Transcript
DR NILESH KATE
MBBS,MDASSOCIATE PROF
ESIC MEDICAL COLLEGE, GULBARGA. DEPT. OF PHYSIOLOGY
CEREBRAL CORTEX.
OBJECTIVES Cerebral cortex
External features. Functional areas. Lobes. Connections , functions
& applied.
White matter of cerebrum. Association Fibres. Commissural Projection.
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Cerebral cortex External features. Cortical functional
areas. Phylogenetical division
of cerebral cortex. Histological structure. Areas , connections,
functions & applied aspects.
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External features. Poles.—
Frontal Occipital Temporal.
Surfaces Superolateral Medial Inferior.
Borders. Superomedial Inferolateral Medial.
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CEREBRAL CORTEX Sulci & Gyri.
Surface area of cortex– 2200cm2
Lobes of cerebral hemispheres. Frontal – Motor. Parietal – Sensory. Temporal – Auditory. Occipital – Vision.
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Cortical functional areas.(Brodmann areas—47)
Motor area Primary motor area. (4) Premotor area. (6) Frontal eye field. (8) Supplementary motor
area.
Sensory area Primary somaesthetic
areas. (3,1,2) Secondary somaesthetic
areas. Somaesthetic association
areas. (5,7 & 40)
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Cortical functional areas.(Brodmann areas—47)
Auditory area Primary auditory area.
(41) Auditory association area.
(42). Higher auditory
association area. (22)
Visual area. Primary visual area. Or
Visuostriate area.(17) Visual association area. Or
Peristriate area.(18) Visual association area. Or
Perastriate area.(19)
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Cortical functional areas.(Brodmann areas—47)
Speech area Motor speech.
Anterior area (44,45) Superior area.
Sensory speech. Reading centre.(39) Area 40. Wernicke’s area. (22)
Smell & Gustatory area. Area 28. Area 43.
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Phylogenetical division of cerebral cortex.
Allocortex – 10 % (also called Limbic Cortex) Archipallium – hippocampus & Dentate Gyrus. Paleopallium – Uncus & part of Parahippocampal
gyrus.
Mesocortex. – transitional zone. Neocortex. – Isocortex
Rest of 90% of cerebral cortex.
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Histological structure. Cells
Pyramidal cells. (2/3rd)
Stellate cells or Granule cells. (1/3rd)
Fusiform cells.
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Histological structure.
Laminae. Molecular / plexiform layer.
Transverse nerve fibre – apical dendrite of pyramidal cells
Horizontal cells. – CAJAL External granular layer.
Granule cells & Pyramidal cells
Dendrite – to Molecular layer.
Axons – to deeper layer.
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Laminae. Outer pyramidal layer.
Mainly pyramidal cells, stellate cells & basket cells.
Inner granular layer. Densely packed stellate
cells. Inner zone prominent
transverse fibres.” External Band of Baillarger.
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Laminae. Inner pyramidal layer.
(Ganglionic) Large pyramidal cells. Developed in motor
cortex. Inner Band of
Baillarger. Polymorphous or
multiform layer. Modified pyramidal cells. Many fusiform cells.
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Types of Neocortex. Type I or agranular
cortex. Granule cells & stellate
cells absent. Pyramidal cells – large,
Betz cells. Seen in Motor cortex
(4) & Broca’s area. (44)
Type II or frontal cortex. Triangular granular
cells Seen in frontal lobe.
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Types of Neocortex. Type III or Parietal
cortex. Depth & density of layer
II & III increased. Granule cells – round. Seen in parietal lobe &
junction of parietal, temporal & occipital lobe.
Type IV or Polar Type. Cortex narrow All layers reduced depth. Seen in frontal &
occipital pole. Type V or granular
cortex. Excess granule cells Seen in sensory cortex &
calcarine region.
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Areas . Frontal lobe Parietal lobe Temporal lobe Occipital lobe.
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Frontal lobe. Precentral cortex.
Also called Excitomotor area of cortex.
