Bringing Microfluidics To Life
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Dr.ir. Maurice van der Beek, Dr. Eduard Pelssers
Philips Applied Technologies
January 21, 2009
Bringing microFluidics to Life
Micro Technology Innovation Forum
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum2
A leading technology center
Founded in 1968
Sales 2007
EUR 149 Million
Worldwide representation
North America: San José (USA), Andover (USA)
Europe: Eindhoven (NL), Redhill (UK)
Asia: Bangalore (India), Singapore
Philips Applied Technologies
University degree / Ph.D.s
± 390Other type of education
± 140 A multinational highly qualified workforce of about
845 people (+ 150 temporary employees)
Bachelors & Engineers
± 315
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
Contract R&D services
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Innovation through turnkey solutions and specialist support
Technology
• Home and Building
Automation & Security
• Instrumentation & Stages
• Opto-electronic modules
• RFID
• Energy
Lifestyle
• Multimedia Experience
• Personal Care, Wellness &
Beauty
• Robotics
• Information, Storage &
Streaming & Retrieval
Healthcare
• Medical devices & implants
• Patient monitoring &
connected care
• Medical imaging & therapy
systems
• Molecular healthcare devices
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum4
R&D for every phase of the innovation process
Concept Design Engineering Industrialization Ramp-up
• Product design
• Process design
• Equipment design
• Technical Product Docu-mentation (TPD)
• Functional models
• Quality and reliability
• Prototypes
• Industry consulting
• Research
• Innovation consulting
• Manufacturing support
• Small volume production
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum5
Customers
Philips Consumer Lifestyle
Philips Lighting
Philips Healthcare
Philips Research
Philips Incubators
Philips IP&S
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
Magnotech - Cozart and Philips
Rapid Drug Screen with
Cozart (a wholly owned subsidiary of Concateno plc) and Philips are engaged to develop
and commercialize an innovative new handheld drugs-of-abuse testing product based on
Magnotech™ technology
6
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, Reference
Magnotech - Platform Elements
Disposable• Sample taking unit
• Pre-treatment
• Detection
Analyser• Magnetic actuation
• Signal processing
• No moving parts
• Embedded software
Bio-chemistry• Magnetic beads
• Printed spots
• Dry reagents
Software• Host software
• Integration with clinical
IT infrastructure
7Philips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, Reference
What is needed: system architecture approach
Disposable• Sample taking unit
• Pre-treatment
• Detection
Reaction vessel enabling all processes
for the detection of drugs from saliva
Pre-treatment Labeling Enabling label detectionSample taking Sample transport
functional
architecture
Capillary force
Pressure difference
Electrowetting
etc.
Immuno-magnetic
Fluorescent
None
etc.
SPR
Optical
Magnetic
Etc.
Filtering
Chemical
Enzymatic
etc.
Cotton swab
Paper
Pipette
etc.
architecture
options
Low cost / mass manufacturableproduct requirements
Product conceptssystem
architecture
8Philips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
What is needed: a multidisciplinary team
Biochemistry
Transport
phenomena
Optics
(Colloid)
Chemistry
Mechanics
Physics
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Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
Concept Design Engineering Industrialization Ramp-up
• ?
Stargate – a lifecycle model for business creation
What is needed: a structured way-of-working
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Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
What is needed: access to techniques for integration
Bio spotting
Plastics molding
Joining / laser welding
Surface modification
Assay development
Microfluidic design
Pre-pilot Assembly
Pilot Production
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Microfluidic functional testing
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
CHALLENGE
• Realization of microfluidic fluid
handling steps realized without
user actuation (autonomous flow)
RESULT
• Sample treatment, aliquoting, and
rapid transport based on capillary
flow
• Realization of an evaluation tool
BENEFITS
• Fully autonomous
• Cost effective implementation in
disposables
• General use – Microfluidic Platform
Microfluidic design and functional testing
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0
5
10
15
20
25
30
35
40
45
0 0.5 1 1.5 2 2.5 3
time (s)
Sp
ot
nr.
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
CHALLENGE
• Mass manufacturing of plastics featuring
submillimeter structures for use in
microfluidic applications
RESULT
• Mold insert creation using various
techniques, i.e. micro-milling, micro-EDM,
laser ablation, focused ion beam,
diamond tip milling
• Replication of micrometer-sized features
into plastics using the process of injection
molding
BENEFITS
• Design freedom
• Dimensional accuracy
• High degree of automation
Micro injection molding
picture
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Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
CHALLENGE
• Hermetic sealing of (transparent) polymer cartridges for
biomedical applications
RESULT
• Thermal joining of parts using standard IR fiberlasers.
• Absorption of laser light by addition of carbon black or by
polymer itself dependent on wavelength.
BENEFITS
• High quality joint for polymer parts
• No addition of chemicals is required
• Accurate and flexible technique.
• Small heat affected zone; no adverse
effect to pre-immobilized antibodies
Laser welding of biomedical cartridges
fluid inlet
channel
filled with
fluid
laser weld
Top view of cartridge
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Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, Reference 15
Deposition and localization of protein activated magnetic
particles
CHALLENGE
• Deposition of small volumes (typical 100 nl)
of a liquid with relative high viscosity
containing protein coated magnetic
particles with high precision of both
volume and location
RESULT
• Selection and modification of existing
dosing system by extending both hardware
(vision) and software of the instrument
BENEFITS
• Cost effective development of equipment
for small scale production with a clear open
route towards larger scale production
Philips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum
CHALLENGE
• Bio-compatible assembly of plastic micro-fluidic
products
RESULT
• Micro-biological clean manufacturing:
• Cross-flow and down-flow boxes
• Clean room class 10000
• Fixed instructions, product tracking
• Automated visual inspection
BENEFITS
• Scalable production
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Pilot-line production in clean room
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