Anxiety and PTSD - MCFP · —Major depression1-4 —Panic disorder1-3 —Social phobia1 —Specific phobia1 —Post-traumatic stress disorder2 —Chronic pain conditions4 —Chronic
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Anxiety and PTSD
Dr. Joseph Polimeni
Psychiatrist
University of Manitoba
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Disclosure: Joseph Polimeni
Financial Interest or Affiliation Commercial Enterprise(s)
Ownership or partnership
Employment
Investments (mutual funds excluded)
Advisory board or similar committee
Clinical trials or studies
Honoraria or other fees (e.g., travel support)
Research grants
Patents
Other (specify) Speaker’s Bureau
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Learning Objectives
At the end of this symposium the learner will be able to:
• List the main pharmacotherapeutic and psychotherapeutic treatment
options for Panic Disorder/Agoraphobia.
• List the main pharmacotherapeutic and psychotherapeutic treatment
options for Generalized Anxiety Disorder.
• List the main pharmacotherapeutic and psychotherapeutic treatment
options for Social Anxiety Disorder.
• List the main pharmacotherapeutic and psychotherapeutic treatment
options for PTSD.
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Forward, Stop, Backwards
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It is better to run away 100 times than be eaten once
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Mismatch Theory Radiation, Divorce, Unemployment
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Anxious Emotions Alert to Danger (They are only a warning light and not the actual danger)
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- Suffering is evolutionarily adaptive- Environmental Mismatch-Genetic variation-Disease
Depression and anxiety are mostly due to threats to social standing (and attachments)
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Threats to Social Standing (as well as attachments and our reputation as cooperators) were very dangerous in the ancestral environment.
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Anxiety Disorders
• Physical Threats
6. Generalized Anxiety Disorder (GAD)
• Social Threats
• Hierarchal status
• Attachments
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Emotions
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• Love, comradery, sexual attraction, mirth and laughter,
happiness, anger, jealousy, revenge, dysphoria,
sadness, anxiety, fear, boredom, adoration, pride,
spirituality.
• Emotions place the organism in a state that makes
certain evolutionarily desirable behaviors more probable.
• Emotions reflect a complex stimulus-response paradigm
• All emotions are irrational (because they are unthinking
reflexes)
• Frontal cortex modulates the intensity of emotions
Why drugs and talk therapy compliment each other
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Anxiety presents in a few common ways
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• Depression is contending with loss
• Anxiety is contending with threat of loss
• Life is complicated and therefore we are often dealing with stresses
with both elements.
• Brains are complicated and therefore anxiety (or depression) can
manifest in different ways.
• Normal anxiety,
• GAD
• Panic Disorder (agoraphobia)
• Social Anxiety Disorder (Social phobia)
• PTSD
Causes of Depression and Anxiety
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• Hierarchal status (job loss, flunking exams)
• Attachments (divorce, break-up)
• Physical threats
• Genetic variation (Bipolar II Disorder)
• Early childhood trauma (borderline personality disorder)
• Disease (hypothyroidism, hyperthyroidism)
Panic Disorder (Agoraphobia alone is uncommon)
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TABLE 1. DSM-IV criteria for panic attackA discrete period of intense fear or discomfort, in which four (or more) of the following symptoms developed abruptly and reached a peak within 10 min
1. Palpitations, pounding heart, or accelerated heart rate 2. Sweating3. Trembling or shaking4. Sensations of shortness of breath or smothering5. Feeling of choking6. Chest pain or discomfort7. Nausea or abdominal distress8. Feeling dizzy, unsteady, lightheaded, or faint9. Derealization (feelings of unreality) or depersonalization (beingdetached from oneself)10. Fear of losing control or going crazy11. Fear of dying12. Paresthesias (numbness or tingling sensations) 13. Chills or hot flushes
Social Anxiety Disorder
• Marked fear or anxiety about one or more social situations in which the individual is exposed to possible scrutiny by others. Examples include social interactions (e.g., having a conversation), being observed (e.g., eating or drinking), or performing in front of others (e.g., giving a speech).
