The Age of Things: Sticks, Stones and the Universe Potassium, Argon, DNA and Walking Upright mmhedman/compton1.html.

The Age of Things:Sticks, Stones and the Universe

Potassium, Argon, DNA and Walking Uprighthttp://cfcp.uchicago.edu/~mmhedman/compton1.html

Proconsul

Sivapithecus

Australopithecus

Proconsul

WARNING!Astrophysicist talking

about Paleoanthropology

Proconsul

Sivapithecus

Australopithecus

Australopithecus afarensis

Australopithecus africanus

Paranthropus robustus

Paranthropus bosei

Homo habilis

Homo erectus

Homo sapiens

Hominids0

1 mya

2 mya

3 mya

4 mya

(mya = millions of years ago)

All these hominids could walk on two legs

Australopitchecus afarensis

Recent hominid finds

Sahelanthropustchadensis

Orrorin tugenensis

Age of the fossils Time when hominids first became bipedal

Based on Geological Data Based on Molecular Data

Carbon 14 Nitrogen 14

electron

neutrino

Potassium 40 Calcium 40

electron

neutrino

Potassium-Argon Dating Proton Neutron

Potassium 40 Argon 40

electron neutrino

Potassium 40 Calcium 40

electron

neutrino

Potassium-40 has two ways it can decay

90%

10%

R

R=Current amount of Potassium-40

Original amount of Potassium-40

Half-Life of Potassium-40 is1.25 billion years

Potassium-40

Argon-40

Calcium-40

Potassium-40 decay in molten rock

Potassium-40

Argon-40

Calcium-40

Potassium-40 decay in solid rock

Potassium-40 Calcium-40

The Rock Today

Argon-40

Potassium-40 Argon-40 Calcium-40

Potassium 40 Calcium-40

The Original Rock

The Rock Today

The East African Rift System

Red Circles=EarthquakesGreen triangles=Volcanoes

2.5 Million Years Ago

3 Million Years Ago

Ardipithecus ramidus

Ardipithecus ramidus

Recent hominid finds

Sahelanthropustchadensis

Orrorin tugenensis

Age of the fossils Time when hominids first became bipedal

Based on Geological Data Based on Molecular Data

Molecular Dating Methods

C C C A A G A G T T C C C A A G A G T T

WARNING!Astrophysicist talking

about Molecular Biology

Molecular Dating Methods

C C C A A G A G T T C C C A A G A G T T

Mutations in DNA

CCCAAGAGTTCACTTCCAAGAGTT

CCCATGAGTTCCCAAGAGTTSubstitution

CCCAATCCCAAGAGTTDeletion

GAGT

Original CCCAAGAGTTCCCAAGAGTT

Insertion

CCCAAGCTTGACCAAGAGTTInversion

CCCAAGAGTT

CCCATGAGTT CCCAAGAGTG

TIME

The accumulation of mutations over time

CCCAAGAGTT

GCCATGAATT CCTCAGAGTG

TIME

The accumulation of mutations over time

CCCAAGAGTT

GCCATGAATT CCTCAGAGTG CACCAGAGTG

CCCCAGAGTG

Could mutations accumulate at a constant rate ?

1. Mutations occur at the same rate in all animals

2. Mutations are equally likely to be passed on in all animals

Possible, mutations are due to biochemical processes that are almost identical in different animals

Unlikely, if mutations affect physical characteristics of animal(Rate depends on environment, etc.)

True if mutations have no impact on the health or appearance of the animalNeutral or “Silent” mutations

Two conditions must be met

Identifying “useful” regions of DNA

Proconsul

Molecular Dating in Humans and Apes

TAGGATCGATATAACATAGCCGAACGAGACTATGGCTAGAGAGCATAGAC

TAGGATCGATATAAGATAGCCGATCGAGACTATGGCTAGAGAGCATAGAC

TACGATCGATATAAGATAGCCGAAGGAGACTATGGATAGAGAGCATAGAC

TAGGATCGATATAAGATAGCCGAACGAGACTATGGCTAGAGTGCATAGAC

Chimp Gorilla OrangutanHuman 1.24% 1.62% 3.08%Chimp 1.63% 3.12%Gorilla 3.09%

Human Chimp Gorilla Orangutan

Chimp Gorilla OrangutanHuman 1.24% 1.62% 3.08%Chimp 1.63% 3.12%Gorilla 3.09%

Human Chimp Gorilla Orangutan

1%

2%

3%

Human Chimp Gorilla Orangutan

1%

2%

3%

Sivapithecus

Proconsul

Calibrating the molecular clock

ProconsulSivapithecus

Human Chimp Gorilla Orangutan

1%

2%

3%

Sivapithecus

Proconsul

15

10

5

Mil

lio

ns

of

year

s ag

o

Calibrating the molecular clock

ProconsulSivapithecus

Ardipithecus ramidus

Estimated time when humans and chimps last had a common ancestor

Next Time:

Molecular Dating and the Many Kinds of Mammals