ATTENTION STUDENTS...EG MAPLE NUMEROUS EXCEPTIONS EG CACTI LF ANATOMY-- CUTICLE -----> WAXY LAYER - INHIBITS H2O LOSS-- UPPER EPIDERMIS ---> SKIN-LIKE PROTECTIVE LAYER-- MESOPHYLL

ATTENTION STUDENTS

!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

BIOLOGY 111

PRINCIPLES OF BIOLOGY

DR. MENAPACE

!!!MAJORS BIOLOGY!!!

CHAPTER 07MEMBRANE

STRUCTURE

MEMBRANE

FUNCTION

****MEMBRANE STRUCTURE & FUNCTION****

***MEMBRANE STRUCTURE***

!!!MEMBRANE STRUCTURE: SIMILAR THROUGHOUT BIOLOGY!!!

-- MOST ACCEPTED MODEL: FLUID MOSAIC MODEL

***FLUID MOSAIC MODEL***

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

**COMPONENTS**

-- PHOSPHOLIPIDS

-- CHOLESTEROL

-- PROTEINS

-- GLYCOPROTEINS

*PHOSPHOLIPIDS*

-- O= PHOSPHOLIPID

PHOSPHATE

H-BONDS W/ H2O: PRESENT

HYDROPHILIC

FATTY ACIDS

NON-POLAR

H-BONDS W/ H2O: ABSENT

HYDROPHOBIC

-- PHOSPHOLIPIDS AMPHIPATHIC MOLECULES

-- PHOSPHOLIPIDS & AQUEOUS SOLUTION -->

PHOSPHOLIPID BILAYER

!!!PRINCIPLE STRUCTURAL MATRIX!!!

!!!PHOSPHOLIPIDS MOVE FREELY!!!

*CHOLESTEROL*

-- EMBEDDED W/IN PHOSPHOLIPID BILAYER

-- INHIBITS MEMBRANE SOLIDIFICATION

!!!ENSURES MEMBRANE FUNCTION AT LOW TEMP!!!

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

PHOSPHATE

HYDROPHILIC

FATTY ACIDS

NON-POLAR

HYDROPHOBIC

*CHOLESTEROL*

!!!CHOLESTEROLMOVES FREELY!!!

*PROTEINS*

---MEMBRANE PROTEIN TYPES---

-- INTEGRAL PROTEINS

-- PERIPHERAL “

--INTEGRAL PROTEINS--

-- I.P. = EMBEDDED W/IN BILAYER

--TYPES--

-- UNILATERAL = INCOMPLETELY SPANS MEMBRANE

-- BILATERAL = COMPLETELY “ “

-- AMPHIPATHIC PROTEINS

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

*PROTEINS*

-- PERIPHERAL “

--TYPES--

--PERIPHERAL PROTEINS--

-- P.P. = NOT EMBEDDED W/IN BILAYER

-- BONDED TO PHOSPHOLIPIDS

-- “ “ INTEGRAL PROTEINS

-- NON-AMPHIPATHIC PROTEINS

!!!PROTEINS PRINCIPLE FUNCTIONAL COMPONENT!!!

!!!PROTEINS MOVE FREELY!!!

*GLYCOPROTEINS*

-- G. = SUGAR-PROTEIN COMPLEX

-- MEMBRANE ID MARKERS

-- DIFF MEMBRANES -->

DIFF GLYCOPROTEINS

EG HUMAN BLOOD TYPES

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

*GLYCOPROTEINS*

DIFF GLYCOPROTEINS

!!!GLYCOPROTEINS MOVE FREELY!!!

!!!DO NOT COPY!!!

---MEMBRANE STRUCTURE: SUMMARY---

FLUID MOSAIC MODEL

FLUID COMPONENT = PHOSPHOLIPID BILAYER

MOSAIC COMPONENT = CHOLESTEROL, PROTEINS, GLYCOPROTEINS

!!!COPY!!!

***MEMBRANE FUNCTION***

-- PROTEINS PRINCIPLE FUNCTIONAL COMPONENT

“ PROTEINS -->

“ FUNCTIONS

EG THYLAKOID & CRISTAE

**MEMBRANE PROTEIN FUNCTIONS**

DIFF GLYCOPROTEINS

!!!DO NOT COPY!!!

FLUID MOSAIC MODEL

!!!COPY!!!

“ PROTEINS -->

“ FUNCTIONS

DIFF GLYCOPROTEINS

!!!DO NOT COPY!!!

FLUID MOSAIC MODEL

!!!COPY!!!