• The individual fears that he or she will act in a way or show anxiety symptoms that will be negatively evaluated (e.g., be humiliated, embarrassed, or rejected) or will offend others.
• The social situation(s) almost always provoke fear or anxiety. (Note: in children, the fear or anxiety may be expressed by crying, tantrums, freezing, clinging, shrinking, or failure to speak in social situations.)
• The social situation(s) are actively avoided or endured with marked fear or anxiety.
• The fear or anxiety is out of proportion to the actual threat posed by the social situation. (Note: “Out of proportion” refers to the sociocultural context.)
• The fear, anxiety, or avoidance is persistent, typically lasting six or more months
• The fear, anxiety, and avoidance cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
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Generalized Anxiety Disorder – core symptoms
• Uncontrollable and excessive worry about day-to-day matters such as finances, family, work, or health
• Worry about the impact of worrying • i.e. they may be concerned that worry will damage their health or they may
think that negative things will occur if they do not worry enough.
• These individuals report more worry about the future than patients with other anxiety problems
• GAD worry is chronic, exaggerated and impairs functioning
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Generalized Anxiety Disorder (GAD): DSM-5 Diagnostic Criteria• Excessive anxiety and worry present most of the time for > 6
months
• Difficult to control worry
• Associated with (at least 3 items – adults; 1 item - children):• Restlessness • Being easily fatigued • Concentration difficulties• Irritability• Muscle tension• Sleep disturbance
• Anxiety, worry or physical symptoms cause clincially significant distress or functional impairment
• Not due to medication or substance or medical condition
• Disturbance not better explained another mental disorder
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Generalized Anxiety Disorder (GAD)
• Prevalence:• 1-year: 1%-4%
• Lifetime: approx. 6%
• Children: 3%
• Adolescents: 10.8%
• More frequent in Caucasians,
elderly, and women
(2-3x more likely)
• Age of onset: variable and may
be bimodal:• Children and adolescents: ages
10-14
• Adults: 31 (median), 32.7 (mean)
• Substantial economic costs
6. Generalized Anxiety Disorder (GAD)
• Frequently under-recognized
• <1/3 of patients adequately
treated
• Diagnosis and treatment in
children complicated by
previous designation of
Overanxious Disorder of
Childhood and its possible
differentiation of childhood
GAD from GAD in adults
• Painful physical symptoms in
60%-94% of patients (initial
reason for presentation to
physician in 72% of cases)
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Most Patients with GAD do NOT Present with Anxiety as the Primary Complaint
Only 13% had anxiety as primary complaint
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Actual Presentation May not be Worry
• Physical symptoms can be the main avenue through which GAD patients express their distress (known as somatization)
• Common presenting physical complaints include:- Insomnia- Muscle tension, trembling, twitching, aching, soreness- Cold, clammy hands- Dry mouth- Sweating- Nausea or diarrhoea- Urinary frequency- Tachycardia, palpitations- Dizziness, light-headedness- Breathing difficulties- Numbness, tingling- Hot or cold flushes
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GAD: A Common Comorbid Condition
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— Major depression1-4
— Panic disorder1-3
— Social phobia1
— Specific phobia1
— Post-traumatic stress disorder2
— Chronic pain conditions4
— Chronic fatigue syndrome2
— Gastrointestinal disease5
— Irritable bowel syndrome2,5
— Hypertension2
— Heart disease2
• GAD is one of the most common conditions that occurs
comorbidly with other disorders
– 91% of patients with GAD have ≥1 additional diagnosis1
• GAD occurs comorbidly with many medical and psychiatric
conditions, including:
• Comorbid psychiatric disorders are related to a poorer prognosis
Work Impairment in GAD and Other Chronic Conditions
Days Work Impairment in Past Month
