ARE VACCINES SAFE AND EFFECTIVE? DR. BOYD E. HALEY PROFESSOR OF CHEMISTRY/BIOCHEMISTRY EMERITUS UNIVERSITY OF KENTUCKY.
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ARE VACCINES SAFE AND EFFECTIVE
DR BOYD E HALEYPROFESSOR OF
CHEMISTRYBIOCHEMISTRY EMERITUS
UNIVERSITY OF KENTUCKY
CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
httpwwwcdcgovvaccinesrecsschedulesdownloadschild0-6yrs-schedule-prpdf
Important Observations1 Today 2011 the USA has the highest infant
vaccination rate in the world yet the USA is number 41 on the infant mortality list
2 The USA has a very high rate of aged individuals being vaccinated yet we are now number 28 on the longevity list
3 A recent report by Generation Rescue clearly shows the USA has the highest vaccine rate and the highest level of autism of 5 major countries
4 If vaccines decrease the rate of childhood death due to infectious diseases what types of death are occurring that make the USA place 41
USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
bull Children mortality rates younger than 5 fell to 77 million down from 119 million two decades agobullUSA now ranks 42nd globally behind much of Europe as well as the United Arab Emirates Cuba and ChilebullTwenty years (1990) ago the USA was 29th bullSingapore has a mortality rate of 25 deaths per 1000 and the USA rate is 67 per 1000bullHigh rates exist among higher income whites a group that traditionally has best access to medical care
CONSIDERATIONS
bullAfter making vaccines compulsory the USA dropped from 3rd in the table of infant mortality to 24th Due no doubt to their high incidence of SID cot-death (8000)bull The Japanese (pop 120 million) after delaying the DPT vaccine until the second year in 1975 amp 76 immediately jumped from 17th place to the country with the lowest infant mortality in the world bullIn 1988 they lowered the minimum age again and the infant mortality immediately increased again
Child Death Rates in the United States
Although the under-5 mortality rate in the United States has fallen in recent decades it is still higher than many other wealthy nations ndash 23 times that of Iceland and more than 75 percent higher than the rate of the Czech Republic Finland Italy Japan Norway Slovenia and Sweden If CDC mandated vaccinations prevent death why is their such disparity in child death rates between these states
Child Deaths in the Developed World
Infant death rate (under 1 year old per 1000 births) 1997 2006
Luxemborg 345Singapore 376Sweden (1996) 382Japan 365Finland (1996) 391Austria 473France (1996) 476Germany 486Spain (1995) 549Slovenia 521Canada 552Uk 586 Czech republic 585Denmark (1996) 551Australia (1995) 555Ireland (1996) 598Iceland (1995) 607Italy (1995) 619Israel (1996) 632 689Malta 641 386Portugal 643 498Greece 643 543New Zealand (1996) 726 576USA 722 per 1000 643Cuba (1996) 790 622Croatia 823 672Hungary 985 839Estonia 1005 773Lithuania 1034 678Poland (1996) 1220 722Latvia 1534 935Moldova 2065 3838Mauritius 2033 1459Brazil (1995) 2625Argentina (1996) 2087
WHO infant deaths httpwww-ntwhointwhosisstatisticswhsawhsa_table2cfmpath=evidencewhsawhsa_table2amplanguage=english
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
httpwwwcdcgovvaccinesrecsschedulesdownloadschild0-6yrs-schedule-prpdf
Important Observations1 Today 2011 the USA has the highest infant
vaccination rate in the world yet the USA is number 41 on the infant mortality list
2 The USA has a very high rate of aged individuals being vaccinated yet we are now number 28 on the longevity list
3 A recent report by Generation Rescue clearly shows the USA has the highest vaccine rate and the highest level of autism of 5 major countries
4 If vaccines decrease the rate of childhood death due to infectious diseases what types of death are occurring that make the USA place 41
USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
bull Children mortality rates younger than 5 fell to 77 million down from 119 million two decades agobullUSA now ranks 42nd globally behind much of Europe as well as the United Arab Emirates Cuba and ChilebullTwenty years (1990) ago the USA was 29th bullSingapore has a mortality rate of 25 deaths per 1000 and the USA rate is 67 per 1000bullHigh rates exist among higher income whites a group that traditionally has best access to medical care
CONSIDERATIONS
bullAfter making vaccines compulsory the USA dropped from 3rd in the table of infant mortality to 24th Due no doubt to their high incidence of SID cot-death (8000)bull The Japanese (pop 120 million) after delaying the DPT vaccine until the second year in 1975 amp 76 immediately jumped from 17th place to the country with the lowest infant mortality in the world bullIn 1988 they lowered the minimum age again and the infant mortality immediately increased again
Child Death Rates in the United States
Although the under-5 mortality rate in the United States has fallen in recent decades it is still higher than many other wealthy nations ndash 23 times that of Iceland and more than 75 percent higher than the rate of the Czech Republic Finland Italy Japan Norway Slovenia and Sweden If CDC mandated vaccinations prevent death why is their such disparity in child death rates between these states
Child Deaths in the Developed World
Infant death rate (under 1 year old per 1000 births) 1997 2006
Luxemborg 345Singapore 376Sweden (1996) 382Japan 365Finland (1996) 391Austria 473France (1996) 476Germany 486Spain (1995) 549Slovenia 521Canada 552Uk 586 Czech republic 585Denmark (1996) 551Australia (1995) 555Ireland (1996) 598Iceland (1995) 607Italy (1995) 619Israel (1996) 632 689Malta 641 386Portugal 643 498Greece 643 543New Zealand (1996) 726 576USA 722 per 1000 643Cuba (1996) 790 622Croatia 823 672Hungary 985 839Estonia 1005 773Lithuania 1034 678Poland (1996) 1220 722Latvia 1534 935Moldova 2065 3838Mauritius 2033 1459Brazil (1995) 2625Argentina (1996) 2087
WHO infant deaths httpwww-ntwhointwhosisstatisticswhsawhsa_table2cfmpath=evidencewhsawhsa_table2amplanguage=english
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Important Observations1 Today 2011 the USA has the highest infant
