE

                  Only remove clear outer wrap

                  bag immediately prior to commencing transfusion and

                  only when all positive identification checks have been

                  completed

                  POST

                  TRANSFUSION

                  Unit No

                  1

                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                  helliphelliphelliphelliphelliphelliphellip

                  2

                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                  helliphelliphelliphelliphelliphelliphellip

                  3

                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                  helliphelliphelliphelliphelliphellip

                  4

                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                  helliphelliphelliphelliphelliphelliphellip

                  THB(MR) 020 V40 - May 2013

                  Identification band insitu amp details verified and correct

                  Patent IV access

                  (Patient safety bundle adhered to)

                  Blood authorised

                  prescribed

                  Check for special

                  requirements amp consent

                  Verbal identification

                  at the bedside

                  (if applicable)

                  Identification band details are verified

                  and correct amp match details

                  on Traceability ldquobagamp tagrdquo

                  label

                  DateTime Transfusion completed

                  Traceability Tag signed with starting time amp date of transfusion recorded

                  Inspect bag

                  (condition amp expiry

                  date)

                  DateTime blood removed from

                  cold temperature

                  storage

                  Baseline Observations recorded on SEWS chart

                  (Temperature Pulse

                  Oxygen sats Respiration rate

                  amp BP)

                  Completion of Observations

                  Noted on the SEWS chart

                  (Temperature Pulse

                  Oxygen Sats Respiration rate

                  50

                  Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                  be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                  Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                  be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                  recorded and concerns escalated to the medical team according to the SEWS

                  Adverse Events

                  bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                  more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                  hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                  Post Transfusion

                  bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                  patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                  bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                  Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                  transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                  patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                  Resources

                  Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                  THB(MR)020 v 40 May 2013

                  Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                  PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                  51

                  9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                  This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                  POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                  Why has this policy been developed

                  Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                  Has a risk control plan been developed and who is the owner of the risk If not why not

                  Who has been involvedconsulted in the development of the policy

                  Has the policy been assessed for Equality and Diversity in relation to-

                  Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                  RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                  Please indicate YesNo for the following YES

                  Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                  Please indicate Ye sNo for the following YES

                  Does the policy contain evidence of the Equality amp

                  Diversity Impact Assessment Process

                  Is there an implementation plan

                  Which officers are responsible for implementation

                  When will the policy take effect

                  Who must comply with the policystrategy

                  How will they be informed of their responsibilities

                  Is any training required

                  If yes has any been arranged

                  Are there any cost implications

                  NO

                  If yes please detail costs and note source of funding

                  Who is responsible for auditing the implementation of the policy

                  What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                  2

                  POLICY MANAGER________________________ DATE______ _____________________

                  • Blood supply in an emergency situation
                  • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                  • Administration of Platelets
                    • Appendix 1 Adult Blood Transfusion Guideline
                      • ADULT BLOOD TRANSFUSION GUIDELINE
                        • Remember
                          • References
                            • Appendix 3a Flowchart Management of a Transfusion Reaction
                              • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                • Consent for Transfusion
                                • THB(MR) 020 V40 May 2013
                                  • PRE- COLLECTION
                                  • PRE-ADMINISTRATION

                    10

                    Appendix 4 provides information on the reporting of adverse transfusion incidents reactions

                    513 PaediatricNeonatal Considerations The procedure for paediatric transfusion in NHS Tayside is outlined in appendix 14 The procedure for emergency neonatal transfusion is attached as appendix 15b Paediatric and neonatal transfusions should be carried out in accordance with BCSH guidance on transfusion for neonates and older children (2004) and the amendments (2005 and 2007) 514 Documentation The NHS Tayside Documentation for Transfusion of Blood Components record should be used for documentation associated with transfusion episodes This is attached as appendix 16

                    6 KEY CONTACTS

                    Perth Royal Infirmary Hospital Transfusion Laboratory Extension 13338Pager 5122 Consultant Haematologist Ninewells Hospital Bleep 4798 Laboratory Manager Perth Laboratory Ext 13338 Biomedical Scientist Perth Laboratory Ext 13338 Bleep 5122 Transfusion Practitioner NHS Tayside Ext Bleep 5082 East of Scotland Blood Transfusion Service -Ninewel ls Hospital

                    Extension 32953 Clinical Director East of Scotland Blood Transfusion Centre Tel ext 74437 Laboratory Manager East of Scotland Blood Transfusion Centre Tel ext 74435 Transfusion Practitioner NHS Tayside Tel ext 74423 or Bleep 5099 Chair Hospital Transfusion Committee Bleep 4864

                    NHS Tayside - Department of Haematology User Guide 2013 httpedstaysidescotnhsukNHSTaysideDocsgroupsblood_sciencesdocumentsdocumentsstaffnet01_haematologypdf East of Scotland Blood Transfusion Centre Laborato ry Users Handbook httpstaffnettaysidescotnhsukNHSTaysideDocsgroupssnbtsdocumentsdocumentsdocs_017112pdf

                    11

                    7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

                    12

                    httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

                    13

                    Appendix 1 Adult Blood Transfusion Guideline

                    ADULT BLOOD TRANSFUSION GUIDELINE

                    bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

                    Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

                    Remember

                    bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

                    consider the cause

                    References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

                    BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

                    Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

                    This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

                    Haemoglobin Less than 8 gdl

                    Haemoglobin 8 to 10 gdl

                    Haemoglobin Greater than 10gdl

                    Yes Possibly if No

                    14

                    Appendix 2

                    Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

                    Tariff for Elective Procedures

                    2013-09-26 NW amp PRI MSBOS V30

                    Procedure

                    Tariff

                    Procedure

                    Tariff

                    Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

                    excision GampS

                    AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

                    If surgery for malignancy and pre-op Hblt120 L gdL

                    If pre-op Hbgt 120L gdL

                    2

                    GampS

                    Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

                    2 Nephrectomy - OPEN 2

                    Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

                    Colposuspension) GampS

                    Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

                    GampS Pyeloplasty GampS

                    Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

                    GampS Total Proctocolectomy 2

                    Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

                    15

                    Appendix 3a Flowchart Management of a Transfusion Reaction

                    Symptoms Signs of Acute Transfusion Reaction

                    Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

                    chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

                    Stop the transfusion and call a doctor

                    Measure temperature pulse blood pressure respiratory rate amp O2 saturation

                    Check identity of the recipient with the details on the unit and compatibility label or tag

                    Any discrepancy noted call the transfusion laboratory

                    Febrile non-haemolytic transfusion

                    reaction

                    If temperature rise less than

                    20˚C the observations are stable

                    and the patient is otherwise well

                    give paracetamol

                    Restart infusion at slower rate

                    and observe more frequently

                    Mild allergic reaction

                    Give Chlopheniramine 10mg

                    slowly iv and restart the

                    transfusion at a slower rate and

                    observe more frequently

                    Reaction

                    involves mild

                    fever or

                    urticarial

                    rash only

                    Mild fever

                    Urticaria

                    ABO incompatibility

                    Stop transfusion

                    Remove unit keeping IV giving set

                    attached and c lamped off for return

                    to Blood Transfusion Laboratory

                    Commence iv saline infusion through

                    a NEW IV administration set

                    Monitor blood pressure pulse urine

                    output (catheterise) frequently Seek

                    help from experts in management of

                    shock where appropriate

                    Treat any DIC with appropriate blood

                    components

                    Inform Hospital Transfusion

                    Laboratory immediately

                    Suspected ABO

                    incompatibility

                    No

                    Haemolytic reaction bacterial

                    infection of unit

                    Stop transfusion

                    Take down unit and giving set

                    Return intact to blood bank with all

                    other usedunused units

                    Take blood cultures repeat blood

                    group crossmatch FBC coagulation

                    screen biochemistry urinalysis

                    Monitor urine output

                    Commence broad spectrum

                    antibiotics if suspected bacterial

                    infection

                    Commence oxygen and fluid support

                    Seek haematological and intensive

                    Severe allergic reaction

                    Other haemolytic reaction bacterial

                    contamination

                    Severe allergic reaction

                    Bronchospasm angioedema

                    abdominal pain hypotension

                    Stop transfusion Call for help

                    Maintain airway give 100 O2

                    If severe hypotension lie patient flat

                    with legs elevated Give adrenaline

                    (05ml of 1 in 1000 intramuscular )

                    NEVER give undiluted epinephrine

                    intravascularly

                    Paediatric doses depend on the age of

                    the child Intramuscular 1 in 1000

                    epinephrine should be administered as

                    follows

                    12 years

                    05 milligrams (05 ml)

                    6-12 years

                    025 milligrams (025ml)

                    gt6 months to 6 years 012

                    milligrams( 012 ml)

                    lt6 months 005 milligrams

                    ( 005ml)

                    Take down unit and giving set

                    Start infusion of crystalloid or colloid

                    through a new iv fluid administration

                    set

                    Secondary therapy

                    Chlopheniramine 10mg slow iv

                    Salbutamol nebuliser

                    Corticosteroids 100-500mg

                    Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

                    Fluid overload

                    Give oxygen

                    Diuretic iv

                    TRALI

                    Clinical features of acute LVF with

                    fever and chills

                    Discontinue transfusion

                    Give 100 Oxygen

                    Treat as ARDS ndash ventilate if hypoxia

                    indicates

                    Acute dyspnoea

                    hypotension

                    Monitor blood gases

                    Perform CXR

                    Measure CVP

                    Pulmonary capillary

                    pressure

                    Raised

                    CVP

                    Normal

                    CVP

                    No

                    Yes

                    Yes

                    Yes

                    No

                    No

                    16

                    Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                    bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                    Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                    bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                    site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                    17

                    The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                    The component unit and any remaining contents with the clamped off IV giving set attached

                    should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                    Any empty used unit packs from this transfusion episode or unused units of blood issued for

                    the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                    Completed Transfusion Reaction form should be returned to the hospital transfusion

                    laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                    o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                    Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                    Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                    bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                    bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                    receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                    18

                    Appendix 4

                    20

                    21

                    22

                    23

                    24

                    25

                    Appendix 5a Jehovah Witness Consent

                    CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                    WILLING TO HAVE IF REQUIRED

                    REFUSE UNDER ANY CIRCUMSTANCES

                    Blood Components Red cells Platelets

                    Fresh frozen plasma Cryoprecipitate

                    Cell Salvage

                    Cell saver- Standard set up

                    Cell saver- set up in continuity only

                    Blood Products Octaplas (Prothrombin complex

                    Concentrate)

                    Anti-D Immunoglobulin Albumin

                    Factor VIII concentrate Factor IX concentrate

                    Fibrinogen Concentrate Recombinant Products

                    Erythropoietin Factor VIIa

                    I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                    26

                    expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                    DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                    27

                    Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                    needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                    to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                    bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                    Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                    bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                    transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                    bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                    must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                    (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                    28

                    Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                    units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                    desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                    bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                    SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                    requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                    Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                    Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                    - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                    29

                    - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                    Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                    bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                    taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                    Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                    unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                    the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                    Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                    date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                    Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                    30

                    bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                    The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                    31

                    Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                    Practitioner

                    bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                    bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                    32

                    Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                    Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                    alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                    patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                    Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                    or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                    33

                    If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                    if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                    the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                    from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                    the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                    34

                    bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                    identity band bull Match all other identifying information

                    35

                    Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                    been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                    had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                    the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                    bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                    Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                    alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                    you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                    bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                    form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                    bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                    is to take place

                    36

                    If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                    inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                    delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                    37

                    Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                    unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                    are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                    storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                    no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                    transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                    available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                    correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                    for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                    38

                    bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                    wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                    blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                    band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                    component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                    checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                    bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                    infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                    2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                    infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                    transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                    Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                    commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                    receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                    blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                    bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                    container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                    Blood Safety and Quality Regulations (2005)

                    39

                    bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                    bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                    a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                    40

                    Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                    inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                    bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                    Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                    depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                    substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                    or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                    urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                    41

                    bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                    haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                    42

                    Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                    bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                    bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                    bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                    43

                    Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                    Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                    Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                    regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                    44

                    Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                    negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                    45

                    Appendix 15A

                    46

                    Appendix 15B

                    47

                    Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                    Please use a new document for each transfusion event

                    PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                    HospitalUnit Affix label here or write patient details Forename

                    Surname

                    Gender

                    Date of birth

                    CHI

                    WardDept

                    Consultant

                    Authorisation Prescription

                    bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                    transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                    chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                    Consent for Transfusion

                    bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                    Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                    after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                    transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                    document in place Yes No Please delete patientguardian as appropriate

                    Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                    I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                    Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                    48

                    THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                    Patient Name Date of birthCHI

                    UN

                    IT 1

                    Blood component

                    Unit Pool mls

                    Special Requirements Instructions (please tick)

                    Affix completed pink portion of compatibility label here

                    Irradiated CMV negative Blood warmer Other medication

                    Reason for transfusion

                    Date Duration Authoriser Prescriber signature

                    Reassess before you progress (Venflon site and observations)

                    UN

                    IT 2

                    Blood component

                    Unit Pool mls

                    Special Requirements Instructions (please tick)

                    Affix completed pink portion of compatibility label here

                    Irradiated CMV negative Blood warmer Other medication

                    Reason for transfusion

                    Date Duration Authoriser Prescriber signature

                    Reassess before you progress (Venflon site and observations)

                    UN

                    IT 3

                    Blood component

                    Unit Pool mls

                    Special Requirements Instructions (please tick)

                    Affix completed pink portion of compatibility label here

                    Irradiated CMV negative Blood warmer Other medication

                    Reason for transfusion

                    Date Duration Authoriser Prescriber signature

                    Reassess before you progress (Venflon site and observations)

                    UN

                    IT 4

                    Blood component

                    Unit Pool mls

                    Special Requirements Instructions (please tick)

                    Affix completed pink portion of compatibility label here

                    Irradiated CMV negative Blood warmer Other medication

                    Reason for transfusion

                    Date Duration Authoriser Prescriber signature

                    THB(MR) 020 V40 May 2013

                    THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                    Patient Na me Date of birthCHI

                    Transfusion Checklist - Please initial each box as checks are completed

                    PRE-

                    COLLECTION

                    Checks below should be completed before collection of component from temperature

                    controlled storage is undertaken

                    PRE-

                    ADMINISTRATION

                    AT BEDSIDE

                    Only remove clear outer wrap

                    bag immediately prior to commencing transfusion and

                    only when all positive identification checks have been

                    completed

                    POST

                    TRANSFUSION

                    Unit No

                    1

                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                    helliphelliphelliphelliphelliphelliphellip

                    2

                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                    helliphelliphelliphelliphelliphelliphellip

                    3

                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                    helliphelliphelliphelliphelliphellip

                    4

                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                    helliphelliphelliphelliphelliphelliphellip

                    THB(MR) 020 V40 - May 2013

                    Identification band insitu amp details verified and correct

                    Patent IV access

                    (Patient safety bundle adhered to)

                    Blood authorised

                    prescribed

                    Check for special

                    requirements amp consent

                    Verbal identification

                    at the bedside

                    (if applicable)

                    Identification band details are verified

                    and correct amp match details

                    on Traceability ldquobagamp tagrdquo

                    label

                    DateTime Transfusion completed

                    Traceability Tag signed with starting time amp date of transfusion recorded

                    Inspect bag

                    (condition amp expiry

                    date)

                    DateTime blood removed from

                    cold temperature

                    storage

                    Baseline Observations recorded on SEWS chart

                    (Temperature Pulse

                    Oxygen sats Respiration rate

                    amp BP)

                    Completion of Observations

                    Noted on the SEWS chart

                    (Temperature Pulse

                    Oxygen Sats Respiration rate

                    50

                    Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                    be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                    Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                    be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                    recorded and concerns escalated to the medical team according to the SEWS

                    Adverse Events

                    bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                    more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                    hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                    Post Transfusion

                    bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                    patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                    bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                    Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                    transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                    patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                    Resources

                    Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                    THB(MR)020 v 40 May 2013

                    Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                    PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                    51

                    9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                    This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                    POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                    Why has this policy been developed

                    Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                    Has a risk control plan been developed and who is the owner of the risk If not why not

                    Who has been involvedconsulted in the development of the policy

                    Has the policy been assessed for Equality and Diversity in relation to-

                    Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                    RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                    Please indicate YesNo for the following YES

                    Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                    Please indicate Ye sNo for the following YES

                    Does the policy contain evidence of the Equality amp

                    Diversity Impact Assessment Process

                    Is there an implementation plan

                    Which officers are responsible for implementation

                    When will the policy take effect

                    Who must comply with the policystrategy

                    How will they be informed of their responsibilities

                    Is any training required

                    If yes has any been arranged

                    Are there any cost implications

                    NO

                    If yes please detail costs and note source of funding

                    Who is responsible for auditing the implementation of the policy

                    What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                    2

                    POLICY MANAGER________________________ DATE______ _____________________

                    • Blood supply in an emergency situation
                    • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                    • Administration of Platelets
                      • Appendix 1 Adult Blood Transfusion Guideline
                        • ADULT BLOOD TRANSFUSION GUIDELINE
                          • Remember
                            • References
                              • Appendix 3a Flowchart Management of a Transfusion Reaction
                                • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                  • Consent for Transfusion
                                  • THB(MR) 020 V40 May 2013
                                    • PRE- COLLECTION
                                    • PRE-ADMINISTRATION

                      11

                      7 References and useful links Advisory Committee on the Safety of Blood Tissues and Organs (SaBTO) Report Patient consent for transfusion (2011) httpswwwgovukgovernmentpublicationspatient-consent-for-blood-transfusion Blood Safety and Quality Regulations (BSQR) 2005 Statutory Instrument 200550 (ISBN 0110990412) wwwopsigovuksisi200520050050htm British Committee for Standards in Haematology Blood Transfusion Taskforce (2006) Guidelines for management of massive blood loss The British Journal of Haematology 135 634-641 httponlinelibrarywileycomdoi101111j1365-2141200606355xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant The British Society for Haematology 126 11 ndash 28 httponlinelibrarywileycomdoi101111j1365-2141200404972xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Addendum to the Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant 2004 httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2004) Transfusion Guidelines for Neonates and Older Children British Journal of Haematology 124 433-453 httponlinelibrarywileycomdoi101111j1365-2141200404815xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2005) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 wwwbcshguidelinescompdfamendments_neonates_091205pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2007) Amendment to the Transfusion Guidelines for Neonates and Older Children 2004 httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf British Committee for Standards in Haematology Blood Transfusion Taskforce (2003) Guidelines for the Use of Platelet Transfusions British Journal of Haematology122(1) 10-23 httponlinelibrarywileycomdoi101046j1365-2141200304468xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2001) The Clinical Use of Red Cell Transfusion British Journal of Haematology 113(1) 24-31 httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components

                      12

                      httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

                      13

                      Appendix 1 Adult Blood Transfusion Guideline

                      ADULT BLOOD TRANSFUSION GUIDELINE

                      bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

                      Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

                      Remember

                      bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

                      consider the cause

                      References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

                      BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

                      Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

                      This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

                      Haemoglobin Less than 8 gdl

                      Haemoglobin 8 to 10 gdl

                      Haemoglobin Greater than 10gdl

                      Yes Possibly if No

                      14

                      Appendix 2

                      Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

                      Tariff for Elective Procedures

                      2013-09-26 NW amp PRI MSBOS V30

                      Procedure

                      Tariff

                      Procedure

                      Tariff

                      Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

                      excision GampS

                      AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

                      If surgery for malignancy and pre-op Hblt120 L gdL

                      If pre-op Hbgt 120L gdL

                      2

                      GampS

                      Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

                      2 Nephrectomy - OPEN 2

                      Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

                      Colposuspension) GampS

                      Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

                      GampS Pyeloplasty GampS

                      Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

                      GampS Total Proctocolectomy 2

                      Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

                      15

                      Appendix 3a Flowchart Management of a Transfusion Reaction

                      Symptoms Signs of Acute Transfusion Reaction

                      Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

                      chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

                      Stop the transfusion and call a doctor

                      Measure temperature pulse blood pressure respiratory rate amp O2 saturation

                      Check identity of the recipient with the details on the unit and compatibility label or tag

                      Any discrepancy noted call the transfusion laboratory

                      Febrile non-haemolytic transfusion

                      reaction

                      If temperature rise less than

                      20˚C the observations are stable

                      and the patient is otherwise well

                      give paracetamol

                      Restart infusion at slower rate

                      and observe more frequently

                      Mild allergic reaction

                      Give Chlopheniramine 10mg

                      slowly iv and restart the

                      transfusion at a slower rate and

                      observe more frequently

                      Reaction

                      involves mild

                      fever or

                      urticarial

                      rash only

                      Mild fever

                      Urticaria

                      ABO incompatibility

                      Stop transfusion

                      Remove unit keeping IV giving set

                      attached and c lamped off for return

                      to Blood Transfusion Laboratory

                      Commence iv saline infusion through

                      a NEW IV administration set

                      Monitor blood pressure pulse urine

                      output (catheterise) frequently Seek

                      help from experts in management of

                      shock where appropriate

                      Treat any DIC with appropriate blood

                      components

                      Inform Hospital Transfusion

                      Laboratory immediately

                      Suspected ABO

                      incompatibility

                      No

                      Haemolytic reaction bacterial

                      infection of unit

                      Stop transfusion

                      Take down unit and giving set

                      Return intact to blood bank with all

                      other usedunused units

                      Take blood cultures repeat blood

                      group crossmatch FBC coagulation

                      screen biochemistry urinalysis

                      Monitor urine output

                      Commence broad spectrum

                      antibiotics if suspected bacterial

                      infection

                      Commence oxygen and fluid support

                      Seek haematological and intensive

                      Severe allergic reaction

                      Other haemolytic reaction bacterial

                      contamination

                      Severe allergic reaction

                      Bronchospasm angioedema

                      abdominal pain hypotension

                      Stop transfusion Call for help

                      Maintain airway give 100 O2

                      If severe hypotension lie patient flat

                      with legs elevated Give adrenaline

                      (05ml of 1 in 1000 intramuscular )

                      NEVER give undiluted epinephrine

                      intravascularly

                      Paediatric doses depend on the age of

                      the child Intramuscular 1 in 1000

                      epinephrine should be administered as

                      follows

                      12 years

                      05 milligrams (05 ml)

                      6-12 years

                      025 milligrams (025ml)

                      gt6 months to 6 years 012

                      milligrams( 012 ml)

                      lt6 months 005 milligrams

                      ( 005ml)

                      Take down unit and giving set

                      Start infusion of crystalloid or colloid

                      through a new iv fluid administration

                      set

                      Secondary therapy

                      Chlopheniramine 10mg slow iv

                      Salbutamol nebuliser

                      Corticosteroids 100-500mg

                      Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

                      Fluid overload

                      Give oxygen

                      Diuretic iv

                      TRALI

                      Clinical features of acute LVF with

                      fever and chills

                      Discontinue transfusion

                      Give 100 Oxygen

                      Treat as ARDS ndash ventilate if hypoxia

                      indicates

                      Acute dyspnoea

                      hypotension

                      Monitor blood gases

                      Perform CXR

                      Measure CVP

                      Pulmonary capillary

                      pressure

                      Raised

                      CVP

                      Normal

                      CVP

                      No

                      Yes

                      Yes

                      Yes

                      No

                      No

                      16

                      Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                      bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                      Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                      bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                      site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                      17

                      The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                      The component unit and any remaining contents with the clamped off IV giving set attached

                      should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                      Any empty used unit packs from this transfusion episode or unused units of blood issued for

                      the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                      Completed Transfusion Reaction form should be returned to the hospital transfusion

                      laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                      o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                      Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                      Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                      bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                      bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                      receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                      18

                      Appendix 4

                      20

                      21

                      22

                      23

                      24

                      25

                      Appendix 5a Jehovah Witness Consent

                      CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                      WILLING TO HAVE IF REQUIRED

                      REFUSE UNDER ANY CIRCUMSTANCES

                      Blood Components Red cells Platelets

                      Fresh frozen plasma Cryoprecipitate

                      Cell Salvage

                      Cell saver- Standard set up

                      Cell saver- set up in continuity only

                      Blood Products Octaplas (Prothrombin complex

                      Concentrate)

                      Anti-D Immunoglobulin Albumin

                      Factor VIII concentrate Factor IX concentrate

                      Fibrinogen Concentrate Recombinant Products

                      Erythropoietin Factor VIIa

                      I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                      26

                      expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                      DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                      27

                      Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                      needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                      to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                      bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                      Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                      bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                      transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                      bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                      must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                      (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                      28

                      Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                      units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                      desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                      bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                      SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                      requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                      Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                      Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                      - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                      29

                      - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                      Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                      bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                      taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                      Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                      unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                      the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                      Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                      date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                      Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                      30

                      bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                      The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                      31

                      Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                      Practitioner

                      bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                      bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                      32

                      Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                      Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                      alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                      patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                      Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                      or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                      33

                      If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                      if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                      the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                      from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                      the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                      34

                      bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                      identity band bull Match all other identifying information

                      35

                      Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                      been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                      had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                      the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                      bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                      Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                      alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                      you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                      bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                      form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                      bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                      is to take place

                      36

                      If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                      inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                      delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                      37

                      Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                      unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                      are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                      storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                      no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                      transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                      available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                      correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                      for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                      38

                      bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                      wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                      blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                      band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                      component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                      checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                      bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                      infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                      2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                      infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                      transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                      Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                      commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                      receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                      blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                      bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                      container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                      Blood Safety and Quality Regulations (2005)

                      39

                      bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                      bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                      a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                      40

                      Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                      inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                      bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                      Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                      depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                      substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                      or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                      urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                      41

                      bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                      haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                      42

                      Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                      bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                      bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                      bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                      43

                      Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                      Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                      Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                      regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                      44

                      Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                      negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                      45

                      Appendix 15A

                      46

                      Appendix 15B

                      47

                      Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                      Please use a new document for each transfusion event

                      PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                      HospitalUnit Affix label here or write patient details Forename

                      Surname

                      Gender

                      Date of birth

                      CHI

                      WardDept

                      Consultant

                      Authorisation Prescription

                      bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                      transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                      chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                      Consent for Transfusion

                      bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                      Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                      after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                      transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                      document in place Yes No Please delete patientguardian as appropriate

                      Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                      I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                      Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                      48

                      THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                      Patient Name Date of birthCHI

                      UN

                      IT 1

                      Blood component

                      Unit Pool mls

                      Special Requirements Instructions (please tick)

                      Affix completed pink portion of compatibility label here

                      Irradiated CMV negative Blood warmer Other medication

                      Reason for transfusion

                      Date Duration Authoriser Prescriber signature

                      Reassess before you progress (Venflon site and observations)

                      UN

                      IT 2

                      Blood component

                      Unit Pool mls

                      Special Requirements Instructions (please tick)

                      Affix completed pink portion of compatibility label here

                      Irradiated CMV negative Blood warmer Other medication

                      Reason for transfusion

                      Date Duration Authoriser Prescriber signature

                      Reassess before you progress (Venflon site and observations)

                      UN

                      IT 3

                      Blood component

                      Unit Pool mls

                      Special Requirements Instructions (please tick)

                      Affix completed pink portion of compatibility label here

                      Irradiated CMV negative Blood warmer Other medication

                      Reason for transfusion

                      Date Duration Authoriser Prescriber signature

                      Reassess before you progress (Venflon site and observations)

                      UN

                      IT 4

                      Blood component

                      Unit Pool mls

                      Special Requirements Instructions (please tick)

                      Affix completed pink portion of compatibility label here

                      Irradiated CMV negative Blood warmer Other medication

                      Reason for transfusion

                      Date Duration Authoriser Prescriber signature

                      THB(MR) 020 V40 May 2013

                      THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                      Patient Na me Date of birthCHI

                      Transfusion Checklist - Please initial each box as checks are completed

                      PRE-

                      COLLECTION

                      Checks below should be completed before collection of component from temperature

                      controlled storage is undertaken

                      PRE-

                      ADMINISTRATION

                      AT BEDSIDE

                      Only remove clear outer wrap

                      bag immediately prior to commencing transfusion and

                      only when all positive identification checks have been

                      completed

                      POST

                      TRANSFUSION

                      Unit No

                      1

                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                      helliphelliphelliphelliphelliphelliphellip

                      2

                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                      helliphelliphelliphelliphelliphelliphellip

                      3

                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                      helliphelliphelliphelliphelliphellip

                      4

                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                      helliphelliphelliphelliphelliphelliphellip

                      THB(MR) 020 V40 - May 2013

                      Identification band insitu amp details verified and correct

                      Patent IV access

                      (Patient safety bundle adhered to)

                      Blood authorised

                      prescribed

                      Check for special

                      requirements amp consent

                      Verbal identification

                      at the bedside

                      (if applicable)

                      Identification band details are verified

                      and correct amp match details

                      on Traceability ldquobagamp tagrdquo

                      label

                      DateTime Transfusion completed

                      Traceability Tag signed with starting time amp date of transfusion recorded

                      Inspect bag

                      (condition amp expiry

                      date)

                      DateTime blood removed from

                      cold temperature

                      storage

                      Baseline Observations recorded on SEWS chart

                      (Temperature Pulse

                      Oxygen sats Respiration rate

                      amp BP)

                      Completion of Observations

                      Noted on the SEWS chart

                      (Temperature Pulse

                      Oxygen Sats Respiration rate

                      50

                      Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                      be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                      Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                      be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                      recorded and concerns escalated to the medical team according to the SEWS

                      Adverse Events

                      bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                      more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                      hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                      Post Transfusion

                      bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                      patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                      bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                      Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                      transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                      patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                      Resources

                      Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                      THB(MR)020 v 40 May 2013

                      Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                      PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                      51

                      9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                      This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                      POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                      Why has this policy been developed

                      Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                      Has a risk control plan been developed and who is the owner of the risk If not why not

                      Who has been involvedconsulted in the development of the policy

                      Has the policy been assessed for Equality and Diversity in relation to-

                      Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                      RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                      Please indicate YesNo for the following YES

                      Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                      Please indicate Ye sNo for the following YES

                      Does the policy contain evidence of the Equality amp

                      Diversity Impact Assessment Process

                      Is there an implementation plan

                      Which officers are responsible for implementation

                      When will the policy take effect

                      Who must comply with the policystrategy

                      How will they be informed of their responsibilities

                      Is any training required

                      If yes has any been arranged

                      Are there any cost implications

                      NO

                      If yes please detail costs and note source of funding

                      Who is responsible for auditing the implementation of the policy

                      What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                      2

                      POLICY MANAGER________________________ DATE______ _____________________

                      • Blood supply in an emergency situation
                      • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                      • Administration of Platelets
                        • Appendix 1 Adult Blood Transfusion Guideline
                          • ADULT BLOOD TRANSFUSION GUIDELINE
                            • Remember
                              • References
                                • Appendix 3a Flowchart Management of a Transfusion Reaction
                                  • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                    • Consent for Transfusion
                                    • THB(MR) 020 V40 May 2013
                                      • PRE- COLLECTION
                                      • PRE-ADMINISTRATION

                        12

                        httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf British Committee for Standards in Haematology (BCSH) Guideline on the Administration of Blood Components Addendum August 2012 Avoidance of Transfusion Associated Circulatory Overload (TACO) and Problems Associated with Over-transfusion httpwwwbcshguidelinescom Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Guideline on the Investigation and Management of Acute Transfusion Reactions Prepared by the BCSH Blood Transfusion Task Force (2012) httponlinelibrarywileycomdoi101111bjh12017full Guidelines on the Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients (2012) httponlinelibrarywileycomdoi101111bjh12143full McClelland DBL (ed) (2007) Handbook of Transfusion Medicine (4th edition) The Stationery Office London wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf National Health Service Quality Improvement Scotland (2006) Clinical Standards for Blood Transfusion httpwwwhealthcareimprovementscotlandorgprevious_resourcesstandardsblood_transfusionaspx http Further Resources Better Blood Transfusion Safe Transfusion e-Learning SCOTBLOOD wwwscotbloodcouk Serious Hazards of Transfusion (SHOT) wwwshotukorg

                        13

                        Appendix 1 Adult Blood Transfusion Guideline

                        ADULT BLOOD TRANSFUSION GUIDELINE

                        bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

                        Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

                        Remember

                        bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

                        consider the cause

                        References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

                        BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

                        Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

                        This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

                        Haemoglobin Less than 8 gdl

                        Haemoglobin 8 to 10 gdl

                        Haemoglobin Greater than 10gdl

                        Yes Possibly if No

                        14

                        Appendix 2

                        Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

                        Tariff for Elective Procedures

                        2013-09-26 NW amp PRI MSBOS V30

                        Procedure

                        Tariff

                        Procedure

                        Tariff

                        Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

                        excision GampS

                        AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

                        If surgery for malignancy and pre-op Hblt120 L gdL

                        If pre-op Hbgt 120L gdL

                        2

                        GampS

                        Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

                        2 Nephrectomy - OPEN 2

                        Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

                        Colposuspension) GampS

                        Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

                        GampS Pyeloplasty GampS

                        Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

                        GampS Total Proctocolectomy 2

                        Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

                        15

                        Appendix 3a Flowchart Management of a Transfusion Reaction

                        Symptoms Signs of Acute Transfusion Reaction

                        Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

                        chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

                        Stop the transfusion and call a doctor

                        Measure temperature pulse blood pressure respiratory rate amp O2 saturation

                        Check identity of the recipient with the details on the unit and compatibility label or tag