Stimulation causes activity in discrete skeletal muscles
Sensorimotor cortex.—sensory & motor cortex.
Prefrontal cortex. Also called prefrontal
lobe or Orbitofrontal cortex.
Ant to area 8 & 44.
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Precentral cortex.Areas.
Primary motor area. (area 4) , Area 45
Premotor area. Area 6 Area 8 Area 44 & 45 or
Broca’s motor speech area.
Supplementary motor area.
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Primary Motor Area (4) Extent – from
Precentral gyrus to Paracentral lobule on medial surface.
Characteristics – 6 layers of cortex. Giant pyramidal cells
(Betz cells)
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Topographic Representation. Contra lateral half of
body in inverted order. Part of body for skilled
movements – larger area.
Body represented upside down.
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Primary Motor Area (4)
Electrical stimulation.– Motor homunculus.
Motor cortex organized in terms of movements.
Stimulation of points of face, pharynx & vocal cords – bilateral response.
Functions – Centre for volition. i.e. initiation of movements & speech.
Area 45 – suppressor area.
Inhibits movements initiated by area 4.
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Sensory Homunculi Motor Homunculi.
Premotor area. (6,8,44,45)
area 6
Structurally similar except Giant Pyramidal Cells.
2 parts – Upper 2a, Lower 2b.
Topographical representation – same.
Functions – Integration of voluntary movements. Make skilled movements accurate & smooth.
Lesions – Hemiplegia with Spastic paralysis.
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Area 8 Frontal Eye field. Location – ant to area 6. Function – control eye
movements. Lesions – turn eye to
opposite side. Conjugate movements --
lost
Afferent – occipital lobe & Dorsomedial N. of Thalamus.
Efferents – N. of III, IV & VI Cranial nerves.
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Area 44 & 45. Broca’s motor
speech area. Area 44 – pars
Triangularis. Area 45 – pars
Opercularis.
Functions – in Dominant Hemisphere concerned with movements responsible for production of voice & articulation of speech.
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Supplementary Motor Area. Locations – medial
surface of frontal lobe behind primary motor area.
Topographical representation.– upper body located dorsal to lower body.
Functions – with Premotor area provide attitudinal movements., fixational movements & positional movements of head & eye.
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Connections of pre central cortex.Afferents Efferents.
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Prefrontal cortex. Major areas. (9-14,
23,24,29,32, 44-47.
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Prefrontal cortex. Afferents
Dorsomedial nucleus of thalamus.
Anterior nuclei of thalamus.
Form Papez circuit– close circuit connection with thalamus.
Responsible for resting EEG & genesis of Emotions.
Efferents Thalamus. (V &M) Tegmental reticular
formation. Pontine nuclei Caudate nucleus. Mammilary bodies.
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Functions. Centre of planned
actions Centre for higher
functions. Emotions, learning,
memory & social behaviour.
Causes autonomic changes during emotional conditions
Seat of intelligence. Register short term
memory Called An organ of
mind. Control of intellectual
activities.
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Control of Intellectual Activities. To prognosticate. Plan future. Concentrate – Central
theme of thought. Delay actions in
response to sensory signals.
Consequences of motor action before it.
Solution of complicated mathematical & philosophical problems.
Controls one’s activity according to moral laws.
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Applied aspects.Frontal lobe syndrome.
Cause – ablation of prefrontal cortex.
Features. (FEEL – FILL) Flight of ideas. Emotional instability. Euphoria. Loss of moral & social
sense.
Functional abnormal— Hyperphagia. Sphincters control loss. Disorientation & tremors.
Impairment of memory. Lack of attention &
concentration. Lack of initiative & decreased
intellectual activity.
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Parietal lobe Primary sensory area.
(3,1,& 2) Secondary sensory
area. Sensory association
areas. (5, 7)
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Primary sensory area. (3,1,& 2) Location – Post
central Gyrus & Post wall of Central sulcus.
Histo – dense stellate cells , few pyramidal cells.