vaccination rate in the world yet the USA is number 41 on the infant mortality list
2 The USA has a very high rate of aged individuals being vaccinated yet we are now number 28 on the longevity list
3 A recent report by Generation Rescue clearly shows the USA has the highest vaccine rate and the highest level of autism of 5 major countries
4 If vaccines decrease the rate of childhood death due to infectious diseases what types of death are occurring that make the USA place 41
USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
bull Children mortality rates younger than 5 fell to 77 million down from 119 million two decades agobullUSA now ranks 42nd globally behind much of Europe as well as the United Arab Emirates Cuba and ChilebullTwenty years (1990) ago the USA was 29th bullSingapore has a mortality rate of 25 deaths per 1000 and the USA rate is 67 per 1000bullHigh rates exist among higher income whites a group that traditionally has best access to medical care
CONSIDERATIONS
bullAfter making vaccines compulsory the USA dropped from 3rd in the table of infant mortality to 24th Due no doubt to their high incidence of SID cot-death (8000)bull The Japanese (pop 120 million) after delaying the DPT vaccine until the second year in 1975 amp 76 immediately jumped from 17th place to the country with the lowest infant mortality in the world bullIn 1988 they lowered the minimum age again and the infant mortality immediately increased again
Child Death Rates in the United States
Although the under-5 mortality rate in the United States has fallen in recent decades it is still higher than many other wealthy nations ndash 23 times that of Iceland and more than 75 percent higher than the rate of the Czech Republic Finland Italy Japan Norway Slovenia and Sweden If CDC mandated vaccinations prevent death why is their such disparity in child death rates between these states
Child Deaths in the Developed World
Infant death rate (under 1 year old per 1000 births) 1997 2006
Luxemborg 345Singapore 376Sweden (1996) 382Japan 365Finland (1996) 391Austria 473France (1996) 476Germany 486Spain (1995) 549Slovenia 521Canada 552Uk 586 Czech republic 585Denmark (1996) 551Australia (1995) 555Ireland (1996) 598Iceland (1995) 607Italy (1995) 619Israel (1996) 632 689Malta 641 386Portugal 643 498Greece 643 543New Zealand (1996) 726 576USA 722 per 1000 643Cuba (1996) 790 622Croatia 823 672Hungary 985 839Estonia 1005 773Lithuania 1034 678Poland (1996) 1220 722Latvia 1534 935Moldova 2065 3838Mauritius 2033 1459Brazil (1995) 2625Argentina (1996) 2087
WHO infant deaths httpwww-ntwhointwhosisstatisticswhsawhsa_table2cfmpath=evidencewhsawhsa_table2amplanguage=english
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
bull Children mortality rates younger than 5 fell to 77 million down from 119 million two decades agobullUSA now ranks 42nd globally behind much of Europe as well as the United Arab Emirates Cuba and ChilebullTwenty years (1990) ago the USA was 29th bullSingapore has a mortality rate of 25 deaths per 1000 and the USA rate is 67 per 1000bullHigh rates exist among higher income whites a group that traditionally has best access to medical care
CONSIDERATIONS
bullAfter making vaccines compulsory the USA dropped from 3rd in the table of infant mortality to 24th Due no doubt to their high incidence of SID cot-death (8000)bull The Japanese (pop 120 million) after delaying the DPT vaccine until the second year in 1975 amp 76 immediately jumped from 17th place to the country with the lowest infant mortality in the world bullIn 1988 they lowered the minimum age again and the infant mortality immediately increased again
Child Death Rates in the United States
Although the under-5 mortality rate in the United States has fallen in recent decades it is still higher than many other wealthy nations ndash 23 times that of Iceland and more than 75 percent higher than the rate of the Czech Republic Finland Italy Japan Norway Slovenia and Sweden If CDC mandated vaccinations prevent death why is their such disparity in child death rates between these states
Child Deaths in the Developed World
Infant death rate (under 1 year old per 1000 births) 1997 2006
Luxemborg 345Singapore 376Sweden (1996) 382Japan 365Finland (1996) 391Austria 473France (1996) 476Germany 486Spain (1995) 549Slovenia 521Canada 552Uk 586 Czech republic 585Denmark (1996) 551Australia (1995) 555Ireland (1996) 598Iceland (1995) 607Italy (1995) 619Israel (1996) 632 689Malta 641 386Portugal 643 498Greece 643 543New Zealand (1996) 726 576USA 722 per 1000 643Cuba (1996) 790 622Croatia 823 672Hungary 985 839Estonia 1005 773Lithuania 1034 678Poland (1996) 1220 722Latvia 1534 935Moldova 2065 3838Mauritius 2033 1459Brazil (1995) 2625Argentina (1996) 2087
WHO infant deaths httpwww-ntwhointwhosisstatisticswhsawhsa_table2cfmpath=evidencewhsawhsa_table2amplanguage=english
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
CONSIDERATIONS
bullAfter making vaccines compulsory the USA dropped from 3rd in the table of infant mortality to 24th Due no doubt to their high incidence of SID cot-death (8000)bull The Japanese (pop 120 million) after delaying the DPT vaccine until the second year in 1975 amp 76 immediately jumped from 17th place to the country with the lowest infant mortality in the world bullIn 1988 they lowered the minimum age again and the infant mortality immediately increased again
Child Death Rates in the United States
Although the under-5 mortality rate in the United States has fallen in recent decades it is still higher than many other wealthy nations ndash 23 times that of Iceland and more than 75 percent higher than the rate of the Czech Republic Finland Italy Japan Norway Slovenia and Sweden If CDC mandated vaccinations prevent death why is their such disparity in child death rates between these states
Child Deaths in the Developed World
Infant death rate (under 1 year old per 1000 births) 1997 2006