                        Any discrepancy noted call the transfusion laboratory

                        Febrile non-haemolytic transfusion

                        reaction

                        If temperature rise less than

                        20˚C the observations are stable

                        and the patient is otherwise well

                        give paracetamol

                        Restart infusion at slower rate

                        and observe more frequently

                        Mild allergic reaction

                        Give Chlopheniramine 10mg

                        slowly iv and restart the

                        transfusion at a slower rate and

                        observe more frequently

                        Reaction

                        involves mild

                        fever or

                        urticarial

                        rash only

                        Mild fever

                        Urticaria

                        ABO incompatibility

                        Stop transfusion

                        Remove unit keeping IV giving set

                        attached and c lamped off for return

                        to Blood Transfusion Laboratory

                        Commence iv saline infusion through

                        a NEW IV administration set

                        Monitor blood pressure pulse urine

                        output (catheterise) frequently Seek

                        help from experts in management of

                        shock where appropriate

                        Treat any DIC with appropriate blood

                        components

                        Inform Hospital Transfusion

                        Laboratory immediately

                        Suspected ABO

                        incompatibility

                        No

                        Haemolytic reaction bacterial

                        infection of unit

                        Stop transfusion

                        Take down unit and giving set

                        Return intact to blood bank with all

                        other usedunused units

                        Take blood cultures repeat blood

                        group crossmatch FBC coagulation

                        screen biochemistry urinalysis

                        Monitor urine output

                        Commence broad spectrum

                        antibiotics if suspected bacterial

                        infection

                        Commence oxygen and fluid support

                        Seek haematological and intensive

                        Severe allergic reaction

                        Other haemolytic reaction bacterial

                        contamination

                        Severe allergic reaction

                        Bronchospasm angioedema

                        abdominal pain hypotension

                        Stop transfusion Call for help

                        Maintain airway give 100 O2

                        If severe hypotension lie patient flat

                        with legs elevated Give adrenaline

                        (05ml of 1 in 1000 intramuscular )

                        NEVER give undiluted epinephrine

                        intravascularly

                        Paediatric doses depend on the age of

                        the child Intramuscular 1 in 1000

                        epinephrine should be administered as

                        follows

                        12 years

                        05 milligrams (05 ml)

                        6-12 years

                        025 milligrams (025ml)

                        gt6 months to 6 years 012

                        milligrams( 012 ml)

                        lt6 months 005 milligrams

                        ( 005ml)

                        Take down unit and giving set

                        Start infusion of crystalloid or colloid

                        through a new iv fluid administration

                        set

                        Secondary therapy

                        Chlopheniramine 10mg slow iv

                        Salbutamol nebuliser

                        Corticosteroids 100-500mg

                        Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

                        Fluid overload

                        Give oxygen

                        Diuretic iv

                        TRALI

                        Clinical features of acute LVF with

                        fever and chills

                        Discontinue transfusion

                        Give 100 Oxygen

                        Treat as ARDS ndash ventilate if hypoxia

                        indicates

                        Acute dyspnoea

                        hypotension

                        Monitor blood gases

                        Perform CXR

                        Measure CVP

                        Pulmonary capillary

                        pressure

                        Raised

                        CVP

                        Normal

                        CVP

                        No

                        Yes

                        Yes

                        Yes

                        No

                        No

                        16

                        Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                        bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                        Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                        bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                        site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                        17

                        The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                        The component unit and any remaining contents with the clamped off IV giving set attached

                        should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                        Any empty used unit packs from this transfusion episode or unused units of blood issued for

                        the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                        Completed Transfusion Reaction form should be returned to the hospital transfusion

                        laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                        o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                        Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                        Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                        bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                        bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                        receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                        18

                        Appendix 4

                        20

                        21

                        22

                        23

                        24

                        25

                        Appendix 5a Jehovah Witness Consent

                        CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                        WILLING TO HAVE IF REQUIRED

                        REFUSE UNDER ANY CIRCUMSTANCES

                        Blood Components Red cells Platelets

                        Fresh frozen plasma Cryoprecipitate

                        Cell Salvage

                        Cell saver- Standard set up

                        Cell saver- set up in continuity only

                        Blood Products Octaplas (Prothrombin complex

                        Concentrate)

                        Anti-D Immunoglobulin Albumin

                        Factor VIII concentrate Factor IX concentrate

                        Fibrinogen Concentrate Recombinant Products

                        Erythropoietin Factor VIIa

                        I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                        26

                        expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                        DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                        27

                        Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                        needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                        to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                        bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                        Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                        bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                        transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                        bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                        must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                        (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                        28

                        Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                        units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                        desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                        bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                        SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                        requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                        Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                        Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                        - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                        29

                        - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                        Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                        bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                        taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                        Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                        unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                        the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                        Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                        date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                        Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                        30

                        bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                        The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                        31

                        Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                        Practitioner

                        bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                        bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                        32

                        Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                        Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                        alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                        patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                        Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                        or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                        33

                        If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                        if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                        the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                        from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                        the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                        34

                        bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                        identity band bull Match all other identifying information

                        35

                        Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                        been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                        had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                        the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                        bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                        Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                        alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                        you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                        bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                        form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                        bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                        is to take place

                        36

                        If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                        inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                        delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                        37

                        Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                        unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                        are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                        storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                        no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                        transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                        available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                        correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                        for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                        38

                        bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                        wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                        blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                        band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                        component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                        checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                        bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                        infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                        2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                        infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                        transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                        Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                        commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                        receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                        blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                        bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                        container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                        Blood Safety and Quality Regulations (2005)

                        39

                        bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                        bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                        a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                        40

                        Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                        inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                        bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                        Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                        depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                        substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                        or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                        urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                        41

                        bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                        haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                        42

                        Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                        bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                        bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                        bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                        43

                        Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                        Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                        Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                        regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                        44

                        Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                        negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                        45

                        Appendix 15A

                        46

                        Appendix 15B

                        47

                        Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                        Please use a new document for each transfusion event

                        PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                        HospitalUnit Affix label here or write patient details Forename

                        Surname

                        Gender

                        Date of birth

                        CHI

                        WardDept

                        Consultant

                        Authorisation Prescription

                        bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                        transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                        chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                        Consent for Transfusion

                        bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                        Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                        after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                        transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                        document in place Yes No Please delete patientguardian as appropriate

                        Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                        I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                        Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                        48

                        THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                        Patient Name Date of birthCHI

                        UN

                        IT 1

                        Blood component

                        Unit Pool mls

                        Special Requirements Instructions (please tick)

                        Affix completed pink portion of compatibility label here

                        Irradiated CMV negative Blood warmer Other medication

                        Reason for transfusion

                        Date Duration Authoriser Prescriber signature

                        Reassess before you progress (Venflon site and observations)

                        UN

                        IT 2

                        Blood component

                        Unit Pool mls

                        Special Requirements Instructions (please tick)

                        Affix completed pink portion of compatibility label here

                        Irradiated CMV negative Blood warmer Other medication

                        Reason for transfusion

                        Date Duration Authoriser Prescriber signature

                        Reassess before you progress (Venflon site and observations)

                        UN

                        IT 3

                        Blood component

                        Unit Pool mls

                        Special Requirements Instructions (please tick)

                        Affix completed pink portion of compatibility label here

                        Irradiated CMV negative Blood warmer Other medication

                        Reason for transfusion

                        Date Duration Authoriser Prescriber signature

                        Reassess before you progress (Venflon site and observations)

                        UN

                        IT 4

                        Blood component

                        Unit Pool mls

                        Special Requirements Instructions (please tick)

                        Affix completed pink portion of compatibility label here

                        Irradiated CMV negative Blood warmer Other medication

                        Reason for transfusion

                        Date Duration Authoriser Prescriber signature

                        THB(MR) 020 V40 May 2013

                        THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                        Patient Na me Date of birthCHI

                        Transfusion Checklist - Please initial each box as checks are completed

                        PRE-

                        COLLECTION

                        Checks below should be completed before collection of component from temperature

                        controlled storage is undertaken

                        PRE-

                        ADMINISTRATION

                        AT BEDSIDE

                        Only remove clear outer wrap

                        bag immediately prior to commencing transfusion and

                        only when all positive identification checks have been

                        completed

                        POST

                        TRANSFUSION

                        Unit No

                        1

                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                        helliphelliphelliphelliphelliphelliphellip

                        2

                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                        helliphelliphelliphelliphelliphelliphellip

                        3

                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                        helliphelliphelliphelliphelliphellip

                        4

                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                        helliphelliphelliphelliphelliphelliphellip

                        THB(MR) 020 V40 - May 2013

                        Identification band insitu amp details verified and correct

                        Patent IV access

                        (Patient safety bundle adhered to)

                        Blood authorised

                        prescribed

                        Check for special

                        requirements amp consent

                        Verbal identification

                        at the bedside

                        (if applicable)

                        Identification band details are verified

                        and correct amp match details

                        on Traceability ldquobagamp tagrdquo

                        label

                        DateTime Transfusion completed

                        Traceability Tag signed with starting time amp date of transfusion recorded

                        Inspect bag

                        (condition amp expiry

                        date)

                        DateTime blood removed from

                        cold temperature

                        storage

                        Baseline Observations recorded on SEWS chart

                        (Temperature Pulse

                        Oxygen sats Respiration rate

                        amp BP)

                        Completion of Observations

                        Noted on the SEWS chart

                        (Temperature Pulse

                        Oxygen Sats Respiration rate

                        50

                        Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                        be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                        Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                        be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                        recorded and concerns escalated to the medical team according to the SEWS

                        Adverse Events

                        bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                        more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                        hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                        Post Transfusion

                        bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                        patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                        bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                        Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                        transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                        patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                        Resources

                        Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                        THB(MR)020 v 40 May 2013

                        Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                        PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                        51

                        9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                        This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                        POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                        Why has this policy been developed

                        Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                        Has a risk control plan been developed and who is the owner of the risk If not why not

                        Who has been involvedconsulted in the development of the policy

                        Has the policy been assessed for Equality and Diversity in relation to-

                        Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                        RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                        Please indicate YesNo for the following YES

                        Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                        Please indicate Ye sNo for the following YES

                        Does the policy contain evidence of the Equality amp

                        Diversity Impact Assessment Process

                        Is there an implementation plan

                        Which officers are responsible for implementation

                        When will the policy take effect

                        Who must comply with the policystrategy

                        How will they be informed of their responsibilities

                        Is any training required

                        If yes has any been arranged

                        Are there any cost implications

                        NO

                        If yes please detail costs and note source of funding

                        Who is responsible for auditing the implementation of the policy

                        What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                        2

                        POLICY MANAGER________________________ DATE______ _____________________

                        • Blood supply in an emergency situation
                        • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                        • Administration of Platelets
                          • Appendix 1 Adult Blood Transfusion Guideline
                            • ADULT BLOOD TRANSFUSION GUIDELINE
                              • Remember
                                • References
                                  • Appendix 3a Flowchart Management of a Transfusion Reaction
                                    • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                      • Consent for Transfusion
                                      • THB(MR) 020 V40 May 2013
                                        • PRE- COLLECTION
                                        • PRE-ADMINISTRATION

                          13

                          Appendix 1 Adult Blood Transfusion Guideline

                          ADULT BLOOD TRANSFUSION GUIDELINE

                          bull Blood transfusion will always be associated with some risk bull Patients under 40 years will tolerate anaemia better than the elderly bull Young patients are at greatest risk of long term complications bull Blood is a scarce and valuable resource and has to be used wisely

                          Is Blood Transfusion likely to be beneficial bull bull Known Cardiovascular Disease bull Symptoms indicating myocardial or cerebral hypoperfusion bull Continuing acute blood loss

                          Remember

                          bull Transfusion of a single unit of blood may be sufficient bull Red cell transfusions should not be used for blood volume replacement bull Post-operative transfusion is unjustified if Hbgt10gdl bull Some anaemias Will respond to treatment of a deficiency eg iron B12 folate ndash always

                          consider the cause

                          References SIGN Guideline 54 Perioperative Blood Transfusion for Elective Surgery 2001 http

                          BCSH Guidelines for the clinical use of red cell Tr ansfusions 2001 Br J Haematol 11324-31

                          Transfusion Triggers 2002 Carson et al Transfusion Medicine Reviews 16187-199

                          This is a Guideline to aid clinical practice final decision to transfuse remains with the clinician

                          Haemoglobin Less than 8 gdl

                          Haemoglobin 8 to 10 gdl

                          Haemoglobin Greater than 10gdl

                          Yes Possibly if No

                          14

                          Appendix 2

                          Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

                          Tariff for Elective Procedures

                          2013-09-26 NW amp PRI MSBOS V30

                          Procedure

                          Tariff

                          Procedure

                          Tariff

                          Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

                          excision GampS

                          AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

                          If surgery for malignancy and pre-op Hblt120 L gdL

                          If pre-op Hbgt 120L gdL

                          2

                          GampS

                          Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

                          2 Nephrectomy - OPEN 2

                          Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

                          Colposuspension) GampS

                          Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

                          GampS Pyeloplasty GampS

                          Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

                          GampS Total Proctocolectomy 2

                          Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

                          15

                          Appendix 3a Flowchart Management of a Transfusion Reaction

                          Symptoms Signs of Acute Transfusion Reaction

                          Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

                          chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

                          Stop the transfusion and call a doctor

                          Measure temperature pulse blood pressure respiratory rate amp O2 saturation

                          Check identity of the recipient with the details on the unit and compatibility label or tag

                          Any discrepancy noted call the transfusion laboratory

                          Febrile non-haemolytic transfusion

                          reaction

                          If temperature rise less than

                          20˚C the observations are stable

                          and the patient is otherwise well

                          give paracetamol

                          Restart infusion at slower rate

                          and observe more frequently

                          Mild allergic reaction

                          Give Chlopheniramine 10mg

                          slowly iv and restart the

                          transfusion at a slower rate and

                          observe more frequently

                          Reaction

                          involves mild

                          fever or

                          urticarial

                          rash only

                          Mild fever

                          Urticaria

                          ABO incompatibility

                          Stop transfusion

                          Remove unit keeping IV giving set

                          attached and c lamped off for return

                          to Blood Transfusion Laboratory

                          Commence iv saline infusion through

                          a NEW IV administration set

                          Monitor blood pressure pulse urine

                          output (catheterise) frequently Seek

                          help from experts in management of

                          shock where appropriate

                          Treat any DIC with appropriate blood

                          components

                          Inform Hospital Transfusion

                          Laboratory immediately

                          Suspected ABO

                          incompatibility

                          No

                          Haemolytic reaction bacterial

                          infection of unit

                          Stop transfusion

                          Take down unit and giving set

                          Return intact to blood bank with all

                          other usedunused units

                          Take blood cultures repeat blood

                          group crossmatch FBC coagulation

                          screen biochemistry urinalysis

                          Monitor urine output

                          Commence broad spectrum

                          antibiotics if suspected bacterial

                          infection

                          Commence oxygen and fluid support

                          Seek haematological and intensive

                          Severe allergic reaction

                          Other haemolytic reaction bacterial

                          contamination

                          Severe allergic reaction

                          Bronchospasm angioedema

                          abdominal pain hypotension

                          Stop transfusion Call for help

                          Maintain airway give 100 O2

                          If severe hypotension lie patient flat

                          with legs elevated Give adrenaline

                          (05ml of 1 in 1000 intramuscular )

                          NEVER give undiluted epinephrine

                          intravascularly

                          Paediatric doses depend on the age of

                          the child Intramuscular 1 in 1000

                          epinephrine should be administered as

                          follows

                          12 years

                          05 milligrams (05 ml)

                          6-12 years

                          025 milligrams (025ml)

                          gt6 months to 6 years 012

                          milligrams( 012 ml)

                          lt6 months 005 milligrams

                          ( 005ml)

                          Take down unit and giving set

                          Start infusion of crystalloid or colloid

                          through a new iv fluid administration

                          set

                          Secondary therapy

                          Chlopheniramine 10mg slow iv

                          Salbutamol nebuliser

                          Corticosteroids 100-500mg

                          Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

                          Fluid overload

                          Give oxygen

                          Diuretic iv

                          TRALI

                          Clinical features of acute LVF with

                          fever and chills

                          Discontinue transfusion

                          Give 100 Oxygen

                          Treat as ARDS ndash ventilate if hypoxia

                          indicates

                          Acute dyspnoea

                          hypotension

                          Monitor blood gases

                          Perform CXR

                          Measure CVP

                          Pulmonary capillary

                          pressure

                          Raised

                          CVP

                          Normal

                          CVP

                          No

                          Yes

                          Yes

                          Yes

                          No

                          No

                          16

                          Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                          bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                          Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                          bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                          site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                          17

                          The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                          The component unit and any remaining contents with the clamped off IV giving set attached

                          should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                          Any empty used unit packs from this transfusion episode or unused units of blood issued for

                          the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                          Completed Transfusion Reaction form should be returned to the hospital transfusion

                          laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                          o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                          Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                          Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                          bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                          bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                          receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                          18

                          Appendix 4

                          20

                          21

                          22

                          23

                          24

                          25

                          Appendix 5a Jehovah Witness Consent

                          CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                          WILLING TO HAVE IF REQUIRED

                          REFUSE UNDER ANY CIRCUMSTANCES

                          Blood Components Red cells Platelets

                          Fresh frozen plasma Cryoprecipitate

                          Cell Salvage

                          Cell saver- Standard set up

                          Cell saver- set up in continuity only

                          Blood Products Octaplas (Prothrombin complex

                          Concentrate)

                          Anti-D Immunoglobulin Albumin

                          Factor VIII concentrate Factor IX concentrate

                          Fibrinogen Concentrate Recombinant Products

                          Erythropoietin Factor VIIa

                          I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                          26

                          expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                          DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                          27

                          Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                          needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                          to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                          bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                          Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                          bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                          transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                          bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                          must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                          (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                          28

                          Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                          units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                          desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                          bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                          SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                          requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                          Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                          Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                          - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                          29

                          - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                          Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                          bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                          taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                          Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                          unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                          the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                          Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                          date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                          Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                          30

                          bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                          The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                          31

                          Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                          Practitioner

                          bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                          bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                          32

                          Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                          Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                          alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                          patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                          Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                          or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                          33

                          If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                          if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                          the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                          from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                          the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                          34

                          bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                          identity band bull Match all other identifying information

                          35

                          Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                          been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                          had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                          the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                          bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                          Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                          alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                          you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                          bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                          form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                          bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                          is to take place

                          36

                          If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                          inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                          delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                          37

                          Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                          unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                          are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                          storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                          no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                          transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                          available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                          correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                          for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                          38

                          bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                          wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                          blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                          band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                          component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                          checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                          bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                          infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                          2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                          infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                          transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                          Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                          commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                          receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                          blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                          bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                          container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                          Blood Safety and Quality Regulations (2005)

                          39

                          bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                          bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                          a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                          40

                          Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                          inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                          bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                          Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                          depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                          substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                          or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                          urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                          41

                          bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                          haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                          42

                          Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                          bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                          bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                          bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                          43

                          Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                          Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                          Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                          regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                          44

                          Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                          negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                          45

                          Appendix 15A

                          46

                          Appendix 15B

                          47

                          Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                          Please use a new document for each transfusion event

                          PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                          HospitalUnit Affix label here or write patient details Forename

                          Surname

                          Gender

                          Date of birth

                          CHI

                          WardDept

                          Consultant

                          Authorisation Prescription

                          bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                          transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                          chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                          Consent for Transfusion

                          bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                          Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                          after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                          transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                          document in place Yes No Please delete patientguardian as appropriate

                          Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                          I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                          Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                          48

                          THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                          Patient Name Date of birthCHI

                          UN

                          IT 1

                          Blood component

                          Unit Pool mls

                          Special Requirements Instructions (please tick)

                          Affix completed pink portion of compatibility label here

                          Irradiated CMV negative Blood warmer Other medication

                          Reason for transfusion

                          Date Duration Authoriser Prescriber signature

                          Reassess before you progress (Venflon site and observations)

                          UN

                          IT 2

                          Blood component

                          Unit Pool mls

                          Special Requirements Instructions (please tick)

                          Affix completed pink portion of compatibility label here

                          Irradiated CMV negative Blood warmer Other medication

                          Reason for transfusion

                          Date Duration Authoriser Prescriber signature

                          Reassess before you progress (Venflon site and observations)

                          UN

                          IT 3

                          Blood component

                          Unit Pool mls

                          Special Requirements Instructions (please tick)

                          Affix completed pink portion of compatibility label here

                          Irradiated CMV negative Blood warmer Other medication

                          Reason for transfusion

                          Date Duration Authoriser Prescriber signature

                          Reassess before you progress (Venflon site and observations)

                          UN

                          IT 4

                          Blood component

                          Unit Pool mls

                          Special Requirements Instructions (please tick)

                          Affix completed pink portion of compatibility label here

                          Irradiated CMV negative Blood warmer Other medication

                          Reason for transfusion

                          Date Duration Authoriser Prescriber signature

                          THB(MR) 020 V40 May 2013

                          THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                          Patient Na me Date of birthCHI

                          Transfusion Checklist - Please initial each box as checks are completed

                          PRE-

                          COLLECTION

                          Checks below should be completed before collection of component from temperature

                          controlled storage is undertaken

                          PRE-

                          ADMINISTRATION

                          AT BEDSIDE

                          Only remove clear outer wrap

                          bag immediately prior to commencing transfusion and

                          only when all positive identification checks have been

                          completed

                          POST

                          TRANSFUSION

                          Unit No

                          1

                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                          helliphelliphelliphelliphelliphelliphellip

                          2

                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                          helliphelliphelliphelliphelliphelliphellip

                          3

                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                          helliphelliphelliphelliphelliphellip

                          4

                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                          helliphelliphelliphelliphelliphelliphellip

                          THB(MR) 020 V40 - May 2013

                          Identification band insitu amp details verified and correct

                          Patent IV access

                          (Patient safety bundle adhered to)

                          Blood authorised

                          prescribed

                          Check for special

                          requirements amp consent

                          Verbal identification

                          at the bedside

                          (if applicable)

                          Identification band details are verified

                          and correct amp match details

                          on Traceability ldquobagamp tagrdquo

                          label

                          DateTime Transfusion completed

                          Traceability Tag signed with starting time amp date of transfusion recorded

                          Inspect bag

                          (condition amp expiry

                          date)

                          DateTime blood removed from

                          cold temperature

                          storage

                          Baseline Observations recorded on SEWS chart

                          (Temperature Pulse

                          Oxygen sats Respiration rate

                          amp BP)

                          Completion of Observations

                          Noted on the SEWS chart

                          (Temperature Pulse

                          Oxygen Sats Respiration rate

                          50

                          Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                          be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                          Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                          be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                          recorded and concerns escalated to the medical team according to the SEWS

                          Adverse Events

                          bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                          more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                          hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                          Post Transfusion

                          bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                          patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                          bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                          Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                          transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                          patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                          Resources

                          Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                          THB(MR)020 v 40 May 2013

                          Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                          PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                          51

                          9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                          This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                          POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                          Why has this policy been developed

                          Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                          Has a risk control plan been developed and who is the owner of the risk If not why not

                          Who has been involvedconsulted in the development of the policy

                          Has the policy been assessed for Equality and Diversity in relation to-

                          Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                          RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                          Please indicate YesNo for the following YES

                          Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                          Please indicate Ye sNo for the following YES

                          Does the policy contain evidence of the Equality amp

                          Diversity Impact Assessment Process

                          Is there an implementation plan

                          Which officers are responsible for implementation

                          When will the policy take effect

                          Who must comply with the policystrategy

                          How will they be informed of their responsibilities

                          Is any training required

                          If yes has any been arranged

                          Are there any cost implications

                          NO

                          If yes please detail costs and note source of funding

                          Who is responsible for auditing the implementation of the policy

                          What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                          2

                          POLICY MANAGER________________________ DATE______ _____________________

                          • Blood supply in an emergency situation
                          • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                          • Administration of Platelets
                            • Appendix 1 Adult Blood Transfusion Guideline
                              • ADULT BLOOD TRANSFUSION GUIDELINE
                                • Remember
                                  • References
                                    • Appendix 3a Flowchart Management of a Transfusion Reaction
                                      • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                        • Consent for Transfusion
                                        • THB(MR) 020 V40 May 2013
                                          • PRE- COLLECTION
                                          • PRE-ADMINISTRATION

                            14

                            Appendix 2

                            Ninewells Hospital and Perth Royal Infirmary Maximum Surgical Blood Ordering Schedule (MSBOS) 20 13

                            Tariff for Elective Procedures

                            2013-09-26 NW amp PRI MSBOS V30

                            Procedure

                            Tariff

                            Procedure

                            Tariff

                            Abdomino -Peroneal Resec tion 2 Laparoscopy GampS Amputation GampS Laparotomy GampS Aortic Aneurysm ndash Elective 2 Liver Biopsy GampS Aortic iliac surgery GampS Liver Resection 3 Appendicectomy 0 Mastectomy or wide local

                            excision GampS

                            AV Shunt for Haemodialysis GampS Maxillofacial Surgery ( major cases)

                            If surgery for malignancy and pre-op Hblt120 L gdL

                            If pre-op Hbgt 120L gdL

                            2

                            GampS

                            Bile Duct StrictureTumour 2 Myomectomy 2 Bowel Resection (inc large bowel)

                            2 Nephrectomy - OPEN 2

                            Breast Biopsy Lump Excision 0 Nephrectomy - Laparosc opic GampS Caesarean Section GampS Nephrolithotomy 2 Carotid Endarterectomy GampS Oesophagectomy 3 Cholecystectomy GampS Ovarian Cystectomy 2 Cone Biopsy 0 Pacemaker Insertion GampS Cystectomy (Total) 2 Panproctocolectomy 2 Cystoscopy GampS Prolapse Repair (inc

                            Colposuspension) GampS

                            Dilatation and Curettage 0 Prostatectomy - Open GampS Endovascular Aortic Aneurysm Repair

                            GampS Pyeloplasty GampS

                            Femoral Popliteal Bypass GampS Splenectomy (Elective) GampS Fracture Neck of Femur GampS Termination of Pregnancy GampS Gastrec tomy Partial GampS THR GampS Gastrectomy Total 3 THR - Revision 3 Haemorrhoidectomy GampS Thyroidectomy GampS Hernia Repair 0 TKR GampS Laparoscopic fundoplication GampS TKR - Revision 2 Hysterectomy - VaginalAbdominal

                            GampS Total Proctocolectomy 2

                            Hysterectomy (Radical) GampS Translumbar Aortogram GampS Ileostomy GampS TUR Biopsy 0 IM Nail for NOF GampS TURP GampS IM Nail for Tibia GampS Varicose Vein Strip 0 Laminectomy GampS Vulvectomy (Radical) 1

                            15

                            Appendix 3a Flowchart Management of a Transfusion Reaction

                            Symptoms Signs of Acute Transfusion Reaction

                            Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

                            chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

                            Stop the transfusion and call a doctor

                            Measure temperature pulse blood pressure respiratory rate amp O2 saturation

                            Check identity of the recipient with the details on the unit and compatibility label or tag

                            Any discrepancy noted call the transfusion laboratory

                            Febrile non-haemolytic transfusion

                            reaction

                            If temperature rise less than

                            20˚C the observations are stable

                            and the patient is otherwise well

                            give paracetamol

                            Restart infusion at slower rate

                            and observe more frequently

                            Mild allergic reaction

                            Give Chlopheniramine 10mg

                            slowly iv and restart the

                            transfusion at a slower rate and

                            observe more frequently

                            Reaction

                            involves mild

                            fever or

                            urticarial

                            rash only

                            Mild fever

                            Urticaria

                            ABO incompatibility

                            Stop transfusion

                            Remove unit keeping IV giving set

                            attached and c lamped off for return

                            to Blood Transfusion Laboratory

                            Commence iv saline infusion through

                            a NEW IV administration set

                            Monitor blood pressure pulse urine

                            output (catheterise) frequently Seek

                            help from experts in management of

                            shock where appropriate

                            Treat any DIC with appropriate blood

                            components

                            Inform Hospital Transfusion

                            Laboratory immediately

                            Suspected ABO

                            incompatibility

                            No

                            Haemolytic reaction bacterial

                            infection of unit

                            Stop transfusion

                            Take down unit and giving set

                            Return intact to blood bank with all

                            other usedunused units

                            Take blood cultures repeat blood

                            group crossmatch FBC coagulation

                            screen biochemistry urinalysis

                            Monitor urine output

                            Commence broad spectrum

                            antibiotics if suspected bacterial

                            infection

                            Commence oxygen and fluid support

                            Seek haematological and intensive

                            Severe allergic reaction

                            Other haemolytic reaction bacterial

                            contamination

                            Severe allergic reaction

                            Bronchospasm angioedema

                            abdominal pain hypotension

                            Stop transfusion Call for help

                            Maintain airway give 100 O2

                            If severe hypotension lie patient flat

                            with legs elevated Give adrenaline

                            (05ml of 1 in 1000 intramuscular )

                            NEVER give undiluted epinephrine

                            intravascularly

                            Paediatric doses depend on the age of

                            the child Intramuscular 1 in 1000

                            epinephrine should be administered as

                            follows

                            12 years

                            05 milligrams (05 ml)

                            6-12 years

                            025 milligrams (025ml)

                            gt6 months to 6 years 012

                            milligrams( 012 ml)

                            lt6 months 005 milligrams

                            ( 005ml)

                            Take down unit and giving set

                            Start infusion of crystalloid or colloid

                            through a new iv fluid administration

                            set

                            Secondary therapy

                            Chlopheniramine 10mg slow iv

                            Salbutamol nebuliser

                            Corticosteroids 100-500mg

                            Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

                            Fluid overload

                            Give oxygen

                            Diuretic iv

                            TRALI

                            Clinical features of acute LVF with

                            fever and chills

                            Discontinue transfusion

                            Give 100 Oxygen

                            Treat as ARDS ndash ventilate if hypoxia

                            indicates

                            Acute dyspnoea

                            hypotension

                            Monitor blood gases

                            Perform CXR

                            Measure CVP

                            Pulmonary capillary

                            pressure

                            Raised

                            CVP

                            Normal

                            CVP

                            No

                            Yes

                            Yes

                            Yes

                            No

                            No

                            16

                            Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                            bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                            Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                            bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                            site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                            17

                            The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                            The component unit and any remaining contents with the clamped off IV giving set attached

                            should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                            Any empty used unit packs from this transfusion episode or unused units of blood issued for

                            the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                            Completed Transfusion Reaction form should be returned to the hospital transfusion

                            laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                            o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                            Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                            Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                            bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                            bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                            receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                            18

                            Appendix 4

                            20

                            21

                            22

                            23

                            24

                            25

                            Appendix 5a Jehovah Witness Consent

                            CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                            WILLING TO HAVE IF REQUIRED

                            REFUSE UNDER ANY CIRCUMSTANCES

                            Blood Components Red cells Platelets

                            Fresh frozen plasma Cryoprecipitate

                            Cell Salvage

                            Cell saver- Standard set up

                            Cell saver- set up in continuity only

                            Blood Products Octaplas (Prothrombin complex

                            Concentrate)

                            Anti-D Immunoglobulin Albumin

                            Factor VIII concentrate Factor IX concentrate

                            Fibrinogen Concentrate Recombinant Products

                            Erythropoietin Factor VIIa

                            I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                            26

                            expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                            DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                            27

                            Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                            needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                            to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                            bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                            Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                            bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                            transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                            bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                            must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                            (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                            28

                            Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                            units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                            desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                            bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                            SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                            requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                            Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                            Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                            - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                            29

                            - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                            Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                            bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                            taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                            Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                            unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                            the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                            Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                            date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                            Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                            30

                            bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                            The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                            31

                            Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                            Practitioner

                            bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                            bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                            32

                            Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                            Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                            alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                            patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                            Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                            or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                            33

                            If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                            if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                            the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                            from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                            the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                            34

                            bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                            identity band bull Match all other identifying information

                            35

                            Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                            been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                            had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                            the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                            bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                            Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                            alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                            you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                            bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                            form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                            bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                            is to take place

                            36

                            If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                            inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                            delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                            37

                            Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                            unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                            are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                            storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                            no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                            transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                            available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                            correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                            for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                            38

                            bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                            wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                            blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                            band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                            component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                            checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                            bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                            infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                            2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                            infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                            transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                            Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                            commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                            receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                            blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                            bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                            container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                            Blood Safety and Quality Regulations (2005)

                            39

                            bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                            bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                            a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                            40

                            Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                            inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                            bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                            Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                            depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                            substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                            or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                            urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                            41

                            bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                            haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                            42

                            Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                            bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                            bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                            bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                            43

                            Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                            Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                            Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                            regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                            44

                            Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                            negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                            45

                            Appendix 15A

                            46

                            Appendix 15B

                            47

                            Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                            Please use a new document for each transfusion event

                            PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                            HospitalUnit Affix label here or write patient details Forename

                            Surname

                            Gender

                            Date of birth

                            CHI

                            WardDept

                            Consultant

                            Authorisation Prescription

                            bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                            transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                            chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                            Consent for Transfusion

                            bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                            Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                            after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                            transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                            document in place Yes No Please delete patientguardian as appropriate

                            Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                            I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                            Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                            48

                            THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                            Patient Name Date of birthCHI

                            UN

                            IT 1

                            Blood component

                            Unit Pool mls

                            Special Requirements Instructions (please tick)

                            Affix completed pink portion of compatibility label here

                            Irradiated CMV negative Blood warmer Other medication

                            Reason for transfusion

                            Date Duration Authoriser Prescriber signature

                            Reassess before you progress (Venflon site and observations)

                            UN

                            IT 2

                            Blood component

                            Unit Pool mls

                            Special Requirements Instructions (please tick)

                            Affix completed pink portion of compatibility label here

                            Irradiated CMV negative Blood warmer Other medication

                            Reason for transfusion

                            Date Duration Authoriser Prescriber signature

                            Reassess before you progress (Venflon site and observations)

                            UN

                            IT 3

                            Blood component

                            Unit Pool mls

                            Special Requirements Instructions (please tick)

                            Affix completed pink portion of compatibility label here

                            Irradiated CMV negative Blood warmer Other medication

                            Reason for transfusion

                            Date Duration Authoriser Prescriber signature

                            Reassess before you progress (Venflon site and observations)

                            UN

                            IT 4

                            Blood component

                            Unit Pool mls

                            Special Requirements Instructions (please tick)

                            Affix completed pink portion of compatibility label here

                            Irradiated CMV negative Blood warmer Other medication

                            Reason for transfusion

                            Date Duration Authoriser Prescriber signature

                            THB(MR) 020 V40 May 2013

                            THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                            Patient Na me Date of birthCHI

                            Transfusion Checklist - Please initial each box as checks are completed

                            PRE-

                            COLLECTION

                            Checks below should be completed before collection of component from temperature

                            controlled storage is undertaken

                            PRE-

                            ADMINISTRATION

                            AT BEDSIDE

                            Only remove clear outer wrap

                            bag immediately prior to commencing transfusion and

                            only when all positive identification checks have been

                            completed

                            POST

                            TRANSFUSION

                            Unit No

                            1

                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                            helliphelliphelliphelliphelliphelliphellip

                            2

                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                            helliphelliphelliphelliphelliphelliphellip

