THE KREB’S CYCLE What Goes Around Comes Around

THE KREB’S CYCLE What Goes Around Comes Around

The Krebs Cycle What Goes Around Comes Around

Part 1: Preparation of Pyruvate

Pyruvate (3C)Acetyl – Coenzyme A

Mitochondria

Cytosol Mitochondria Outer Membrane

CO2

H

NAD+ NADH

Coenzyme A

(2C)

Acetic Acid

Transport Protein

Acetyl CoA (2C)

Oxaloacetate (4C)

CoEnzyme A

Citrate (6C)

H2O

Isocitrate (6C)

CO2

NAD+

NADH

a-Ketoglutarate (5C)

CoEnzyme A

CO2NAD+

NAD+

NADH

NADHSuccinyl- CoA

(4C)

CoEnzyme A

GTP GDP

ADPATP

FAD+FADH

H2O

Succinate

(4C)

Fumarate

(4C)

Malate

(4C)

Part 2: Kreb’s Cycle

09-12-KrebsCycle.mov

TOTALSATP =

NADH =

FADH =

CO2 =

1 X 2 = 2

4 X 2 = 8

THE KREB’S CYCLE

1 X 2 = 2

3 X 2 = 6Kreb’s Cycle Song

Slide 2

CHORUS

The Krebs Cycle

Acetyl CoA combines with oxaloacetic acidTo create a citric acid. That's how it begins.Then a water removed and added makes it isocitric acid,Which, in turn, oxidized and loses CO2.Then alpha-ketoglutaric is oxidized again,Losing carbon dioxide with an NADH spin.Then through a phosphorylationSuccinyl CoA congeals a GDP to GTP to toss back CoASH.

CHORUS:Acetyl CoA, citric acid, iso-,Alpha-ketoglutaric, succinyl CoA,Succeeded by succinic, fumaric and malic,Then oxaloacetic starts the cycle again.

Soon we see succinic acid forming a fumaric acidAs it forms an FADH2 along the way.Water washed upon fumaric makes it into acid malic.Now there's only one step left, so let's be on our way.With one more oxidation, resisting degradation,A final NADH is made and brings us to the end.Oxaloacetic acid, first and last, a simple acidThen accepts an acetyl CoA and starts again.

melody and lyrics by Lynda Jones; adapted by Do Peterson and Greg CrowtheGreg: geek vocals, keyboard Lori: lead vocals Kirk L. Van Scoyoc: banjoDo: bass, hyper-dramatic vocals, keyboard, acoustic and electric guitar, drum