Antidepressant activity of moringa oleifera flower extract in

ANTIDEPRESSANT ACTIVITY OF MORINGA OLEIFERA

FLOWER EXTRACT

BY SREEREMYA.SM.phil

INTRODUCTION Depression is a widespread psychiatric disorder that effect several millions of the world population.

Recognized to be symptomatically, psychologically & biologically heterogeneous .

The disorder is characterized by change in mood, lack of interest in the surroundings, lack of motivation, feelings of gloominess,retardation of thinking and activity , sense of hopelessness , lack of physical energy and despair and suicidal ideation etc……..

Major depressive disorder is a disability condition that adversely affects a person’s family , work or school life , sleeping & eating habit& general health.

CONTI…………The major causes are decrease in the neurotransmitter level

in the brain , oxidative stress and biochemical imbalance etc…….

Depression may treated with antidepressent medication , psychotherapy , self neglect ,etc………

Both synthetic drugs (imipramine & diazepam) and herbal drugs are used for antidepression treatments. in them herbal drugs are more preferable because of less side effects & wider safety margin .

Works have been done on several medicinal plants like citrus maxima

leaves , Artemisia absinthium , Passiflora foetida leaves etc……..

Moringa oleifera

Conti……… Moringa Oleifera is a highly valued medicinal

plant which is also known as “miracle tree”.

It is most widely cultivated species & it’s grown mainly in semi arid ,tropical & sub tropical areas.

Flower , root , leaves , gum , bark , fruits , seeds are also have medicinal values.

Conti……….

several researches have already done in moringa which are anti tumer , anti ulser , anti inflamatory , antiepileptic , anti bacterial , antifungal , anti hepatoprotective , cholestrol lowering , anti alzheimer’s etc……

Different part of this plant contain important minerals , vitamins ,mode of sleeping power, beta-carotene in addition to it’s compelling water purifying power & high nutritional values.

Conti…..Phytochemical assays

1 Test for total phenolic content2 Test for flavonoid content3 Alkaloids4 Tannins5 Resin6 Carbohydrate 7 Steroids & steroid8 Saponin9 Terpanoid10 Glycoside .

Conti…..

Anti oxidant studies

1, DPPH radical –scavinging activity

2, FRAP(Ferric radical scavenging activity)

3, SO2 (Super oxide scavinging activity)

4, nitric oxide scavinging activity

Conti…….

Behavioral test

Tail suspention test

Forced swimming test

Open field test

Conti…..Evaluate the neurotransmitter level

in mice brain

Noradrenaline level

Serotonin level

WORKDONEPrepared extractThe powderd sample was extracted using soxhlet method in ethanol .

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