                            3

                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                            helliphelliphelliphelliphelliphellip

                            4

                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                            helliphelliphelliphelliphelliphelliphellip

                            THB(MR) 020 V40 - May 2013

                            Identification band insitu amp details verified and correct

                            Patent IV access

                            (Patient safety bundle adhered to)

                            Blood authorised

                            prescribed

                            Check for special

                            requirements amp consent

                            Verbal identification

                            at the bedside

                            (if applicable)

                            Identification band details are verified

                            and correct amp match details

                            on Traceability ldquobagamp tagrdquo

                            label

                            DateTime Transfusion completed

                            Traceability Tag signed with starting time amp date of transfusion recorded

                            Inspect bag

                            (condition amp expiry

                            date)

                            DateTime blood removed from

                            cold temperature

                            storage

                            Baseline Observations recorded on SEWS chart

                            (Temperature Pulse

                            Oxygen sats Respiration rate

                            amp BP)

                            Completion of Observations

                            Noted on the SEWS chart

                            (Temperature Pulse

                            Oxygen Sats Respiration rate

                            50

                            Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                            be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                            Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                            be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                            recorded and concerns escalated to the medical team according to the SEWS

                            Adverse Events

                            bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                            more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                            hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                            Post Transfusion

                            bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                            patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                            bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                            Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                            transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                            patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                            Resources

                            Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                            THB(MR)020 v 40 May 2013

                            Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                            PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                            51

                            9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                            This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                            POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                            Why has this policy been developed

                            Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                            Has a risk control plan been developed and who is the owner of the risk If not why not

                            Who has been involvedconsulted in the development of the policy

                            Has the policy been assessed for Equality and Diversity in relation to-

                            Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                            RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                            Please indicate YesNo for the following YES

                            Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                            Please indicate Ye sNo for the following YES

                            Does the policy contain evidence of the Equality amp

                            Diversity Impact Assessment Process

                            Is there an implementation plan

                            Which officers are responsible for implementation

                            When will the policy take effect

                            Who must comply with the policystrategy

                            How will they be informed of their responsibilities

                            Is any training required

                            If yes has any been arranged

                            Are there any cost implications

                            NO

                            If yes please detail costs and note source of funding

                            Who is responsible for auditing the implementation of the policy

                            What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                            2

                            POLICY MANAGER________________________ DATE______ _____________________

                            • Blood supply in an emergency situation
                            • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                            • Administration of Platelets
                              • Appendix 1 Adult Blood Transfusion Guideline
                                • ADULT BLOOD TRANSFUSION GUIDELINE
                                  • Remember
                                    • References
                                      • Appendix 3a Flowchart Management of a Transfusion Reaction
                                        • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                          • Consent for Transfusion
                                          • THB(MR) 020 V40 May 2013
                                            • PRE- COLLECTION
                                            • PRE-ADMINISTRATION

                              15

                              Appendix 3a Flowchart Management of a Transfusion Reaction

                              Symptoms Signs of Acute Transfusion Reaction

                              Fever chills tachycardia hyper or hypotension collapse rigors flushing urticaria pain (bone muscle

                              chest andor abdominal) shortness of breath nausea generally feeling unwell respiratory distress

                              Stop the transfusion and call a doctor

                              Measure temperature pulse blood pressure respiratory rate amp O2 saturation

                              Check identity of the recipient with the details on the unit and compatibility label or tag

                              Any discrepancy noted call the transfusion laboratory

                              Febrile non-haemolytic transfusion

                              reaction

                              If temperature rise less than

                              20˚C the observations are stable

                              and the patient is otherwise well

                              give paracetamol

                              Restart infusion at slower rate

                              and observe more frequently

                              Mild allergic reaction

                              Give Chlopheniramine 10mg

                              slowly iv and restart the

                              transfusion at a slower rate and

                              observe more frequently

                              Reaction

                              involves mild

                              fever or

                              urticarial

                              rash only

                              Mild fever

                              Urticaria

                              ABO incompatibility

                              Stop transfusion

                              Remove unit keeping IV giving set

                              attached and c lamped off for return

                              to Blood Transfusion Laboratory

                              Commence iv saline infusion through

                              a NEW IV administration set

                              Monitor blood pressure pulse urine

                              output (catheterise) frequently Seek

                              help from experts in management of

                              shock where appropriate

                              Treat any DIC with appropriate blood

                              components

                              Inform Hospital Transfusion

                              Laboratory immediately

                              Suspected ABO

                              incompatibility

                              No

                              Haemolytic reaction bacterial

                              infection of unit

                              Stop transfusion

                              Take down unit and giving set

                              Return intact to blood bank with all

                              other usedunused units

                              Take blood cultures repeat blood

                              group crossmatch FBC coagulation

                              screen biochemistry urinalysis

                              Monitor urine output

                              Commence broad spectrum

                              antibiotics if suspected bacterial

                              infection

                              Commence oxygen and fluid support

                              Seek haematological and intensive

                              Severe allergic reaction

                              Other haemolytic reaction bacterial

                              contamination

                              Severe allergic reaction

                              Bronchospasm angioedema

                              abdominal pain hypotension

                              Stop transfusion Call for help

                              Maintain airway give 100 O2

                              If severe hypotension lie patient flat

                              with legs elevated Give adrenaline

                              (05ml of 1 in 1000 intramuscular )

                              NEVER give undiluted epinephrine

                              intravascularly

                              Paediatric doses depend on the age of

                              the child Intramuscular 1 in 1000

                              epinephrine should be administered as

                              follows

                              12 years

                              05 milligrams (05 ml)

                              6-12 years

                              025 milligrams (025ml)

                              gt6 months to 6 years 012

                              milligrams( 012 ml)

                              lt6 months 005 milligrams

                              ( 005ml)

                              Take down unit and giving set

                              Start infusion of crystalloid or colloid

                              through a new iv fluid administration

                              set

                              Secondary therapy

                              Chlopheniramine 10mg slow iv

                              Salbutamol nebuliser

                              Corticosteroids 100-500mg

                              Adapted from Handbook of transfusion medicine 4th edition DBL McClelland Ed The Stationery Office London 2007

                              Fluid overload

                              Give oxygen

                              Diuretic iv

                              TRALI

                              Clinical features of acute LVF with

                              fever and chills

                              Discontinue transfusion

                              Give 100 Oxygen

                              Treat as ARDS ndash ventilate if hypoxia

                              indicates

                              Acute dyspnoea

                              hypotension

                              Monitor blood gases

                              Perform CXR

                              Measure CVP

                              Pulmonary capillary

                              pressure

                              Raised

                              CVP

                              Normal

                              CVP

                              No

                              Yes

                              Yes

                              Yes

                              No

                              No

                              16

                              Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                              bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                              Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                              bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                              site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                              17

                              The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                              The component unit and any remaining contents with the clamped off IV giving set attached

                              should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                              Any empty used unit packs from this transfusion episode or unused units of blood issued for

                              the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                              Completed Transfusion Reaction form should be returned to the hospital transfusion

                              laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                              o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                              Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                              Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                              bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                              bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                              receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                              18

                              Appendix 4

                              20

                              21

                              22

                              23

                              24

                              25

                              Appendix 5a Jehovah Witness Consent

                              CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                              WILLING TO HAVE IF REQUIRED

                              REFUSE UNDER ANY CIRCUMSTANCES

                              Blood Components Red cells Platelets

                              Fresh frozen plasma Cryoprecipitate

                              Cell Salvage

                              Cell saver- Standard set up

                              Cell saver- set up in continuity only

                              Blood Products Octaplas (Prothrombin complex

                              Concentrate)

                              Anti-D Immunoglobulin Albumin

                              Factor VIII concentrate Factor IX concentrate

                              Fibrinogen Concentrate Recombinant Products

                              Erythropoietin Factor VIIa

                              I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                              26

                              expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                              DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                              27

                              Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                              needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                              to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                              bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                              Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                              bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                              transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                              bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                              must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                              (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                              28

                              Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                              units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                              desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                              bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                              SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                              requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                              Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                              Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                              - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                              29

                              - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                              Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                              bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                              taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                              Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                              unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                              the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                              Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                              date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                              Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                              30

                              bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                              The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                              31

                              Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                              Practitioner

                              bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                              bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                              32

                              Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                              Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                              alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                              patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                              Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                              or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                              33

                              If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                              if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                              the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                              from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                              the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                              34

                              bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                              identity band bull Match all other identifying information

                              35

                              Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                              been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                              had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                              the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                              bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                              Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                              alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                              you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                              bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                              form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                              bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                              is to take place

                              36

                              If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                              inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                              delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                              37

                              Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                              unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                              are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                              storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                              no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                              transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                              available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                              correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                              for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                              38

                              bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                              wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                              blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                              band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                              component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                              checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                              bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                              infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                              2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                              infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                              transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                              Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                              commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                              receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                              blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                              bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                              container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                              Blood Safety and Quality Regulations (2005)

                              39

                              bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                              bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                              a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                              40

                              Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                              inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                              bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                              Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                              depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                              substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                              or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                              urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                              41

                              bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                              haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                              42

                              Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                              bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                              bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                              bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                              43

                              Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                              Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                              Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                              regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                              44

                              Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                              negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                              45

                              Appendix 15A

                              46

                              Appendix 15B

                              47

                              Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                              Please use a new document for each transfusion event

                              PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                              HospitalUnit Affix label here or write patient details Forename

                              Surname

                              Gender

                              Date of birth

                              CHI

                              WardDept

                              Consultant

                              Authorisation Prescription

                              bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                              transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                              chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                              Consent for Transfusion

                              bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                              Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                              after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                              transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                              document in place Yes No Please delete patientguardian as appropriate

                              Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                              I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                              Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                              48

                              THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                              Patient Name Date of birthCHI

                              UN

                              IT 1

                              Blood component

                              Unit Pool mls

                              Special Requirements Instructions (please tick)

                              Affix completed pink portion of compatibility label here

                              Irradiated CMV negative Blood warmer Other medication

                              Reason for transfusion

                              Date Duration Authoriser Prescriber signature

                              Reassess before you progress (Venflon site and observations)

                              UN

                              IT 2

                              Blood component

                              Unit Pool mls

                              Special Requirements Instructions (please tick)

                              Affix completed pink portion of compatibility label here

                              Irradiated CMV negative Blood warmer Other medication

                              Reason for transfusion

                              Date Duration Authoriser Prescriber signature

                              Reassess before you progress (Venflon site and observations)

                              UN

                              IT 3

                              Blood component

                              Unit Pool mls

                              Special Requirements Instructions (please tick)

                              Affix completed pink portion of compatibility label here

                              Irradiated CMV negative Blood warmer Other medication

                              Reason for transfusion

                              Date Duration Authoriser Prescriber signature

                              Reassess before you progress (Venflon site and observations)

                              UN

                              IT 4

                              Blood component

                              Unit Pool mls

                              Special Requirements Instructions (please tick)

                              Affix completed pink portion of compatibility label here

                              Irradiated CMV negative Blood warmer Other medication

                              Reason for transfusion

                              Date Duration Authoriser Prescriber signature

                              THB(MR) 020 V40 May 2013

                              THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                              Patient Na me Date of birthCHI

                              Transfusion Checklist - Please initial each box as checks are completed

                              PRE-

                              COLLECTION

                              Checks below should be completed before collection of component from temperature

                              controlled storage is undertaken

                              PRE-

                              ADMINISTRATION

                              AT BEDSIDE

                              Only remove clear outer wrap

                              bag immediately prior to commencing transfusion and

                              only when all positive identification checks have been

                              completed

                              POST

                              TRANSFUSION

                              Unit No

                              1

                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                              helliphelliphelliphelliphelliphelliphellip

                              2

                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                              helliphelliphelliphelliphelliphelliphellip

                              3

                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                              helliphelliphelliphelliphelliphellip

                              4

                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                              helliphelliphelliphelliphelliphelliphellip

                              THB(MR) 020 V40 - May 2013

                              Identification band insitu amp details verified and correct

                              Patent IV access

                              (Patient safety bundle adhered to)

                              Blood authorised

                              prescribed

                              Check for special

                              requirements amp consent

                              Verbal identification

                              at the bedside

                              (if applicable)

                              Identification band details are verified

                              and correct amp match details

                              on Traceability ldquobagamp tagrdquo

                              label

                              DateTime Transfusion completed

                              Traceability Tag signed with starting time amp date of transfusion recorded

                              Inspect bag

                              (condition amp expiry

                              date)

                              DateTime blood removed from

                              cold temperature

                              storage

                              Baseline Observations recorded on SEWS chart

                              (Temperature Pulse

                              Oxygen sats Respiration rate

                              amp BP)

                              Completion of Observations

                              Noted on the SEWS chart

                              (Temperature Pulse

                              Oxygen Sats Respiration rate

                              50

                              Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                              be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                              Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                              be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                              recorded and concerns escalated to the medical team according to the SEWS

                              Adverse Events

                              bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                              more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                              hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                              Post Transfusion

                              bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                              patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                              bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                              Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                              transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                              patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                              Resources

                              Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                              THB(MR)020 v 40 May 2013

                              Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                              PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                              51

                              9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                              This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                              POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                              Why has this policy been developed

                              Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                              Has a risk control plan been developed and who is the owner of the risk If not why not

                              Who has been involvedconsulted in the development of the policy

                              Has the policy been assessed for Equality and Diversity in relation to-

                              Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                              RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                              Please indicate YesNo for the following YES

                              Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                              Please indicate Ye sNo for the following YES

                              Does the policy contain evidence of the Equality amp

                              Diversity Impact Assessment Process

                              Is there an implementation plan

                              Which officers are responsible for implementation

                              When will the policy take effect

                              Who must comply with the policystrategy

                              How will they be informed of their responsibilities

                              Is any training required

                              If yes has any been arranged

                              Are there any cost implications

                              NO

                              If yes please detail costs and note source of funding

                              Who is responsible for auditing the implementation of the policy

                              What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                              2

                              POLICY MANAGER________________________ DATE______ _____________________

                              • Blood supply in an emergency situation
                              • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                              • Administration of Platelets
                                • Appendix 1 Adult Blood Transfusion Guideline
                                  • ADULT BLOOD TRANSFUSION GUIDELINE
                                    • Remember
                                      • References
                                        • Appendix 3a Flowchart Management of a Transfusion Reaction
                                          • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                            • Consent for Transfusion
                                            • THB(MR) 020 V40 May 2013
                                              • PRE- COLLECTION
                                              • PRE-ADMINISTRATION

                                16

                                Appendix 3b Mild Acute Transfusion Reaction Signs amp Symptoms

                                bull Allergic reactions are not uncommon minor urticarial skin reactions or pruritis bull Rise in temperature less than 20 0C above baseline

                                Management of a Mild Acute Transfusion Reaction 1 Stop the transfusion (check patient and component compatibility) 2 Seek medical advice 3 Assess patient 4 Commence appropriate treatment If signs amp symptoms worsen within 15 minutes treat as a severe reaction When treating a mild reaction you should advise the practitioner to continue transfusion at the normal rate if there is no progression of symptoms after 30 minutes It is important that you continue to monitor your patient Severe Transfusion Reaction Signs amp Symptoms More serious reactions are associated with

                                bull Pyrexia of more than 20 0C above baseline bull Rigors Hypotension LoinBack Pain Increasing anxiety Severe Tachycardia Pain at infusion

                                site Dark urine Respiratory Distress Unexpected bleeding (DIC) Management of a Severe Transfusion Reaction 1 Stop and disconnect the transfusion - ensure IV giving set remains intact in the outlet port of the unit pack and the regulating clamp is firmly closed (return pack + giving set to Hospital Transfusion Laboratory(HTL) in a plastic disposal bag clearly marked ldquotransfusion reaction investigationrdquo) 2 Replace the administration set IV access should be maintained with normal saline 3 Call the doctor to see the patient urgently 4 Assess patient - resuscitate as required 5 Check compatibility of unit with patient documentation and ID band 6 Inform the Hospital Transfusion Laboratory and request a Transfusion Reaction Report form 7 Contact on call Medical Officer Haematologist for Hospital Transfusion Laboratory giving details of the reaction indicating the degree of urgency of further transfusion(s) 8 Reassess patient and treat appropriately 9 Check urine for signs of Haemoglobinuria 10 Document event in patient case notes 11 Report via NHS Tayside Adverse Incident Management reporting scheme(DATIX) 12 Maintain airway and give high flow Oxygen Administer adrenaline andor diuretic The clinician should seek expert advice if patientrsquos condition continues to deteriorate

                                17

                                The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                                The component unit and any remaining contents with the clamped off IV giving set attached

                                should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                                Any empty used unit packs from this transfusion episode or unused units of blood issued for

                                the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                                Completed Transfusion Reaction form should be returned to the hospital transfusion

                                laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                                o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                                Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                                Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                                bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                                bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                                receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                                18

                                Appendix 4

                                20

                                21

                                22

                                23

                                24

                                25

                                Appendix 5a Jehovah Witness Consent

                                CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                WILLING TO HAVE IF REQUIRED

                                REFUSE UNDER ANY CIRCUMSTANCES

                                Blood Components Red cells Platelets

                                Fresh frozen plasma Cryoprecipitate

                                Cell Salvage

                                Cell saver- Standard set up

                                Cell saver- set up in continuity only

                                Blood Products Octaplas (Prothrombin complex

                                Concentrate)

                                Anti-D Immunoglobulin Albumin

                                Factor VIII concentrate Factor IX concentrate

                                Fibrinogen Concentrate Recombinant Products

                                Erythropoietin Factor VIIa

                                I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                26

                                expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                27

                                Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                28

                                Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                29

                                - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                30

                                bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                31

                                Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                Practitioner

                                bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                32

                                Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                33

                                If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                34

                                bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                identity band bull Match all other identifying information

                                35

                                Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                is to take place

                                36

                                If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                37

                                Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                38

                                bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                Blood Safety and Quality Regulations (2005)

                                39

                                bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                40

                                Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                41

                                bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                42

                                Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                43

                                Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                44

                                Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                45

                                Appendix 15A

                                46

                                Appendix 15B

                                47

                                Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                Please use a new document for each transfusion event

                                PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                HospitalUnit Affix label here or write patient details Forename

                                Surname

                                Gender

                                Date of birth

                                CHI

                                WardDept

                                Consultant

                                Authorisation Prescription

                                bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                Consent for Transfusion

                                bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                document in place Yes No Please delete patientguardian as appropriate

                                Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                48

                                THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                Patient Name Date of birthCHI

                                UN

                                IT 1

                                Blood component

                                Unit Pool mls

                                Special Requirements Instructions (please tick)

                                Affix completed pink portion of compatibility label here

                                Irradiated CMV negative Blood warmer Other medication

                                Reason for transfusion

                                Date Duration Authoriser Prescriber signature

                                Reassess before you progress (Venflon site and observations)

                                UN

                                IT 2

                                Blood component

                                Unit Pool mls

                                Special Requirements Instructions (please tick)

                                Affix completed pink portion of compatibility label here

                                Irradiated CMV negative Blood warmer Other medication

                                Reason for transfusion

                                Date Duration Authoriser Prescriber signature

                                Reassess before you progress (Venflon site and observations)

                                UN

                                IT 3

                                Blood component

                                Unit Pool mls

                                Special Requirements Instructions (please tick)

                                Affix completed pink portion of compatibility label here

                                Irradiated CMV negative Blood warmer Other medication

                                Reason for transfusion

                                Date Duration Authoriser Prescriber signature

                                Reassess before you progress (Venflon site and observations)

                                UN

                                IT 4

                                Blood component

                                Unit Pool mls

                                Special Requirements Instructions (please tick)

                                Affix completed pink portion of compatibility label here

                                Irradiated CMV negative Blood warmer Other medication

                                Reason for transfusion

                                Date Duration Authoriser Prescriber signature

                                THB(MR) 020 V40 May 2013

                                THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                Patient Na me Date of birthCHI

                                Transfusion Checklist - Please initial each box as checks are completed

                                PRE-

                                COLLECTION

                                Checks below should be completed before collection of component from temperature

                                controlled storage is undertaken

                                PRE-

                                ADMINISTRATION

                                AT BEDSIDE

                                Only remove clear outer wrap

                                bag immediately prior to commencing transfusion and

                                only when all positive identification checks have been

                                completed

                                POST

                                TRANSFUSION

                                Unit No

                                1

                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                helliphelliphelliphelliphelliphelliphellip

                                2

                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                helliphelliphelliphelliphelliphelliphellip

                                3

                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                helliphelliphelliphelliphelliphellip

                                4

                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                helliphelliphelliphelliphelliphelliphellip

                                THB(MR) 020 V40 - May 2013

                                Identification band insitu amp details verified and correct

                                Patent IV access

                                (Patient safety bundle adhered to)

                                Blood authorised

                                prescribed

                                Check for special

                                requirements amp consent

                                Verbal identification

                                at the bedside

                                (if applicable)

                                Identification band details are verified

                                and correct amp match details

                                on Traceability ldquobagamp tagrdquo

                                label

                                DateTime Transfusion completed

                                Traceability Tag signed with starting time amp date of transfusion recorded

                                Inspect bag

                                (condition amp expiry

                                date)

                                DateTime blood removed from

                                cold temperature

                                storage

                                Baseline Observations recorded on SEWS chart

                                (Temperature Pulse

                                Oxygen sats Respiration rate

                                amp BP)

                                Completion of Observations

                                Noted on the SEWS chart

                                (Temperature Pulse

                                Oxygen Sats Respiration rate

                                50

                                Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                recorded and concerns escalated to the medical team according to the SEWS

                                Adverse Events

                                bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                Post Transfusion

                                bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                Resources

                                Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                THB(MR)020 v 40 May 2013

                                Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                51

                                9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                Why has this policy been developed

                                Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                Has a risk control plan been developed and who is the owner of the risk If not why not

                                Who has been involvedconsulted in the development of the policy

                                Has the policy been assessed for Equality and Diversity in relation to-

                                Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                Please indicate YesNo for the following YES

                                Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                Please indicate Ye sNo for the following YES

                                Does the policy contain evidence of the Equality amp

                                Diversity Impact Assessment Process

                                Is there an implementation plan

                                Which officers are responsible for implementation

                                When will the policy take effect

                                Who must comply with the policystrategy

                                How will they be informed of their responsibilities

                                Is any training required

                                If yes has any been arranged

                                Are there any cost implications

                                NO

                                If yes please detail costs and note source of funding

                                Who is responsible for auditing the implementation of the policy

                                What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                2

                                POLICY MANAGER________________________ DATE______ _____________________

                                • Blood supply in an emergency situation
                                • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                • Administration of Platelets
                                  • Appendix 1 Adult Blood Transfusion Guideline
                                    • ADULT BLOOD TRANSFUSION GUIDELINE
                                      • Remember
                                        • References
                                          • Appendix 3a Flowchart Management of a Transfusion Reaction
                                            • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                              • Consent for Transfusion
                                              • THB(MR) 020 V40 May 2013
                                                • PRE- COLLECTION
                                                • PRE-ADMINISTRATION

                                  17

                                  The following must be completed as part of reaction Investigation Report reaction to Hospital transfusion Laboratory and request a Transfusion Reaction form

                                  The component unit and any remaining contents with the clamped off IV giving set attached

                                  should be sent to the transfusion laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                                  Any empty used unit packs from this transfusion episode or unused units of blood issued for

                                  the patient should be returned to Hospital Transfusion Laboratory clearly marked with ldquotransfusion reaction investigationrdquo include patients name date amp time and clinical area

                                  Completed Transfusion Reaction form should be returned to the hospital transfusion

                                  laboratory with a post transfusion sample 6ml EDTA pink top ndash for serological investigation The following post transfusion samples must also be obtained

                                  o Aerobic and anaerobic blood cultures should be sent to Microbiology o 4ml Sodium Citrate light blue top ndash for Coagulation screen o 5ml SST gold top - for haptoglobin haemoglobinaemia investigations o 4ml EDTA purple top ndash for full blood count

                                  Also obtain o First available MSU after the reaction ndash for culture o Next available MSU for haemoglobinuria investigations

                                  Incident Reporting The health care practitioner who discovers or deals with any transfusion reaction or incident is also responsible for reporting through the elect ronic NHS Tayside Adverse Incident Management System (ie DATIX)

                                  bull Under the Blood Safety and Quality Regulations (2005 as amended) the Transfusion Laboratory is legally responsible for the reporting of all serious adverse events and reactions to the Government identified competent authority currently the Medicines and Healthcare products Regulatory Agency (MHRA)

                                  bull The Blood Transfusion Laboratory will notify SHOT or SABRE as appropriate when they

                                  receive notification of the incident Transmissible Disease following Transfusion Report to the Blood Transfusion Service any patient showing evidence of unexpected hepatic dysfunction clinical or sub-clinical particularly within six months of any transfusion of blood components or blood products Report any other condition which you think may have been transmitted by blood or blood products

                                  18

                                  Appendix 4

                                  20

                                  21

                                  22

                                  23

                                  24

                                  25

                                  Appendix 5a Jehovah Witness Consent

                                  CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                  WILLING TO HAVE IF REQUIRED

                                  REFUSE UNDER ANY CIRCUMSTANCES

                                  Blood Components Red cells Platelets

                                  Fresh frozen plasma Cryoprecipitate

                                  Cell Salvage

                                  Cell saver- Standard set up

                                  Cell saver- set up in continuity only

                                  Blood Products Octaplas (Prothrombin complex

                                  Concentrate)

                                  Anti-D Immunoglobulin Albumin

                                  Factor VIII concentrate Factor IX concentrate

                                  Fibrinogen Concentrate Recombinant Products

                                  Erythropoietin Factor VIIa

                                  I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                  26

                                  expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                  DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                  27

                                  Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                  needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                  to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                  bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                  Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                  bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                  transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                  bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                  must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                  (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                  28

                                  Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                  units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                  desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                  bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                  SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                  requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                  Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                  Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                  - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                  29

                                  - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                  Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                  bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                  taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                  Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                  unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                  the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                  Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                  date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                  Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                  30

                                  bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                  The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                  31

                                  Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                  Practitioner

                                  bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                  bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                  32

                                  Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                  Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                  alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                  patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                  Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                  or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                  33

                                  If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                  if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                  the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                  from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                  the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                  34

                                  bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                  identity band bull Match all other identifying information

                                  35

                                  Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                  been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                  had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                  the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                  bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                  Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                  alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                  you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                  bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                  form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                  bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                  is to take place

                                  36

                                  If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                  inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                  delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                  37

                                  Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                  unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                  are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                  storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                  no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                  transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                  available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                  correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                  for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                  38

                                  bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                  wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                  blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                  band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                  component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                  checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                  bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                  infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                  2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                  infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                  transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                  Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                  commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                  receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                  blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                  bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                  container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                  Blood Safety and Quality Regulations (2005)

                                  39

                                  bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                  bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                  a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                  40

                                  Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                  inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                  bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                  Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                  depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                  substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                  or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                  urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                  41

                                  bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                  haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                  42

                                  Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                  bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                  bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                  bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                  43

                                  Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                  Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                  Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                  regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                  44

                                  Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                  negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                  45

                                  Appendix 15A

                                  46

                                  Appendix 15B

                                  47

                                  Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                  Please use a new document for each transfusion event

                                  PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                  HospitalUnit Affix label here or write patient details Forename

                                  Surname

                                  Gender

                                  Date of birth

                                  CHI

                                  WardDept

                                  Consultant

                                  Authorisation Prescription

                                  bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                  transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                  chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                  Consent for Transfusion

                                  bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                  Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                  after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                  transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                  document in place Yes No Please delete patientguardian as appropriate

                                  Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                  I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                  Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                  48

                                  THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                  Patient Name Date of birthCHI

                                  UN

                                  IT 1

                                  Blood component

                                  Unit Pool mls

                                  Special Requirements Instructions (please tick)

                                  Affix completed pink portion of compatibility label here

                                  Irradiated CMV negative Blood warmer Other medication

                                  Reason for transfusion

                                  Date Duration Authoriser Prescriber signature

                                  Reassess before you progress (Venflon site and observations)

                                  UN

                                  IT 2

                                  Blood component

                                  Unit Pool mls

                                  Special Requirements Instructions (please tick)

                                  Affix completed pink portion of compatibility label here

                                  Irradiated CMV negative Blood warmer Other medication

                                  Reason for transfusion

                                  Date Duration Authoriser Prescriber signature

                                  Reassess before you progress (Venflon site and observations)

                                  UN

                                  IT 3

                                  Blood component

                                  Unit Pool mls

                                  Special Requirements Instructions (please tick)

                                  Affix completed pink portion of compatibility label here

                                  Irradiated CMV negative Blood warmer Other medication

                                  Reason for transfusion

                                  Date Duration Authoriser Prescriber signature

                                  Reassess before you progress (Venflon site and observations)

                                  UN

                                  IT 4

                                  Blood component

                                  Unit Pool mls

                                  Special Requirements Instructions (please tick)

                                  Affix completed pink portion of compatibility label here

                                  Irradiated CMV negative Blood warmer Other medication

                                  Reason for transfusion

                                  Date Duration Authoriser Prescriber signature

                                  THB(MR) 020 V40 May 2013

                                  THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                  Patient Na me Date of birthCHI

                                  Transfusion Checklist - Please initial each box as checks are completed

                                  PRE-

                                  COLLECTION

                                  Checks below should be completed before collection of component from temperature

                                  controlled storage is undertaken

                                  PRE-

                                  ADMINISTRATION

                                  AT BEDSIDE

                                  Only remove clear outer wrap

                                  bag immediately prior to commencing transfusion and

                                  only when all positive identification checks have been

                                  completed

                                  POST

                                  TRANSFUSION

                                  Unit No

                                  1

                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                  helliphelliphelliphelliphelliphelliphellip

                                  2

                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                  helliphelliphelliphelliphelliphelliphellip

                                  3

                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                  helliphelliphelliphelliphelliphellip

                                  4

                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                  helliphelliphelliphelliphelliphelliphellip

                                  THB(MR) 020 V40 - May 2013

                                  Identification band insitu amp details verified and correct

                                  Patent IV access

                                  (Patient safety bundle adhered to)

                                  Blood authorised

                                  prescribed

                                  Check for special

                                  requirements amp consent

                                  Verbal identification

                                  at the bedside

                                  (if applicable)

                                  Identification band details are verified

                                  and correct amp match details

                                  on Traceability ldquobagamp tagrdquo

                                  label

                                  DateTime Transfusion completed

                                  Traceability Tag signed with starting time amp date of transfusion recorded

                                  Inspect bag

                                  (condition amp expiry

                                  date)

                                  DateTime blood removed from

                                  cold temperature

                                  storage

                                  Baseline Observations recorded on SEWS chart

                                  (Temperature Pulse

                                  Oxygen sats Respiration rate

                                  amp BP)

                                  Completion of Observations

                                  Noted on the SEWS chart

                                  (Temperature Pulse

                                  Oxygen Sats Respiration rate

                                  50

                                  Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                  be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                  Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                  be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                  recorded and concerns escalated to the medical team according to the SEWS

                                  Adverse Events

                                  bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                  more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                  hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                  Post Transfusion

                                  bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                  patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                  bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                  Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                  transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                  patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                  Resources

                                  Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                  THB(MR)020 v 40 May 2013

                                  Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                  PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                  51

                                  9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                  This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                  POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                  Why has this policy been developed

                                  Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                  Has a risk control plan been developed and who is the owner of the risk If not why not

                                  Who has been involvedconsulted in the development of the policy

                                  Has the policy been assessed for Equality and Diversity in relation to-

                                  Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                  RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                  Please indicate YesNo for the following YES

                                  Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                  Please indicate Ye sNo for the following YES

                                  Does the policy contain evidence of the Equality amp

                                  Diversity Impact Assessment Process

                                  Is there an implementation plan

                                  Which officers are responsible for implementation

                                  When will the policy take effect

                                  Who must comply with the policystrategy

                                  How will they be informed of their responsibilities

                                  Is any training required

                                  If yes has any been arranged

                                  Are there any cost implications

                                  NO

                                  If yes please detail costs and note source of funding

                                  Who is responsible for auditing the implementation of the policy

                                  What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                  2

                                  POLICY MANAGER________________________ DATE______ _____________________

                                  • Blood supply in an emergency situation
                                  • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                  • Administration of Platelets
                                    • Appendix 1 Adult Blood Transfusion Guideline
                                      • ADULT BLOOD TRANSFUSION GUIDELINE
                                        • Remember
                                          • References
                                            • Appendix 3a Flowchart Management of a Transfusion Reaction
                                              • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                • Consent for Transfusion
                                                • THB(MR) 020 V40 May 2013
                                                  • PRE- COLLECTION
                                                  • PRE-ADMINISTRATION

                                    18

                                    Appendix 4

                                    20

                                    21

                                    22

                                    23

                                    24

                                    25

                                    Appendix 5a Jehovah Witness Consent

                                    CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                    WILLING TO HAVE IF REQUIRED

                                    REFUSE UNDER ANY CIRCUMSTANCES

                                    Blood Components Red cells Platelets

                                    Fresh frozen plasma Cryoprecipitate

                                    Cell Salvage

                                    Cell saver- Standard set up

                                    Cell saver- set up in continuity only

                                    Blood Products Octaplas (Prothrombin complex

                                    Concentrate)

                                    Anti-D Immunoglobulin Albumin

                                    Factor VIII concentrate Factor IX concentrate

                                    Fibrinogen Concentrate Recombinant Products

                                    Erythropoietin Factor VIIa

                                    I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                    26

                                    expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                    DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                    27

                                    Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                    needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                    to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                    bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                    Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                    bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                    transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                    bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                    must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                    (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                    28

                                    Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                    units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                    desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                    bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                    SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                    requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                    Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                    Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                    - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                    29

                                    - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                    Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                    bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                    taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                    Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                    unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                    the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                    Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                    date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                    Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                    30

                                    bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                    The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                    31

                                    Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                    Practitioner

                                    bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                    bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                    32

                                    Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                    Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                    alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                    patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                    Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                    or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                    33

                                    If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                    if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                    the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                    from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                    the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                    34

                                    bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                    identity band bull Match all other identifying information

                                    35

                                    Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                    been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                    had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                    the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                    bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                    Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                    alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                    you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                    bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                    form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                    bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                    is to take place

                                    36

                                    If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                    inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                    delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                    37