Luxemborg 345Singapore 376Sweden (1996) 382Japan 365Finland (1996) 391Austria 473France (1996) 476Germany 486Spain (1995) 549Slovenia 521Canada 552Uk 586 Czech republic 585Denmark (1996) 551Australia (1995) 555Ireland (1996) 598Iceland (1995) 607Italy (1995) 619Israel (1996) 632 689Malta 641 386Portugal 643 498Greece 643 543New Zealand (1996) 726 576USA 722 per 1000 643Cuba (1996) 790 622Croatia 823 672Hungary 985 839Estonia 1005 773Lithuania 1034 678Poland (1996) 1220 722Latvia 1534 935Moldova 2065 3838Mauritius 2033 1459Brazil (1995) 2625Argentina (1996) 2087
WHO infant deaths httpwww-ntwhointwhosisstatisticswhsawhsa_table2cfmpath=evidencewhsawhsa_table2amplanguage=english
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Child Death Rates in the United States
Although the under-5 mortality rate in the United States has fallen in recent decades it is still higher than many other wealthy nations ndash 23 times that of Iceland and more than 75 percent higher than the rate of the Czech Republic Finland Italy Japan Norway Slovenia and Sweden If CDC mandated vaccinations prevent death why is their such disparity in child death rates between these states
Child Deaths in the Developed World
Infant death rate (under 1 year old per 1000 births) 1997 2006
Luxemborg 345Singapore 376Sweden (1996) 382Japan 365Finland (1996) 391Austria 473France (1996) 476Germany 486Spain (1995) 549Slovenia 521Canada 552Uk 586 Czech republic 585Denmark (1996) 551Australia (1995) 555Ireland (1996) 598Iceland (1995) 607Italy (1995) 619Israel (1996) 632 689Malta 641 386Portugal 643 498Greece 643 543New Zealand (1996) 726 576USA 722 per 1000 643Cuba (1996) 790 622Croatia 823 672Hungary 985 839Estonia 1005 773Lithuania 1034 678Poland (1996) 1220 722Latvia 1534 935Moldova 2065 3838Mauritius 2033 1459Brazil (1995) 2625Argentina (1996) 2087
WHO infant deaths httpwww-ntwhointwhosisstatisticswhsawhsa_table2cfmpath=evidencewhsawhsa_table2amplanguage=english
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Child Deaths in the Developed World
Infant death rate (under 1 year old per 1000 births) 1997 2006
Luxemborg 345Singapore 376Sweden (1996) 382Japan 365Finland (1996) 391Austria 473France (1996) 476Germany 486Spain (1995) 549Slovenia 521Canada 552Uk 586 Czech republic 585Denmark (1996) 551Australia (1995) 555Ireland (1996) 598Iceland (1995) 607Italy (1995) 619Israel (1996) 632 689Malta 641 386Portugal 643 498Greece 643 543New Zealand (1996) 726 576USA 722 per 1000 643Cuba (1996) 790 622Croatia 823 672Hungary 985 839Estonia 1005 773Lithuania 1034 678Poland (1996) 1220 722Latvia 1534 935Moldova 2065 3838Mauritius 2033 1459Brazil (1995) 2625Argentina (1996) 2087
WHO infant deaths httpwww-ntwhointwhosisstatisticswhsawhsa_table2cfmpath=evidencewhsawhsa_table2amplanguage=english
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Infant death rate (under 1 year old per 1000 births) 1997 2006
Luxemborg 345Singapore 376Sweden (1996) 382Japan 365Finland (1996) 391Austria 473France (1996) 476Germany 486Spain (1995) 549Slovenia 521Canada 552Uk 586 Czech republic 585Denmark (1996) 551Australia (1995) 555Ireland (1996) 598Iceland (1995) 607Italy (1995) 619Israel (1996) 632 689Malta 641 386Portugal 643 498Greece 643 543New Zealand (1996) 726 576USA 722 per 1000 643Cuba (1996) 790 622Croatia 823 672Hungary 985 839Estonia 1005 773Lithuania 1034 678Poland (1996) 1220 722Latvia 1534 935Moldova 2065 3838Mauritius 2033 1459Brazil (1995) 2625Argentina (1996) 2087
WHO infant deaths httpwww-ntwhointwhosisstatisticswhsawhsa_table2cfmpath=evidencewhsawhsa_table2amplanguage=english
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
TABLE 7 Number of Live Births and IMRs for 2004 2005 and 2006 for Countries of 2500000 With IMRs Less Than the United States in 2006Country No of Births INFANT MORTALITY RATE
in 2006 2006 2005 2004Hong Kong 65 626 18a 23 27Japan 1092 674 26 28 28Sweden 105 913 28 24 31Finland 58 840 28 30 33Norway 58 545 32 31 32Czech Republic 105 831 33 34 37Portugal 105 449 33 35 38France 796 896 36 36 39Austria 77 914 36 42 45Greece 112 042 37 38 41Italy 560 010 38 38 39Spain 481 102 38 38 40Germany 672 724 38 39 41Korea 451 514 38 42 46Denmark 64 984 38 44 44Israel 148 170 40 44 46Belgium 121 382 40 37 38Switzerland 73 371 44 42 42Netherlands 185 057 44 49 44Australia 265 423 47 50 46United Kingdom 748 563 50 51 50New Zealand 59 193 51 51 56Croatia 41 446 52 57 61Cuba 111 323 53 62 58Canada 350 181 NA 54 53Hungary 99 871 57 62 66Poland 374 244 60 64 68Malaysia 465 112 62 66 65United States 4 265 555 67 69 68Data source Tables 9 and 15 In United Nations Demographic Yearbook 2007 New York NY United Nations 2009328 ndash338 405ndash 413PEDIATRICS 20101254-15 M Heron et al
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
The Effects of a High Infant Death RatebullTop four best averaged = 18 + 26 + 28 +28 = 104 = 25 deaths per 1000 bullUSA death rate = 67 Therefore 67 ndash 25= 42 more deaths per 1000 than the top four bestbullUSA yearly birth population = 4 265 555 or 42655 times 1000 birthsbull42655 X 42 more deaths per 1000 = 17915 more infants die in the USA than would if we had an infant mortality equal to the average of the four best countriesbullRIGHT TO LIFE AFTER BIRTH NEEDS ATTENTION
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF
VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Death Rate for Infectious Diseases
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Anti-vaccine Activists Get Jabbed By Michael FumentoScripps Howard News Service March 11 2004
Truncated graphs made to make vaccines look much more effective than they really are
WHAT WAS THE RATE DECLINE BEFORE THE START DATES ON THESE PRO-VACCINE GRAPHS
NOW FOR THE REST OF THE STORY
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
What ended this epidemic of polio
Salk era polio epidemic
Most rapid decline of deaths due to infectious diseases occurred before the advent of vaccines to treat them
Diphtheria amp Pertussis vaccines 1949
Measles Vaccine started
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
DATA FROM ENGLAND
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
QUESTIONABLE EFFICACY
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