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GAD Course of Illness
• Chronic • Waxing and waning of symptoms1
• Low rates of remission over long term1,2
• Intermittent exacerbations • Exaggerated response to stress1,3
• Symptom overlap with medical and psychiatric disorders3
• Many are undiagnosed4
• Episodes may be more persistent with age5
• Duration: Mean 6.5 – 10.4 yrs (ECA)
• Poorer outcomes in patients with psychiatric comorbidities6
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GAD-7: Generalized Anxiety Disorder 7-item Scale
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Main Points of Treating GAD
1. Treat based on comorbidity
2. SSRI’s/SNRIs are first line
3. Benzodiazepines are not evil
4. Buspirone and Pregabalin can be considered
5. Antipsychotics are not the cure for everything but have a place in treating GAD
6. In cases of treatment resistance, carefully review the diagnosis
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Medications approved by Health Canada for GAD
• Venlafaxine
• Paroxetine
• E-citalopram
• Duloxetine
• Buspirone
• Note: Benzodiazepines have been approved for
treatment of anxiety disorders not specifically GAD
• All other Meds are Off-label use in the treatment of GAD
27Katzman et al. BMC Psychiatry 2014
Katzman et al. Canadian Clinical Practice Guidelines for Anxiety…. BMC Psychiatry 2014
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SSRI’s/SNRIs Are First Line
• Ecitalopram, Venlafaxine have strong evidence in
treating GAD• Gelenberg JAMA 2000 – 6month RCT with Venlalfaxine
• Lenze JAMA 2009- 12-week RCT in older adults with ecitalopram
• But, pick your favorite based on patient’s side effect
profile.
• Start low, go slow, aim high.
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Can J Psychiatry 2009
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Antidepressants vs. Benzodiazepines in Treating GAD
• Berney et al 2008 reviewed the literature and found that
there were 22 RCTs comparing ADs to BZDs.
• None of them showed superiority of ADs over BZDs in
the treatment of GAD. They concluded that there has
been a shift in prescribing ADs instead of BZDs for GAD
without any evidence to support this shift.
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Risk of Fractures Not Just With Benzodiazepines
1. Bolton JM, Metge C, Lix L, et al. Fracture risk from psychotropic medications: a population-based analysis. J Clin Psychopharmacol. 2008;28(4):384 –391.
2. Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169(21):1952–1960.
3. Wagner AK, Ross-Degnan D, Gurwitz JH, et al. Effect of New York State regulatory action on benzodiazepine prescribing and hip fracture rates. Ann Intern Med. 2007;146(2):96 –103.
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Antipsychotics Are Not the Cure for Everything, But Have a Place
• Atypical Antipsychotics- may have utility in people
• GAD + Bipolar disorder
• GAD + borderline personality disorder
• Zahreddenni et al. Current Clinical Pharmacotherapy Opinion 2013
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Generalized Anxiety DisorderOverview of Psychological Strategies
• CBT (preventing worry behaviors, problem solving,
allaying guilt and anger, imagery exposure,
psycheducation)
• Mindfulness-based strategies (meditation, acceptance of
emotions, focus on here and now, Buddhist principles )
• Relaxation Therapies (progressive muscle relaxation)
• Psychodynamic psychotherapy
• Motivational Interviewing
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CBT vs. Medication for GAD
• Only three controlled studies were found that examined
the relative and combined effects of CBT vs. medication
(buspirone, diazepam, venlafaxine), with mixed results
• In a recent meta-analysis, CBT plus medication was
generally more effective than CBT plus placebo at
posttreatment, but not at follow-up for the treatment of
GAD (Hofmann et al., 2009)
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PTSD – Haunted by an Experience
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Which criterion of DSM-IV ACUTE stress Disorder and PTSD was removed in DSM-5?
• A. Persistent avoidance of places that remind the
person of the traumatic event.