                                    Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                    unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                    are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                    storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                    no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                    transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                    available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                    correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                    for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                    38

                                    bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                    wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                    blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                    band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                    component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                    checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                    bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                    infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                    2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                    infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                    transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                    Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                    commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                    receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                    blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                    bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                    container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                    Blood Safety and Quality Regulations (2005)

                                    39

                                    bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                    bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                    a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                    40

                                    Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                    inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                    bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                    Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                    depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                    substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                    or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                    urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                    41

                                    bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                    haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                    42

                                    Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                    bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                    bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                    bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                    43

                                    Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                    Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                    Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                    regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                    44

                                    Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                    negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                    45

                                    Appendix 15A

                                    46

                                    Appendix 15B

                                    47

                                    Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                    Please use a new document for each transfusion event

                                    PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                    HospitalUnit Affix label here or write patient details Forename

                                    Surname

                                    Gender

                                    Date of birth

                                    CHI

                                    WardDept

                                    Consultant

                                    Authorisation Prescription

                                    bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                    transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                    chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                    Consent for Transfusion

                                    bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                    Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                    after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                    transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                    document in place Yes No Please delete patientguardian as appropriate

                                    Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                    I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                    Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                    48

                                    THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                    Patient Name Date of birthCHI

                                    UN

                                    IT 1

                                    Blood component

                                    Unit Pool mls

                                    Special Requirements Instructions (please tick)

                                    Affix completed pink portion of compatibility label here

                                    Irradiated CMV negative Blood warmer Other medication

                                    Reason for transfusion

                                    Date Duration Authoriser Prescriber signature

                                    Reassess before you progress (Venflon site and observations)

                                    UN

                                    IT 2

                                    Blood component

                                    Unit Pool mls

                                    Special Requirements Instructions (please tick)

                                    Affix completed pink portion of compatibility label here

                                    Irradiated CMV negative Blood warmer Other medication

                                    Reason for transfusion

                                    Date Duration Authoriser Prescriber signature

                                    Reassess before you progress (Venflon site and observations)

                                    UN

                                    IT 3

                                    Blood component

                                    Unit Pool mls

                                    Special Requirements Instructions (please tick)

                                    Affix completed pink portion of compatibility label here

                                    Irradiated CMV negative Blood warmer Other medication

                                    Reason for transfusion

                                    Date Duration Authoriser Prescriber signature

                                    Reassess before you progress (Venflon site and observations)

                                    UN

                                    IT 4

                                    Blood component

                                    Unit Pool mls

                                    Special Requirements Instructions (please tick)

                                    Affix completed pink portion of compatibility label here

                                    Irradiated CMV negative Blood warmer Other medication

                                    Reason for transfusion

                                    Date Duration Authoriser Prescriber signature

                                    THB(MR) 020 V40 May 2013

                                    THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                    Patient Na me Date of birthCHI

                                    Transfusion Checklist - Please initial each box as checks are completed

                                    PRE-

                                    COLLECTION

                                    Checks below should be completed before collection of component from temperature

                                    controlled storage is undertaken

                                    PRE-

                                    ADMINISTRATION

                                    AT BEDSIDE

                                    Only remove clear outer wrap

                                    bag immediately prior to commencing transfusion and

                                    only when all positive identification checks have been

                                    completed

                                    POST

                                    TRANSFUSION

                                    Unit No

                                    1

                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                    helliphelliphelliphelliphelliphelliphellip

                                    2

                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                    helliphelliphelliphelliphelliphelliphellip

                                    3

                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                    helliphelliphelliphelliphelliphellip

                                    4

                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                    helliphelliphelliphelliphelliphelliphellip

                                    THB(MR) 020 V40 - May 2013

                                    Identification band insitu amp details verified and correct

                                    Patent IV access

                                    (Patient safety bundle adhered to)

                                    Blood authorised

                                    prescribed

                                    Check for special

                                    requirements amp consent

                                    Verbal identification

                                    at the bedside

                                    (if applicable)

                                    Identification band details are verified

                                    and correct amp match details

                                    on Traceability ldquobagamp tagrdquo

                                    label

                                    DateTime Transfusion completed

                                    Traceability Tag signed with starting time amp date of transfusion recorded

                                    Inspect bag

                                    (condition amp expiry

                                    date)

                                    DateTime blood removed from

                                    cold temperature

                                    storage

                                    Baseline Observations recorded on SEWS chart

                                    (Temperature Pulse

                                    Oxygen sats Respiration rate

                                    amp BP)

                                    Completion of Observations

                                    Noted on the SEWS chart

                                    (Temperature Pulse

                                    Oxygen Sats Respiration rate

                                    50

                                    Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                    be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                    Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                    be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                    recorded and concerns escalated to the medical team according to the SEWS

                                    Adverse Events

                                    bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                    more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                    hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                    Post Transfusion

                                    bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                    patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                    bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                    Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                    transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                    patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                    Resources

                                    Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                    THB(MR)020 v 40 May 2013

                                    Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                    PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                    51

                                    9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                    This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                    POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                    Why has this policy been developed

                                    Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                    Has a risk control plan been developed and who is the owner of the risk If not why not

                                    Who has been involvedconsulted in the development of the policy

                                    Has the policy been assessed for Equality and Diversity in relation to-

                                    Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                    RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                    Please indicate YesNo for the following YES

                                    Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                    Please indicate Ye sNo for the following YES

                                    Does the policy contain evidence of the Equality amp

                                    Diversity Impact Assessment Process

                                    Is there an implementation plan

                                    Which officers are responsible for implementation

                                    When will the policy take effect

                                    Who must comply with the policystrategy

                                    How will they be informed of their responsibilities

                                    Is any training required

                                    If yes has any been arranged

                                    Are there any cost implications

                                    NO

                                    If yes please detail costs and note source of funding

                                    Who is responsible for auditing the implementation of the policy

                                    What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                    2

                                    POLICY MANAGER________________________ DATE______ _____________________

                                    • Blood supply in an emergency situation
                                    • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                    • Administration of Platelets
                                      • Appendix 1 Adult Blood Transfusion Guideline
                                        • ADULT BLOOD TRANSFUSION GUIDELINE
                                          • Remember
                                            • References
                                              • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                  • Consent for Transfusion
                                                  • THB(MR) 020 V40 May 2013
                                                    • PRE- COLLECTION
                                                    • PRE-ADMINISTRATION

                                      20

                                      21

                                      22

                                      23

                                      24

                                      25

                                      Appendix 5a Jehovah Witness Consent

                                      CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                      WILLING TO HAVE IF REQUIRED

                                      REFUSE UNDER ANY CIRCUMSTANCES

                                      Blood Components Red cells Platelets

                                      Fresh frozen plasma Cryoprecipitate

                                      Cell Salvage

                                      Cell saver- Standard set up

                                      Cell saver- set up in continuity only

                                      Blood Products Octaplas (Prothrombin complex

                                      Concentrate)

                                      Anti-D Immunoglobulin Albumin

                                      Factor VIII concentrate Factor IX concentrate

                                      Fibrinogen Concentrate Recombinant Products

                                      Erythropoietin Factor VIIa

                                      I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                      26

                                      expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                      DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                      27

                                      Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                      needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                      to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                      bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                      Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                      bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                      transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                      bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                      must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                      (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                      28

                                      Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                      units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                      desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                      bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                      SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                      requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                      Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                      Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                      - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                      29

                                      - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                      Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                      bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                      taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                      Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                      unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                      the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                      Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                      date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                      Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                      30

                                      bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                      The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                      31

                                      Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                      Practitioner

                                      bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                      bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                      32

                                      Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                      Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                      alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                      patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                      Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                      or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                      33

                                      If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                      if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                      the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                      from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                      the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                      34

                                      bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                      identity band bull Match all other identifying information

                                      35

                                      Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                      been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                      had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                      the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                      bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                      Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                      alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                      you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                      bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                      form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                      bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                      is to take place

                                      36

                                      If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                      inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                      delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                      37

                                      Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                      unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                      are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                      storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                      no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                      transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                      available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                      correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                      for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                      38

                                      bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                      wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                      blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                      band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                      component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                      checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                      bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                      infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                      2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                      infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                      transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                      Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                      commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                      receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                      blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                      bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                      container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                      Blood Safety and Quality Regulations (2005)

                                      39

                                      bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                      bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                      a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                      40

                                      Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                      inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                      bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                      Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                      depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                      substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                      or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                      urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                      41

                                      bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                      haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                      42

                                      Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                      bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                      bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                      bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                      43

                                      Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                      Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                      Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                      regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                      44

                                      Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                      negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                      45

                                      Appendix 15A

                                      46

                                      Appendix 15B

                                      47

                                      Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                      Please use a new document for each transfusion event

                                      PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                      HospitalUnit Affix label here or write patient details Forename

                                      Surname

                                      Gender

                                      Date of birth

                                      CHI

                                      WardDept

                                      Consultant

                                      Authorisation Prescription

                                      bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                      transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                      chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                      Consent for Transfusion

                                      bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                      Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                      after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                      transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                      document in place Yes No Please delete patientguardian as appropriate

                                      Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                      I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                      Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                      48

                                      THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                      Patient Name Date of birthCHI

                                      UN

                                      IT 1

                                      Blood component

                                      Unit Pool mls

                                      Special Requirements Instructions (please tick)

                                      Affix completed pink portion of compatibility label here

                                      Irradiated CMV negative Blood warmer Other medication

                                      Reason for transfusion

                                      Date Duration Authoriser Prescriber signature

                                      Reassess before you progress (Venflon site and observations)

                                      UN

                                      IT 2

                                      Blood component

                                      Unit Pool mls

                                      Special Requirements Instructions (please tick)

                                      Affix completed pink portion of compatibility label here

                                      Irradiated CMV negative Blood warmer Other medication

                                      Reason for transfusion

                                      Date Duration Authoriser Prescriber signature

                                      Reassess before you progress (Venflon site and observations)

                                      UN

                                      IT 3

                                      Blood component

                                      Unit Pool mls

                                      Special Requirements Instructions (please tick)

                                      Affix completed pink portion of compatibility label here

                                      Irradiated CMV negative Blood warmer Other medication

                                      Reason for transfusion

                                      Date Duration Authoriser Prescriber signature

                                      Reassess before you progress (Venflon site and observations)

                                      UN

                                      IT 4

                                      Blood component

                                      Unit Pool mls

                                      Special Requirements Instructions (please tick)

                                      Affix completed pink portion of compatibility label here

                                      Irradiated CMV negative Blood warmer Other medication

                                      Reason for transfusion

                                      Date Duration Authoriser Prescriber signature

                                      THB(MR) 020 V40 May 2013

                                      THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                      Patient Na me Date of birthCHI

                                      Transfusion Checklist - Please initial each box as checks are completed

                                      PRE-

                                      COLLECTION

                                      Checks below should be completed before collection of component from temperature

                                      controlled storage is undertaken

                                      PRE-

                                      ADMINISTRATION

                                      AT BEDSIDE

                                      Only remove clear outer wrap

                                      bag immediately prior to commencing transfusion and

                                      only when all positive identification checks have been

                                      completed

                                      POST

                                      TRANSFUSION

                                      Unit No

                                      1

                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                      helliphelliphelliphelliphelliphelliphellip

                                      2

                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                      helliphelliphelliphelliphelliphelliphellip

                                      3

                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                      helliphelliphelliphelliphelliphellip

                                      4

                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                      helliphelliphelliphelliphelliphelliphellip

                                      THB(MR) 020 V40 - May 2013

                                      Identification band insitu amp details verified and correct

                                      Patent IV access

                                      (Patient safety bundle adhered to)

                                      Blood authorised

                                      prescribed

                                      Check for special

                                      requirements amp consent

                                      Verbal identification

                                      at the bedside

                                      (if applicable)

                                      Identification band details are verified

                                      and correct amp match details

                                      on Traceability ldquobagamp tagrdquo

                                      label

                                      DateTime Transfusion completed

                                      Traceability Tag signed with starting time amp date of transfusion recorded

                                      Inspect bag

                                      (condition amp expiry

                                      date)

                                      DateTime blood removed from

                                      cold temperature

                                      storage

                                      Baseline Observations recorded on SEWS chart

                                      (Temperature Pulse

                                      Oxygen sats Respiration rate

                                      amp BP)

                                      Completion of Observations

                                      Noted on the SEWS chart

                                      (Temperature Pulse

                                      Oxygen Sats Respiration rate

                                      50

                                      Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                      be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                      Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                      be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                      recorded and concerns escalated to the medical team according to the SEWS

                                      Adverse Events

                                      bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                      more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                      hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                      Post Transfusion

                                      bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                      patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                      bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                      Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                      transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                      patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                      Resources

                                      Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                      THB(MR)020 v 40 May 2013

                                      Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                      PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                      51

                                      9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                      This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                      POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                      Why has this policy been developed

                                      Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                      Has a risk control plan been developed and who is the owner of the risk If not why not

                                      Who has been involvedconsulted in the development of the policy

                                      Has the policy been assessed for Equality and Diversity in relation to-

                                      Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                      RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                      Please indicate YesNo for the following YES

                                      Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                      Please indicate Ye sNo for the following YES

                                      Does the policy contain evidence of the Equality amp

                                      Diversity Impact Assessment Process

                                      Is there an implementation plan

                                      Which officers are responsible for implementation

                                      When will the policy take effect

                                      Who must comply with the policystrategy

                                      How will they be informed of their responsibilities

                                      Is any training required

                                      If yes has any been arranged

                                      Are there any cost implications

                                      NO

                                      If yes please detail costs and note source of funding

                                      Who is responsible for auditing the implementation of the policy

                                      What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                      2

                                      POLICY MANAGER________________________ DATE______ _____________________

                                      • Blood supply in an emergency situation
                                      • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                      • Administration of Platelets
                                        • Appendix 1 Adult Blood Transfusion Guideline
                                          • ADULT BLOOD TRANSFUSION GUIDELINE
                                            • Remember
                                              • References
                                                • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                  • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                    • Consent for Transfusion
                                                    • THB(MR) 020 V40 May 2013
                                                      • PRE- COLLECTION
                                                      • PRE-ADMINISTRATION

                                        21

                                        22

                                        23

                                        24

                                        25

                                        Appendix 5a Jehovah Witness Consent

                                        CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                        WILLING TO HAVE IF REQUIRED

                                        REFUSE UNDER ANY CIRCUMSTANCES

                                        Blood Components Red cells Platelets

                                        Fresh frozen plasma Cryoprecipitate

                                        Cell Salvage

                                        Cell saver- Standard set up

                                        Cell saver- set up in continuity only

                                        Blood Products Octaplas (Prothrombin complex

                                        Concentrate)

                                        Anti-D Immunoglobulin Albumin

                                        Factor VIII concentrate Factor IX concentrate

                                        Fibrinogen Concentrate Recombinant Products

                                        Erythropoietin Factor VIIa

                                        I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                        26

                                        expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                        DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                        27

                                        Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                        needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                        to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                        bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                        Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                        bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                        transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                        bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                        must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                        (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                        28

                                        Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                        units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                        desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                        bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                        SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                        requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                        Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                        Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                        - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                        29

                                        - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                        Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                        bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                        taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                        Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                        unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                        the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                        Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                        date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                        Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                        30

                                        bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                        The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                        31

                                        Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                        Practitioner

                                        bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                        bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                        32

                                        Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                        Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                        alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                        patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                        Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                        or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                        33

                                        If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                        if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                        the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                        from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                        the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                        34

                                        bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                        identity band bull Match all other identifying information

                                        35

                                        Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                        been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                        had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                        the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                        bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                        Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                        alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                        you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                        bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                        form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                        bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                        is to take place

                                        36

                                        If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                        inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                        delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                        37

                                        Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                        unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                        are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                        storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                        no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                        transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                        available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                        correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                        for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                        38

                                        bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                        wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                        blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                        band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                        component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                        checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                        bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                        infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                        2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                        infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                        transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                        Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                        commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                        receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                        blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                        bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                        container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                        Blood Safety and Quality Regulations (2005)

                                        39

                                        bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                        bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                        a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                        40

                                        Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                        inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                        bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                        Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                        depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                        substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                        or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                        urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                        41

                                        bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                        haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                        42

                                        Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                        bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                        bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                        bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                        43

                                        Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                        Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                        Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                        regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                        44

                                        Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                        negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                        45

                                        Appendix 15A

                                        46

                                        Appendix 15B

                                        47

                                        Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                        Please use a new document for each transfusion event

                                        PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                        HospitalUnit Affix label here or write patient details Forename

                                        Surname

                                        Gender

                                        Date of birth

                                        CHI

                                        WardDept

                                        Consultant

                                        Authorisation Prescription

                                        bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                        transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                        chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                        Consent for Transfusion

                                        bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                        Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                        after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                        transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                        document in place Yes No Please delete patientguardian as appropriate

                                        Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                        I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                        Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                        48

                                        THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                        Patient Name Date of birthCHI

                                        UN

                                        IT 1

                                        Blood component

                                        Unit Pool mls

                                        Special Requirements Instructions (please tick)

                                        Affix completed pink portion of compatibility label here

                                        Irradiated CMV negative Blood warmer Other medication

                                        Reason for transfusion

                                        Date Duration Authoriser Prescriber signature

                                        Reassess before you progress (Venflon site and observations)

                                        UN

                                        IT 2

                                        Blood component

                                        Unit Pool mls

                                        Special Requirements Instructions (please tick)

                                        Affix completed pink portion of compatibility label here

                                        Irradiated CMV negative Blood warmer Other medication

                                        Reason for transfusion

                                        Date Duration Authoriser Prescriber signature

                                        Reassess before you progress (Venflon site and observations)

                                        UN

                                        IT 3

                                        Blood component

                                        Unit Pool mls

                                        Special Requirements Instructions (please tick)

                                        Affix completed pink portion of compatibility label here

                                        Irradiated CMV negative Blood warmer Other medication

                                        Reason for transfusion

                                        Date Duration Authoriser Prescriber signature

                                        Reassess before you progress (Venflon site and observations)

                                        UN

                                        IT 4

                                        Blood component

                                        Unit Pool mls

                                        Special Requirements Instructions (please tick)

                                        Affix completed pink portion of compatibility label here

                                        Irradiated CMV negative Blood warmer Other medication

                                        Reason for transfusion

                                        Date Duration Authoriser Prescriber signature

                                        THB(MR) 020 V40 May 2013

                                        THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                        Patient Na me Date of birthCHI

                                        Transfusion Checklist - Please initial each box as checks are completed

                                        PRE-

                                        COLLECTION

                                        Checks below should be completed before collection of component from temperature

                                        controlled storage is undertaken

                                        PRE-

                                        ADMINISTRATION

                                        AT BEDSIDE

                                        Only remove clear outer wrap

                                        bag immediately prior to commencing transfusion and

                                        only when all positive identification checks have been

                                        completed

                                        POST

                                        TRANSFUSION

                                        Unit No

                                        1

                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                        helliphelliphelliphelliphelliphelliphellip

                                        2

                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                        helliphelliphelliphelliphelliphelliphellip

                                        3

                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                        helliphelliphelliphelliphelliphellip

                                        4

                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                        helliphelliphelliphelliphelliphelliphellip

                                        THB(MR) 020 V40 - May 2013

                                        Identification band insitu amp details verified and correct

                                        Patent IV access

                                        (Patient safety bundle adhered to)

                                        Blood authorised

                                        prescribed

                                        Check for special

                                        requirements amp consent

                                        Verbal identification

                                        at the bedside

                                        (if applicable)

                                        Identification band details are verified

                                        and correct amp match details

                                        on Traceability ldquobagamp tagrdquo

                                        label

                                        DateTime Transfusion completed

                                        Traceability Tag signed with starting time amp date of transfusion recorded

                                        Inspect bag

                                        (condition amp expiry

                                        date)

                                        DateTime blood removed from

                                        cold temperature

                                        storage

                                        Baseline Observations recorded on SEWS chart

                                        (Temperature Pulse

                                        Oxygen sats Respiration rate

                                        amp BP)

                                        Completion of Observations

                                        Noted on the SEWS chart

                                        (Temperature Pulse

                                        Oxygen Sats Respiration rate

                                        50

                                        Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                        be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                        Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                        be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                        recorded and concerns escalated to the medical team according to the SEWS

                                        Adverse Events

                                        bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                        more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                        hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                        Post Transfusion

                                        bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                        patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                        bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                        Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                        transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                        patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                        Resources

                                        Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                        THB(MR)020 v 40 May 2013

                                        Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                        PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                        51

                                        9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                        This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                        POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                        Why has this policy been developed

                                        Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                        Has a risk control plan been developed and who is the owner of the risk If not why not

                                        Who has been involvedconsulted in the development of the policy

                                        Has the policy been assessed for Equality and Diversity in relation to-

                                        Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                        RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                        Please indicate YesNo for the following YES

                                        Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                        Please indicate Ye sNo for the following YES

                                        Does the policy contain evidence of the Equality amp

                                        Diversity Impact Assessment Process

                                        Is there an implementation plan

                                        Which officers are responsible for implementation

                                        When will the policy take effect

                                        Who must comply with the policystrategy

                                        How will they be informed of their responsibilities

                                        Is any training required

                                        If yes has any been arranged

                                        Are there any cost implications

                                        NO

                                        If yes please detail costs and note source of funding

                                        Who is responsible for auditing the implementation of the policy

                                        What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                        2

                                        POLICY MANAGER________________________ DATE______ _____________________

                                        • Blood supply in an emergency situation
                                        • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                        • Administration of Platelets
                                          • Appendix 1 Adult Blood Transfusion Guideline
                                            • ADULT BLOOD TRANSFUSION GUIDELINE
                                              • Remember
                                                • References
                                                  • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                    • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                      • Consent for Transfusion
                                                      • THB(MR) 020 V40 May 2013
                                                        • PRE- COLLECTION
                                                        • PRE-ADMINISTRATION

                                          22

                                          23

                                          24

                                          25

                                          Appendix 5a Jehovah Witness Consent

                                          CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                          WILLING TO HAVE IF REQUIRED

                                          REFUSE UNDER ANY CIRCUMSTANCES

                                          Blood Components Red cells Platelets

                                          Fresh frozen plasma Cryoprecipitate

                                          Cell Salvage

                                          Cell saver- Standard set up

                                          Cell saver- set up in continuity only

                                          Blood Products Octaplas (Prothrombin complex

                                          Concentrate)

                                          Anti-D Immunoglobulin Albumin

                                          Factor VIII concentrate Factor IX concentrate

                                          Fibrinogen Concentrate Recombinant Products

                                          Erythropoietin Factor VIIa

                                          I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                          26

                                          expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                          DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                          27

                                          Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                          needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                          to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                          bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                          Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                          bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                          transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                          bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                          must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                          (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                          28

                                          Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                          units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                          desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                          bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                          SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                          requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                          Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                          Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                          - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                          29

                                          - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                          Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                          bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                          taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                          Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                          unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                          the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                          Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                          date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                          Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                          30

                                          bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                          The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                          31

                                          Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                          Practitioner

                                          bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                          bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                          32

                                          Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                          Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                          alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                          patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                          Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                          or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                          33

                                          If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                          if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                          the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                          from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                          the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                          34

                                          bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                          identity band bull Match all other identifying information

                                          35

                                          Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                          been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                          had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                          the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                          bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                          Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                          alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                          you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                          bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                          form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                          bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                          is to take place

                                          36

                                          If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                          inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                          delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                          37

                                          Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                          unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                          are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                          storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                          no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                          transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                          available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                          correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                          for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                          38

                                          bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                          wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                          blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                          band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                          component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                          checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                          bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                          infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                          2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                          infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                          transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                          Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                          commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                          receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                          blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                          bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                          container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                          Blood Safety and Quality Regulations (2005)

                                          39

                                          bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                          bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                          a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                          40

                                          Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                          inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                          bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                          Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                          depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                          substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                          or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                          urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                          41

                                          bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                          haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                          42

                                          Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                          bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                          bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                          bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                          43

                                          Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                          Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                          Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                          regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                          44

                                          Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                          negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                          45

                                          Appendix 15A

                                          46

                                          Appendix 15B

                                          47

                                          Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                          Please use a new document for each transfusion event

                                          PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                          HospitalUnit Affix label here or write patient details Forename

                                          Surname

                                          Gender

                                          Date of birth

                                          CHI

                                          WardDept

                                          Consultant

                                          Authorisation Prescription

                                          bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                          transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                          chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                          Consent for Transfusion

                                          bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                          Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                          after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                          transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                          document in place Yes No Please delete patientguardian as appropriate

                                          Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                          I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                          Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                          48

                                          THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                          Patient Name Date of birthCHI

                                          UN

                                          IT 1

                                          Blood component

                                          Unit Pool mls

                                          Special Requirements Instructions (please tick)

                                          Affix completed pink portion of compatibility label here

                                          Irradiated CMV negative Blood warmer Other medication

                                          Reason for transfusion

                                          Date Duration Authoriser Prescriber signature

                                          Reassess before you progress (Venflon site and observations)

                                          UN

                                          IT 2

                                          Blood component

                                          Unit Pool mls

                                          Special Requirements Instructions (please tick)

                                          Affix completed pink portion of compatibility label here

                                          Irradiated CMV negative Blood warmer Other medication

                                          Reason for transfusion

                                          Date Duration Authoriser Prescriber signature

                                          Reassess before you progress (Venflon site and observations)

                                          UN

                                          IT 3

                                          Blood component

                                          Unit Pool mls

                                          Special Requirements Instructions (please tick)

                                          Affix completed pink portion of compatibility label here

                                          Irradiated CMV negative Blood warmer Other medication

                                          Reason for transfusion

                                          Date Duration Authoriser Prescriber signature

                                          Reassess before you progress (Venflon site and observations)

                                          UN

                                          IT 4

                                          Blood component

                                          Unit Pool mls

                                          Special Requirements Instructions (please tick)

                                          Affix completed pink portion of compatibility label here

                                          Irradiated CMV negative Blood warmer Other medication

                                          Reason for transfusion

                                          Date Duration Authoriser Prescriber signature

                                          THB(MR) 020 V40 May 2013

                                          THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                          Patient Na me Date of birthCHI

                                          Transfusion Checklist - Please initial each box as checks are completed

                                          PRE-

                                          COLLECTION

                                          Checks below should be completed before collection of component from temperature

                                          controlled storage is undertaken

                                          PRE-

                                          ADMINISTRATION

                                          AT BEDSIDE

                                          Only remove clear outer wrap

                                          bag immediately prior to commencing transfusion and

                                          only when all positive identification checks have been

                                          completed

                                          POST

                                          TRANSFUSION

                                          Unit No

                                          1

                                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                                          helliphelliphelliphelliphelliphelliphellip

                                          2

                                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                                          helliphelliphelliphelliphelliphelliphellip

                                          3

                                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                                          helliphelliphelliphelliphelliphellip

                                          4

                                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                                          helliphelliphelliphelliphelliphelliphellip

                                          THB(MR) 020 V40 - May 2013

                                          Identification band insitu amp details verified and correct

                                          Patent IV access

                                          (Patient safety bundle adhered to)

                                          Blood authorised

                                          prescribed

                                          Check for special

                                          requirements amp consent

                                          Verbal identification

                                          at the bedside

                                          (if applicable)

                                          Identification band details are verified

                                          and correct amp match details

                                          on Traceability ldquobagamp tagrdquo

                                          label

                                          DateTime Transfusion completed

                                          Traceability Tag signed with starting time amp date of transfusion recorded

                                          Inspect bag

                                          (condition amp expiry

                                          date)

                                          DateTime blood removed from

                                          cold temperature

                                          storage

                                          Baseline Observations recorded on SEWS chart

                                          (Temperature Pulse

                                          Oxygen sats Respiration rate

                                          amp BP)

                                          Completion of Observations

                                          Noted on the SEWS chart

                                          (Temperature Pulse

                                          Oxygen Sats Respiration rate

                                          50

                                          Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                          be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                          Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                          be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                          recorded and concerns escalated to the medical team according to the SEWS

                                          Adverse Events

                                          bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                          more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                          hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                          Post Transfusion

                                          bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                          patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                          bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                          Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                          transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                          patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                          Resources

                                          Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                          THB(MR)020 v 40 May 2013

                                          Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                          PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                          51

                                          9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                          This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                          POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                          Why has this policy been developed

                                          Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                          Has a risk control plan been developed and who is the owner of the risk If not why not

                                          Who has been involvedconsulted in the development of the policy

                                          Has the policy been assessed for Equality and Diversity in relation to-

                                          Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                          RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                          Please indicate YesNo for the following YES

                                          Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                          Please indicate Ye sNo for the following YES

                                          Does the policy contain evidence of the Equality amp

                                          Diversity Impact Assessment Process

                                          Is there an implementation plan

                                          Which officers are responsible for implementation

                                          When will the policy take effect

                                          Who must comply with the policystrategy

                                          How will they be informed of their responsibilities

                                          Is any training required

                                          If yes has any been arranged

                                          Are there any cost implications

                                          NO

                                          If yes please detail costs and note source of funding

                                          Who is responsible for auditing the implementation of the policy

                                          What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                          2

                                          POLICY MANAGER________________________ DATE______ _____________________

                                          • Blood supply in an emergency situation
                                          • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                          • Administration of Platelets
                                            • Appendix 1 Adult Blood Transfusion Guideline
                                              • ADULT BLOOD TRANSFUSION GUIDELINE
                                                • Remember
                                                  • References
                                                    • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                      • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                        • Consent for Transfusion
                                                        • THB(MR) 020 V40 May 2013
                                                          • PRE- COLLECTION
                                                          • PRE-ADMINISTRATION

                                            23

                                            24

                                            25

                                            Appendix 5a Jehovah Witness Consent

                                            CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                            WILLING TO HAVE IF REQUIRED

                                            REFUSE UNDER ANY CIRCUMSTANCES

                                            Blood Components Red cells Platelets

                                            Fresh frozen plasma Cryoprecipitate

                                            Cell Salvage

                                            Cell saver- Standard set up

                                            Cell saver- set up in continuity only

                                            Blood Products Octaplas (Prothrombin complex

                                            Concentrate)

                                            Anti-D Immunoglobulin Albumin

                                            Factor VIII concentrate Factor IX concentrate

                                            Fibrinogen Concentrate Recombinant Products

                                            Erythropoietin Factor VIIa

                                            I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                            26

                                            expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                            DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                            27

                                            Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                            needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                            to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                            bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                            Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                            bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                            transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                            bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                            must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                            (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                            28

                                            Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                            units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                            desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                            bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                            SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                            requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                            Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                            Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                            - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                            29

                                            - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                            Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                            bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                            taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                            Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                            unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                            the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                            Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                            date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                            Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                            30

                                            bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                            The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                            31

                                            Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                            Practitioner

                                            bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                            bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                            32

                                            Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                            Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                            alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                            patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                            Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                            or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                            33

                                            If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                            if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                            the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                            from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                            the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                            34

                                            bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                            identity band bull Match all other identifying information

                                            35

                                            Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                            been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                            had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                            the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                            bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                            Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                            alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                            you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                            bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                            form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                            bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                            is to take place

                                            36

                                            If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                            inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                            delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                            37

                                            Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                            unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                            are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                            storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                            no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                            transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                            available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                            correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                            for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                            38

                                            bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                            wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                            blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                            band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                            component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                            checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                            bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                            infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                            2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                            infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                            transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                            Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                            commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                            receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                            blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                            bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                            container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                            Blood Safety and Quality Regulations (2005)

                                            39

                                            bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                            bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                            a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                            40

                                            Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                            inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                            bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                            Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                            depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                            substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                            or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                            urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                            41

                                            bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                            haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                            42

                                            Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                            bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                            bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                            bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                            43

                                            Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                            Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                            Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                            regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                            44

                                            Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                            negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                            45

                                            Appendix 15A

                                            46

                                            Appendix 15B

                                            47

                                            Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                            Please use a new document for each transfusion event

                                            PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                            HospitalUnit Affix label here or write patient details Forename

                                            Surname

                                            Gender

                                            Date of birth

                                            CHI

                                            WardDept

                                            Consultant

                                            Authorisation Prescription

                                            bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                            transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                            chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                            Consent for Transfusion

                                            bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                            Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                            after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                            transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                            document in place Yes No Please delete patientguardian as appropriate

                                            Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                            I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                            Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                            48

                                            THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                            Patient Name Date of birthCHI

                                            UN

                                            IT 1

                                            Blood component

                                            Unit Pool mls

                                            Special Requirements Instructions (please tick)

                                            Affix completed pink portion of compatibility label here

                                            Irradiated CMV negative Blood warmer Other medication

                                            Reason for transfusion

                                            Date Duration Authoriser Prescriber signature

                                            Reassess before you progress (Venflon site and observations)

                                            UN

                                            IT 2

                                            Blood component

                                            Unit Pool mls

                                            Special Requirements Instructions (please tick)

                                            Affix completed pink portion of compatibility label here

                                            Irradiated CMV negative Blood warmer Other medication

                                            Reason for transfusion

                                            Date Duration Authoriser Prescriber signature

                                            Reassess before you progress (Venflon site and observations)

                                            UN

                                            IT 3

                                            Blood component

                                            Unit Pool mls

                                            Special Requirements Instructions (please tick)

                                            Affix completed pink portion of compatibility label here

                                            Irradiated CMV negative Blood warmer Other medication

                                            Reason for transfusion

                                            Date Duration Authoriser Prescriber signature

                                            Reassess before you progress (Venflon site and observations)

                                            UN

                                            IT 4

                                            Blood component

                                            Unit Pool mls

                                            Special Requirements Instructions (please tick)

                                            Affix completed pink portion of compatibility label here

                                            Irradiated CMV negative Blood warmer Other medication

                                            Reason for transfusion

                                            Date Duration Authoriser Prescriber signature

                                            THB(MR) 020 V40 May 2013

                                            THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                            Patient Na me Date of birthCHI

                                            Transfusion Checklist - Please initial each box as checks are completed

                                            PRE-

                                            COLLECTION

                                            Checks below should be completed before collection of component from temperature

                                            controlled storage is undertaken

                                            PRE-

                                            ADMINISTRATION

                                            AT BEDSIDE

                                            Only remove clear outer wrap

                                            bag immediately prior to commencing transfusion and

                                            only when all positive identification checks have been

                                            completed

                                            POST

                                            TRANSFUSION

                                            Unit No

                                            1

                                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                                            helliphelliphelliphelliphelliphelliphellip