“ PROTEINS -->

“ FUNCTIONS

DIFF GLYCOPROTEINS

!!!DO NOT COPY!!!

FLUID MOSAIC MODEL

!!!COPY!!!

“ PROTEINS -->

“ FUNCTIONS

DIFF GLYCOPROTEINS

!!!DO NOT COPY!!!

FLUID MOSAIC MODEL

!!!COPY!!!

“ PROTEINS -->

“ FUNCTIONS

DIFF GLYCOPROTEINS

!!!DO NOT COPY!!!

FLUID MOSAIC MODEL

!!!COPY!!!

“ PROTEINS -->

“ FUNCTIONS

DIFF GLYCOPROTEINS

!!!DO NOT COPY!!!

FLUID MOSAIC MODEL

!!!COPY!!!

“ PROTEINS -->

“ FUNCTIONS

DIFF GLYCOPROTEINS

!!!DO NOT COPY!!!

FLUID MOSAIC MODEL

!!!COPY!!!

“ PROTEINS -->

“ FUNCTIONS

DIFF GLYCOPROTEINS

!!!DO NOT COPY!!!

FLUID MOSAIC MODEL

!!!COPY!!!

“ PROTEINS -->

“ FUNCTIONS

-- ENZYMATIC = CATALYST

INTEGRAL & PERIPHERAL PROTEINS

-- TRANSPORT = MOVE POLAR SOLUTES ACROSS MEMBRANE

BILATERAL INTEGRAL PROTEINS

***MEMBRANE PERMEABILITY***

-- SELECTIVELY PERMEABLE = BIO-MEMBRANE REGULATES PASSAGE

**PHOSPHOLIPID BILAYER - PERMEABILITY**

---NON-POLAR SOLUTES---

-- PHOSPHOLIPID BILAYER PERMITS PASSAGE

---POLAR SOLUTES---

-- PHOSPHOLIPID BILAYER INHIBITS PASSAGE

---POLAR SOLUTES---

-- TRANSPORT

---POLAR SOLUTES---

!!!POLAR SOLUTES REQUIRE: TRANSPORT PROTEINS!!!

**TRANSPORT PROTEINS**

---TYPES---

-- CHANNEL T.P. = H2O CHANNEL PERMITS POLAR SOLUTES ACROSS

MEMBRANE

CONFORMATION CHANGE: ABSENT

ATP EXPENSE: ABSENT

-- CARRIER T.P. = SHUNTS POLAR SOLUTES ACROSS MEMBRANE

CONFORMATION CHANGE: REQUIRED

ATP EXPENSE: REQUIRED

!!!DO NOT COPY!!!

---TRANSPORT PROTEINS: SUMMARY---

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

---POLAR SOLUTES---

---TYPES---

MEMBRANE

ATP EXPENSE: ABSENT

!!!DO NOT COPY!!!

!!!COPY!!!

***SOLUTE MEMBRANE TRANSPORT***

---TYPES---

-- PASSIVE TRANSPORT

-- PASSIVE FACILITATED TRANSPORT

-- ACTIVE TRANSPORT

---SOLUTION TERMS---

-- SOLUTION = SOLVENT & SOLUTE MIXTURE

-- SOLVENT = LIQUID COMPONENT

-- SOLUTE = DISSOLVED “

-- GRADIENT = 2 SOLUTIONS W/ DIFF SOLUTE CONCENTRATION

-- CONCENTRATION = AMOUNT DISSOLVED SOLUTE

__________________________________________________________________

**PASSIVE TRANSPORT**

__________________________________________________________________

!!!COPY!!!

---TYPES---

-- ACTIVE TRANSPORT

__________________________________________________________________

!!!COPY!!!

---TYPES---

-- ACTIVE TRANSPORT

__________________________________________________________________

!!!COPY!!!

---TYPES---

-- ACTIVE TRANSPORT

__________________________________________________________________

!!!COPY!!!

---TYPES---

-- ACTIVE TRANSPORT

__________________________________________________________________

ATTENTION STUDENTS...EG MAPLE NUMEROUS EXCEPTIONS EG CACTI LF ANATOMY-- CUTICLE -----> WAXY LAYER - INHIBITS H2O LOSS-- UPPER EPIDERMIS ---> SKIN-LIKE PROTECTIVE LAYER-- MESOPHYLL

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ATTENTION STUDENTS...EG MAPLE NUMEROUS EXCEPTIONS EG CACTI LF ANATOMY-- CUTICLE -----> WAXY LAYER - INHIBITS H2O LOSS-- UPPER EPIDERMIS ---> SKIN-LIKE PROTECTIVE LAYER-- MESOPHYLL