DATA FROM THE USA
Data amp graphs supplied by Roman Bystrianyk
Deaths from Diphtheria dropped dramatically before the advent of vaccines
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Scarlet Fever Death Rate (England amp Wales)reveals that in the period of 1865 to 1935 before sulfonamides had become available in England and Wales the annual death rate from scarlet fever declined by approximately 96 percent UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
There has never been a vaccine for scarlet fever
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Deaths from Pertussis dropped dramatically before advent of vaccine
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
UTD = up-to-date with age appropriate pertussis vaccinations by immunization record review or parent reportNUTD = not up-to-date with age appropriate pertussis vaccinationsPBE = personal belief exemption reported by parent andor physicianUNK = unknownTDAP DUE = any child 11-18 years old who had only 5 pertussis containing immunizations with no Tdap noted(source San Diego County Health amp Human Services Agency)
1 332 ndash 8 = 3242 197324 = 06083 197 + 45 + 20 = 2624 262324 = 809
AT LEAST 61 WERE UP TO DATE VACCINATED ABOUT 81 WERE VACCINATED
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
bullCDC Statement On Why Vaccinated People In Calif Are Contracting PertussisbullVaccines for pertussis are very effective but no vaccine protects forever in 100 percent of those vaccinated Protection wanes over time which is the reason for intermittent ldquobooster dosesrdquo bullHigh vaccination coverage in communities and in families also protects others including those who are too young to be vaccinated or whose immunity from vaccination has wanedbullCA is experiencing a significant increase in pertussis circulating in the community That disease pressure is causing more fully vaccinated and recently vaccinated people to become infected than in a typical year It does not mean the vaccine is not workingbullRather the higher the vaccine coverage the higher the proportion of cases who have been vaccinated This is commonly misinterpreted to mean that a vaccine is not working when in fact it means that coverage is highhttpwwwkpbsorgnews2010sep07whooping-cough-vaccine-working
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
ANOTHER PERSPECTIVEbullIF YOU BUY THE LOGIC OF THE CDC YOU CAN NEVER DETERMINE THAT A VACCINE IS NOT EFFECTIVEbullVACCINES ARE MEANT TO PREVENT INFECTIONS NO MATTER THE SOURCE THE PRECEDING DATA SHOWS THAT THE WHOOPING COUGH VACCINE DOES NOT WORK EFFECTIVELY AT BESTbullHOW DO OTHER VACCINES COMPARE WITH REGARDS TO PREVENTION OF INFECTIOUS DISEASESbullDOES DATA REALLY EXIST TO SHOW GOOD EFFICACY FOR ANY COMMERCIAL VACCINE
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
This graph shows a magnified view of the devastation caused by tuberculosis and influenza was far greater than the other infectious diseases of scarlet fever measles diphtheria whooping cough and typhoid The
graph also reveals the horrible death rate during the 1918 flu pandemic
Vaccine started What stopped the decline
FLU
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Poliomyelitis (Dominican Republic)reveals that in the period of 1980 to mid 1983--before implementation of EPI the poliomyelitis morbidity rate underwent a natural decline equivalent to 985 percent to what is practically an eradication level of only 1 per million EPI was followed by a continuing natural decline to zero however the incidence of poliomyelitis then underwent a minor increase for two years and gradually returned to a zero level in 1980 UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Put simply polio rates decreased before the use of any vaccine
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Polio Myth
Polio cases rose about 300 to 400 in these 5 places that made the Salk vaccine compulsory by law
mdashNorth Carolina 78 cases in 1958 before compulsory shots 313 cases in 1959 A 401 INCREASEmdashConnecticut 45 cases in 1958 before compulsory shots 123 cases in 1959 A 273 INCREASEmdashTennessee 119 cases in 1958 before compulsory shots 386 cases in 1959 A 324 INCREASEmdashOhio 17 cases in 1958 before compulsory shots 52 cases in 1959 A 305 INCREASEmdashLos Angeles 89 cases in 1958 before compulsory shots 190 cases in 1959 A 213 INCREASE
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
1900 1920 1940 1960 1980
WW I
Highest compliance for vaccination
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
Typhoid and dysentery decreased dramatically without the presence of a vaccine to prevent them This was the result of improve hygiene
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Trends in Infectious Disease Mortality in the United States During the 20th Century Gregory L Armstrong Laura A Conn Robert W Pinner JAMA 1999281(1)61-66
The scourge of syphilis was decreased by the advent of antibiotics
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
THE FLU SEASON AND THE CDC WARNING DOES IT MAKE
SENSEEVERY FLU SEASON THE MEDIA POUNDS CITIZENS WITH THE WARNING FROM THE CDC THAT 36000 AMERICAN DIE EVERY YEAR FROM COMPLICATIONS CAUSED BY THE FLUCONSIDER 3600050 STATES = 720 DEATHSSTATE AVERAGE WHEN HAVE YOU EVER HEARD OF THIS MANY FOLKS DYING OF THE FLU THE CDC REPORT IS JUST TOTALLY INACCURATE AND MISLEADING AND IS PART OF THEIR ENTIRE ldquoPROGRAM OF FEARrdquo
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E Cochrane Database Syst Rev 2010 Jul 7(7)CD001269 Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061Abstract