                                            2

                                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                                            helliphelliphelliphelliphelliphelliphellip

                                            3

                                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                                            helliphelliphelliphelliphelliphellip

                                            4

                                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                                            helliphelliphelliphelliphelliphelliphellip

                                            THB(MR) 020 V40 - May 2013

                                            Identification band insitu amp details verified and correct

                                            Patent IV access

                                            (Patient safety bundle adhered to)

                                            Blood authorised

                                            prescribed

                                            Check for special

                                            requirements amp consent

                                            Verbal identification

                                            at the bedside

                                            (if applicable)

                                            Identification band details are verified

                                            and correct amp match details

                                            on Traceability ldquobagamp tagrdquo

                                            label

                                            DateTime Transfusion completed

                                            Traceability Tag signed with starting time amp date of transfusion recorded

                                            Inspect bag

                                            (condition amp expiry

                                            date)

                                            DateTime blood removed from

                                            cold temperature

                                            storage

                                            Baseline Observations recorded on SEWS chart

                                            (Temperature Pulse

                                            Oxygen sats Respiration rate

                                            amp BP)

                                            Completion of Observations

                                            Noted on the SEWS chart

                                            (Temperature Pulse

                                            Oxygen Sats Respiration rate

                                            50

                                            Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                            be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                            Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                            be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                            recorded and concerns escalated to the medical team according to the SEWS

                                            Adverse Events

                                            bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                            more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                            hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                            Post Transfusion

                                            bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                            patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                            bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                            Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                            transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                            patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                            Resources

                                            Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                            THB(MR)020 v 40 May 2013

                                            Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                            PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                            51

                                            9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                            This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                            POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                            Why has this policy been developed

                                            Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                            Has a risk control plan been developed and who is the owner of the risk If not why not

                                            Who has been involvedconsulted in the development of the policy

                                            Has the policy been assessed for Equality and Diversity in relation to-

                                            Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                            RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                            Please indicate YesNo for the following YES

                                            Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                            Please indicate Ye sNo for the following YES

                                            Does the policy contain evidence of the Equality amp

                                            Diversity Impact Assessment Process

                                            Is there an implementation plan

                                            Which officers are responsible for implementation

                                            When will the policy take effect

                                            Who must comply with the policystrategy

                                            How will they be informed of their responsibilities

                                            Is any training required

                                            If yes has any been arranged

                                            Are there any cost implications

                                            NO

                                            If yes please detail costs and note source of funding

                                            Who is responsible for auditing the implementation of the policy

                                            What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                            2

                                            POLICY MANAGER________________________ DATE______ _____________________

                                            • Blood supply in an emergency situation
                                            • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                            • Administration of Platelets
                                              • Appendix 1 Adult Blood Transfusion Guideline
                                                • ADULT BLOOD TRANSFUSION GUIDELINE
                                                  • Remember
                                                    • References
                                                      • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                        • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                          • Consent for Transfusion
                                                          • THB(MR) 020 V40 May 2013
                                                            • PRE- COLLECTION
                                                            • PRE-ADMINISTRATION

                                              24

                                              25

                                              Appendix 5a Jehovah Witness Consent

                                              CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                              WILLING TO HAVE IF REQUIRED

                                              REFUSE UNDER ANY CIRCUMSTANCES

                                              Blood Components Red cells Platelets

                                              Fresh frozen plasma Cryoprecipitate

                                              Cell Salvage

                                              Cell saver- Standard set up

                                              Cell saver- set up in continuity only

                                              Blood Products Octaplas (Prothrombin complex

                                              Concentrate)

                                              Anti-D Immunoglobulin Albumin

                                              Factor VIII concentrate Factor IX concentrate

                                              Fibrinogen Concentrate Recombinant Products

                                              Erythropoietin Factor VIIa

                                              I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                              26

                                              expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                              DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                              27

                                              Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                              needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                              to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                              bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                              Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                              bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                              transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                              bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                              must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                              (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                              28

                                              Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                              units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                              desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                              bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                              SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                              requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                              Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                              Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                              - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                              29

                                              - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                              Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                              bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                              taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                              Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                              unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                              the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                              Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                              date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                              Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                              30

                                              bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                              The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                              31

                                              Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                              Practitioner

                                              bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                              bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                              32

                                              Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                              Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                              alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                              patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                              Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                              or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                              33

                                              If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                              if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                              the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                              from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                              the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                              34

                                              bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                              identity band bull Match all other identifying information

                                              35

                                              Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                              been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                              had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                              the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                              bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                              Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                              alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                              you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                              bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                              form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                              bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                              is to take place

                                              36

                                              If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                              inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                              delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                              37

                                              Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                              unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                              are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                              storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                              no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                              transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                              available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                              correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                              for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                              38

                                              bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                              wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                              blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                              band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                              component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                              checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                              bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                              infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                              2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                              infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                              transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                              Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                              commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                              receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                              blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                              bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                              container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                              Blood Safety and Quality Regulations (2005)

                                              39

                                              bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                              bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                              a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                              40

                                              Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                              inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                              bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                              Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                              depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                              substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                              or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                              urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                              41

                                              bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                              haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                              42

                                              Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                              bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                              bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                              bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                              43

                                              Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                              Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                              Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                              regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                              44

                                              Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                              negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                              45

                                              Appendix 15A

                                              46

                                              Appendix 15B

                                              47

                                              Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                              Please use a new document for each transfusion event

                                              PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                              HospitalUnit Affix label here or write patient details Forename

                                              Surname

                                              Gender

                                              Date of birth

                                              CHI

                                              WardDept

                                              Consultant

                                              Authorisation Prescription

                                              bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                              transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                              chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                              Consent for Transfusion

                                              bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                              Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                              after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                              transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                              document in place Yes No Please delete patientguardian as appropriate

                                              Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                              I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                              Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                              48

                                              THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                              Patient Name Date of birthCHI

                                              UN

                                              IT 1

                                              Blood component

                                              Unit Pool mls

                                              Special Requirements Instructions (please tick)

                                              Affix completed pink portion of compatibility label here

                                              Irradiated CMV negative Blood warmer Other medication

                                              Reason for transfusion

                                              Date Duration Authoriser Prescriber signature

                                              Reassess before you progress (Venflon site and observations)

                                              UN

                                              IT 2

                                              Blood component

                                              Unit Pool mls

                                              Special Requirements Instructions (please tick)

                                              Affix completed pink portion of compatibility label here

                                              Irradiated CMV negative Blood warmer Other medication

                                              Reason for transfusion

                                              Date Duration Authoriser Prescriber signature

                                              Reassess before you progress (Venflon site and observations)

                                              UN

                                              IT 3

                                              Blood component

                                              Unit Pool mls

                                              Special Requirements Instructions (please tick)

                                              Affix completed pink portion of compatibility label here

                                              Irradiated CMV negative Blood warmer Other medication

                                              Reason for transfusion

                                              Date Duration Authoriser Prescriber signature

                                              Reassess before you progress (Venflon site and observations)

                                              UN

                                              IT 4

                                              Blood component

                                              Unit Pool mls

                                              Special Requirements Instructions (please tick)

                                              Affix completed pink portion of compatibility label here

                                              Irradiated CMV negative Blood warmer Other medication

                                              Reason for transfusion

                                              Date Duration Authoriser Prescriber signature

                                              THB(MR) 020 V40 May 2013

                                              THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                              Patient Na me Date of birthCHI

                                              Transfusion Checklist - Please initial each box as checks are completed

                                              PRE-

                                              COLLECTION

                                              Checks below should be completed before collection of component from temperature

                                              controlled storage is undertaken

                                              PRE-

                                              ADMINISTRATION

                                              AT BEDSIDE

                                              Only remove clear outer wrap

                                              bag immediately prior to commencing transfusion and

                                              only when all positive identification checks have been

                                              completed

                                              POST

                                              TRANSFUSION

                                              Unit No

                                              1

                                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                                              helliphelliphelliphelliphelliphelliphellip

                                              2

                                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                                              helliphelliphelliphelliphelliphelliphellip

                                              3

                                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                                              helliphelliphelliphelliphelliphellip

                                              4

                                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                                              helliphelliphelliphelliphelliphelliphellip

                                              THB(MR) 020 V40 - May 2013

                                              Identification band insitu amp details verified and correct

                                              Patent IV access

                                              (Patient safety bundle adhered to)

                                              Blood authorised

                                              prescribed

                                              Check for special

                                              requirements amp consent

                                              Verbal identification

                                              at the bedside

                                              (if applicable)

                                              Identification band details are verified

                                              and correct amp match details

                                              on Traceability ldquobagamp tagrdquo

                                              label

                                              DateTime Transfusion completed

                                              Traceability Tag signed with starting time amp date of transfusion recorded

                                              Inspect bag

                                              (condition amp expiry

                                              date)

                                              DateTime blood removed from

                                              cold temperature

                                              storage

                                              Baseline Observations recorded on SEWS chart

                                              (Temperature Pulse

                                              Oxygen sats Respiration rate

                                              amp BP)

                                              Completion of Observations

                                              Noted on the SEWS chart

                                              (Temperature Pulse

                                              Oxygen Sats Respiration rate

                                              50

                                              Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                              be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                              Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                              be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                              recorded and concerns escalated to the medical team according to the SEWS

                                              Adverse Events

                                              bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                              more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                              hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                              Post Transfusion

                                              bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                              patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                              bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                              Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                              transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                              patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                              Resources

                                              Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                              THB(MR)020 v 40 May 2013

                                              Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                              PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                              51

                                              9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                              This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                              POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                              Why has this policy been developed

                                              Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                              Has a risk control plan been developed and who is the owner of the risk If not why not

                                              Who has been involvedconsulted in the development of the policy

                                              Has the policy been assessed for Equality and Diversity in relation to-

                                              Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                              RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                              Please indicate YesNo for the following YES

                                              Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                              Please indicate Ye sNo for the following YES

                                              Does the policy contain evidence of the Equality amp

                                              Diversity Impact Assessment Process

                                              Is there an implementation plan

                                              Which officers are responsible for implementation

                                              When will the policy take effect

                                              Who must comply with the policystrategy

                                              How will they be informed of their responsibilities

                                              Is any training required

                                              If yes has any been arranged

                                              Are there any cost implications

                                              NO

                                              If yes please detail costs and note source of funding

                                              Who is responsible for auditing the implementation of the policy

                                              What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                              2

                                              POLICY MANAGER________________________ DATE______ _____________________

                                              • Blood supply in an emergency situation
                                              • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                              • Administration of Platelets
                                                • Appendix 1 Adult Blood Transfusion Guideline
                                                  • ADULT BLOOD TRANSFUSION GUIDELINE
                                                    • Remember
                                                      • References
                                                        • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                          • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                            • Consent for Transfusion
                                                            • THB(MR) 020 V40 May 2013
                                                              • PRE- COLLECTION
                                                              • PRE-ADMINISTRATION

                                                25

                                                Appendix 5a Jehovah Witness Consent

                                                CONSENT FOR PATIENTS WHO MAY REFUSE SOME BLOOD COMP ONENTS AND PRODUCTS I (Name amp CHIAddressograph) I confirm that the doctor named on this form has explained to me the potential for major haemorrhage associated with pregnancy labour and delivery I have been advised that in some cases major haemorrhage if not controlled can be fatal I have agreed to the use of non- blood volume expanders and pharmaceuticals that control haemorrhage andor stimulate the production of red blood cells However I have told the doctor that I am a Jehovahlsquos Witness with firm religious convictions With full realization of the implications of this position and knowledge that it may pose additional risks to my health or life I have decided to impose the following further restrictions on what the doctors may do in the course of my treatment I do so exercising my own choice I expressly withhold my consent to the following

                                                WILLING TO HAVE IF REQUIRED

                                                REFUSE UNDER ANY CIRCUMSTANCES

                                                Blood Components Red cells Platelets

                                                Fresh frozen plasma Cryoprecipitate

                                                Cell Salvage

                                                Cell saver- Standard set up

                                                Cell saver- set up in continuity only

                                                Blood Products Octaplas (Prothrombin complex

                                                Concentrate)

                                                Anti-D Immunoglobulin Albumin

                                                Factor VIII concentrate Factor IX concentrate

                                                Fibrinogen Concentrate Recombinant Products

                                                Erythropoietin Factor VIIa

                                                I understand that I am free to delete any of the words which appear above in order to modify these restrictions I understand that this limitation of consent will remain in force and bind all those treating me unless and until I expressly revoke it I understand that I may not be managed by the doctor who is treating me so far and that the express limitation of my consent as described above will be regarded as absolute by all the doctors who treat me and will not be overridden in any circumstances by a purported consent of a relative or other person or body I understand that such refusal will be regarded as remaining in force and binding upon those who care for me even though I may be unconscious or affected by medication or medical condition rendering me incapable of

                                                26

                                                expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                                DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                27

                                                Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                                needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                                to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                                bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                                Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                                bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                                transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                                bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                                must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                                (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                                28

                                                Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                                units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                                desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                                bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                                SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                                requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                                Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                                Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                                - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                                29

                                                - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                                Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                                bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                                taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                                Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                                unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                                the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                                Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                                date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                                Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                                30

                                                bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                                The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                                31

                                                Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                                Practitioner

                                                bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                                bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                                32

                                                Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                                patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                                Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                                or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                                33

                                                If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                34

                                                bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                identity band bull Match all other identifying information

                                                35

                                                Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                is to take place

                                                36

                                                If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                37

                                                Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                38

                                                bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                Blood Safety and Quality Regulations (2005)

                                                39

                                                bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                40

                                                Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                41

                                                bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                42

                                                Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                43

                                                Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                44

                                                Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                45

                                                Appendix 15A

                                                46

                                                Appendix 15B

                                                47

                                                Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                Please use a new document for each transfusion event

                                                PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                HospitalUnit Affix label here or write patient details Forename

                                                Surname

                                                Gender

                                                Date of birth

                                                CHI

                                                WardDept

                                                Consultant

                                                Authorisation Prescription

                                                bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                Consent for Transfusion

                                                bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                document in place Yes No Please delete patientguardian as appropriate

                                                Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                48

                                                THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                Patient Name Date of birthCHI

                                                UN

                                                IT 1

                                                Blood component

                                                Unit Pool mls

                                                Special Requirements Instructions (please tick)

                                                Affix completed pink portion of compatibility label here

                                                Irradiated CMV negative Blood warmer Other medication

                                                Reason for transfusion

                                                Date Duration Authoriser Prescriber signature

                                                Reassess before you progress (Venflon site and observations)

                                                UN

                                                IT 2

                                                Blood component

                                                Unit Pool mls

                                                Special Requirements Instructions (please tick)

                                                Affix completed pink portion of compatibility label here

                                                Irradiated CMV negative Blood warmer Other medication

                                                Reason for transfusion

                                                Date Duration Authoriser Prescriber signature

                                                Reassess before you progress (Venflon site and observations)

                                                UN

                                                IT 3

                                                Blood component

                                                Unit Pool mls

                                                Special Requirements Instructions (please tick)

                                                Affix completed pink portion of compatibility label here

                                                Irradiated CMV negative Blood warmer Other medication

                                                Reason for transfusion

                                                Date Duration Authoriser Prescriber signature

                                                Reassess before you progress (Venflon site and observations)

                                                UN

                                                IT 4

                                                Blood component

                                                Unit Pool mls

                                                Special Requirements Instructions (please tick)

                                                Affix completed pink portion of compatibility label here

                                                Irradiated CMV negative Blood warmer Other medication

                                                Reason for transfusion

                                                Date Duration Authoriser Prescriber signature

                                                THB(MR) 020 V40 May 2013

                                                THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                Patient Na me Date of birthCHI

                                                Transfusion Checklist - Please initial each box as checks are completed

                                                PRE-

                                                COLLECTION

                                                Checks below should be completed before collection of component from temperature

                                                controlled storage is undertaken

                                                PRE-

                                                ADMINISTRATION

                                                AT BEDSIDE

                                                Only remove clear outer wrap

                                                bag immediately prior to commencing transfusion and

                                                only when all positive identification checks have been

                                                completed

                                                POST

                                                TRANSFUSION

                                                Unit No

                                                1

                                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                helliphelliphelliphelliphelliphelliphellip

                                                2

                                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                helliphelliphelliphelliphelliphelliphellip

                                                3

                                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                helliphelliphelliphelliphelliphellip

                                                4

                                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                helliphelliphelliphelliphelliphelliphellip

                                                THB(MR) 020 V40 - May 2013

                                                Identification band insitu amp details verified and correct

                                                Patent IV access

                                                (Patient safety bundle adhered to)

                                                Blood authorised

                                                prescribed

                                                Check for special

                                                requirements amp consent

                                                Verbal identification

                                                at the bedside

                                                (if applicable)

                                                Identification band details are verified

                                                and correct amp match details

                                                on Traceability ldquobagamp tagrdquo

                                                label

                                                DateTime Transfusion completed

                                                Traceability Tag signed with starting time amp date of transfusion recorded

                                                Inspect bag

                                                (condition amp expiry

                                                date)

                                                DateTime blood removed from

                                                cold temperature

                                                storage

                                                Baseline Observations recorded on SEWS chart

                                                (Temperature Pulse

                                                Oxygen sats Respiration rate

                                                amp BP)

                                                Completion of Observations

                                                Noted on the SEWS chart

                                                (Temperature Pulse

                                                Oxygen Sats Respiration rate

                                                50

                                                Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                recorded and concerns escalated to the medical team according to the SEWS

                                                Adverse Events

                                                bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                Post Transfusion

                                                bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                Resources

                                                Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                THB(MR)020 v 40 May 2013

                                                Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                51

                                                9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                Why has this policy been developed

                                                Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                Has a risk control plan been developed and who is the owner of the risk If not why not

                                                Who has been involvedconsulted in the development of the policy

                                                Has the policy been assessed for Equality and Diversity in relation to-

                                                Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                Please indicate YesNo for the following YES

                                                Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                Please indicate Ye sNo for the following YES

                                                Does the policy contain evidence of the Equality amp

                                                Diversity Impact Assessment Process

                                                Is there an implementation plan

                                                Which officers are responsible for implementation

                                                When will the policy take effect

                                                Who must comply with the policystrategy

                                                How will they be informed of their responsibilities

                                                Is any training required

                                                If yes has any been arranged

                                                Are there any cost implications

                                                NO

                                                If yes please detail costs and note source of funding

                                                Who is responsible for auditing the implementation of the policy

                                                What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                2

                                                POLICY MANAGER________________________ DATE______ _____________________

                                                • Blood supply in an emergency situation
                                                • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                • Administration of Platelets
                                                  • Appendix 1 Adult Blood Transfusion Guideline
                                                    • ADULT BLOOD TRANSFUSION GUIDELINE
                                                      • Remember
                                                        • References
                                                          • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                            • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                              • Consent for Transfusion
                                                              • THB(MR) 020 V40 May 2013
                                                                • PRE- COLLECTION
                                                                • PRE-ADMINISTRATION

                                                  26

                                                  expressing my wishes and that doctors treating me will continue to be bound by my refusal even though they may believe that the treatment is immediately necessary in order to save my life I further understand that details of my treatment and any consequences resulting will not be disclosed to any other person without my express consent unless required by law Signature Namehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Dated Witnessed by Signature helliphellip Name Dated

                                                  DOCTOR ndash (this part to he completed by Registered Medical Practitioner) I confirm that I have explained the potential for major haemorrhage associated with pregnancy labour and delivery to helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip in terms which in my judgment are suited to the understanding of the person named above I have spoken to this individual alone I further confirm that I have emphasised my clinical judgment of the potential risks to the patient who nonetheless understood and imposed the limitation expressed above I acknowledge that this limited consent will not be over-ridden unless revoked or modified Signature Date Name of Registered Medical Practitioner Witnessed by helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                  27

                                                  Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                                  needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                                  to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                                  bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                                  Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                                  bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                                  transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                                  bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                                  must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                                  (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                                  28

                                                  Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                                  units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                                  desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                                  bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                                  SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                                  requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                                  Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                                  Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                                  - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                                  29

                                                  - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                                  Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                                  bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                                  taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                                  Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                                  unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                                  the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                                  Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                                  date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                                  Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                                  30

                                                  bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                                  The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                                  31

                                                  Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                                  Practitioner

                                                  bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                                  bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                                  32

                                                  Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                  Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                  alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                                  patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                                  Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                                  or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                                  33

                                                  If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                  if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                  the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                  from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                  the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                  34

                                                  bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                  identity band bull Match all other identifying information

                                                  35

                                                  Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                  been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                  had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                  the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                  bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                  Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                  alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                  you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                  bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                  form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                  bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                  is to take place

                                                  36

                                                  If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                  inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                  delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                  37

                                                  Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                  unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                  are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                  storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                  no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                  transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                  available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                  correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                  for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                  38

                                                  bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                  wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                  blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                  band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                  component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                  checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                  bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                  infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                  2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                  infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                  transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                  Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                  commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                  receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                  blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                  bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                  container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                  Blood Safety and Quality Regulations (2005)

                                                  39

                                                  bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                  bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                  a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                  40

                                                  Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                  inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                  bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                  Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                  depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                  substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                  or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                  urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                  41

                                                  bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                  haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                  42

                                                  Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                  bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                  bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                  bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                  43

                                                  Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                  Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                  Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                  regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                  44

                                                  Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                  negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                  45

                                                  Appendix 15A

                                                  46

                                                  Appendix 15B

                                                  47

                                                  Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                  Please use a new document for each transfusion event

                                                  PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                  HospitalUnit Affix label here or write patient details Forename

                                                  Surname

                                                  Gender

                                                  Date of birth

                                                  CHI

                                                  WardDept

                                                  Consultant

                                                  Authorisation Prescription

                                                  bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                  transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                  chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                  Consent for Transfusion

                                                  bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                  Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                  after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                  transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                  document in place Yes No Please delete patientguardian as appropriate

                                                  Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                  I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                  Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                  48

                                                  THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                  Patient Name Date of birthCHI

                                                  UN

                                                  IT 1

                                                  Blood component

                                                  Unit Pool mls

                                                  Special Requirements Instructions (please tick)

                                                  Affix completed pink portion of compatibility label here

                                                  Irradiated CMV negative Blood warmer Other medication

                                                  Reason for transfusion

                                                  Date Duration Authoriser Prescriber signature

                                                  Reassess before you progress (Venflon site and observations)

                                                  UN

                                                  IT 2

                                                  Blood component

                                                  Unit Pool mls

                                                  Special Requirements Instructions (please tick)

                                                  Affix completed pink portion of compatibility label here

                                                  Irradiated CMV negative Blood warmer Other medication

                                                  Reason for transfusion

                                                  Date Duration Authoriser Prescriber signature

                                                  Reassess before you progress (Venflon site and observations)

                                                  UN

                                                  IT 3

                                                  Blood component

                                                  Unit Pool mls

                                                  Special Requirements Instructions (please tick)

                                                  Affix completed pink portion of compatibility label here

                                                  Irradiated CMV negative Blood warmer Other medication

                                                  Reason for transfusion

                                                  Date Duration Authoriser Prescriber signature

                                                  Reassess before you progress (Venflon site and observations)

                                                  UN

                                                  IT 4

                                                  Blood component

                                                  Unit Pool mls

                                                  Special Requirements Instructions (please tick)

                                                  Affix completed pink portion of compatibility label here

                                                  Irradiated CMV negative Blood warmer Other medication

                                                  Reason for transfusion

                                                  Date Duration Authoriser Prescriber signature

                                                  THB(MR) 020 V40 May 2013

                                                  THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                  Patient Na me Date of birthCHI

                                                  Transfusion Checklist - Please initial each box as checks are completed

                                                  PRE-

                                                  COLLECTION

                                                  Checks below should be completed before collection of component from temperature

                                                  controlled storage is undertaken

                                                  PRE-

                                                  ADMINISTRATION

                                                  AT BEDSIDE

                                                  Only remove clear outer wrap

                                                  bag immediately prior to commencing transfusion and

                                                  only when all positive identification checks have been

                                                  completed

                                                  POST

                                                  TRANSFUSION

                                                  Unit No

                                                  1

                                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                  helliphelliphelliphelliphelliphelliphellip

                                                  2

                                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                  helliphelliphelliphelliphelliphelliphellip

                                                  3

                                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                  helliphelliphelliphelliphelliphellip

                                                  4

                                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                  helliphelliphelliphelliphelliphelliphellip

                                                  THB(MR) 020 V40 - May 2013

                                                  Identification band insitu amp details verified and correct

                                                  Patent IV access

                                                  (Patient safety bundle adhered to)

                                                  Blood authorised

                                                  prescribed

                                                  Check for special

                                                  requirements amp consent

                                                  Verbal identification

                                                  at the bedside

                                                  (if applicable)

                                                  Identification band details are verified

                                                  and correct amp match details

                                                  on Traceability ldquobagamp tagrdquo

                                                  label

                                                  DateTime Transfusion completed

                                                  Traceability Tag signed with starting time amp date of transfusion recorded

                                                  Inspect bag

                                                  (condition amp expiry

                                                  date)

                                                  DateTime blood removed from

                                                  cold temperature

                                                  storage

                                                  Baseline Observations recorded on SEWS chart

                                                  (Temperature Pulse

                                                  Oxygen sats Respiration rate

                                                  amp BP)

                                                  Completion of Observations

                                                  Noted on the SEWS chart

                                                  (Temperature Pulse

                                                  Oxygen Sats Respiration rate

                                                  50

                                                  Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                  be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                  Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                  be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                  recorded and concerns escalated to the medical team according to the SEWS

                                                  Adverse Events

                                                  bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                  more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                  hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                  Post Transfusion

                                                  bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                  patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                  bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                  Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                  transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                  patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                  Resources

                                                  Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                  THB(MR)020 v 40 May 2013

                                                  Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                  PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                  51

                                                  9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                  This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                  POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                  Why has this policy been developed

                                                  Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                  Has a risk control plan been developed and who is the owner of the risk If not why not

                                                  Who has been involvedconsulted in the development of the policy

                                                  Has the policy been assessed for Equality and Diversity in relation to-

                                                  Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                  RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                  Please indicate YesNo for the following YES

                                                  Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                  Please indicate Ye sNo for the following YES

                                                  Does the policy contain evidence of the Equality amp

                                                  Diversity Impact Assessment Process

                                                  Is there an implementation plan

                                                  Which officers are responsible for implementation

                                                  When will the policy take effect

                                                  Who must comply with the policystrategy

                                                  How will they be informed of their responsibilities

                                                  Is any training required

                                                  If yes has any been arranged

                                                  Are there any cost implications

                                                  NO

                                                  If yes please detail costs and note source of funding

                                                  Who is responsible for auditing the implementation of the policy

                                                  What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                  2

                                                  POLICY MANAGER________________________ DATE______ _____________________

                                                  • Blood supply in an emergency situation
                                                  • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                  • Administration of Platelets
                                                    • Appendix 1 Adult Blood Transfusion Guideline
                                                      • ADULT BLOOD TRANSFUSION GUIDELINE
                                                        • Remember
                                                          • References
                                                            • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                              • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                • Consent for Transfusion
                                                                • THB(MR) 020 V40 May 2013
                                                                  • PRE- COLLECTION
                                                                  • PRE-ADMINISTRATION

                                                    27

                                                    Appendix 5b - Decision to Transfuse bull The decision to transfuse must be based on a thorough clinical assessment of the patient and their individual

                                                    needs bull The decision process leading to transfusion should be documented in the patientrsquos clinical record bull If you anticipate any difficulties in transfusing a blood component or blood product eg you require smaller units

                                                    to be supplied or the patient is known to have irregular red cell antibodies you should inform the Hospital Transfusion Laboratory of this as early as possible so that they can act or advise appropriately

                                                    bull Arrangements should be made locally to ensure that any communication from the Hospital Transfusion

                                                    Laboratory regarding a delay in the provision of transfusion support due to antibodies is disseminated appropriately

                                                    bull Prior to commencing a transfusion it is essential to ensure that any patient who refuses consent to a blood

                                                    transfusion or administration of blood products on religious or other grounds is sensitively advised of the implications and alternatives

                                                    bull Please refer to the NHS Tayside Informed Consent Policy for specific guidance on how these circumstances

                                                    must be managed Patients who do not wish to receive blood products or components should be identified using a red identity band in accordance with the NHS Tayside Es tablishing Patient Identity Policy Information relating to the appropriate use of blood components is not included in this guideline For more detailed guidance refer to the following BCSH guidelines bull The Clinical Use of Red Cell Transfusion (2001) httponlinelibrarywileycomdoi101046j1365-2141200102701xfull British Committee for Standards in Haematology (2009) Guidelines on the Administration of Blood Components httpwwwbcshguidelinescomdocumentsAdmin_blood_components_bcsh_05012010pdf bull Guidelines for the Use of Platelet Transfusions (2003) httponlinelibrarywileycomdoi101046j1365-2141200304468xfull bull Guidelines for the Use of Fresh-Frozen Plasma Cryoprecipitate and Cryosupernatant (2004) and amendment

                                                    (2007) httponlinelibrarywileycomdoi101111j1365-2141200404972xfull httpwwwbcshguidelinescomdocumentsFFPAmendment_2_17_Oct_2007pdf bull Transfusion Guidelines for Neonates and Older Children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf bull Guidelines for Management of Massive Blood Loss (2006) httponlinelibrarywileycomdoi101111j1365-2141200606355xfull Advice is also available in the Handbook of Transfusion Medicine (4th Edition McClelland (ed) 2007) wwwtransfusionguidelinesorgukdocspdfshtm_edition-4_all-pagespdf

                                                    28

                                                    Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                                    units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                                    desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                                    bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                                    SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                                    requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                                    Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                                    Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                                    - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                                    29

                                                    - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                                    Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                                    bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                                    taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                                    Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                                    unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                                    the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                                    Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                                    date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                                    Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                                    30

                                                    bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                                    The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                                    31

                                                    Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                                    Practitioner

                                                    bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                                    bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                                    32

                                                    Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                    Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                    alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                                    patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                                    Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                                    or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                                    33

                                                    If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                    if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                    the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                    from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                    the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                    34

                                                    bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                    identity band bull Match all other identifying information

                                                    35

                                                    Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                    been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                    had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                    the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                    bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                    Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                    alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                    you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                    bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                    form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                    bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                    is to take place

                                                    36

                                                    If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                    inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                    delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                    37

                                                    Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                    unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                    are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                    storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                    no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                    transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                    available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                    correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                    for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                    38

                                                    bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                    wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                    blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                    band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                    component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                    checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                    bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                    infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                    2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                    infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                    transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                    Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                    commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                    receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                    blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                    bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                    container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                    Blood Safety and Quality Regulations (2005)

                                                    39

                                                    bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                    bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                    a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                    40

                                                    Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                    inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                    bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                    Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                    depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                    substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                    or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                    urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                    41

                                                    bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                    haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                    42

                                                    Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                    bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                    bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                    bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                    43

                                                    Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                    Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                    Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                    regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                    44

                                                    Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                    negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                    45

                                                    Appendix 15A

                                                    46

                                                    Appendix 15B

                                                    47

                                                    Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                    Please use a new document for each transfusion event

                                                    PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                    HospitalUnit Affix label here or write patient details Forename

                                                    Surname

                                                    Gender

                                                    Date of birth

                                                    CHI

                                                    WardDept

                                                    Consultant

                                                    Authorisation Prescription

                                                    bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                    transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                    chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                    Consent for Transfusion

                                                    bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                    Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                    after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                    transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                    document in place Yes No Please delete patientguardian as appropriate

                                                    Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                    I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                    Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                    48

                                                    THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                    Patient Name Date of birthCHI

                                                    UN

                                                    IT 1

                                                    Blood component

                                                    Unit Pool mls

                                                    Special Requirements Instructions (please tick)

                                                    Affix completed pink portion of compatibility label here

                                                    Irradiated CMV negative Blood warmer Other medication

                                                    Reason for transfusion

                                                    Date Duration Authoriser Prescriber signature

                                                    Reassess before you progress (Venflon site and observations)

                                                    UN

                                                    IT 2

                                                    Blood component

                                                    Unit Pool mls

                                                    Special Requirements Instructions (please tick)

                                                    Affix completed pink portion of compatibility label here

                                                    Irradiated CMV negative Blood warmer Other medication

                                                    Reason for transfusion

                                                    Date Duration Authoriser Prescriber signature

                                                    Reassess before you progress (Venflon site and observations)

                                                    UN

                                                    IT 3

                                                    Blood component

                                                    Unit Pool mls

                                                    Special Requirements Instructions (please tick)

                                                    Affix completed pink portion of compatibility label here

                                                    Irradiated CMV negative Blood warmer Other medication

                                                    Reason for transfusion

                                                    Date Duration Authoriser Prescriber signature

                                                    Reassess before you progress (Venflon site and observations)

                                                    UN

                                                    IT 4

                                                    Blood component

                                                    Unit Pool mls

                                                    Special Requirements Instructions (please tick)

                                                    Affix completed pink portion of compatibility label here

                                                    Irradiated CMV negative Blood warmer Other medication

                                                    Reason for transfusion

                                                    Date Duration Authoriser Prescriber signature

                                                    THB(MR) 020 V40 May 2013

                                                    THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                    Patient Na me Date of birthCHI

                                                    Transfusion Checklist - Please initial each box as checks are completed

                                                    PRE-

                                                    COLLECTION

                                                    Checks below should be completed before collection of component from temperature

                                                    controlled storage is undertaken

                                                    PRE-

                                                    ADMINISTRATION

                                                    AT BEDSIDE

                                                    Only remove clear outer wrap

                                                    bag immediately prior to commencing transfusion and

                                                    only when all positive identification checks have been

                                                    completed

                                                    POST

                                                    TRANSFUSION

                                                    Unit No

                                                    1

                                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                    helliphelliphelliphelliphelliphelliphellip

                                                    2

                                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                    helliphelliphelliphelliphelliphelliphellip

                                                    3

                                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                    helliphelliphelliphelliphelliphellip

                                                    4

                                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                    helliphelliphelliphelliphelliphelliphellip

                                                    THB(MR) 020 V40 - May 2013

                                                    Identification band insitu amp details verified and correct

                                                    Patent IV access

                                                    (Patient safety bundle adhered to)

