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Thyroid Gland by Dr Roomi

Apr 06, 2018

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    HISTOLOGYOF

    THYROID AND PARATHYROID GLANDS

    BY

    DR. MUDASSAR ALI ROOMI (MBBS, M. Phil.)

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    THYROID GLAND

    LOCATED IN THE LOWER PART OF NECK

    BILOBED STRUCTURE

    CONNECTED BY ISTHMUS

    A HIGHLY VASCULAR GLAND

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    CLINICAL PROBLEMS OF THYROID

    HYPOTHYROIDISM HYPERTHYROIDISM

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    THYROID AND PARATHYROID GLANDS

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    THYROID GLAND

    Components:

    1. True Capsule

    2. C.T. Stroma

    3. parenchyma

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    TrueCapsule: Narrow layer of dense

    connective tissue

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    HISTOLOGY OF THYROID GLAND

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    Parenchymaofthyroid

    made by the thyroid follicles andpara-follicular cells.

    Folliclesare round, oval, or

    irregular in outline, completelyclosed (diameter= 0.02-0.9 mm)

    Simple cuboidal epithelium with ahollow centers containing colloid.

    Epithelium may become simplesquamous (inactive state) or simplecolumnar (hyperactivity state).

    Thin basement membrane ispresent around the follicles. It issurrounded by fenestratedcapilaries.

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    HISTOLOGY OF THYROID GLAND

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    Colloid

    gel like, clear material.

    It is glycoprotein in nature

    (iodinated thyroglobulin).

    stored secretion, 10months supply!

    effect of processing of

    tissue on colloid= it is

    coagulated and mayshows irregularities under

    microscope.

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    Parafollicular cellsor C (Clear) Cells

    Present as singly or as small isolated clusters of cells outsideof follicles.

    Cells are larger than follicular cells.

    Pale staining cells(secrete Calcitonin)

    PTH antagonist (lowers Ca level), blocks osteoclast activity

    C-cells act independent of pituitary gland hormones, instead

    depend on plasma calcium level.

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