BACKGROUND Different types of influenza vaccines are currently produced worldwide Healthy adults are presently targeted mainly in North AmericaOBJECTIVES Identify retrieve and assess all studies evaluating the effects of vaccines against influenza in healthy adultsSEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010 issue 2) MEDLINE (January 1966 to June 2010) and EMBASE (1990 to June 2010)SELECTION CRITERIA Randomised controlled trials (RCTs) or quasi-RCTs comparing influenza vaccines with placebo or no intervention in naturally-occurring influenza in healthy individuals aged 16 to 65 years We also included comparative studies assessing serious and rare harmsDATA COLLECTION AND ANALYSIS Two review authors independently assessed trial quality and extracted dataMAIN RESULTS We included 50 reports Forty (59 sub-studies) were clinical trials of over 70000 people Eight were comparative non-RCTs and assessed serious harms Two were reports of harms which could not be introduced in the data analysis In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation 4 of unvaccinated people versus 1 of vaccinated people developed influenza symptoms (risk difference (RD) 3 95 confidence interval (CI) 2 to 5) The corresponding figures for poor vaccine matching were 2 and 1 (RD 1 95 CI 0 to 3) These differences were not likely to be due to chance Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates Inactivated vaccines caused local harms and an estimated 16 additional cases of Guillain-Barreacute Syndrome per million vaccinations The harms evidence base is limited
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Cochrane Database Syst Rev 2010 Jul 7(7)CD001269Vaccines for preventing influenza in healthy adultsJefferson T Di Pietrantonj C Rivetti A Bawazeer GA Al-Ansary LA Ferroni E
Vaccines Field The Cochrane Collaboration Via Adige 28a Anguillara Sabazia Roma Italy 00061
AUTHORS CONCLUSIONS Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost There is no evidence that they affect complications such as pneumonia or transmissionWARNING This review includes 15 out of 36 trials funded by industry (four had no funding declaration) An earlier systematic review of 274 influenza vaccine studies published up to 2007 found industry funded studies were published in more prestigious journals and cited more than other studies independently from methodological quality and size Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies The content and conclusions of this review should be interpreted in light of this finding
PMID 20614424 [PubMed - indexed for MEDLINE]
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
As Vaccination Rates Rise Flu Deaths Little Changed p F4 Tuesday October 25 2005 Washington Post
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
REASONINGbullIT IS RATHER EASY TO FIND DATA THAT WOULD QUESTION THE INTELLIGENCE OF THE SUPPORT FOR A LARGE FLU VACCINE PROGRAMSbullIT SEEMS THE VACCINE INDUSTRY USES FEAR AND INTIMIDATION TO PUSH THE VACCINATION RATES RATHER THAN PROVIDE PROOF OF EFFICACY AND SAFETYbullFOLLOW THE MONEY TRAIL HAS THE USA PRODUCED AN INDUSTRY THAT FIGHTS FOR ITS SURVIVAL BASED ON FALSE DATAbullLATEST FROM THE CDC YOU CAN CHOOSE TO GET YOUR VACCINE USING A DRAMATICALLY SMALLER NEEDLE WALMART RITE AID AND FLEA MARKETS WILL HAVE ADEQUATE SUPPLIES
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Typhoid and Scarlet Fever vanished without vaccines but with clean water better nutrition sanitation and living conditions
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
The incidence of Pertussis (Whopping Cough) spiked after the vaccine was first introduced One of the symptoms related to the earlier vaccines was a cough that was similar to the whopping cough What many medical professionals feel is that Whopping Cough was misdiagnosed and that caused the apparent increase in this disease
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage
By Dr Raymond ObomsawinbullIf Vaccine Lymph isnt enough for anyone to see the absurdity of smallpox vaccination then the smallpox graphs give the picture in a second bullAnd the rest of the vaccine graphs paint a similar picture of the great vaccine fraud with the measles one being a special eye opener 994 reduction in death rate from 19012 (England amp Wales) to 1968 when they introduced measles vaccination bullAnd parents are sold the outrageous lie that vaccination was the only factor in its decline when it didnt in fact do anything
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
bullldquoThe four diseases (pneumonia influenza whooping cough and diphtheria) exhibit relatively smooth mortality trends which are unaffected by the medical measures even though these were introduced relatively early when the death rates were still notablerdquo bullldquoit is only for poliomyelitis that the medical measure appears to have produced any noticeable change in the trendsrdquo bullldquoClearly for tuberculosis typhoid measles and scarlet fever the medical measures considered were introduced at the point when the death rate for each of these diseases was already negligible Any change in the rates of decline which may have occurred subsequent to the interventions could only be minuterdquobullldquoMore specifically with reference to those five conditions (influenza pneumonia diphtheria whooping cough and poliomyelitis) for which the decline in mortality appears substantial after the point of intervention-and on the unlikely assumption that all of this decline is attributable to the intervention-it is estimated that at most 35 percent of the total decline in mortality since 1900 could be ascribed to medical measures introduced for the diseases consideredbullhererdquo
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Based on the official death numbers as recorded in the Official Year Books of the Commonwealth of Australia are taken from Greg Beatties excellent book Vaccination A Parents Dilemma and represent the decline in death rates from infectious disease in Australia They clearly show that vaccines had nothing to do with the decline in death rates
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
SUMMARYbullVaccines cannot take credit for the massive improvement in human survival from infectious diseases Hygiene good housing antibiotics plus dietary improvements have played the major role in decrease in infectious diseasesbullIt is very questionable that certain individual vaccines are efficaciousbullThe cost of our vaccine programs may not be cost effective and the funds could be better spent improving hygiene and dietsbullVaccine may even be responsible for the increased infant deaths in the USA compared to other modern countriesbullTo mandate citizens be vaccinated based on the existing science is unsupportable