                                                    Blood authorised

                                                    prescribed

                                                    Check for special

                                                    requirements amp consent

                                                    Verbal identification

                                                    at the bedside

                                                    (if applicable)

                                                    Identification band details are verified

                                                    and correct amp match details

                                                    on Traceability ldquobagamp tagrdquo

                                                    label

                                                    DateTime Transfusion completed

                                                    Traceability Tag signed with starting time amp date of transfusion recorded

                                                    Inspect bag

                                                    (condition amp expiry

                                                    date)

                                                    DateTime blood removed from

                                                    cold temperature

                                                    storage

                                                    Baseline Observations recorded on SEWS chart

                                                    (Temperature Pulse

                                                    Oxygen sats Respiration rate

                                                    amp BP)

                                                    Completion of Observations

                                                    Noted on the SEWS chart

                                                    (Temperature Pulse

                                                    Oxygen Sats Respiration rate

                                                    50

                                                    Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                    be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                    Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                    be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                    recorded and concerns escalated to the medical team according to the SEWS

                                                    Adverse Events

                                                    bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                    more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                    hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                    Post Transfusion

                                                    bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                    patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                    bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                    Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                    transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                    patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                    Resources

                                                    Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                    THB(MR)020 v 40 May 2013

                                                    Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                    PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                    51

                                                    9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                    This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                    POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                    Why has this policy been developed

                                                    Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                    Has a risk control plan been developed and who is the owner of the risk If not why not

                                                    Who has been involvedconsulted in the development of the policy

                                                    Has the policy been assessed for Equality and Diversity in relation to-

                                                    Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                    RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                    Please indicate YesNo for the following YES

                                                    Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                    Please indicate Ye sNo for the following YES

                                                    Does the policy contain evidence of the Equality amp

                                                    Diversity Impact Assessment Process

                                                    Is there an implementation plan

                                                    Which officers are responsible for implementation

                                                    When will the policy take effect

                                                    Who must comply with the policystrategy

                                                    How will they be informed of their responsibilities

                                                    Is any training required

                                                    If yes has any been arranged

                                                    Are there any cost implications

                                                    NO

                                                    If yes please detail costs and note source of funding

                                                    Who is responsible for auditing the implementation of the policy

                                                    What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                    2

                                                    POLICY MANAGER________________________ DATE______ _____________________

                                                    • Blood supply in an emergency situation
                                                    • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                    • Administration of Platelets
                                                      • Appendix 1 Adult Blood Transfusion Guideline
                                                        • ADULT BLOOD TRANSFUSION GUIDELINE
                                                          • Remember
                                                            • References
                                                              • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                  • Consent for Transfusion
                                                                  • THB(MR) 020 V40 May 2013
                                                                    • PRE- COLLECTION
                                                                    • PRE-ADMINISTRATION

                                                      28

                                                      Appendix 6 - Requesting Transfusion Support bull Clearly document within the notes the indication for the transfusion including the rationale for the number of

                                                      units to be transfused as per BCSH (2009) guidelines bull Wherever possible and appropriate explain the reason for the proposed treatment outline the procedure and

                                                      desired outcome to the patient relative carer Check understanding and obtain verbal consent and document this in the medical andor nursing notes If a pre-transfusion discussion is not possible arrangements must be made to discuss the reasons for transfusion with the patient or relatives at the earliest opportunity

                                                      bull Information leaflets written by the Scottish national Blood Transfusion Service (SNBTS) are available through

                                                      SNBTS Public Affairs Dept on tel 01413577752 Copies should be available in every clinical area where transfusions take place bull In addition to asking the patient refer to the case notes for evidence of previous transfusion reaction special

                                                      requirements and antibodies Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody negative blood components

                                                      Indications for irradiated red cells include - All patients undergoing autologous bone marrow transplant or peripheral blood stem cell transplant should receive irradiated cellular blood components from initiation of conditioning chemoradiotherapy until 3 months post-transplant (6 months if total body irradiation was used in conditioning) - Recipients of allogeneic haemopoietic stem cell transplantation (SCT) must receive irradiated blood components from the time of initiation of conditioning radiotherapy This should be continued while the patient continues to receive graft-versus-host disease prophylaxis ie usually for 6 months post-transplant or until lymphocytes are gt1 middot 109l - Allogeneic blood transfused to Patients undergoing bone marrow or peripheral blood stem cell lsquoharvestingrsquo for future autologous re-infusion should receive irradiated cellular blood components during and for 7 days before the bone marrowstem cell harvest - All adults and children with Hodgkin lymphoma at any stage of the disease should have irradiated red cells and platelets for life - Patients treated with Purine Analogue drugs (Fludarabine Cladribine and Deoxycoformicin) should receive irradiated blood components indefinitely The situation with other Purine Antagonists and new and related agents such as Bendamustine and Clofarabine is unclear but use of irradiated blood components is recommended as these agents have a similar mode of action - Irradiated blood components should be used after Alemtuzumab (anti-CD52) therapy

                                                      Neonatal Paediatric Indications for irradiated cel ls - All blood for intrauterine transfusion (IUT) should be irradiated

                                                      - It is essential to irradiate blood for neonatal exchange transfusion (ET) if there has been a previous IUT or if the donation comes from a first- or second-degree relative - For other neonatal ET cases irradiation is recommended provided this does not unduly delay transfusion - It is not necessary to irradiate red cells for routine lsquotop-uprsquo transfusions of premature or term infants unless either there has been a previous IUT in which case irradiated components should be administered until 6 months after the expected delivery date (40 weeks gestation)

                                                      29

                                                      - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                                      Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                                      bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                                      taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                                      Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                                      unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                                      the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                                      Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                                      date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                                      Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                                      30

                                                      bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                                      The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                                      31

                                                      Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                                      Practitioner

                                                      bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                                      bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                                      32

                                                      Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                      Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                      alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                                      patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                                      Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                                      or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                                      33

                                                      If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                      if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                      the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                      from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                      the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                      34

                                                      bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                      identity band bull Match all other identifying information

                                                      35

                                                      Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                      been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                      had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                      the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                      bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                      Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                      alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                      you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                      bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                      form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                      bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                      is to take place

                                                      36

                                                      If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                      inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                      delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                      37

                                                      Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                      unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                      are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                      storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                      no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                      transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                      available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                      correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                      for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                      38

                                                      bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                      wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                      blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                      band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                      component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                      checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                      bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                      infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                      2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                      infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                      transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                      Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                      commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                      receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                      blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                      bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                      container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                      Blood Safety and Quality Regulations (2005)

                                                      39

                                                      bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                      bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                      a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                      40

                                                      Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                      inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                      bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                      Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                      depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                      substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                      or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                      urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                      41

                                                      bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                      haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                      42

                                                      Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                      bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                      bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                      bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                      43

                                                      Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                      Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                      Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                      regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                      44

                                                      Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                      negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                      45

                                                      Appendix 15A

                                                      46

                                                      Appendix 15B

                                                      47

                                                      Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                      Please use a new document for each transfusion event

                                                      PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                      HospitalUnit Affix label here or write patient details Forename

                                                      Surname

                                                      Gender

                                                      Date of birth

                                                      CHI

                                                      WardDept

                                                      Consultant

                                                      Authorisation Prescription

                                                      bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                      transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                      chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                      Consent for Transfusion

                                                      bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                      Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                      after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                      transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                      document in place Yes No Please delete patientguardian as appropriate

                                                      Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                      I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                      Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                      48

                                                      THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                      Patient Name Date of birthCHI

                                                      UN

                                                      IT 1

                                                      Blood component

                                                      Unit Pool mls

                                                      Special Requirements Instructions (please tick)

                                                      Affix completed pink portion of compatibility label here

                                                      Irradiated CMV negative Blood warmer Other medication

                                                      Reason for transfusion

                                                      Date Duration Authoriser Prescriber signature

                                                      Reassess before you progress (Venflon site and observations)

                                                      UN

                                                      IT 2

                                                      Blood component

                                                      Unit Pool mls

                                                      Special Requirements Instructions (please tick)

                                                      Affix completed pink portion of compatibility label here

                                                      Irradiated CMV negative Blood warmer Other medication

                                                      Reason for transfusion

                                                      Date Duration Authoriser Prescriber signature

                                                      Reassess before you progress (Venflon site and observations)

                                                      UN

                                                      IT 3

                                                      Blood component

                                                      Unit Pool mls

                                                      Special Requirements Instructions (please tick)

                                                      Affix completed pink portion of compatibility label here

                                                      Irradiated CMV negative Blood warmer Other medication

                                                      Reason for transfusion

                                                      Date Duration Authoriser Prescriber signature

                                                      Reassess before you progress (Venflon site and observations)

                                                      UN

                                                      IT 4

                                                      Blood component

                                                      Unit Pool mls

                                                      Special Requirements Instructions (please tick)

                                                      Affix completed pink portion of compatibility label here

                                                      Irradiated CMV negative Blood warmer Other medication

                                                      Reason for transfusion

                                                      Date Duration Authoriser Prescriber signature

                                                      THB(MR) 020 V40 May 2013

                                                      THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                      Patient Na me Date of birthCHI

                                                      Transfusion Checklist - Please initial each box as checks are completed

                                                      PRE-

                                                      COLLECTION

                                                      Checks below should be completed before collection of component from temperature

                                                      controlled storage is undertaken

                                                      PRE-

                                                      ADMINISTRATION

                                                      AT BEDSIDE

                                                      Only remove clear outer wrap

                                                      bag immediately prior to commencing transfusion and

                                                      only when all positive identification checks have been

                                                      completed

                                                      POST

                                                      TRANSFUSION

                                                      Unit No

                                                      1

                                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                      helliphelliphelliphelliphelliphelliphellip

                                                      2

                                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                      helliphelliphelliphelliphelliphelliphellip

                                                      3

                                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                      helliphelliphelliphelliphelliphellip

                                                      4

                                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                      helliphelliphelliphelliphelliphelliphellip

                                                      THB(MR) 020 V40 - May 2013

                                                      Identification band insitu amp details verified and correct

                                                      Patent IV access

                                                      (Patient safety bundle adhered to)

                                                      Blood authorised

                                                      prescribed

                                                      Check for special

                                                      requirements amp consent

                                                      Verbal identification

                                                      at the bedside

                                                      (if applicable)

                                                      Identification band details are verified

                                                      and correct amp match details

                                                      on Traceability ldquobagamp tagrdquo

                                                      label

                                                      DateTime Transfusion completed

                                                      Traceability Tag signed with starting time amp date of transfusion recorded

                                                      Inspect bag

                                                      (condition amp expiry

                                                      date)

                                                      DateTime blood removed from

                                                      cold temperature

                                                      storage

                                                      Baseline Observations recorded on SEWS chart

                                                      (Temperature Pulse

                                                      Oxygen sats Respiration rate

                                                      amp BP)

                                                      Completion of Observations

                                                      Noted on the SEWS chart

                                                      (Temperature Pulse

                                                      Oxygen Sats Respiration rate

                                                      50

                                                      Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                      be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                      Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                      be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                      recorded and concerns escalated to the medical team according to the SEWS

                                                      Adverse Events

                                                      bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                      more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                      hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                      Post Transfusion

                                                      bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                      patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                      bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                      Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                      transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                      patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                      Resources

                                                      Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                      THB(MR)020 v 40 May 2013

                                                      Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                      PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                      51

                                                      9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                      This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                      POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                      Why has this policy been developed

                                                      Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                      Has a risk control plan been developed and who is the owner of the risk If not why not

                                                      Who has been involvedconsulted in the development of the policy

                                                      Has the policy been assessed for Equality and Diversity in relation to-

                                                      Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                      RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                      Please indicate YesNo for the following YES

                                                      Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                      Please indicate Ye sNo for the following YES

                                                      Does the policy contain evidence of the Equality amp

                                                      Diversity Impact Assessment Process

                                                      Is there an implementation plan

                                                      Which officers are responsible for implementation

                                                      When will the policy take effect

                                                      Who must comply with the policystrategy

                                                      How will they be informed of their responsibilities

                                                      Is any training required

                                                      If yes has any been arranged

                                                      Are there any cost implications

                                                      NO

                                                      If yes please detail costs and note source of funding

                                                      Who is responsible for auditing the implementation of the policy

                                                      What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                      2

                                                      POLICY MANAGER________________________ DATE______ _____________________

                                                      • Blood supply in an emergency situation
                                                      • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                      • Administration of Platelets
                                                        • Appendix 1 Adult Blood Transfusion Guideline
                                                          • ADULT BLOOD TRANSFUSION GUIDELINE
                                                            • Remember
                                                              • References
                                                                • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                  • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                    • Consent for Transfusion
                                                                    • THB(MR) 020 V40 May 2013
                                                                      • PRE- COLLECTION
                                                                      • PRE-ADMINISTRATION

                                                        29

                                                        - Platelets transfused in utero to treat alloimmune thrombocytopenia should be irradiated and any subsequent red cell or platelet transfusions irradiated until 6 months after the expected date of delivery (40 weeks gestation) There is no need to irradiate other platelet transfusions for pre-term or term infants All severe T lymphocyte immunodeficiency syndromes should be considered as indications for irradiation of cellular blood components Once a diagnosis of immunodeficiency has been suspected irradiated components should be given while further diagnostic tests are being undertaken Further guidance and information can be sought from the Hospital Transfusion Laboratory It is the responsibility of the clinician requestin g transfusion support to ensure that the laboratory is informed regarding any special requirements Guidelines on the Use of Irradiated Blood Components prepared by the British Committee for Standards in Haematology Blood Transfusion Task Force (2010) httponlinelibrarywileycomdoi101111j1365-2141201008444xfull British Committee for Standards in Haematology Blood Transfusion Taskforce (2012) Amendment to the Guidelines on the Use of Irradiated Blood Components 2010 httpwwwbcshguidelinescomdocumentsBCSH_TTF_addendum_irradiation_guidelines_final_6_11_12pdf Request Forms A request to the blood transfusion laboratory for grouping andor compatibility testing must be made on a request form which contains the following information for identification bull The patients forename (no abbreviations) surname date of birth CHI (Community Health Index) number or

                                                        Typenex (use of a unique numbered label system that allows an unambiguous link to be established between the patient and the sample) and casualty number gender

                                                        bull Location and clinical details bull Signature and details of the person making the transfusion request and the date and time the sample was

                                                        taken bull In addition the Hospital Transfusion Laboratory needs an indication of urgency and any special requirements

                                                        Samples taken in the community should specify where and when the patient will attend for transfusion All information should be unambiguous and written i n block capitals as instructed on the request form All transfusion requests must be appropriate accurate and specific bull A request for a group and screen means that samples will be tested but no blood will be made available

                                                        unless the Hospital Transfusion Laboratory is contacted to provide transfusion support bull A request for a crossmatch means that the sample will be tested and blood issued for the patient based on

                                                        the urgency denoted on the request form bull Requests for emergency transfusion support should include a phone call to the Hospital Transfusion

                                                        Laboratory advising them of the situation bull Request for infants under 4 months old should include the full maternal details ie surname forename(s)

                                                        date of birth and CHI bull In situations where a unique number is not available the use of the patientrsquos address may be of benefit

                                                        Alternatively where the patient cannot be identified the use of the Typenex system must be used please refer to the NHS Tayside Establishing Patient Identity Policy

                                                        30

                                                        bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                                        The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                                        31

                                                        Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                                        Practitioner

                                                        bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                                        bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                                        32

                                                        Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                        Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                        alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                                        patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                                        Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                                        or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                                        33

                                                        If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                        if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                        the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                        from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                        the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                        34

                                                        bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                        identity band bull Match all other identifying information

                                                        35

                                                        Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                        been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                        had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                        the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                        bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                        Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                        alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                        you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                        bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                        form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                        bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                        is to take place

                                                        36

                                                        If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                        inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                        delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                        37

                                                        Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                        unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                        are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                        storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                        no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                        transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                        available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                        correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                        for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                        38

                                                        bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                        wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                        blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                        band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                        component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                        checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                        bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                        infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                        2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                        infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                        transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                        Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                        commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                        receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                        blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                        bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                        container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                        Blood Safety and Quality Regulations (2005)

                                                        39

                                                        bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                        bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                        a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                        40

                                                        Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                        inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                        bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                        Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                        depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                        substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                        or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                        urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                        41

                                                        bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                        haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                        42

                                                        Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                        bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                        bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                        bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                        43

                                                        Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                        Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                        Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                        regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                        44

                                                        Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                        negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                        45

                                                        Appendix 15A

                                                        46

                                                        Appendix 15B

                                                        47

                                                        Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                        Please use a new document for each transfusion event

                                                        PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                        HospitalUnit Affix label here or write patient details Forename

                                                        Surname

                                                        Gender

                                                        Date of birth

                                                        CHI

                                                        WardDept

                                                        Consultant

                                                        Authorisation Prescription

                                                        bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                        transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                        chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                        Consent for Transfusion

                                                        bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                        Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                        after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                        transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                        document in place Yes No Please delete patientguardian as appropriate

                                                        Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                        I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                        Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                        48

                                                        THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                        Patient Name Date of birthCHI

                                                        UN

                                                        IT 1

                                                        Blood component

                                                        Unit Pool mls

                                                        Special Requirements Instructions (please tick)

                                                        Affix completed pink portion of compatibility label here

                                                        Irradiated CMV negative Blood warmer Other medication

                                                        Reason for transfusion

                                                        Date Duration Authoriser Prescriber signature

                                                        Reassess before you progress (Venflon site and observations)

                                                        UN

                                                        IT 2

                                                        Blood component

                                                        Unit Pool mls

                                                        Special Requirements Instructions (please tick)

                                                        Affix completed pink portion of compatibility label here

                                                        Irradiated CMV negative Blood warmer Other medication

                                                        Reason for transfusion

                                                        Date Duration Authoriser Prescriber signature

                                                        Reassess before you progress (Venflon site and observations)

                                                        UN

                                                        IT 3

                                                        Blood component

                                                        Unit Pool mls

                                                        Special Requirements Instructions (please tick)

                                                        Affix completed pink portion of compatibility label here

                                                        Irradiated CMV negative Blood warmer Other medication

                                                        Reason for transfusion

                                                        Date Duration Authoriser Prescriber signature

                                                        Reassess before you progress (Venflon site and observations)

                                                        UN

                                                        IT 4

                                                        Blood component

                                                        Unit Pool mls

                                                        Special Requirements Instructions (please tick)

                                                        Affix completed pink portion of compatibility label here

                                                        Irradiated CMV negative Blood warmer Other medication

                                                        Reason for transfusion

                                                        Date Duration Authoriser Prescriber signature

                                                        THB(MR) 020 V40 May 2013

                                                        THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                        Patient Na me Date of birthCHI

                                                        Transfusion Checklist - Please initial each box as checks are completed

                                                        PRE-

                                                        COLLECTION

                                                        Checks below should be completed before collection of component from temperature

                                                        controlled storage is undertaken

                                                        PRE-

                                                        ADMINISTRATION

                                                        AT BEDSIDE

                                                        Only remove clear outer wrap

                                                        bag immediately prior to commencing transfusion and

                                                        only when all positive identification checks have been

                                                        completed

                                                        POST

                                                        TRANSFUSION

                                                        Unit No

                                                        1

                                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                        helliphelliphelliphelliphelliphelliphellip

                                                        2

                                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                        helliphelliphelliphelliphelliphelliphellip

                                                        3

                                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                        helliphelliphelliphelliphelliphellip

                                                        4

                                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                        helliphelliphelliphelliphelliphelliphellip

                                                        THB(MR) 020 V40 - May 2013

                                                        Identification band insitu amp details verified and correct

                                                        Patent IV access

                                                        (Patient safety bundle adhered to)

                                                        Blood authorised

                                                        prescribed

                                                        Check for special

                                                        requirements amp consent

                                                        Verbal identification

                                                        at the bedside

                                                        (if applicable)

                                                        Identification band details are verified

                                                        and correct amp match details

                                                        on Traceability ldquobagamp tagrdquo

                                                        label

                                                        DateTime Transfusion completed

                                                        Traceability Tag signed with starting time amp date of transfusion recorded

                                                        Inspect bag

                                                        (condition amp expiry

                                                        date)

                                                        DateTime blood removed from

                                                        cold temperature

                                                        storage

                                                        Baseline Observations recorded on SEWS chart

                                                        (Temperature Pulse

                                                        Oxygen sats Respiration rate

                                                        amp BP)

                                                        Completion of Observations

                                                        Noted on the SEWS chart

                                                        (Temperature Pulse

                                                        Oxygen Sats Respiration rate

                                                        50

                                                        Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                        be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                        Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                        be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                        recorded and concerns escalated to the medical team according to the SEWS

                                                        Adverse Events

                                                        bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                        more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                        hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                        Post Transfusion

                                                        bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                        patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                        bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                        Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                        transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                        patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                        Resources

                                                        Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                        THB(MR)020 v 40 May 2013

                                                        Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                        PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                        51

                                                        9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                        This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                        POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                        Why has this policy been developed

                                                        Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                        Has a risk control plan been developed and who is the owner of the risk If not why not

                                                        Who has been involvedconsulted in the development of the policy

                                                        Has the policy been assessed for Equality and Diversity in relation to-

                                                        Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                        RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                        Please indicate YesNo for the following YES

                                                        Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                        Please indicate Ye sNo for the following YES

                                                        Does the policy contain evidence of the Equality amp

                                                        Diversity Impact Assessment Process

                                                        Is there an implementation plan

                                                        Which officers are responsible for implementation

                                                        When will the policy take effect

                                                        Who must comply with the policystrategy

                                                        How will they be informed of their responsibilities

                                                        Is any training required

                                                        If yes has any been arranged

                                                        Are there any cost implications

                                                        NO

                                                        If yes please detail costs and note source of funding

                                                        Who is responsible for auditing the implementation of the policy

                                                        What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                        2

                                                        POLICY MANAGER________________________ DATE______ _____________________

                                                        • Blood supply in an emergency situation
                                                        • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                        • Administration of Platelets
                                                          • Appendix 1 Adult Blood Transfusion Guideline
                                                            • ADULT BLOOD TRANSFUSION GUIDELINE
                                                              • Remember
                                                                • References
                                                                  • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                    • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                      • Consent for Transfusion
                                                                      • THB(MR) 020 V40 May 2013
                                                                        • PRE- COLLECTION
                                                                        • PRE-ADMINISTRATION

                                                          30

                                                          bull It is the responsibility of the person completing the request form to fully complete all details on the request form including the need for any special requirements ie irradiation The requesting medical officer (or suitably trained nurse) must sign and accept the responsibility for completion of the request form

                                                          The person who takes the blood sample must sign the sample container They must also initial the form if they are not the same person as completed the request form

                                                          31

                                                          Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                                          Practitioner

                                                          bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                                          bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                                          32

                                                          Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                          Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                          alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                                          patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                                          Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                                          or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                                          33

                                                          If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                          if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                          the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                          from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                          the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                          34

                                                          bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                          identity band bull Match all other identifying information

                                                          35

                                                          Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                          been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                          had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                          the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                          bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                          Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                          alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                          you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                          bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                          form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                          bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                          is to take place

                                                          36

                                                          If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                          inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                          delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                          37

                                                          Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                          unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                          are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                          storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                          no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                          transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                          available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                          correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                          for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                          38

                                                          bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                          wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                          blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                          band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                          component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                          checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                          bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                          infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                          2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                          infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                          transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                          Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                          commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                          receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                          blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                          bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                          container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                          Blood Safety and Quality Regulations (2005)

                                                          39

                                                          bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                          bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                          a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                          40

                                                          Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                          inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                          bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                          Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                          depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                          substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                          or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                          urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                          41

                                                          bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                          haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                          42

                                                          Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                          bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                          bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                          bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                          43

                                                          Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                          Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                          Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                          regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                          44

                                                          Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                          negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                          45

                                                          Appendix 15A

                                                          46

                                                          Appendix 15B

                                                          47

                                                          Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                          Please use a new document for each transfusion event

                                                          PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                          HospitalUnit Affix label here or write patient details Forename

                                                          Surname

                                                          Gender

                                                          Date of birth

                                                          CHI

                                                          WardDept

                                                          Consultant

                                                          Authorisation Prescription

                                                          bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                          transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                          chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                          Consent for Transfusion

                                                          bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                          Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                          after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                          transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                          document in place Yes No Please delete patientguardian as appropriate

                                                          Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                          I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                          Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                          48

                                                          THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                          Patient Name Date of birthCHI

                                                          UN

                                                          IT 1

                                                          Blood component

                                                          Unit Pool mls

                                                          Special Requirements Instructions (please tick)

                                                          Affix completed pink portion of compatibility label here

                                                          Irradiated CMV negative Blood warmer Other medication

                                                          Reason for transfusion

                                                          Date Duration Authoriser Prescriber signature

                                                          Reassess before you progress (Venflon site and observations)

                                                          UN

                                                          IT 2

                                                          Blood component

                                                          Unit Pool mls

                                                          Special Requirements Instructions (please tick)

                                                          Affix completed pink portion of compatibility label here

                                                          Irradiated CMV negative Blood warmer Other medication

                                                          Reason for transfusion

                                                          Date Duration Authoriser Prescriber signature

                                                          Reassess before you progress (Venflon site and observations)

                                                          UN

                                                          IT 3

                                                          Blood component

                                                          Unit Pool mls

                                                          Special Requirements Instructions (please tick)

                                                          Affix completed pink portion of compatibility label here

                                                          Irradiated CMV negative Blood warmer Other medication

                                                          Reason for transfusion

                                                          Date Duration Authoriser Prescriber signature

                                                          Reassess before you progress (Venflon site and observations)

                                                          UN

                                                          IT 4

                                                          Blood component

                                                          Unit Pool mls

                                                          Special Requirements Instructions (please tick)

                                                          Affix completed pink portion of compatibility label here

                                                          Irradiated CMV negative Blood warmer Other medication

                                                          Reason for transfusion

                                                          Date Duration Authoriser Prescriber signature

                                                          THB(MR) 020 V40 May 2013

                                                          THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                          Patient Na me Date of birthCHI

                                                          Transfusion Checklist - Please initial each box as checks are completed

                                                          PRE-

                                                          COLLECTION

                                                          Checks below should be completed before collection of component from temperature

                                                          controlled storage is undertaken

                                                          PRE-

                                                          ADMINISTRATION

                                                          AT BEDSIDE

                                                          Only remove clear outer wrap

                                                          bag immediately prior to commencing transfusion and

                                                          only when all positive identification checks have been

                                                          completed

                                                          POST

                                                          TRANSFUSION

                                                          Unit No

                                                          1

                                                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                          helliphelliphelliphelliphelliphelliphellip

                                                          2

                                                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                          helliphelliphelliphelliphelliphelliphellip

                                                          3

                                                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                          helliphelliphelliphelliphelliphellip

                                                          4

                                                          helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                          helliphelliphelliphelliphelliphelliphellip

                                                          THB(MR) 020 V40 - May 2013

                                                          Identification band insitu amp details verified and correct

                                                          Patent IV access

                                                          (Patient safety bundle adhered to)

                                                          Blood authorised

                                                          prescribed

                                                          Check for special

                                                          requirements amp consent

                                                          Verbal identification

                                                          at the bedside

                                                          (if applicable)

                                                          Identification band details are verified

                                                          and correct amp match details

                                                          on Traceability ldquobagamp tagrdquo

                                                          label

                                                          DateTime Transfusion completed

                                                          Traceability Tag signed with starting time amp date of transfusion recorded

                                                          Inspect bag

                                                          (condition amp expiry

                                                          date)

                                                          DateTime blood removed from

                                                          cold temperature

                                                          storage

                                                          Baseline Observations recorded on SEWS chart

                                                          (Temperature Pulse

                                                          Oxygen sats Respiration rate

                                                          amp BP)

                                                          Completion of Observations

                                                          Noted on the SEWS chart

                                                          (Temperature Pulse

                                                          Oxygen Sats Respiration rate

                                                          50

                                                          Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                          be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                          Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                          be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                          recorded and concerns escalated to the medical team according to the SEWS

                                                          Adverse Events

                                                          bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                          more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                          hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                          Post Transfusion

                                                          bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                          patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                          bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                          Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                          transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                          patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                          Resources

                                                          Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                          THB(MR)020 v 40 May 2013

                                                          Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                          PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                          51

                                                          9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                          This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                          POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                          Why has this policy been developed

                                                          Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                          Has a risk control plan been developed and who is the owner of the risk If not why not

                                                          Who has been involvedconsulted in the development of the policy

                                                          Has the policy been assessed for Equality and Diversity in relation to-

                                                          Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                          RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                          Please indicate YesNo for the following YES

                                                          Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                          Please indicate Ye sNo for the following YES

                                                          Does the policy contain evidence of the Equality amp

                                                          Diversity Impact Assessment Process

                                                          Is there an implementation plan

                                                          Which officers are responsible for implementation

                                                          When will the policy take effect

                                                          Who must comply with the policystrategy

                                                          How will they be informed of their responsibilities

                                                          Is any training required

                                                          If yes has any been arranged

                                                          Are there any cost implications

                                                          NO

                                                          If yes please detail costs and note source of funding

                                                          Who is responsible for auditing the implementation of the policy

                                                          What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                          2

                                                          POLICY MANAGER________________________ DATE______ _____________________

                                                          • Blood supply in an emergency situation
                                                          • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                          • Administration of Platelets
                                                            • Appendix 1 Adult Blood Transfusion Guideline
                                                              • ADULT BLOOD TRANSFUSION GUIDELINE
                                                                • Remember
                                                                  • References
                                                                    • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                      • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                        • Consent for Transfusion
                                                                        • THB(MR) 020 V40 May 2013
                                                                          • PRE- COLLECTION
                                                                          • PRE-ADMINISTRATION

                                                            31

                                                            Appendix 7 Authorising Prescribing Transfusion S upport bull The authorisation prescription must be signed by a medical practitioner or an authorised Advanced Nurse

                                                            Practitioner

                                                            bull It must specify the blood component to be administered the number of units duration and any special requirements or instructions (BCSH 2009)

                                                            bull Blood and blood components must always be authorised prescribed prior to commencement of treatment

                                                            32

                                                            Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                            Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                            alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                                            patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                                            Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                                            or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                                            33

                                                            If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                            if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                            the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                            from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                            the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                            34

                                                            bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                            identity band bull Match all other identifying information

                                                            35

                                                            Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                            been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                            had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                            the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                            bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                            Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                            alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                            you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                            bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                            form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                            bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                            is to take place

                                                            36

                                                            If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                            inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                            delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                            37

                                                            Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                            unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                            are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                            storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                            no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                            transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                            available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                            correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                            for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                            38

                                                            bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                            wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                            blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                            band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                            component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                            checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                            bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                            infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                            2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                            infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                            transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                            Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                            commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                            receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                            blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                            bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                            container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                            Blood Safety and Quality Regulations (2005)

                                                            39

                                                            bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                            bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                            a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                            40

                                                            Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                            inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                            bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                            Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                            depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                            substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                            or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                            urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                            41

                                                            bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                            haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                            42

                                                            Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                            bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                            bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                            bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                            43

                                                            Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                            Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                            Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                            regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                            44

                                                            Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                            negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                            45

                                                            Appendix 15A

                                                            46

                                                            Appendix 15B

                                                            47

                                                            Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                            Please use a new document for each transfusion event

                                                            PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                            HospitalUnit Affix label here or write patient details Forename

                                                            Surname

                                                            Gender

                                                            Date of birth

                                                            CHI

                                                            WardDept

                                                            Consultant

                                                            Authorisation Prescription

                                                            bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                            transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                            chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                            Consent for Transfusion

                                                            bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                            Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                            after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                            transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                            document in place Yes No Please delete patientguardian as appropriate

                                                            Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                            I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                            Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                            48

                                                            THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                            Patient Name Date of birthCHI

                                                            UN

                                                            IT 1

                                                            Blood component

                                                            Unit Pool mls

                                                            Special Requirements Instructions (please tick)

                                                            Affix completed pink portion of compatibility label here

                                                            Irradiated CMV negative Blood warmer Other medication

                                                            Reason for transfusion

                                                            Date Duration Authoriser Prescriber signature

                                                            Reassess before you progress (Venflon site and observations)

                                                            UN

                                                            IT 2

                                                            Blood component

                                                            Unit Pool mls

                                                            Special Requirements Instructions (please tick)

                                                            Affix completed pink portion of compatibility label here

                                                            Irradiated CMV negative Blood warmer Other medication

                                                            Reason for transfusion

                                                            Date Duration Authoriser Prescriber signature

                                                            Reassess before you progress (Venflon site and observations)

                                                            UN

                                                            IT 3

                                                            Blood component

                                                            Unit Pool mls

                                                            Special Requirements Instructions (please tick)

                                                            Affix completed pink portion of compatibility label here

                                                            Irradiated CMV negative Blood warmer Other medication

                                                            Reason for transfusion

                                                            Date Duration Authoriser Prescriber signature

                                                            Reassess before you progress (Venflon site and observations)

                                                            UN

                                                            IT 4

                                                            Blood component

                                                            Unit Pool mls

                                                            Special Requirements Instructions (please tick)

                                                            Affix completed pink portion of compatibility label here

                                                            Irradiated CMV negative Blood warmer Other medication

                                                            Reason for transfusion

                                                            Date Duration Authoriser Prescriber signature

                                                            THB(MR) 020 V40 May 2013

                                                            THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                            Patient Na me Date of birthCHI

                                                            Transfusion Checklist - Please initial each box as checks are completed

                                                            PRE-

                                                            COLLECTION

                                                            Checks below should be completed before collection of component from temperature

                                                            controlled storage is undertaken

                                                            PRE-

                                                            ADMINISTRATION

                                                            AT BEDSIDE

                                                            Only remove clear outer wrap

                                                            bag immediately prior to commencing transfusion and

                                                            only when all positive identification checks have been

                                                            completed

                                                            POST

                                                            TRANSFUSION

                                                            Unit No

                                                            1

                                                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                            helliphelliphelliphelliphelliphelliphellip

                                                            2

                                                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                            helliphelliphelliphelliphelliphelliphellip

                                                            3

                                                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                            helliphelliphelliphelliphelliphellip

                                                            4

                                                            helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                            helliphelliphelliphelliphelliphelliphellip