• B. The person's response involved intense fear,
helplessness, or horror.
• C. Persistent symptoms of increased arousal (not
present before the trauma).
• D. Persistent re-experiencing of the trauma (e.g.,
nightmares, intrusive thoughts)
PTSD Criteria (DSM-5)
• A. Exposure to actual or threatened a) death, b) serious injury, or c)
sexual violation, in one or more of the following ways:
• 1. directly experiencing the traumatic event(s)
• 2. witnessing, in person, the traumatic event(s) as they occurred
to others
• 3. learning that the traumatic event(s) occurred to a close family
member or close friend; cases of actual or threatened death must
have been violent or accidental
• 4. experiencing repeated or extreme exposure to aversive details
of the traumatic event(s) (e.g., first responders collecting human
remains; police officers repeatedly exposed to details of child
abuse); this does not apply to exposure through electronic
media, television, movies, or pictures, unless this exposure is
work-related.
American Psychiatric Association, DSM-5
PTSD core symptoms
• Re-experiencing the trauma – “Intrusion Symptoms”
(distressing memories, flashbacks, nightmares)
• Hyperarousal (panic attacks, anxiety, poor
concentration, startle reflex, irritable, insomnia)
• Active Avoidance
• Negative mood and Cognitions (depressed mood,
emotional numbing, anger, guilt, pessimism)
• Greater than 1 month
DSM-5 Acute Stress Disorder
• PTSD Criteria
• Greater than 3 days and less than 1 month.
Prevalence of traumatic events in US General Population
Husarewycz N, El-Gabalawy R, Logsetty S, Sareen J. Gen Hosp Psych, 2014
PTSD
Pre-Trauma Factors
Female sexLow IQPrior trauma exposurePrior mental disorderPersonality factorsGenetics
Trauma FactorsPerceived fear of deathAssaultive traumaSeverity of traumaPhysical injury
Post-Trauma FactorsHigh heart rate Low Social supportFinancial stressPain severityIntensive care unit stayTraumatic brain injuryPeritraumatic dissociationAcute stress disorderDisability
Sareen J. Can J Psychiatry 2014Sareen et al. Depression and Anxiety 2013Bryant et al. JAMAPsychiatry 2013Brewin et. Al JCCP 2000
DSM-IV PTSD Prevalence
• Canadian general Population• Lifetime 9.2%
• US general population• Lifetime 6.8% (se 0.4) in NCS-R
• Female:Male ~ 2:1
• Prevalence higher in some US subpopulations• 2 to 3X in American Indians on reservations2
• Most prevalent disorder in women is PTSD (~20%)
• Cambodian refugees in US, 20 years later3
• 12-month prevalence 62%
• Combat veterans 30-50%
Van Ameringen et al. 2003 NCS-R, National Comorbidity Survey Replication; 1Kessler RC et al. Arch Gen Psychiatry. 2005;62:617-627; 2Beals J et al. Arch Gen Psychiatry. 2005;62:99-108; 3Marshall G et al. JAMA. 2005:294:571-579.
Prevention and Treatment
• 1. Pharmacological interventions in the acute stage of
injury have not shown efficacy in reducing PTSD (but
being drunk during the trauma helps!).
• 2. Group based Critical Incident Stress Debriefing does
not have evidence of reducing PTSD.
• 3. Cognitive-behavioral therapy (CBT), and Exposure
therapy (systematic desensitization) are more efficacious
than citalopram or waiting list in preventing PTSD
(however, access for CBT is difficult).
• 4. Treatment approach for a person with PTSD
should consider comorbidity
• 5. EMDR - Eye Movement Desensitization
Reprocessing
• “What is effective in EMDR is not new, and what
is new is not effective”
• 6. SSRIs and SNRIs are the first line treatment.
• 7. Management of insomnia is crucial with
zopiclone, trazodone, quetiapine, prazosin.
(minimize benzodiazepines)
Questions
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