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the US Population
Delong G J Toxicol Environ Health A 2011 Jan74(14)903-16pdf here
The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery Although individuals probably have a genetic predisposition to develop autism researchers suspect that one or more environmental triggers are also needed One of those triggers might be the battery of vaccinations that young children receive Using regression analysis and controlling for family income and ethnicity the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each US state from 2001 and 2007 was determined A positive and statistically significant relationship was found The higher the proportion of children receiving recommended vaccinations the higher was the prevalence of AUT or SLI A 1 increase in vaccination was associated with an additional 680 children having AUT or SLI Neither parental behavior nor access to care affected the results since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a US state The results suggest that although mercury has been removed from many vaccines other culprits may link vaccines to autism Further study into the relationship between vaccines and autism is warranted
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Increase over the last 15 years Children with Autism ASD age 6-21 in US Schools Source US Department of Education
CDC MANDATED VACCINE PROGRAM 1988
Thimerosal reduced vaccines available
Thimerosal preserved flu vaccine recommended by CDC for pregnant mothers and infants 6 months old
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Data and graph are from a 2001 peer reviewed paper by Jick amp Kaye The dates of changes to the vaccine schedule superimposed - Sources stated on them - British Medical Journal Source Clifford G Miller
DTP AND HIB VACCINES CONTAINED THIMEROSAL
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
AUTISM AND THE RATE OF ASD IN EIGHT YEAR OLDS FROM 1992 1994 AND 1996 AND RELATIONSHIP TO COMPLIANCY IN RECEIVING THE HEPATITIS-B VACCINE
VACCINE DATE YEAR EVALUATED ASD10000(ADDM) HEP-B (CDC DATA)
1992 2000 67 8 1994 2002 74 27 1996 2004 gt100 82 2000 2008
Thimerosal removed() from infant vaccines in 2003 ADDM (Autismamp Developmental Disabilities Monitoring network CDCrsquos Morbidity and Mortality Weekly Report) Hep-B introduced in 1991 with 25mcgs thimerosal Hep-B rates were from National Immunization Survey
FACTSbullThere is no CDC data on the autism rate after thimerosal removalbullHepatitis B vaccine to newborn baby boys more than triples the risk of ASD Annals of EpidemiologybullInfant male primates who received one dose of the Hepatitis-B were far more likely to display developmental delays than unvaccinated controls NeurotoxicologybullBoys getting the 3-shot HepB vaccine series were eight times more likely to require early intervention services than boys who did not have the series Toxicological and Environmental ChemistrybullChildren who received the Hepatitis B vaccine series were 50 to 74 more likely to develop central nervous system inflammatory demyelination than children who did not receive the vaccine depending on the vaccine manufacturer Neurology
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
SPECIAL REPORT AUTISM AND VACCINES AROUND THE WORLDVaccine Schedules Autism Rates and Under 5 MortalityGeneration Rescue Inc April 2009
The United States has the highest number of mandated vaccines for children under 5 in the world (36 double the Western world average of 18) the highest autism rate in the world (1 in 150 children 10 times or more the rate of some other Western countries) but only places 34th in the world for its children under 5 mortality rate Whatrsquos going on
Context There is an intense debate over the correlation between rising autism prevalence and the United States vaccine schedule The vaccine schedule for children aged 5 and under has nearly tripled in 25 years In 1983 the Centers for Disease Control recommended 10 vaccines for this age group Today the recommendation is 36 vaccines Calls by advocacy organizations for a ldquosafer and leaner vaccine schedulerdquo have been dismissed with health authorities implying that mortality rates from childhood diseases would materially increase Objective To compare vaccine schedules autism rates and under 5 mortality rates of the United States to other countries to see if any differences emerge Design A full publication and literature review was completed to determine vaccine schedules and under 5 mortality rates for 30 countries including the United States The 29 other countries all had lower (better) under 5 mortality rates than the US Additionally autism rates were compared for certain countries with reliable published autism prevalence data Results The United States mandates the most vaccines in the Western world (36) double the average of the 30 countries studied (18) All countries with lower vaccine mandates have better under 5 mortality rates and many have materially
lower autism rates Conclusions The analysis lends credibility to the relationship between vaccines and autism and challenges the public view of both the Centers for Disease Control and American Academy of Pediatrics that more vaccines is always positive for public health
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Mitochondrial dysfunction in Autism Spectrum Disorders cause or effectPalmieri L Persico AM Laboratory of Biochemistry and Molecular Biology Department of Pharmaco-Biology University of Bari Via Orabona 4 70125 Bari Italy Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics Bari ItalyBiochim Biophys Acta 2010 May 1 [Epub ahead of print]httpwwwncbinlmnihgovpubmed20441769
Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language communication and social skills as well as by repetitive and stereotypic patterns of behaviour Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction such as (a) elevated lactate pyruvate and alanine levels in blood urine andor cerebrospinal fluid (b) serum carnitine deficiency andor (c) enhanced oxidative stress These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder In some patients these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA However in the majority of cases abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca2+) signalling
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells a major role of mitochondrial pathwayMakani S Gollapudi S Yel L Chiplunkar S Gupta S Genes Immun 2002 Aug3(5)270-8Cellular and Molecular Immunology Laboratories Division of Basic and Clinical Immunology University of California Irvine 92697 USA
AbstractThe major source of thimerosal (ethyl mercury thiosalicylate) exposure is childhood vaccines It is believed that the children are exposed to significant accumulative dosage of thimerosal during the first 2 years of life via immunization Because of health-related concerns for exposure to mercury we examined the effects of thimerosal on the biochemical and molecular steps of mitochondrial pathway of apoptosis in Jurkat T cells Thimerosal and not thiosalcylic acid (non-mercury component of thimerosal) in a concentration-dependent manner induced apoptosis in T cells as determined by TUNEL and propidium iodide assays suggesting a role of mercury in T cell apoptosis Apoptosis was associated with depolarization of mitochondrial membrane release of cytochrome c and apoptosis inducing factor (AIF) from the mitochondria and activation of caspase-9 and caspase-3 but not of caspase-8 In addition thimerosal in a concentration-dependent manner inhibited the expression of XIAP cIAP-1 but did not influence cIAP-2 expression Furthermore thimerosal enhanced intracellular reactive oxygen species and reduced intracellular glutathione (GSH) Finally exogenous glutathione protected T cells from thimerosal-induced apoptosis by upregulation of XIAP and cIAP1 and by inhibiting activation of both caspase-9 and caspase-3 These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSHPMID 12140745 [PubMed - indexed for MEDLINE]
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaYel L Brown LE Su K Gollapudi S Gupta S Int J Mol Med 2005 Dec16(6)971-7
Department of Medicine University of California Irvine CA 92697 USA lyelucieduAbstractThere is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative In this study we show that thimerosal at nanomolar concentrations induces neuronal cell death through the mitochondrial pathway Thimerosal in a concentration- and time-dependent manner decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane generation of reactive oxygen species and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol Although thimerosal did not affect cellular expression of Bax at the protein level we observed translocation of Bax from cytosol to mitochondria Finally caspase-9 and caspase-3 were activated in the absence of caspase-8 activation Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironmentPMID 16273274 [PubMed - indexed for MEDLINE]
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)Humphrey ML Cole MP Pendergrass JC Kiningham KK Neurotoxicology 2005 Jun26(3)407-16Department of Pharmacology Joan C Edwards School of Medicine Marshall University Huntington WV 25704-9388 USAAbstractEnvironmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune renal and neurological function Recently the safety of thimerosal an ethyl mercury-containing preservative used in vaccines has been questioned due to exposure of infants during immunization Mercurials have been reported to cause apoptosis in cultured neurons however the signaling pathways resulting in cell death have not been well characterized Therefore the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity and more specifically to elucidate signaling pathways which might serve as pharmacological targets Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line SK-N-SH morphological changes including membrane alterations and cell shrinkage were observed Cell viability assessed by measurement of lactate dehydrogenase (LDH) activity in the medium as well as the 3-[45-dimethylthiazol-2-yl]-25-diphenyltetrazolium bromide (MTT) assay showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure In cells treated for 24 h with thimerosal fluorescence microscopy indicated cells undergoing both apoptosis and oncosisnecrosis To identify the apoptotic pathway associated with thimerosal-mediated cell death we first evaluated the mitochondrial cascade as both inorganic and organic mercurials have been reported to accumulate in the organelle Cytochrome c was shown to leak from the mitochondria followed by caspase 9 cleavage within 8 h of treatment In addition poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISMCM Gallagher MS Goodman Graduate Program in Public Health Stony Brook University Medical Center Stony Brook NY Annals of Epidemiology Vol 19 No 9 ABSTRACTS (ACE) September 2009 651ndash680 p 659 P24
PURPOSE Universal newborn immunization with hepatitis B vaccine was recommended in 1991 however safety findings are mixed The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events Other studies found positive associations between hepatitis B vaccination and ear infection pharyngitis and chronic arthritis as well as receipt of early intervention special education services (EIS) in probability samples of US children Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD METHODS This cross-sectional study used US probability samples obtained from National Health Interview Survey 1997ndash2002 datasets Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASD risk among boys age 3ndash17 years with shot records adjusted for race maternal education and two-parent household RESULTS Boys who received the hepatitis B vaccine during the first month of life had 294 greater odds for ASD (Nz31 of 7486 OR Z 294 p Z 003 95 CI Z 110 790) compared to later- or unvaccinated boys Non-Hispanic white boys were 61 less likely to have ASD (ORZ039 pZ004 95 CIZ016 094) relative to non-white boysCONCLUSION Findings suggest that US male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD risk was greatest for non-white boys