                                                            THB(MR) 020 V40 - May 2013

                                                            Identification band insitu amp details verified and correct

                                                            Patent IV access

                                                            (Patient safety bundle adhered to)

                                                            Blood authorised

                                                            prescribed

                                                            Check for special

                                                            requirements amp consent

                                                            Verbal identification

                                                            at the bedside

                                                            (if applicable)

                                                            Identification band details are verified

                                                            and correct amp match details

                                                            on Traceability ldquobagamp tagrdquo

                                                            label

                                                            DateTime Transfusion completed

                                                            Traceability Tag signed with starting time amp date of transfusion recorded

                                                            Inspect bag

                                                            (condition amp expiry

                                                            date)

                                                            DateTime blood removed from

                                                            cold temperature

                                                            storage

                                                            Baseline Observations recorded on SEWS chart

                                                            (Temperature Pulse

                                                            Oxygen sats Respiration rate

                                                            amp BP)

                                                            Completion of Observations

                                                            Noted on the SEWS chart

                                                            (Temperature Pulse

                                                            Oxygen Sats Respiration rate

                                                            50

                                                            Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                            be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                            Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                            be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                            recorded and concerns escalated to the medical team according to the SEWS

                                                            Adverse Events

                                                            bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                            more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                            hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                            Post Transfusion

                                                            bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                            patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                            bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                            Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                            transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                            patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                            Resources

                                                            Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                            THB(MR)020 v 40 May 2013

                                                            Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                            PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                            51

                                                            9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                            This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                            POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                            Why has this policy been developed

                                                            Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                            Has a risk control plan been developed and who is the owner of the risk If not why not

                                                            Who has been involvedconsulted in the development of the policy

                                                            Has the policy been assessed for Equality and Diversity in relation to-

                                                            Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                            RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                            Please indicate YesNo for the following YES

                                                            Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                            Please indicate Ye sNo for the following YES

                                                            Does the policy contain evidence of the Equality amp

                                                            Diversity Impact Assessment Process

                                                            Is there an implementation plan

                                                            Which officers are responsible for implementation

                                                            When will the policy take effect

                                                            Who must comply with the policystrategy

                                                            How will they be informed of their responsibilities

                                                            Is any training required

                                                            If yes has any been arranged

                                                            Are there any cost implications

                                                            NO

                                                            If yes please detail costs and note source of funding

                                                            Who is responsible for auditing the implementation of the policy

                                                            What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                            2

                                                            POLICY MANAGER________________________ DATE______ _____________________

                                                            • Blood supply in an emergency situation
                                                            • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                            • Administration of Platelets
                                                              • Appendix 1 Adult Blood Transfusion Guideline
                                                                • ADULT BLOOD TRANSFUSION GUIDELINE
                                                                  • Remember
                                                                    • References
                                                                      • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                        • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                          • Consent for Transfusion
                                                                          • THB(MR) 020 V40 May 2013
                                                                            • PRE- COLLECTION
                                                                            • PRE-ADMINISTRATION

                                                              32

                                                              Appendix 8 Taking the Blood Sample The person collecting the sample is responsible for positive identification of the patient prior to taking sample bull Full legible labelling of the sample in black ballpoint ink (see also Infant Samples) This is a critical step in the transfusion process bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                              Please can you tell me your full name and date of birthrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                              alternative) and these details in turn must match those on the request form The information must be hand written on the sample tube and must contain a minimum of forename surname date of birth CHI gender and signature o f the person taking the sample Inpatient samples must also include the hospital and wardclinic area bull Collection of the blood sample must be carried out individually for each Patient bull Subsequent labelling of the sample tubes should be performed as one continuous uninterrupted event at the

                                                              patientrsquos (bed) side after drawing the sample and before leaving patient bull Please note that as soon as a blood transfusion sample is taken it must be sent to the Hospital Transfusion

                                                              Laboratory with a request form bull Blood transfusion samples must not be retained in the clinical area for delivery to the laboratory at a later time

                                                              or date bull Request forms must state which hospital ward clinic GP surgery sample was taken and which hospitalclinical area any transfusion is to take place Sample label and request form must bear 1 Full name of patient 2 Date of birth CHI number 3 Gender of patient 4 Time and date of collection 5 Hospital and wardclinic area 6 Both sample and form must be signed and initialled by person taking blood USING ADDRESSOGRAPH LABELS ON TRANSFUSION SAMPLES I S PROHIBITED INADEQUATELY or INCORRECTLY LABELLED SPECIMENS WILL NOT BE ACCEPTED Samples required bull 7 ml EDTA blood (pink top) for adults and large children bull 4 ml EDTA blood (purple top) for small children needing only 1-2 units of blood If patient has been transfused within 3-14 days a sample taken will be valid for 24 hours for provision of cross-matched blood before a new sample is required

                                                              33

                                                              If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                              if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                              the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                              from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                              the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                              34

                                                              bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                              identity band bull Match all other identifying information

                                                              35

                                                              Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                              been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                              had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                              the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                              bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                              Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                              alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                              you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                              bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                              form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                              bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                              is to take place

                                                              36

                                                              If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                              inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                              delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                              37

                                                              Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                              unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                              are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                              storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                              no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                              transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                              available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                              correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                              for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                              38

                                                              bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                              wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                              blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                              band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                              component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                              checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                              bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                              infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                              2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                              infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                              transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                              Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                              commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                              receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                              blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                              bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                              container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                              Blood Safety and Quality Regulations (2005)

                                                              39

                                                              bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                              bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                              a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                              40

                                                              Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                              inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                              bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                              Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                              depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                              substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                              or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                              urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                              41

                                                              bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                              haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                              42

                                                              Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                              bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                              bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                              bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                              43

                                                              Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                              Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                              Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                              regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                              44

                                                              Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                              negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                              45

                                                              Appendix 15A

                                                              46

                                                              Appendix 15B

                                                              47

                                                              Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                              Please use a new document for each transfusion event

                                                              PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                              HospitalUnit Affix label here or write patient details Forename

                                                              Surname

                                                              Gender

                                                              Date of birth

                                                              CHI

                                                              WardDept

                                                              Consultant

                                                              Authorisation Prescription

                                                              bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                              transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                              chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                              Consent for Transfusion

                                                              bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                              Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                              after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                              transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                              document in place Yes No Please delete patientguardian as appropriate

                                                              Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                              I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                              Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                              48

                                                              THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                              Patient Name Date of birthCHI

                                                              UN

                                                              IT 1

                                                              Blood component

                                                              Unit Pool mls

                                                              Special Requirements Instructions (please tick)

                                                              Affix completed pink portion of compatibility label here

                                                              Irradiated CMV negative Blood warmer Other medication

                                                              Reason for transfusion

                                                              Date Duration Authoriser Prescriber signature

                                                              Reassess before you progress (Venflon site and observations)

                                                              UN

                                                              IT 2

                                                              Blood component

                                                              Unit Pool mls

                                                              Special Requirements Instructions (please tick)

                                                              Affix completed pink portion of compatibility label here

                                                              Irradiated CMV negative Blood warmer Other medication

                                                              Reason for transfusion

                                                              Date Duration Authoriser Prescriber signature

                                                              Reassess before you progress (Venflon site and observations)

                                                              UN

                                                              IT 3

                                                              Blood component

                                                              Unit Pool mls

                                                              Special Requirements Instructions (please tick)

                                                              Affix completed pink portion of compatibility label here

                                                              Irradiated CMV negative Blood warmer Other medication

                                                              Reason for transfusion

                                                              Date Duration Authoriser Prescriber signature

                                                              Reassess before you progress (Venflon site and observations)

                                                              UN

                                                              IT 4

                                                              Blood component

                                                              Unit Pool mls

                                                              Special Requirements Instructions (please tick)

                                                              Affix completed pink portion of compatibility label here

                                                              Irradiated CMV negative Blood warmer Other medication

                                                              Reason for transfusion

                                                              Date Duration Authoriser Prescriber signature

                                                              THB(MR) 020 V40 May 2013

                                                              THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                              Patient Na me Date of birthCHI

                                                              Transfusion Checklist - Please initial each box as checks are completed

                                                              PRE-

                                                              COLLECTION

                                                              Checks below should be completed before collection of component from temperature

                                                              controlled storage is undertaken

                                                              PRE-

                                                              ADMINISTRATION

                                                              AT BEDSIDE

                                                              Only remove clear outer wrap

                                                              bag immediately prior to commencing transfusion and

                                                              only when all positive identification checks have been

                                                              completed

                                                              POST

                                                              TRANSFUSION

                                                              Unit No

                                                              1

                                                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                              helliphelliphelliphelliphelliphelliphellip

                                                              2

                                                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                              helliphelliphelliphelliphelliphelliphellip

                                                              3

                                                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                              helliphelliphelliphelliphelliphellip

                                                              4

                                                              helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                              helliphelliphelliphelliphelliphelliphellip

                                                              THB(MR) 020 V40 - May 2013

                                                              Identification band insitu amp details verified and correct

                                                              Patent IV access

                                                              (Patient safety bundle adhered to)

                                                              Blood authorised

                                                              prescribed

                                                              Check for special

                                                              requirements amp consent

                                                              Verbal identification

                                                              at the bedside

                                                              (if applicable)

                                                              Identification band details are verified

                                                              and correct amp match details

                                                              on Traceability ldquobagamp tagrdquo

                                                              label

                                                              DateTime Transfusion completed

                                                              Traceability Tag signed with starting time amp date of transfusion recorded

                                                              Inspect bag

                                                              (condition amp expiry

                                                              date)

                                                              DateTime blood removed from

                                                              cold temperature

                                                              storage

                                                              Baseline Observations recorded on SEWS chart

                                                              (Temperature Pulse

                                                              Oxygen sats Respiration rate

                                                              amp BP)

                                                              Completion of Observations

                                                              Noted on the SEWS chart

                                                              (Temperature Pulse

                                                              Oxygen Sats Respiration rate

                                                              50

                                                              Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                              be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                              Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                              be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                              recorded and concerns escalated to the medical team according to the SEWS

                                                              Adverse Events

                                                              bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                              more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                              hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                              Post Transfusion

                                                              bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                              patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                              bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                              Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                              transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                              patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                              Resources

                                                              Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                              THB(MR)020 v 40 May 2013

                                                              Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                              PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                              51

                                                              9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                              This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                              POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                              Why has this policy been developed

                                                              Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                              Has a risk control plan been developed and who is the owner of the risk If not why not

                                                              Who has been involvedconsulted in the development of the policy

                                                              Has the policy been assessed for Equality and Diversity in relation to-

                                                              Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                              RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                              Please indicate YesNo for the following YES

                                                              Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                              Please indicate Ye sNo for the following YES

                                                              Does the policy contain evidence of the Equality amp

                                                              Diversity Impact Assessment Process

                                                              Is there an implementation plan

                                                              Which officers are responsible for implementation

                                                              When will the policy take effect

                                                              Who must comply with the policystrategy

                                                              How will they be informed of their responsibilities

                                                              Is any training required

                                                              If yes has any been arranged

                                                              Are there any cost implications

                                                              NO

                                                              If yes please detail costs and note source of funding

                                                              Who is responsible for auditing the implementation of the policy

                                                              What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                              2

                                                              POLICY MANAGER________________________ DATE______ _____________________

                                                              • Blood supply in an emergency situation
                                                              • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                              • Administration of Platelets
                                                                • Appendix 1 Adult Blood Transfusion Guideline
                                                                  • ADULT BLOOD TRANSFUSION GUIDELINE
                                                                    • Remember
                                                                      • References
                                                                        • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                          • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                            • Consent for Transfusion
                                                                            • THB(MR) 020 V40 May 2013
                                                                              • PRE- COLLECTION
                                                                              • PRE-ADMINISTRATION

                                                                33

                                                                If patient has been transfused within 15-28 days a sample taken will be valid for 72 hours for provision of cross-matched blood before new sample is required If patient has been transfused more than 29 days before [or never transfused] a sample taken will be valid for 7 days for provision of cross-matched blood before new sample is required Pregnant Women bull A blood sample should be sent to the transfusion laboratory on the day of surgery for a pregnant woman even

                                                                if a sample has been taken within 7 days bull Blood will be released based on the group and save sample received within 7 days but the sample taken on

                                                                the day of delivery will be used to retrospectively check should a transfusion reaction occur This is accordance with BCSH guidance on blood transfusion support for obstetrics (2004) Infant Samples bull For infants less than 4 months a maternal sample of EDTA blood must accompany the first sample taken

                                                                from the infant bull Samples from infants are collected in labelled small plastic vials bull Label must include full name and date of birth bull The sample must be signed and initialled by person taking blood bull Also include name date of birth and CHI number of the mother on babyrsquos request form bull The Blood transfusion Laboratory must be informed in writing if the babyrsquos forename or surname changes Patients carrying Blood Group Antibody Reference Ca rds Please include information given on the Reference Card when requesting group and antibody screen or cross match Unidentified Patients Admitted Via AampE Use TYPENEX (red) identification bands These unique number bands are designed to correlate positive identification of patient sample request form and cross matched blood Instruction (also displayed in AampE) bull Write any identification available (Casualty Number approximate age gender etc) on the red blank part of

                                                                the label near the clip bull Peel off and attach to blood sample tube bull The information is duplicated on the band bull Wrap band once round patientrsquos wrist or ankle close tamperproof clip bull Use encoded label from end of band and AampE number to identify request form bull Attach remainder to request form and send it to blood transfusion laboratory

                                                                34

                                                                bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                                identity band bull Match all other identifying information

                                                                35

                                                                Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                                been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                                had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                                the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                                bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                                Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                                alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                                you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                                bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                                form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                                bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                                is to take place

                                                                36

                                                                If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                                inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                                delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                                37

                                                                Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                                unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                                are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                                storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                                no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                                transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                                available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                                correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                                for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                                38

                                                                bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                                wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                                blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                                band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                                component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                                checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                                bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                                infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                                2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                                infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                                transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                                Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                                commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                                receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                                blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                                bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                                container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                                Blood Safety and Quality Regulations (2005)

                                                                39

                                                                bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                                bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                                a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                                40

                                                                Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                                inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                                bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                                Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                                depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                                substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                                or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                                urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                                41

                                                                bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                                haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                                42

                                                                Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                                bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                                bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                                bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                                43

                                                                Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                                Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                                Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                                regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                                44

                                                                Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                                negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                                45

                                                                Appendix 15A

                                                                46

                                                                Appendix 15B

                                                                47

                                                                Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                                Please use a new document for each transfusion event

                                                                PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                                HospitalUnit Affix label here or write patient details Forename

                                                                Surname

                                                                Gender

                                                                Date of birth

                                                                CHI

                                                                WardDept

                                                                Consultant

                                                                Authorisation Prescription

                                                                bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                                transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                                chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                                Consent for Transfusion

                                                                bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                                Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                                after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                                transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                                document in place Yes No Please delete patientguardian as appropriate

                                                                Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                                I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                                48

                                                                THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                                Patient Name Date of birthCHI

                                                                UN

                                                                IT 1

                                                                Blood component

                                                                Unit Pool mls

                                                                Special Requirements Instructions (please tick)

                                                                Affix completed pink portion of compatibility label here

                                                                Irradiated CMV negative Blood warmer Other medication

                                                                Reason for transfusion

                                                                Date Duration Authoriser Prescriber signature

                                                                Reassess before you progress (Venflon site and observations)

                                                                UN

                                                                IT 2

                                                                Blood component

                                                                Unit Pool mls

                                                                Special Requirements Instructions (please tick)

                                                                Affix completed pink portion of compatibility label here

                                                                Irradiated CMV negative Blood warmer Other medication

                                                                Reason for transfusion

                                                                Date Duration Authoriser Prescriber signature

                                                                Reassess before you progress (Venflon site and observations)

                                                                UN

                                                                IT 3

                                                                Blood component

                                                                Unit Pool mls

                                                                Special Requirements Instructions (please tick)

                                                                Affix completed pink portion of compatibility label here

                                                                Irradiated CMV negative Blood warmer Other medication

                                                                Reason for transfusion

                                                                Date Duration Authoriser Prescriber signature

                                                                Reassess before you progress (Venflon site and observations)

                                                                UN

                                                                IT 4

                                                                Blood component

                                                                Unit Pool mls

                                                                Special Requirements Instructions (please tick)

                                                                Affix completed pink portion of compatibility label here

                                                                Irradiated CMV negative Blood warmer Other medication

                                                                Reason for transfusion

                                                                Date Duration Authoriser Prescriber signature

                                                                THB(MR) 020 V40 May 2013

                                                                THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                                Patient Na me Date of birthCHI

                                                                Transfusion Checklist - Please initial each box as checks are completed

                                                                PRE-

                                                                COLLECTION

                                                                Checks below should be completed before collection of component from temperature

                                                                controlled storage is undertaken

                                                                PRE-

                                                                ADMINISTRATION

                                                                AT BEDSIDE

                                                                Only remove clear outer wrap

                                                                bag immediately prior to commencing transfusion and

                                                                only when all positive identification checks have been

                                                                completed

                                                                POST

                                                                TRANSFUSION

                                                                Unit No

                                                                1

                                                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                helliphelliphelliphelliphelliphelliphellip

                                                                2

                                                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                helliphelliphelliphelliphelliphelliphellip

                                                                3

                                                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                helliphelliphelliphelliphelliphellip

                                                                4

                                                                helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                helliphelliphelliphelliphelliphelliphellip

                                                                THB(MR) 020 V40 - May 2013

                                                                Identification band insitu amp details verified and correct

                                                                Patent IV access

                                                                (Patient safety bundle adhered to)

                                                                Blood authorised

                                                                prescribed

                                                                Check for special

                                                                requirements amp consent

                                                                Verbal identification

                                                                at the bedside

                                                                (if applicable)

                                                                Identification band details are verified

                                                                and correct amp match details

                                                                on Traceability ldquobagamp tagrdquo

                                                                label

                                                                DateTime Transfusion completed

                                                                Traceability Tag signed with starting time amp date of transfusion recorded

                                                                Inspect bag

                                                                (condition amp expiry

                                                                date)

                                                                DateTime blood removed from

                                                                cold temperature

                                                                storage

                                                                Baseline Observations recorded on SEWS chart

                                                                (Temperature Pulse

                                                                Oxygen sats Respiration rate

                                                                amp BP)

                                                                Completion of Observations

                                                                Noted on the SEWS chart

                                                                (Temperature Pulse

                                                                Oxygen Sats Respiration rate

                                                                50

                                                                Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                                be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                                Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                                be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                                recorded and concerns escalated to the medical team according to the SEWS

                                                                Adverse Events

                                                                bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                                more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                                hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                                Post Transfusion

                                                                bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                                patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                                bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                                Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                                transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                                patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                                Resources

                                                                Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                                THB(MR)020 v 40 May 2013

                                                                Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                                PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                                51

                                                                9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                                This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                                POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                                Why has this policy been developed

                                                                Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                                Has a risk control plan been developed and who is the owner of the risk If not why not

                                                                Who has been involvedconsulted in the development of the policy

                                                                Has the policy been assessed for Equality and Diversity in relation to-

                                                                Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                                RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                                Please indicate YesNo for the following YES

                                                                Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                                Please indicate Ye sNo for the following YES

                                                                Does the policy contain evidence of the Equality amp

                                                                Diversity Impact Assessment Process

                                                                Is there an implementation plan

                                                                Which officers are responsible for implementation

                                                                When will the policy take effect

                                                                Who must comply with the policystrategy

                                                                How will they be informed of their responsibilities

                                                                Is any training required

                                                                If yes has any been arranged

                                                                Are there any cost implications

                                                                NO

                                                                If yes please detail costs and note source of funding

                                                                Who is responsible for auditing the implementation of the policy

                                                                What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                                2

                                                                POLICY MANAGER________________________ DATE______ _____________________

                                                                • Blood supply in an emergency situation
                                                                • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                                • Administration of Platelets
                                                                  • Appendix 1 Adult Blood Transfusion Guideline
                                                                    • ADULT BLOOD TRANSFUSION GUIDELINE
                                                                      • Remember
                                                                        • References
                                                                          • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                            • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                              • Consent for Transfusion
                                                                              • THB(MR) 020 V40 May 2013
                                                                                • PRE- COLLECTION
                                                                                • PRE-ADMINISTRATION

                                                                  34

                                                                  bull In the laboratory the labels are used to identify each unit of blood for the Patient bull Before transfusion confirm that the TYPENEX labels on blood pack and report form match code on patientrsquos

                                                                  identity band bull Match all other identifying information

                                                                  35

                                                                  Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                                  been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                                  had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                                  the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                                  bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                                  Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                                  alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                                  you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                                  bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                                  form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                                  bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                                  is to take place

                                                                  36

                                                                  If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                                  inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                                  delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                                  37

                                                                  Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                                  unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                                  are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                                  storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                                  no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                                  transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                                  available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                                  correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                                  for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                                  38

                                                                  bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                                  wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                                  blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                                  band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                                  component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                                  checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                                  bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                                  infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                                  2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                                  infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                                  transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                                  Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                                  commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                                  receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                                  blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                                  bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                                  container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                                  Blood Safety and Quality Regulations (2005)

                                                                  39

                                                                  bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                                  bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                                  a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                                  40

                                                                  Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                                  inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                                  bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                                  Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                                  depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                                  substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                                  or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                                  urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                                  41

                                                                  bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                                  haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                                  42

                                                                  Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                                  bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                                  bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                                  bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                                  43

                                                                  Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                                  Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                                  Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                                  regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                                  44

                                                                  Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                                  negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                                  45

                                                                  Appendix 15A

                                                                  46

                                                                  Appendix 15B

                                                                  47

                                                                  Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                                  Please use a new document for each transfusion event

                                                                  PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                                  HospitalUnit Affix label here or write patient details Forename

                                                                  Surname

                                                                  Gender

                                                                  Date of birth

                                                                  CHI

                                                                  WardDept

                                                                  Consultant

                                                                  Authorisation Prescription

                                                                  bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                                  transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                                  chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                                  Consent for Transfusion

                                                                  bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                                  Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                                  after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                                  transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                                  document in place Yes No Please delete patientguardian as appropriate

                                                                  Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                                  I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                  Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                                  48

                                                                  THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                                  Patient Name Date of birthCHI

                                                                  UN

                                                                  IT 1

                                                                  Blood component

                                                                  Unit Pool mls

                                                                  Special Requirements Instructions (please tick)

                                                                  Affix completed pink portion of compatibility label here

                                                                  Irradiated CMV negative Blood warmer Other medication

                                                                  Reason for transfusion

                                                                  Date Duration Authoriser Prescriber signature

                                                                  Reassess before you progress (Venflon site and observations)

                                                                  UN

                                                                  IT 2

                                                                  Blood component

                                                                  Unit Pool mls

                                                                  Special Requirements Instructions (please tick)

                                                                  Affix completed pink portion of compatibility label here

                                                                  Irradiated CMV negative Blood warmer Other medication

                                                                  Reason for transfusion

                                                                  Date Duration Authoriser Prescriber signature

                                                                  Reassess before you progress (Venflon site and observations)

                                                                  UN

                                                                  IT 3

                                                                  Blood component

                                                                  Unit Pool mls

                                                                  Special Requirements Instructions (please tick)

                                                                  Affix completed pink portion of compatibility label here

                                                                  Irradiated CMV negative Blood warmer Other medication

                                                                  Reason for transfusion

                                                                  Date Duration Authoriser Prescriber signature

                                                                  Reassess before you progress (Venflon site and observations)

                                                                  UN

                                                                  IT 4

                                                                  Blood component

                                                                  Unit Pool mls

                                                                  Special Requirements Instructions (please tick)

                                                                  Affix completed pink portion of compatibility label here

                                                                  Irradiated CMV negative Blood warmer Other medication

                                                                  Reason for transfusion

                                                                  Date Duration Authoriser Prescriber signature

                                                                  THB(MR) 020 V40 May 2013

                                                                  THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                                  Patient Na me Date of birthCHI

                                                                  Transfusion Checklist - Please initial each box as checks are completed

                                                                  PRE-

                                                                  COLLECTION

                                                                  Checks below should be completed before collection of component from temperature

                                                                  controlled storage is undertaken

                                                                  PRE-

                                                                  ADMINISTRATION

                                                                  AT BEDSIDE

                                                                  Only remove clear outer wrap

                                                                  bag immediately prior to commencing transfusion and

                                                                  only when all positive identification checks have been

                                                                  completed

                                                                  POST

                                                                  TRANSFUSION

                                                                  Unit No

                                                                  1

                                                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                  helliphelliphelliphelliphelliphelliphellip

                                                                  2

                                                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                  helliphelliphelliphelliphelliphelliphellip

                                                                  3

                                                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                  helliphelliphelliphelliphelliphellip

                                                                  4

                                                                  helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                  helliphelliphelliphelliphelliphelliphellip

                                                                  THB(MR) 020 V40 - May 2013

                                                                  Identification band insitu amp details verified and correct

                                                                  Patent IV access

                                                                  (Patient safety bundle adhered to)

                                                                  Blood authorised

                                                                  prescribed

                                                                  Check for special

                                                                  requirements amp consent

                                                                  Verbal identification

                                                                  at the bedside

                                                                  (if applicable)

                                                                  Identification band details are verified

                                                                  and correct amp match details

                                                                  on Traceability ldquobagamp tagrdquo

                                                                  label

                                                                  DateTime Transfusion completed

                                                                  Traceability Tag signed with starting time amp date of transfusion recorded

                                                                  Inspect bag

                                                                  (condition amp expiry

                                                                  date)

                                                                  DateTime blood removed from

                                                                  cold temperature

                                                                  storage

                                                                  Baseline Observations recorded on SEWS chart

                                                                  (Temperature Pulse

                                                                  Oxygen sats Respiration rate

                                                                  amp BP)

                                                                  Completion of Observations

                                                                  Noted on the SEWS chart

                                                                  (Temperature Pulse

                                                                  Oxygen Sats Respiration rate

                                                                  50

                                                                  Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                                  be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                                  Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                                  be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                                  recorded and concerns escalated to the medical team according to the SEWS

                                                                  Adverse Events

                                                                  bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                                  more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                                  hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                                  Post Transfusion

                                                                  bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                                  patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                                  bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                                  Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                                  transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                                  patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                                  Resources

                                                                  Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                                  THB(MR)020 v 40 May 2013

                                                                  Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                                  PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                                  51

                                                                  9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                                  This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                                  POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                                  Why has this policy been developed

                                                                  Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                                  Has a risk control plan been developed and who is the owner of the risk If not why not

                                                                  Who has been involvedconsulted in the development of the policy

                                                                  Has the policy been assessed for Equality and Diversity in relation to-

                                                                  Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                                  RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                                  Please indicate YesNo for the following YES

                                                                  Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                                  Please indicate Ye sNo for the following YES

                                                                  Does the policy contain evidence of the Equality amp

                                                                  Diversity Impact Assessment Process

                                                                  Is there an implementation plan

                                                                  Which officers are responsible for implementation

                                                                  When will the policy take effect

                                                                  Who must comply with the policystrategy

                                                                  How will they be informed of their responsibilities

                                                                  Is any training required

                                                                  If yes has any been arranged

                                                                  Are there any cost implications

                                                                  NO

                                                                  If yes please detail costs and note source of funding

                                                                  Who is responsible for auditing the implementation of the policy

                                                                  What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                                  2

                                                                  POLICY MANAGER________________________ DATE______ _____________________

                                                                  • Blood supply in an emergency situation
                                                                  • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                                  • Administration of Platelets
                                                                    • Appendix 1 Adult Blood Transfusion Guideline
                                                                      • ADULT BLOOD TRANSFUSION GUIDELINE
                                                                        • Remember
                                                                          • References
                                                                            • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                              • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                                • Consent for Transfusion
                                                                                • THB(MR) 020 V40 May 2013
                                                                                  • PRE- COLLECTION
                                                                                  • PRE-ADMINISTRATION

                                                                    35

                                                                    Appendix 9 Collection and Delivery of Blood and Bl ood Components Only members of staff who have completed appropriate transfusion training may collect blood and blood components Prior to collection of blood components clinical st aff should ensure bull Transfusion Authorisationprescription chart has been completed bull Patient has viable venous access and an Intravenous Blood giving-set is available bull Baseline observations of Temperature Pulse Blood Pressure Oxygen Saturation and Respirations have

                                                                    been completed and recorded no more than 1 hour pre transfusion bull Review the patientrsquos case notes to check for any special requirements and to confirm that the patient has not

                                                                    had a transfusion reaction in the past Clinical staff are required to complete a blood com ponent collection form for each component bull The person completing the collection form is responsible for positively identifying the patient and ensuring that

                                                                    the patient identification details written on collection form have been confirmed against the patientrsquos identification wristband (or risk assessed alternative)

                                                                    bull Whenever possible patients should be asked to identify themselves verbally with an open question egrdquo

                                                                    Please can you tell me your name and date of birth in fullrdquo bull The details given by the patient must match those written on the patientrsquos wristband (or risk assessed

                                                                    alternative) and these details in turn must match those written on the collection form Details must include bull Patients full name bull Date of birth and CHI bull Ward clinical area bull Component required bull Record of the date and time and signature of practitioner Collection bull Withdraw component from blood bankblood fridge only immediately before it is due to be administered when

                                                                    you have 1 confirmed that reliable venous access has been secured 2 confirmed that transfusion has been authorisedprescribed

                                                                    bull Withdraw only one unit at a time except in a life-threatening emergency bull Ensure fridge door is closed after removal of Red Cell Component prior to completing identification checks bull Patient identification details (forename surname date of birth and CHI) on the Blood Component Collection

                                                                    form must be checked with the patient identification details on blood pack compatibility tag( visible through the clear outer wrap bag) and the details on fridge register sheet allocated for patient

                                                                    bull Clear plastic outer wrap bag should remain intact until final bedside checks are complete and administration

                                                                    is to take place

                                                                    36

                                                                    If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                                    inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                                    delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                                    37

                                                                    Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                                    unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                                    are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                                    storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                                    no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                                    transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                                    available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                                    correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                                    for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                                    38

                                                                    bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                                    wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                                    blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                                    band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                                    component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                                    checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                                    bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                                    infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                                    2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                                    infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                                    transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                                    Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                                    commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                                    receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                                    blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                                    bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                                    container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                                    Blood Safety and Quality Regulations (2005)

                                                                    39

                                                                    bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                                    bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                                    a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                                    40

                                                                    Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                                    inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                                    bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                                    Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                                    depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                                    substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                                    or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                                    urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                                    41

                                                                    bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                                    haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                                    42

                                                                    Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                                    bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                                    bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                                    bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                                    43

                                                                    Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                                    Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                                    Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                                    regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                                    44

                                                                    Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                                    negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                                    45

                                                                    Appendix 15A

                                                                    46

                                                                    Appendix 15B

                                                                    47

                                                                    Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                                    Please use a new document for each transfusion event

                                                                    PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                                    HospitalUnit Affix label here or write patient details Forename

                                                                    Surname

                                                                    Gender

                                                                    Date of birth

                                                                    CHI

                                                                    WardDept

                                                                    Consultant

                                                                    Authorisation Prescription

                                                                    bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                                    transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                                    chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                                    Consent for Transfusion

                                                                    bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                                    Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                                    after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                                    transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                                    document in place Yes No Please delete patientguardian as appropriate

                                                                    Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                                    I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                    Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                                    48

                                                                    THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                                    Patient Name Date of birthCHI

                                                                    UN

                                                                    IT 1

                                                                    Blood component

                                                                    Unit Pool mls

                                                                    Special Requirements Instructions (please tick)

                                                                    Affix completed pink portion of compatibility label here

                                                                    Irradiated CMV negative Blood warmer Other medication

                                                                    Reason for transfusion

                                                                    Date Duration Authoriser Prescriber signature

                                                                    Reassess before you progress (Venflon site and observations)

                                                                    UN

                                                                    IT 2

                                                                    Blood component

                                                                    Unit Pool mls

                                                                    Special Requirements Instructions (please tick)

                                                                    Affix completed pink portion of compatibility label here

                                                                    Irradiated CMV negative Blood warmer Other medication

                                                                    Reason for transfusion

                                                                    Date Duration Authoriser Prescriber signature

                                                                    Reassess before you progress (Venflon site and observations)

                                                                    UN

                                                                    IT 3

                                                                    Blood component

                                                                    Unit Pool mls

                                                                    Special Requirements Instructions (please tick)

                                                                    Affix completed pink portion of compatibility label here

                                                                    Irradiated CMV negative Blood warmer Other medication

                                                                    Reason for transfusion

                                                                    Date Duration Authoriser Prescriber signature

                                                                    Reassess before you progress (Venflon site and observations)

                                                                    UN

                                                                    IT 4

                                                                    Blood component

                                                                    Unit Pool mls

                                                                    Special Requirements Instructions (please tick)

                                                                    Affix completed pink portion of compatibility label here

                                                                    Irradiated CMV negative Blood warmer Other medication

                                                                    Reason for transfusion

                                                                    Date Duration Authoriser Prescriber signature

                                                                    THB(MR) 020 V40 May 2013

                                                                    THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                                    Patient Na me Date of birthCHI

                                                                    Transfusion Checklist - Please initial each box as checks are completed

                                                                    PRE-

                                                                    COLLECTION

                                                                    Checks below should be completed before collection of component from temperature

                                                                    controlled storage is undertaken

                                                                    PRE-

                                                                    ADMINISTRATION

                                                                    AT BEDSIDE

                                                                    Only remove clear outer wrap

                                                                    bag immediately prior to commencing transfusion and

                                                                    only when all positive identification checks have been

                                                                    completed

                                                                    POST

                                                                    TRANSFUSION

                                                                    Unit No

                                                                    1

                                                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                    helliphelliphelliphelliphelliphelliphellip

                                                                    2

                                                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                    helliphelliphelliphelliphelliphelliphellip

                                                                    3

                                                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                    helliphelliphelliphelliphelliphellip

                                                                    4

                                                                    helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                    helliphelliphelliphelliphelliphelliphellip

                                                                    THB(MR) 020 V40 - May 2013

                                                                    Identification band insitu amp details verified and correct

                                                                    Patent IV access

                                                                    (Patient safety bundle adhered to)

