1. Basic Concepts of molecular cell biology - KOCWcontents.kocw.net › KOCW › document › 2011 › konkuk › LeeHoonTae… · 2016-09-09 · Basic Concepts of Molecular Cell

1. Basic Concepts of molecular cell biology

2. How to study molecular cell biology

3. Terminology explanation

지난 시간 학습 내용

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1. 生(living)의 의미

2. Basic mechanism of living phenomena

3. Ecological hierachy

4. Cell Theory

학습 개요

生(living)의 의미

1) Production of energy from metabolism

2) Motility

3) Respiration

4) Irritability

5) Synthesis of macromolecules

6) Reproduction

Am I living??

Basic mechanism of living phenomena

1) Energy transduction (轉移) : food - digestion

2) Information transduction :

Genetic information (DNA, RNA)

3) Signal transduction : Nerve, hormone, other stimulations

Ecological hierachy

Population

Organism

System

Organs

Tissues

Cells

Organelles

molecules

Atom

Non-

living

living

SI (system international) unit

Cell Theory (1983, Schuman)

1) All living organisms are made up of one or more living

cell(s)

2) Each cell maintain its living properties independently

but organism life is based on each cell properties.

3) The smallest clearly defined unit of life is the cell.

4) Cells arise only from other cells.

1665 (Hooke) Cell of plant tissue

1838 (Mulder) Protein = key components of living matter

1865 (Mendel) Rules of heredity

1875 (Hertwig) embryo (2n) from 2 nuclei of egg (n) & sperm (n)

1926 (Morgan) chromosome map

1941 (Beadle & Tatum) gene control protein

History of molecular cell biology

1943 (Avery) DNA = genetic material

1953 (Watson & Crick) double-helical structure of DNA

1982 (Brinster, Palmiter) production of supermouse with hGH

1996 (Wilmut) Cloned sheep (Dolly)

2000 (Thomson) Human embryonic stem cell

2007 (Yamanaka) Induced pluripotent stem cells (iPS cells)

2010 (Han & Scholer) Direct reprogrammed stem cells

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