Topographical representations. – Sensory Homunculus.
Lesion – without thalamus only discriminative functions lost
With thalamus – all sensation from opp half of body.
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Secondary sensory area. Location – post central
Gyrus below 1st somatic sensory area.
Topographical representation – body represented twice in area I & area II.
Lesion – discriminative power lost.
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Sensory Association Areas. (5, 7) Post to area S1. Point to point
representation. Lesion – Tactile
Agnosia. (Asteriognosis & Tactile Aphasia)
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Connections of Parietal Lobe Afferents. SI – Thalamus
(VPM,VPL) Exteroceptive & Proprioceptive from opp side & both sides of face.
SII – from SI & thalamus Sensory Association
area. – SI & SII
Efferents. Corticospinal Corticobulbar Corticonuclear tracts.
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Connections of Parietal Lobe Association fibres. To other cortical
areas. Involve in somatic
sensation.
Commissural fibres. Mostly pyramidal cells
connect to opp hemisphere.
Opp area SI & SII
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Functions of Parietal Lobe First somatic sensory area. (SI)
Localize, analyze & Discriminate Cutaneous & Proprioceptive senses.
Area 3 – touch, pressure, position & vibrations. Area 1 – Cutaneous & joint sense. Area 2 – deep sense from muscles & joints.
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Parietal Lobe Second somatic sensory area. (SII)
From S1 & thalamus directly. Perception of sensation.
Sensory association area. (5,7) Discriminate stimuli related to intensity. Warm, warmer, cold, colder
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Temporal lobe.Primary auditory area.
41, 42 Audio sensory Area. HEARING CENTRE. Middle of superior
temporal gyrus. From – MGB, Thalamus. To – MGB, Superior
colliculus. Perceives – loudness,
pitch, source & direction of sound.
Auditory association area
22,21 & 20 22- Wernicke's area, also
called sensory speech area in dominant hemisphere.
Interpretation of meaning, comprehension of spoken language & formation of ideas.
21,20 – interpretation & integration of auditory impulses.
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Applied Aspects Unilateral removal
of temporal lobe Causes no deafness As ear bilaterally
represented in auditory pathway & project equally to 2 cerebral hemispheres.
Temporal lobe syndrome. (Kluver-Bucy syndrome) Bilateral removal of
temporal lobe with amygdala & Uncus.
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Temporal lobe syndrome. (Kluver-Bucy syndrome)
Features. (HHH-VADIA) Hyperphagia & omniphagia. Hyper sexuality. Hyper metamorphosis. Visual Agnosia. Aphasia. Dreaming states. Increased oral activity. Auditory disturbances.
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Occipital lobe Primary visual cortex.
(17) Visual association
area. (18) Visual association area
or occipital eye field. (19)
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Connections & functions. Afferents.
LGB via optic radiations. Efferents.
Frontal eye field for eye movements.
Superior colliculus. Cortico geniculate
projections. Thalamus.
Functions Area 17– perception of
visual impulses. Area 18, 19 –
interpretation , recognition & identification from memory.
occipital eye field area.– movement of eye ball.
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White matter of cerebrum. Association fibres. Commissural fibres. Projection fibres.
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Association fibres. Short.
Between adjacent Gyri. Long.
Superior longitudinal fasciculus.
Inferior longitudinal fasciculus.
Cingulum. Fronto-occipital
fasciculus.
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Commissural fibres. Corpus callosum. Anterior commissure. Posterior commissure. Habenular
commissure. Hippocampal
commissure.
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Projection fibres. Afferents.
Thalamic radiations Anterior. Posterior. Superior. Inferior.
Efferents. Corticobulbar &
corticospinal tract. Cortico pontine Cortico Rubral Cortico Thalamic.
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Internal capsule Thick curved band. Fans out up as corona
radiata & down as crus cerebri.
Most common part of Infarction & Hemorrhage.
Most common artery – Striate branch of middle cerebral artery so called Artery of cerebral hemorrhage of Charcot’s artery.
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Thank You
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