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Enhanced toxicity for mice of pertussis vaccines when preserved with Merthiolate (aka thimerosal)
Nelson EA Gottshall RY Appl Microbiol 1967 May15(3)590-3
Pertussis vaccines preserved with 001 Merthiolate (thimerosal) are more toxic for mice than unpreserved vaccines prepared from the same parent concentrate and containing the same number of organisms The toxicities of both Merthiolate (001)-preserved and unpreserved vaccines increased when the number of organisms injected was increased An increase in mortality was observed when Merthiolate (thimerosal) was injected separately before or after an unpreserved saline suspension of pertussis vaccinePMID 6035051 [PubMed - indexed for MEDLINE]
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
THE ENDbullI AM NOT ANTI-VACCINE I AM VERY PRO-VACCINES THAT ARE PROVEN TO WORK ON HUMANSbullI AM AGAINST MANDATING VACCINES THAT HAVE NOT BEEN SHOWN TO BE SAFE AND EFFICACIOUSbullI AM AGAINST THE USE OF VACCINES THAT HAVE BEEN STUDIED AND SHOWN NOT TO BE EFFECTIVEbullYOU CANNOT HAVE A SINGLE AGENCY BE IN CHARGE OF BOTH COMPLIANCE AND SAFETY AND HAVE A QUALITY VACCINE PROGRAMbullI FEEL A CONGRESSIONAL COMMITTEE SHOULD BE FORMED TO INVESTIGATE CDC-VACCINE INDUSTRY RELATIONSHIPS
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Measles (England amp Wales)shows that in England and Wales the annual death rate of children (under age 15) from measles declined from over 1100 per million in the mid-nineteenth century to a level of virtually 0 by the mid 1960s UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Measles vaccine 1968
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
The Questionable Contribution of Medical Measures to the Decline of Mortality in the United States in the Twentieth Century John B McKinlay Sonja M McKinlay The Milbank Memorial Fund Quarterly Health and Society Vol 55 No 3 (Summer 1977) pp405-428
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
DECLINE IN DEATH RATES FROM INFECTIOUS DISEASE---AUSTRALIAtaken from Greg Beatties excellent book Vaccination A Parents Dilemma
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
DATA FROM THE USA Data amp graphs supplied by Roman Bystrianyk
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Slide 20
- Slide 21
- Slide 22
- ANOTHER PERSPECTIVE
- Slide 24
- Slide 25
- Slide 26
- Slide 27
- Slide 28
- Slide 29
- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- REASONING
- Slide 36
- Slide 37
- Slide 38
- Slide 39
- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
- Slide 41
- Slide 42
- Slide 43
- Slide 44
- Slide 45
- Slide 46
- Slide 47
- SUMMARY
- Slide 49
- Slide 50
- Slide 51
- Slide 52
- Slide 53
- Slide 54
- Slide 55
- Slide 56
- Slide 57
- Slide 58
- Slide 59
- THE END
- Slide 61
- Slide 62
- Slide 63
- Slide 64
- Slide 65
- Slide 66
- Slide 67
- Slide 68
- Slide 69
- Slide 70
- Slide 71
- Slide 72
- Slide 73
- Slide 74
- Slide 75
- Slide 76
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood
Yann Mikaeloff MD PhD Guillaume Caridade MSc Samy Suissa PhD and Marc Tardieu MD PhD NEUROLOGY 200972873-880
Background The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated with studies reporting conflicting findings
Methods We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994ndash2003) Each case was matched on age sex and geographic location to up to 12 controls randomly selected from the general population Information on vaccinations was confirmed by a copy of the vaccination
certificate The odds ratios (ORs) of CNS inflammatory demyelination associated with HB vaccination were estimated using conditional logistic regression
Results The rates of HB vaccination in the 3 years before the index date were 244 for the 349 cases and 273 for their 2941 matched controls HB vaccination within this period was not associated with an increase in the rate of CNS inflammatory demyelination (adjusted OR 074 054ndash102) neither gt3 years nor as a function of the number of injections or brand type When the analysis was restricted to subjects compliant with vaccination HB vaccine exposure gt3 years before index date was associated with an increased trend (150 093ndash243) essentially from the Engerix B vaccine (174 103ndash295) The OR was particularly elevated for this brand in patients with confirmed multiple sclerosis (277 123ndash624)
Conclusions Hepatitis B vaccination does not generally increase the risk of CNS inflammatory demyelination in childhood However the Engerix B vaccine appears to increase this risk particularly for confirmed multiple sclerosis in the longer term Our results require confirmation in future studies
ADEM = acute disseminated encephalomyelitis BCG = Bacille CalmettendashGuegraverin HB = hepatitis B MS = multiple sclerosis OR = odds ratio
- ARE VACCINES SAFE AND EFFECTIVE
- Slide 2
- CDC Recommended Immunization Schedule for Persons Aged 0 Through 6 YearsmdashUnited States bull 2011
- Important Observations
- USA Lags on Child Mortality Figures Show---by Noam N Levey Chicago Tribune May 23 2010
- CONSIDERATIONS
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- The Effects of a High Infant Death Rate
- WHAT DOES HISTORY IMPLY ABOUT THE CONTRIBUTION OF VACCINE TO THE ERRADICATION OF INFECTIOUS DISEASES
- Slide 13
- Slide 14
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- ANOTHER PERSPECTIVE
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- THE FLU SEASON AND THE CDC WARNING DOES IT MAKE SENSE
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- REASONING
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- UNIVERSAL IMMUNIZATION Medical Miracle or Masterful Mirage By Dr Raymond Obomsawin
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- SUMMARY
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- THE END
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