TB Alliance's presentation at World TB Day 2016 webinar

8/19/2019 TB Alliance's presentation at World TB Day 2016 webinar

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Progress in

Uptake ofPediatricMedicines

Shelly Malhotra and Joanna Breitstein

TB Alliance


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•

1 million children develop TB each year. 53million carry the TB infection, but don’t show

symptoms (yet).

• 140,000 children die each year of a disease that

can be prevented & treated.

• Child health and survival is improving, with

fewer deaths from diseases such as malaria and

pneumonia. But TB lingers, and lacks

attention/resources to the problem.

Childhood TB: Hiding in the shadows


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• In 2010, WHO changed their dosingrecommendations for children with TB,

but manufacturers were unresponsive

• With no appropriately-dosed, child-

friendly TB medicines, providers had to

cut, crush, or combine tablets toachieve desired dose

• Poor tasting medicines made

administration challenging and caused

vomiting, decreasing adherence

• Inconsistent administration fromcountry to country has meant there is

no unified response to the problem

Lack of consideration of the unique needs of children

Sub-optimal treatment for children


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• With investment from UNITAID and others,

and together with WHO and partners, TB

Alliance has announced availability of child-

friendly medicines in the correct doses

o Rifampicin 75 mg + Isoniazid 50 mg +

Pyrazinamide 150 mgo Rifampicin 75 mg + Isoniazid 50 mg

• Available through the Global Drug Facility

(GDF) and directly through the manufacturer

(Macleods)

•WHO Prequalification anticipated in mid 2016

• The average treatment cost is $15.54

Simple to use, affordable, and appropriately dosed

Child-Friendly FDCs Now Available


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Improving treatment for children


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• Registration: – Filings underway, with accelerated pathways being sought in some countries

– Registration secured in India and Cote d’Ivoire already

• Policy: –

Policy guidelines adopted in 19 of 22 high burden countries• Funding:

– Countries have proactively budgeted for pediatric procurement

– Gaps possible in supporting costs related to product transition

• Procurement: – Underway with 30,000,000 tablets ordered to date – Technical support being provided to facilitate phasing out of old treatment and

phasing in of new treatments

Progress in Introducing New Child-Friendly FDCs

From Availability to Uptake


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EVERY CHILD

HAS ACCESSTO THE NEWPRODUCT

ADVOCATES/CIVIL SOCIETY

- Encourage government to

register and adopt new products

- Advocate for scale up ofeffective childhood TB

interventions

COMMUNITY/PROVIDERS

- Integrate questions about TB into child healthscreening

- Ask about availability of child-friendlytreatments

- Scale up contact-tracing

GOVERNMENTS/HEALTH PROGRAMS

- Include Child TB in strategies and budgets

- Fast-track product registration

- Implement current guidelines

- Develop plans for phasing in improved

treatments

- Scale-up effective childhood TB interventions

DONORS

- Fund new treatments andintroduction related costs

- Support technical assistance tofacilitate transition

Everyone can play a role

Adoption-ready: Speeding access to new products


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There’s still work to be done

It’s time to get

Louder Than TB!


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Louder Than TB Campaign

Global leaders are joining forces with leaders from the private &public sectors and media to:

• Raise awareness of childhood TB as a critical issue on the

maternal and child health and survival agenda and as partof the Global Goals;

• Promote the need for integration of TB into other

maternal and childhood services at the country level to

find children with TB and treat them with the best

solutions available;

• Ensure the most vulnerable have access to TB prevention;

• Drive further investment in innovation of new TB drugs,

diagnostic tools, and vaccines


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10Introduction of Child-Friendly TB Medicines

Come Join Us on World TB Day & Beyond


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Come Join Us on World TB Day & Beyond


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Here’s how you can raise your voice

•

Visit LouderThanTB.org to learn more!•Join our Coalition of Partners!

•Post, share, follow the Campaign to raise the volume around

childhood TB on World TB Day, March 24th

•Stay tuned for future initiatives!

TB Alliance's presentation at World TB Day 2016 webinar

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