                                                                    Blood authorised

                                                                    prescribed

                                                                    Check for special

                                                                    requirements amp consent

                                                                    Verbal identification

                                                                    at the bedside

                                                                    (if applicable)

                                                                    Identification band details are verified

                                                                    and correct amp match details

                                                                    on Traceability ldquobagamp tagrdquo

                                                                    label

                                                                    DateTime Transfusion completed

                                                                    Traceability Tag signed with starting time amp date of transfusion recorded

                                                                    Inspect bag

                                                                    (condition amp expiry

                                                                    date)

                                                                    DateTime blood removed from

                                                                    cold temperature

                                                                    storage

                                                                    Baseline Observations recorded on SEWS chart

                                                                    (Temperature Pulse

                                                                    Oxygen sats Respiration rate

                                                                    amp BP)

                                                                    Completion of Observations

                                                                    Noted on the SEWS chart

                                                                    (Temperature Pulse

                                                                    Oxygen Sats Respiration rate

                                                                    50

                                                                    Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                                    be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                                    Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                                    be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                                    recorded and concerns escalated to the medical team according to the SEWS

                                                                    Adverse Events

                                                                    bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                                    more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                                    hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                                    Post Transfusion

                                                                    bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                                    patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                                    bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                                    Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                                    transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                                    patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                                    Resources

                                                                    Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                                    THB(MR)020 v 40 May 2013

                                                                    Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                                    PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                                    51

                                                                    9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                                    This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                                    POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                                    Why has this policy been developed

                                                                    Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                                    Has a risk control plan been developed and who is the owner of the risk If not why not

                                                                    Who has been involvedconsulted in the development of the policy

                                                                    Has the policy been assessed for Equality and Diversity in relation to-

                                                                    Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                                    RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                                    Please indicate YesNo for the following YES

                                                                    Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                                    Please indicate Ye sNo for the following YES

                                                                    Does the policy contain evidence of the Equality amp

                                                                    Diversity Impact Assessment Process

                                                                    Is there an implementation plan

                                                                    Which officers are responsible for implementation

                                                                    When will the policy take effect

                                                                    Who must comply with the policystrategy

                                                                    How will they be informed of their responsibilities

                                                                    Is any training required

                                                                    If yes has any been arranged

                                                                    Are there any cost implications

                                                                    NO

                                                                    If yes please detail costs and note source of funding

                                                                    Who is responsible for auditing the implementation of the policy

                                                                    What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                                    2

                                                                    POLICY MANAGER________________________ DATE______ _____________________

                                                                    • Blood supply in an emergency situation
                                                                    • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                                    • Administration of Platelets
                                                                      • Appendix 1 Adult Blood Transfusion Guideline
                                                                        • ADULT BLOOD TRANSFUSION GUIDELINE
                                                                          • Remember
                                                                            • References
                                                                              • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                                • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                                  • Consent for Transfusion
                                                                                  • THB(MR) 020 V40 May 2013
                                                                                    • PRE- COLLECTION
                                                                                    • PRE-ADMINISTRATION

                                                                      36

                                                                      If there is any discrepancy noted inform the Trans fusion Laboratory immediately and reconfirm patient rsquos details before proceeding any further bull Undertake visual inspection of blood component and check for leaks or discolouration bull Check expiry date bull The member of staff who collects the component must complete appropriate fridge register documentation

                                                                      inventory for the named patient and record against the unique donation number for component removed 1 The date and time of removal from the fridge 2 Sign their initials signature 3 The date and time of returning the unit(s) to the refrigerator if not Transfused Once they have left the Hospital Transfusion Laboratory or Satellite Fridge blood components must not be left unattended and must be received by a member of staff in the clinical area bull On receipt in clinical area the component should be checked to ensure that the correct blood has been

                                                                      delivered bull The component should then be immediately taken to the patientrsquos bedside and administered appropriately If emergency blood is withdrawn from any of the blo od fridges the Hospital Transfusion Laboratory must be informed immediately in order to supply further transfusion support and to replace the emergency blood

                                                                      37

                                                                      Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                                      unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                                      are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                                      storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                                      no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                                      transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                                      available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                                      correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                                      for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                                      38

                                                                      bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                                      wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                                      blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                                      band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                                      component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                                      checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                                      bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                                      infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                                      2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                                      infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                                      transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                                      Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                                      commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                                      receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                                      blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                                      bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                                      container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                                      Blood Safety and Quality Regulations (2005)

                                                                      39

                                                                      bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                                      bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                                      a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                                      40

                                                                      Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                                      inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                                      bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                                      Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                                      depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                                      substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                                      or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                                      urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                                      41

                                                                      bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                                      haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                                      42

                                                                      Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                                      bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                                      bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                                      bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                                      43

                                                                      Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                                      Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                                      Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                                      regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                                      44

                                                                      Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                                      negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                                      45

                                                                      Appendix 15A

                                                                      46

                                                                      Appendix 15B

                                                                      47

                                                                      Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                                      Please use a new document for each transfusion event

                                                                      PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                                      HospitalUnit Affix label here or write patient details Forename

                                                                      Surname

                                                                      Gender

                                                                      Date of birth

                                                                      CHI

                                                                      WardDept

                                                                      Consultant

                                                                      Authorisation Prescription

                                                                      bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                                      transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                                      chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                                      Consent for Transfusion

                                                                      bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                                      Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                                      after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                                      transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                                      document in place Yes No Please delete patientguardian as appropriate

                                                                      Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                                      I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                      Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                                      48

                                                                      THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                                      Patient Name Date of birthCHI

                                                                      UN

                                                                      IT 1

                                                                      Blood component

                                                                      Unit Pool mls

                                                                      Special Requirements Instructions (please tick)

                                                                      Affix completed pink portion of compatibility label here

                                                                      Irradiated CMV negative Blood warmer Other medication

                                                                      Reason for transfusion

                                                                      Date Duration Authoriser Prescriber signature

                                                                      Reassess before you progress (Venflon site and observations)

                                                                      UN

                                                                      IT 2

                                                                      Blood component

                                                                      Unit Pool mls

                                                                      Special Requirements Instructions (please tick)

                                                                      Affix completed pink portion of compatibility label here

                                                                      Irradiated CMV negative Blood warmer Other medication

                                                                      Reason for transfusion

                                                                      Date Duration Authoriser Prescriber signature

                                                                      Reassess before you progress (Venflon site and observations)

                                                                      UN

                                                                      IT 3

                                                                      Blood component

                                                                      Unit Pool mls

                                                                      Special Requirements Instructions (please tick)

                                                                      Affix completed pink portion of compatibility label here

                                                                      Irradiated CMV negative Blood warmer Other medication

                                                                      Reason for transfusion

                                                                      Date Duration Authoriser Prescriber signature

                                                                      Reassess before you progress (Venflon site and observations)

                                                                      UN

                                                                      IT 4

                                                                      Blood component

                                                                      Unit Pool mls

                                                                      Special Requirements Instructions (please tick)

                                                                      Affix completed pink portion of compatibility label here

                                                                      Irradiated CMV negative Blood warmer Other medication

                                                                      Reason for transfusion

                                                                      Date Duration Authoriser Prescriber signature

                                                                      THB(MR) 020 V40 May 2013

                                                                      THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                                      Patient Na me Date of birthCHI

                                                                      Transfusion Checklist - Please initial each box as checks are completed

                                                                      PRE-

                                                                      COLLECTION

                                                                      Checks below should be completed before collection of component from temperature

                                                                      controlled storage is undertaken

                                                                      PRE-

                                                                      ADMINISTRATION

                                                                      AT BEDSIDE

                                                                      Only remove clear outer wrap

                                                                      bag immediately prior to commencing transfusion and

                                                                      only when all positive identification checks have been

                                                                      completed

                                                                      POST

                                                                      TRANSFUSION

                                                                      Unit No

                                                                      1

                                                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                      helliphelliphelliphelliphelliphelliphellip

                                                                      2

                                                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                      helliphelliphelliphelliphelliphelliphellip

                                                                      3

                                                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                      helliphelliphelliphelliphelliphellip

                                                                      4

                                                                      helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                      helliphelliphelliphelliphelliphelliphellip

                                                                      THB(MR) 020 V40 - May 2013

                                                                      Identification band insitu amp details verified and correct

                                                                      Patent IV access

                                                                      (Patient safety bundle adhered to)

                                                                      Blood authorised

                                                                      prescribed

                                                                      Check for special

                                                                      requirements amp consent

                                                                      Verbal identification

                                                                      at the bedside

                                                                      (if applicable)

                                                                      Identification band details are verified

                                                                      and correct amp match details

                                                                      on Traceability ldquobagamp tagrdquo

                                                                      label

                                                                      DateTime Transfusion completed

                                                                      Traceability Tag signed with starting time amp date of transfusion recorded

                                                                      Inspect bag

                                                                      (condition amp expiry

                                                                      date)

                                                                      DateTime blood removed from

                                                                      cold temperature

                                                                      storage

                                                                      Baseline Observations recorded on SEWS chart

                                                                      (Temperature Pulse

                                                                      Oxygen sats Respiration rate

                                                                      amp BP)

                                                                      Completion of Observations

                                                                      Noted on the SEWS chart

                                                                      (Temperature Pulse

                                                                      Oxygen Sats Respiration rate

                                                                      50

                                                                      Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                                      be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                                      Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                                      be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                                      recorded and concerns escalated to the medical team according to the SEWS

                                                                      Adverse Events

                                                                      bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                                      more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                                      hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                                      Post Transfusion

                                                                      bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                                      patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                                      bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                                      Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                                      transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                                      patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                                      Resources

                                                                      Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                                      THB(MR)020 v 40 May 2013

                                                                      Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                                      PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                                      51

                                                                      9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                                      This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                                      POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                                      Why has this policy been developed

                                                                      Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                                      Has a risk control plan been developed and who is the owner of the risk If not why not

                                                                      Who has been involvedconsulted in the development of the policy

                                                                      Has the policy been assessed for Equality and Diversity in relation to-

                                                                      Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                                      RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                                      Please indicate YesNo for the following YES

                                                                      Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                                      Please indicate Ye sNo for the following YES

                                                                      Does the policy contain evidence of the Equality amp

                                                                      Diversity Impact Assessment Process

                                                                      Is there an implementation plan

                                                                      Which officers are responsible for implementation

                                                                      When will the policy take effect

                                                                      Who must comply with the policystrategy

                                                                      How will they be informed of their responsibilities

                                                                      Is any training required

                                                                      If yes has any been arranged

                                                                      Are there any cost implications

                                                                      NO

                                                                      If yes please detail costs and note source of funding

                                                                      Who is responsible for auditing the implementation of the policy

                                                                      What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                                      2

                                                                      POLICY MANAGER________________________ DATE______ _____________________

                                                                      • Blood supply in an emergency situation
                                                                      • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                                      • Administration of Platelets
                                                                        • Appendix 1 Adult Blood Transfusion Guideline
                                                                          • ADULT BLOOD TRANSFUSION GUIDELINE
                                                                            • Remember
                                                                              • References
                                                                                • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                                  • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                                    • Consent for Transfusion
                                                                                    • THB(MR) 020 V40 May 2013
                                                                                      • PRE- COLLECTION
                                                                                      • PRE-ADMINISTRATION

                                                                        37

                                                                        Appendix 10 Administration of Red Cells As a minimum all staff involved in the administration process must have completed Level 1 Safe Transfusion Practice or equivalent (QIS 2006) bull The minimum acceptable details required to transfuse are surname forename date of birth gender

                                                                        unique identifier ie CHI bull The typenex system should always be used for patients for whom no forename surname and date of birth

                                                                        are available bull Any information supplied on the blood component or compatibility tag must match the patients ID wristband bull Any discrepancies should be queried with the Hospital Transfusion Laboratory bull Do not transfuse overnight unless clinically indica ted for a life threatening situation bull Transfusion must be complete within 4 hours of removing blood component from temperature controlled

                                                                        storage If blood component is out of temperature controlled storage for bull Less than 30 minutes the intact unit pack may be returned to transfusion laboratory or satellite blood fridge if

                                                                        no longer required record date and time of return on fridge register and inform transfusion laboratory bull More than 30 minutes it can still be transfused if transfusion is completed within 4 hours of initial removal time bull Where blood has been out of fridge for more than 30 mins and cannot will not be transfused please inform

                                                                        transfusion laboratory and follow advice given BLOOD MUST NOT BE STORED IN WARD REFRIDGERATORS bull Two registered practitioners are required to perform the administration Checks bull All checks should take place at the patientrsquos side with no interruption bull If staff are interrupted they must start the checking procedure again Pre-Administration bull Confirm blood component has been prescribedauthorised bull Check patient has patent IV access and an IV blood giving set with an integral aggregate micron filter is

                                                                        available bull Confirm baseline set of observations has been completed and recorded bull Ensure patient can be easily observed and has access to a call bell should they begin to feel unwell bull Do not remove the blood component from the outer plastic bag until you have confirmed the component is the

                                                                        correct one for the patient and you are ready to administer the component bull While the component is still in the sealed outer bag carry out a visual examination of the blood pack to check

                                                                        for signs of discoloration clotting and haemolysis Test integrity of pack for leaks by squeezing gently but firmly

                                                                        38

                                                                        bull Check expiry date on pack If any discrepancies are found the unit must not b e transfused The Hospital Transfusion Laboratory and relevant me dical staff must be informed immediately Administration bull Ask the patient (or parent guardian) to state his her full name and date of birth Ensure that the patient is

                                                                        wearing an identity band and that the details correspond Reliance must not be placed on familiarity bull Failure to perform the final bedside check of patient identification details is the commonest cause of incorrect

                                                                        blood component transfused related incidents bull A silent two person individual checking process is required at this point by the two registered practitioners bull Check patient details on component unit traceability compatibility label against the patientrsquos identification

                                                                        band ndash full name date of birth CHIunique number gender bull Check traceability compatibility tag details against blood bag label to confirm positive match of donor

                                                                        component number blood group and Rh D group bull Both practitioners must sign pink adhesive section of traceability compatibility tag to confirm they have

                                                                        checked blood component against patientrsquos identification band including date and time (this should then be attached to the transfusion record sheet or transfusion pathway document in patient notes)

                                                                        bull Commence transfusion bull Blood components must be transfused using a giving set with an integral micron aggregate filter Where

                                                                        infusion devices are to be used special giving sets for transfusion must be used bull Blood transfusion giving sets must be changed every 12 hours in order to prevent bacterial growth (BCSH

                                                                        2009) bull Only Sodium Chloride 09 may be used to prime the giving set No other infusion fluids or drugs should be

                                                                        infused through the same venflon whilst a transfusion is in progress bull The duration of the transfusion is entirely dependent on the clinical situation although each red cell

                                                                        transfusion has to be completed within 4 hours of blood leaving the fridge (taking into consideration the time already elapsed to collectdeliver and complete final identification administration checks)

                                                                        Blue tear off tags Transfusion Traceability bull The tear off traceability labels should not be detached from the bag nor completed until transfusion has

                                                                        commenced bull Once transfusion has commenced the blue tear off tag must be fully completed as so on as the patient

                                                                        receives even a small amount of the blood or blood component bull One of the two registered practitioners undertaking the administration checks must fully complete the

                                                                        blue tear-off traceability tag( details required include printing amp signing their full name with date amp start time of transfusion )

                                                                        bull Fully completed traceability tags should be returned to the Hospital Transfusion Laboratory using the

                                                                        container provided or locally agreed method for outlying hospitals bull The return of the blue tear-off tag to the transfusion laboratory is a legal requirement outlined in the UK

                                                                        Blood Safety and Quality Regulations (2005)

                                                                        39

                                                                        bull If three days after the blood has been issued the laboratory has not received the blue tear-off tag a Letter A will be issued to the Senior Charge Nurse on the ward requesting return of the completed blue tag or confirmation that component transfusion has taken place (photocopy of the completed pink adhesive label is permissible)

                                                                        bull If after 7 days following issue of letter A the blue tag or a photocopy of the pink label has not been received

                                                                        a letter B will be issued bull If after another 7 days no reply has been received an NHS Tayside incident report will be generated

                                                                        40

                                                                        Appendix 11 Administration of Other Blood Componen tsFFP Cryoprecipitate Platelets Prothrombin Complex Concentrate( PCC) and Anti-D These are ordered for individual patients Return any unused components to BTS without delay Fresh Frozen Plasma (FFP) bull Request FFP using a BTS Request form bull For un-grouped patients send 7 ml of EDTA blood for grouping with the request form bull FFP is stored frozen and needs to be defrosted before it is released from the laboratory This leads to an

                                                                        inevitable delay from request to delivery of FFP bull It is realistic to expect at least an hour to pass between requesting and receiving FFP bull It supplied ready thawed and should be used immediately bull The infusion rate for FFP is entirely dependent on the clinical circumstances However each unit should be completed in a maximum of 4 hours from the time that the FFP leaves the blood transfusion laboratory

                                                                        bull FFP should not be infused through a giving set that has been used for bloodother blood components or any other substance

                                                                        Administration of Cryoprecipitate bull This is as for red cells except that cryoprecipitate is usually administered over 30ndash60 minutes or less

                                                                        depending on clinical circumstances bull Cryoprecipitate should not be infused through a giving set that has been used for blood or any other

                                                                        substance Administration of Platelets bull Platelets are used to treat patients who are bleeding or who are at risk of bleeding due to a low platelet count

                                                                        or platelets that do not function properly bull Platelets are stored in the laboratory at room temperature bull Once platelets have been prepared and received on the ward they should be infused immediately bull They must not be refrigerated bull Platelets are usually given over 15-30 minutes using a standard gravity feed blood giving set bull Platelets should not be infused through a giving set that has been used for blood or any other substance Since platelets may not be immediately available f orward planning of treatment is essential bull Contact haematology on call medical staff stating name of patient diagnosis platelet count degree of

                                                                        urgency and likely duration of treatment bull Send request on BTS request form together with a grouping sample if patientrsquos group is not yet known

                                                                        41

                                                                        bull Maintenance treatment should be planned ahead in consultation with haematology medical staff bull Use a standard gravity feed blood giving set for infusion pre-primed with 09 sodium chloride solution Coagulation Factors bull Prothrombin complex concentrate for warfarin reversal ndash only issued after discussion with on call

                                                                        haematology medical staff bull Dose required is dependent on INR patientrsquos weight product used and clinical circumstances Specific immunoglobulins (Anti-D) This can be requested after discussion with haematology lab staff Hyperimmune immunoglobulins are obtained through pharmacy

                                                                        42

                                                                        Appendix 12 Blood Components Available from ESBTC Transfusion Laboratory bull Platelets bull Fresh Frozen Plasma bull Fresh Frozen Plasma Methylene Blue Treated and Removed bull Cryoprecipitate (Pooled Frozen) bull Cryoprecipitate Methylene Blue Treated and Removed For all blood component requests please complete a Blue Blood Transfusion Request Form

                                                                        bull To request FFP and platelets contact Compatibility Laboratory on Ex 32953

                                                                        bull In certain cases requests for FFP and platelets may be referred to the BTS Duty Medical Officer

                                                                        bull All requests for cryoprecipitate must be discussed with BTS Duty Medical Officer Unless otherwise specified all components are leucodepleted and conform to the UKBTSNIBSC Guidelines for the Blood Transfusion Service and any nationally agreed revisions Special Requirements For patients with special requirements (eg CMV negative or irradiated) these must be stated on the request form for each request for blood components Blood Product Requests ESBTC provides the following blood products bull bull Anti D Immunoglobulin bull Factor VIII Concentrates bull Factor IX Concentrates bull Octaplex bull Berinet P (C1-esterase inhibitor) bull NovoSeven (factor Vila) bull Octoplas (solvent detergent treated human plasma) All the products listed are licensed by the MHRA For all blood product requests please complete a Blood Transfusion Request Form To request human immunoglobulin for intravenous use human normal immunoglobulin or specific immunoglobulin contact Compatibility Laboratory on Ext 32953 Requests for Factor VIII and Factor IX concentrates should be discussed with the Regional Haemophilia Centre

                                                                        43

                                                                        Appendix 13 Monitoring For each blood component transfused bull Record pre-transfusion observations no more than 60 minutes before start of transfusion -

                                                                        Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Record observations at 15 minutes and again at 30 minutes after transfusion has commenced Temperature Pulse Blood Pressure Respiration rate and Oxygen Saturation rate bull Thereafter record Temperature Blood Pressure and Pulse hourly until completion of component unit (If recordings have changed from baseline values also record respiration rate) bull If patient shows signs or symptoms of a transfusion reaction STOP transfusion (see Appendix 3a and 3b on Adverse Reaction to Transfusion ) bull Record post-transfusion observations within 60 minutes of completion of transfusion -Temperature Pulse

                                                                        Blood Pressure Respiration rate and Oxygen Saturation rate bull Record post-transfusion full blood count and clinical outcome in patient records bull Further measurement and recording of vital signs may be undertaken at the discretion of clinical staff and with

                                                                        regard to the patients clinical status bull Urine output should also be monitored at regular intervals throughout the Transfusion

                                                                        44

                                                                        Appendix 14 PaediatricNeonatal Considerations Blood for Infants bull Red cell paediatric unitsrsquo dosing is based on patientrsquos weight ndash seek paediatric advice bull Paediatric blood is supplied in packs which usually contain a quarter of the volume of an adult pack bull Paediatric giving sets should be used for transfusion in infants microbore tubing is used in the neonatal unit bull Micro-aggregate filters should be used in neonates bull Volume of blood to be given is usually dependent on the childrsquos weight (BJH 2004) bull Certain conditions may also apply with regard to indications for irradiated blood components or CMV antibody

                                                                        negative blood components Further guidance and information may be sought from the Hospital Transfusion Laboratory bull Transfusion guidelines for neonates and older children (2004) and amendments (2005 and 2007) httponlinelibrarywileycomdoi101111j1365-2141200404815xfull wwwbcshguidelinescompdfamendments_neonates_091205pdf httpwwwbcshguidelinescomdocumentsFFP_neonate_Amendment_1_17_Oct_2007pdf

                                                                        45

                                                                        Appendix 15A

                                                                        46

                                                                        Appendix 15B

                                                                        47

                                                                        Appendix 16 NHS Tayside Documentation for Transfusion of Blood Components This is a formal record of transfusion and must be filed in the appropriate case records

                                                                        Please use a new document for each transfusion event

                                                                        PATIENT DETAILS - CHECK AGAINST PATIEN TrsquoS IDENTIFICATION B AND

                                                                        HospitalUnit Affix label here or write patient details Forename

                                                                        Surname

                                                                        Gender

                                                                        Date of birth

                                                                        CHI

                                                                        WardDept

                                                                        Consultant

                                                                        Authorisation Prescription

                                                                        bull This section should be completed by the person Authorising prescribing the transfusion bull It is the responsibility of the authoriser prescriber of the blood components(s) to ensure that any special

                                                                        transfusion requirements are met (eg irradiatedCMV negative units use of blood warmer) bull Medications related to transfusion (eg diuretics antipyretics) must be prescribed on a Drug Prescription

                                                                        chart Before authorising prescribing blood or blood components check patients previous transfusion history for bull Blood group amp Presence of antibodies bull Any previous transfusions reactions

                                                                        Consent for Transfusion

                                                                        bull Intended procedure explained No Yes bull Reasons for transfusion explained to patient guardian No Yes bull Transfusion alternatives discussed Cell Salvage Iron supplementation No Yes NA bull Was the patient guardian offered a Transfusion

                                                                        Patient Information Leaflet (PIL) Yes No bull Was the patient offered an opportunity to ask questions

                                                                        after reading the PIL Yes No bull Does this patient guardian agree to have a blood

                                                                        transfusion No Yes bull Is an advanced directive (refusal of transfusion)

                                                                        document in place Yes No Please delete patientguardian as appropriate

                                                                        Risks Hepatitis (11000000) HIV (15000000) Variant CJD (very small) Bacterial Contamination ( 12000) Serious incident related to blood transfusion (wrong blood transfusion reaction acute lung injury circulatory overload Inappropriate or unnecessary transfusion) (12270) Emergency Transfusion-Discussion is not possible

                                                                        I confirm that I have current valid training in safe blood tr ansfusion and have obtained consent Name amp Designation helliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip helliphellip hellip Signaturehelliphelliphelliphelliphelliphelliphelliphelliphellip Datehelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                        Patient Information Leaflets rdquoReceiving a Transfusion - Information for Patients and Relativesrdquo are available free of charge from Scottish National Transfusion Service (SNBTS) Public Affairs Department on tel 0141 357 7752 THB (MR) 020 V40

                                                                        48

                                                                        THIS SECTION SHOULD BE COMPLETED BY THE PERSON AUTH ORISING PRESCRIBING THE TRANSFUSION

                                                                        Patient Name Date of birthCHI

                                                                        UN

                                                                        IT 1

                                                                        Blood component

                                                                        Unit Pool mls

                                                                        Special Requirements Instructions (please tick)

                                                                        Affix completed pink portion of compatibility label here

                                                                        Irradiated CMV negative Blood warmer Other medication

                                                                        Reason for transfusion

                                                                        Date Duration Authoriser Prescriber signature

                                                                        Reassess before you progress (Venflon site and observations)

                                                                        UN

                                                                        IT 2

                                                                        Blood component

                                                                        Unit Pool mls

                                                                        Special Requirements Instructions (please tick)

                                                                        Affix completed pink portion of compatibility label here

                                                                        Irradiated CMV negative Blood warmer Other medication

                                                                        Reason for transfusion

                                                                        Date Duration Authoriser Prescriber signature

                                                                        Reassess before you progress (Venflon site and observations)

                                                                        UN

                                                                        IT 3

                                                                        Blood component

                                                                        Unit Pool mls

                                                                        Special Requirements Instructions (please tick)

                                                                        Affix completed pink portion of compatibility label here

                                                                        Irradiated CMV negative Blood warmer Other medication

                                                                        Reason for transfusion

                                                                        Date Duration Authoriser Prescriber signature

                                                                        Reassess before you progress (Venflon site and observations)

                                                                        UN

                                                                        IT 4

                                                                        Blood component

                                                                        Unit Pool mls

                                                                        Special Requirements Instructions (please tick)

                                                                        Affix completed pink portion of compatibility label here

                                                                        Irradiated CMV negative Blood warmer Other medication

                                                                        Reason for transfusion

                                                                        Date Duration Authoriser Prescriber signature

                                                                        THB(MR) 020 V40 May 2013

                                                                        THIS SECTION SHOULD BE COMPLETED BY THE PERSON ADMI NISTERING THE TRANSFUSION

                                                                        Patient Na me Date of birthCHI

                                                                        Transfusion Checklist - Please initial each box as checks are completed

                                                                        PRE-

                                                                        COLLECTION

                                                                        Checks below should be completed before collection of component from temperature

                                                                        controlled storage is undertaken

                                                                        PRE-

                                                                        ADMINISTRATION

                                                                        AT BEDSIDE

                                                                        Only remove clear outer wrap

                                                                        bag immediately prior to commencing transfusion and

                                                                        only when all positive identification checks have been

                                                                        completed

                                                                        POST

                                                                        TRANSFUSION

                                                                        Unit No

                                                                        1

                                                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                        helliphelliphelliphelliphelliphelliphellip

                                                                        2

                                                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                        helliphelliphelliphelliphelliphelliphellip

                                                                        3

                                                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                        helliphelliphelliphelliphelliphellip

                                                                        4

                                                                        helliphelliphelliphelliphelliphelliphelliphelliphellip

                                                                        helliphelliphelliphelliphelliphelliphellip

                                                                        THB(MR) 020 V40 - May 2013

                                                                        Identification band insitu amp details verified and correct

                                                                        Patent IV access

                                                                        (Patient safety bundle adhered to)

                                                                        Blood authorised

                                                                        prescribed

                                                                        Check for special

                                                                        requirements amp consent

                                                                        Verbal identification

                                                                        at the bedside

                                                                        (if applicable)

                                                                        Identification band details are verified

                                                                        and correct amp match details

                                                                        on Traceability ldquobagamp tagrdquo

                                                                        label

                                                                        DateTime Transfusion completed

                                                                        Traceability Tag signed with starting time amp date of transfusion recorded

                                                                        Inspect bag

                                                                        (condition amp expiry

                                                                        date)

                                                                        DateTime blood removed from

                                                                        cold temperature

                                                                        storage

                                                                        Baseline Observations recorded on SEWS chart

                                                                        (Temperature Pulse

                                                                        Oxygen sats Respiration rate

                                                                        amp BP)

                                                                        Completion of Observations

                                                                        Noted on the SEWS chart

                                                                        (Temperature Pulse

                                                                        Oxygen Sats Respiration rate

                                                                        50

                                                                        Observations All patient observations must be highlighted as blood transfusion observations utilising patientrsquos current observation chart for example SEWS chart The minimum observations that must be recorded for each unit are bull Baseline observations (Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse) must

                                                                        be recorded no more than 60 minutes prior to transfusion commencing bull 15 minutes after the start of the transfusion vital signs (Temperature Blood Pressure Oxygen Saturation

                                                                        Respiration Rate amp Pulse ) must be recorded and repeated again at another 15 minute interval bull Thereafter Temperature Blood Pressure and Pulse hourly until completion of the blood component bull At end of transfusion Temperature Blood Pressure Oxygen Saturation Respiration Rate amp Pulse must also

                                                                        be monitored within 60 minutes of completion NB if any of these measurements have altered from baseline values Respiratory Rate must also be

                                                                        recorded and concerns escalated to the medical team according to the SEWS

                                                                        Adverse Events

                                                                        bull Transfusion reactions in unconscious or compromised patients may be more difficult to identify therefore

                                                                        more frequent observation may be required bull Any adverse transfusion incident must be reported to the attending medical team in the first instance and the

                                                                        hospital transfusion laboratory at the earliest opportunity after the clinical symptoms have been dealt with Thereafter the adverse incident must also be reported through the local adverse incident management scheme(DATIX)

                                                                        Post Transfusion

                                                                        bull Adverse reactions may manifest many hours after the transfusion is completed It is recommended that

                                                                        patients discharged within 24 hours of transfusion are issued with a contact card giving 24-hour access to clinical advice through NHS 24 Parents of paediatric patients should be advised to contact the ward directly for advice

                                                                        bull When pre-transfusion discussion has not taken place the reasons for transfusion should be discussed with the patient and written information offered retrospectively Confirmation that this discussion has taken place must be written in the patientrsquos nursing and medical notes

                                                                        Best Practice Points bull Positive patient identification is essential at all stages of the blood transfusion process bull A patient identification band (or risk assessed equivalent) must be worn by all patients receiving a blood

                                                                        transfusion and include minimum patient data set bull It is the responsibility of the healthcare professional administering the blood component to perform the final

                                                                        patient identification check before administering the blood component bull Only staff who have been assessed as competent should collect blood components bull It is a legal requirement to complete the blue traceability label and return it to the hospital transfusion laboratory bull Transfusion should not take place during overnight periods unless clinically indicated

                                                                        Resources

                                                                        Reference British Committee for Standards in Haem atology (BCSH) Guidelines httpwwwbcshguidelinescom

                                                                        THB(MR)020 v 40 May 2013

                                                                        Transfusion Laboratory Contact Numbers Hospital Transfusion Laboratory Ninewells ext 32953

                                                                        PRI ext 13338(out of hours page 5122) Transfusion Practitioner Ninewells page 5099 PRI page 5082

                                                                        51

                                                                        9 NHS TAYSIDE - POLICY APPROVAL CHECKLIST

                                                                        This checklist must be completed and forwarded with policy to the Executive Team Clinical Quality Forum or Area Partnership Forum for approval and to the appropriate Committee for endorsement

                                                                        POLICY AREA ___CLINICAL______________________ ____________________________________________ POLICY TITLE _ Use of Blood and Blood Components Policy POLICY MANAGER _DR CATRIONA CONNOLLY E LEANOR HAZRA

                                                                        Why has this policy been developed

                                                                        Has the policy been developed in accordance with or related to legislation ndash Please give details of applicable legislation

                                                                        Has a risk control plan been developed and who is the owner of the risk If not why not

                                                                        Who has been involvedconsulted in the development of the policy

                                                                        Has the policy been assessed for Equality and Diversity in relation to-

                                                                        Has the policy been assessed For Equality and Diversity not to disadvantage the following groups-

                                                                        RaceEthnicity Gender Age ReligionBelief Disability Sexual Orientation Transgender

                                                                        Please indicate YesNo for the following YES

                                                                        Minority Ethnic Communities (includes GypsyTravellers Refugees amp Asylum Seekers) Women and Men Religious amp Faith Groups Disabled People Children and Young People Lesbian Gay Bisexual amp Transgender Community

                                                                        Please indicate Ye sNo for the following YES

                                                                        Does the policy contain evidence of the Equality amp

                                                                        Diversity Impact Assessment Process

                                                                        Is there an implementation plan

                                                                        Which officers are responsible for implementation

                                                                        When will the policy take effect

                                                                        Who must comply with the policystrategy

                                                                        How will they be informed of their responsibilities

                                                                        Is any training required

                                                                        If yes has any been arranged

                                                                        Are there any cost implications

                                                                        NO

                                                                        If yes please detail costs and note source of funding

                                                                        Who is responsible for auditing the implementation of the policy

                                                                        What is the audit interval Who will receive the audit reports When will the policy be reviewed and provide details of policy review period (1 2 or 3 years)

                                                                        2

                                                                        POLICY MANAGER________________________ DATE______ _____________________

                                                                        • Blood supply in an emergency situation
                                                                        • PROCEDURAL GUIDANCE AND MANAGEMENT OF RISK
                                                                        • Administration of Platelets
                                                                          • Appendix 1 Adult Blood Transfusion Guideline
                                                                            • ADULT BLOOD TRANSFUSION GUIDELINE
                                                                              • Remember
                                                                                • References
                                                                                  • Appendix 3a Flowchart Management of a Transfusion Reaction
                                                                                    • PATIENT DETAILS - CHECK AGAINST PATIENTS IDENTIFICATION BAND
                                                                                      • Consent for Transfusion
                                                                                      • THB(MR) 020 V40 May 2013
                                                                                        • PRE- COLLECTION
                                                                                        • PRE-ADMINISTRATION

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